• Journal of Life Science
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• v.32 no.5
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• pp.331-339
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• 2022

Melanin is a pigment produced by melanocytes to protect the skin from external stimuli, mainly ultraviolet (UV) rays. However, abnormal and excessive production of melanin causes hyperpigmentation disorders, such as freckles, age spots, and discoloration. Natural cosmeceuticals are a new trend for treating or preventing hyperpigmentation due to fewer side effects and biocompatibility. In this context, the current study focused on Cnidium japonicum, a halophyte with several uses in folk medicine, to evaluate its potential as a skin-whitening agent. The effect of C. japonicum extract (CJE) on melanin production was analyzed in melanogenesis-stimulated B16F10 melanoma cells. The results showed that CJE successfully inhibited the oxidation of tyrosine and L-DOPA by tyrosinase and subsequently decreased the production of the key enzymes responsible for melanin production: tyrosinase, tyrosinase-related protein-1, and protein-2. This effect was confirmed by decreased intracellular and extracellular melanin levels in B16F10 melanoma cells after CJE treatment. Further experiments to elucidate the action mechanism revealed that CJE treatment suppressed melanin production by inhibiting the activation of glycogen synthase kinase 3 β (GSKβ)/β-catenin and protein kinase A (PKA)/cAMP-response element binding protein (CREB) pathways, which are the upstream activators of melanogenesis. In conclusion, the present study suggests that C. japonicum is a potential natural source of bioactive substances for the development of novel cosmeceuticals that can act against hyperpigmentation.

• Journal of the Korea Society of Computer and Information
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• v.28 no.1
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• pp.49-54
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• 2023

The Global Positioning System (GPS) was developed for military purposes and developed as it is today by opening civilian signals (GPS L1 frequency C/A signals). The current satellite orbits the earth about twice a day to measure the position, and receives more than 3 satellite signals (initially, 4 to calculate even the time error). The three-dimensional position of the ground receiver is determined using the data from the radio wave departure time to the radio wave Time of Arrival(TOA) of the received satellite signal through trilateration. In the case of navigation using GPS in recent years, a location error of 5 to 10 m usually occurs, and quite a lot of areas, such as apartments, indoors, tunnels, factory areas, and mountainous areas, exist as blind spots or neutralized areas outside the error range of GPS. Therefore, in order to acquire one's own location information in an area where GPS satellite signal reception is impossible, another method should be proposed. In this study, IMU(Inertial Measurement Unit) combined with an acceleration and gyro sensor and a geomagnetic sensor were used to design a system to enable location recognition even in terrain where GPS signal reception is impossible. A method to track the current position by calculating the instantaneous velocity value using a 9-DOF IMU and a geomagnetic sensor was studied, and its feasibility was verified through production and experimentation.

• Journal of the Korean Association of Geographic Information Studies
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• v.25 no.4
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• pp.81-93
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• 2022

There are many natural hot springs and mineral springs as well as the cultural heritage of the three kingdoms period in the Geum River basin including Chungcheong region. No specific regeneration and publicity plans for deteriorated facilities in this area has been presented. This study aims to suggest promising hot spots and complex water culture belt in the Chungcheong region and Geum River basin through the spatial interpretation of resources. The northern part of the Geum River basin is expected to become a therapeutic spring belt with many hot springs and CO₂-rich springs. In the central and southern parts of the Geum River basin, it is considered that it will be possible to promote convergence publicity by using groundwater resources and cultural assets.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.40 no.3
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• pp.46-56
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• 2022

This study aimed to analyze the locational characteristics of heritage sites in Seoul in order to identify flood susceptibility by type. As for the location factors related to flood susceptibility, elevation, slope, distance to streams, and topographic location were analyzed. Literature review was supplemented for the historical and humanistic environments of heritage sites. The results of the study are as follows. First, heritage sites in Seoul are distributed throughout the city, and are especially highly dense in the Hanyangdoseong fortress. It was also confirmed that heritage sites were concentrated around Jung-gu, Jongno-gu, Jingwan-dong, and Ui-dong in the quantitative spatial analyses. Second, types of heritage sites at the circumstance susceptible to flood damage were related to commerce and distribution, traffic, modern traffic and communication, geological monument, residence, government office, and palace. Third, heritage types with locational characteristics that showed low flood susceptibility were found to be natural scenic spots, telecommunication, ceramics, Buddhism, tombs, and tomb sculptural heritage assets. In a time when risk factors that can damage the value of heritage are gradually increasing due to anthropogenic influences along with changes in the natural environment, this study provides basic data for vulnerability analysis that reflects the unique characteristics of heritage assets. The results can contribute to more comprehensive and comprehensive insights for the management and protection of heritage by including the humanities and social science data together with natural factors in the analysis.

• The Journal of the Convergence on Culture Technology
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• v.8 no.5
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• pp.641-651
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• 2022

This research compares and analyzes evacuation time depending on the change in stair width in case of fire at Goshiwons. For this, a simulation has been conducted based on possible evacuation time according to the calculation method for the number of people admittable to a specific target for fire fighting equipped with accommodation. Currently, Gosiwon, which is classified as an accommodation facility (a total floor area of 500 m² or more), uses blind spots prescribed by the Fire Services Act, Building Act, and Parking Act to build a high-rise building on a small area of land, and most Gosiwon is transformed into a modified accommodation. This is in line with the owner's operating profit, so it is expected to show a continuous increase. Securing the golden time of Gosiwon evacuation time is the last bastion of Gosiwon residents who belong to the economically disadvantaged in our society, and we hope this study will serve as a starting point for discussions on revising related laws and regulations to establish a social safety net As a result of the evacuation simulation analysis, the evacuation time was the least when the width of the group and the evacuation stairs were expanded to 200cm, and the evacuation time of the existing building was reduced by up to 166.3 seconds by comparing 648.4 seconds and scenario 6. This analysis can be meaningful, in that the width of the evacuation stairs revision of related laws and regulations for the safety of multiplex available premises.

• Journal of the Society of Disaster Information
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• v.19 no.1
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• pp.117-127
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• 2023

Purpose: The number of Cold Storages at home and abroad is on the rise, fires in large Cold Storages have recently occurred. As fires continue to occur and property damage is on the rise every year, the importance of preventing fires in large Cold Storage is growing. Method: Real Cold Storages were investigated on-site and fire cases were analyzed to derive and analyze fire risk, and the ORS, which is emerging as an adaptive fire prevention technology of Cold Storage, was investigated through FDS. Result: oxygen concentration 21, 15.7% and 17.7, 16.7% were analyzed through FDS, and flashover was reached within 3~4 minutes from 21, 17.7, 16.7%, but if oxygen concentration was lowered to 15.7%, it didn't ignite for 13 minutes. Conclusion: This study understood the concept and general part of the ORS, modeled the freezer through FDS, and analyzed the oxygen concentration to analyze the fire protection adaptability of the ORS. In the future, it is expected that large-scale empirical experiments and related regulations will be prepared to provide solutions for fire prevention in Cold Storages in blind spots of fire.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.67 no.4
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• pp.211-221
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• 2022

Recently, the demand for the cultivation of upland soil has been increasing, and the rate of conversion of paddy soil into upland soil is also increasing. Theincrease in uneven precipitation due to climate change has resulted in dramatic effects of waterlogging stress on upland crops. Therefore, the present study was conducted to investigate the changes in growth characteristics and the expression patterns of proteins at the two-leaf stage of adzuki beans. The domestic cultivar, Arari (Miryang No. 8), was used to test waterlogging stress. At the two-leaf stage of adzuki beans, plant height slightly decreased androot fresh weight showed significant changes after 3 days of waterlogging treatment. Chlorophyll content was also significantly different after 3 days of waterlogging treatment compared to its content in control plants. Using two-dimensional gel electrophoresis, more than 400 protein spots were identified. Twenty-one differentially expressed proteins from the two-leaf stage were analyzed using linear trap quadrupole-Fourier transform-ion cyclotron resonance mass spectrometry. Of these 21 proteins, 9 were up-regulated and 12 were down-regulated under waterlogging treatment. Protein information resource (https://pir.georgetown.edu/) categories were assigned to all 49 proteins according to their molecular function, cellular component localization, and biological processes. Most of the proteins were found to be involved in the biological process, carbohydrate metabolism and were localized in chloroplasts.

• The Korean Society of Law and Medicine
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• v.24 no.1
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• pp.101-130
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• 2023

Korea has very easy access to tertiary hospitals, including university hospitals, among OECD countries, and patients can reach the emergency room of a university hospital within 1-2 hours. However, there are many so-called 'essential medical' blind spots where people die because they do not receive surgery in time. In particular, in the case of essential medical care in the surgical field, despite basic surgery, there is a shortage of medical staff to perform outpatient surgery in emergency situations at university hospitals. Although this lack of manpower has a problem with low insurance premiums for surgery, it also has a very large impact on the burden of criminal liability for medical malpractice, which increases the incidence in case of emergencies. Here, we propose crime immunity to solve the manpower shortage of converged smart surgical essential medical (SES) hospitals. Currently, the medical community agrees on the need for crime immunity, but it is an ambiguous scope of immunity that has not reached a national consensus. We would like to present clear standards for essential medical practices (surgery) that require criminal immunity.

• Journal of Korea Entertainment Industry Association
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• v.13 no.4
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• pp.185-194
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• 2019

The purpose of this study is to examine the effects of short-term foresters on brain waves and pulse waves. For this purpose, 484 foresters who visited the natural recreation forest located in Cheongpyeong city, Gyeonggi province, measured the before and after experiences of EEG and pulse waves, and the following results were obtained. First, foresters have been shown to be effective on concentration, brain activity, and brain stress. Second, foresters had positive effects on cardiac health and autonomic health. In other words, when various substances released from the forest come into the body through the respiratory system, it firstly affects the heart activity positively, and it seems to be able to expect various improvements by acting on the emotional side of the brain. Therefore, based on the scientific basis of the forest experience, it is expected that the experience of forests will be widely used as a guide for healthy life by creating conditions for participation by many people. In addition, the mechanism of respiration, heartbeat, and brain interaction is also possible, and various experimental studies on the forest experience in the future are important.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.05a
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• pp.50-53
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• 2022

Recently, there have been cases in which counterfeit foreign ships have entered and left domestic ports several times. Vessels have a ship-specific serial number given by the International Maritime Organization (IMO) to identify the vessel, and IMO marking is mandatory on all ships built since 2004. In the case of airports and ports, which are representative logistics platforms, a security system is essential, but it is difficult to establish a security system at a port and there are many blind spots, which can cause security problems due to insufficient security systems. In this paper, a port security system is designed using deep learning object recognition and OpenCV. The security system process extracts the IMO number of the ship after recognizing the object when entering the ship, determines whether it is the same ship through feature point matching for ships with entry records, and stores the ship image and IMO number in the entry/exit DB for the first arrival vessel. Through the system of this paper, port security can be strengthened by improving the efficiency and system of port logistics by increasing the efficiency of port management personnel and reducing incidental costs caused by unauthorized entry.