• Journal of Astronomy and Space Sciences
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• v.30 no.4
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• pp.223-230
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• 2013

Sudden enhancements of daytime NmF2 appeared in Anyang ionosonde data during summer seasons in 2006-2007. In order to investigate the causes of this unusual enhancement, we compared Anyang NmF2's with the total electron contents (GPS TECs) observed at Daejeon, and also with ionosonde data at at mid-latitude stations. First, we found no similar increase in Daejeon GPS TEC when the sudden enhancements of Anyang NmF2 occurred. Second, we investigated NmF2's observed at other ionosonde stations that use the same ionosonde model and auto-scaling program as the Anyang ionosonde. We found similar enhancements of NmF2 at these ionosonde stations. Moreover, the analysis of ionograms from Athens and Rome showed that there were sporadic-E layers with high electron density during the enhancements in NmF2. The auto-scaling program (ARTIST 4.5) used seems to recognize sporadic-E layer echoes as a F2 layer trace, resulting in the erroneous critical frequency of F2 layer (foF2). Other versions of the ARTIST scaling program also seem to produce similar erroneous results. Therefore we conclude that the sudden enhancements of NmF2 in Anyang data were due to the misrecognition of sporadic-E echoes as a F-layer by the auto-scaling program. We also noticed that although the scaling program flagged confidence level (C-level) of an ionogram as uncertain when a sporadic-E layer occurs, it still automatically computed erroneous foF2's. Therefore one should check the confidence level before using long term ionosonde data that were produced by an auto-scaling program.

• Journal of Astronomy and Space Sciences
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• v.36 no.2
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• pp.61-68
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• 2019

We have investigated the variations of sporadic E (Es) layer using the measurements of digisondes at Icheon ($37.14^{\circ}N$, $127.54^{\circ}E$, IC) and Jeju ($33.4^{\circ}N$, $126.30^{\circ}E$, JJ) in 2011-2018. The Es occurrence rate and its critical frequency (foEs) have peak values in summer at both IC and JJ in consistent with their known seasonal variations at mid-latitudes. The virtual height of the Es layer (h'Es) during equinox months is greater than that in other months. It may be related to the similar variation of meteor peak heights. The h'Es shows the semidiurnal variations with two peaks at early in the morning and late in the afternoon during equinoxes and summer. However, the semi-diurnal variation is not obvious in winter. The semi-diurnal variation is generally thought to be caused by the semi-diurnal tidal variation in the neutral wind shear, whose measurements, however, are rare and not available in the region of interest. To investigate the formation mechanism of Es, we have derived the vertical ion drift velocity using the Horizontal Wind Model (HWM) 14, International Geomagnetic Reference Field, and Naval Research Laboratory Mass Spectrometer and Incoherent Scatter Radar-00 models. Our results show that h'Es preferentially occur at the altitudes where the direction of the vertical ion velocity changes. This result indicates the significant role of ion convergence in the creation of Es.

• Journal of Astronomy and Space Sciences
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• v.32 no.2
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• pp.137-140
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• 2015

The results of the study of ionospheric variations in the summer months of 1998-2002 at an ionospheric station of vertical sounding "Petropavlovsk-Kamchatsky" are presented. Anomalous variations of virtual sporadic-E height (h'Es), Es blanketing frequency (fbEs), and the critical frequency of the ionospheric F2 layer (foF2) (which can be attributed to the possible earthquake precursors) are selected. The high efficiency of the selection of ionospheric earthquake precursors based on the several parameters of Es and F2 layers is shown. The empirical dependence, which reflects the connection between the lead-time of the earthquake moment, the distance to the epicenter from the observation point, and the magnitude of the earthquake are obtained. This empirical dependence is consistent with the results of the detection of earthquake precursors by measuring the physical parameters of the Earth's crust in the same region.

• Kyungpook Mathematical Journal
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• v.60 no.2
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• pp.255-277
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• 2020

Divide knots and links, defined by A'Campo in the singularity theory of complex curves, is a method to present knots or links by real plane curves. The present paper is a sequel of the author's previous result that every knot in the major subfamilies of Berge's lens space surgery (i.e., knots yielding a lens space by Dehn surgery) is presented by an L-shaped curve as a divide knot. In the present paper, L-shaped curves are generalized and it is shown that every knot in the minor subfamilies, called sporadic examples of Berge's lens space surgery, is presented by a generalized L-shaped curve as a divide knot. A formula on the surgery coefficients and the presentation is also considered.

• Publications of The Korean Astronomical Society
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• v.15 no.spc2
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• pp.21-25
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• 2000

The ionosphere, the atmosphere of the earth ionized by solar radiations, has been strongly varied with solar activity. The ionosphere varies with the solar cycle, the seasons, the latitudes and during any given day. Radio wave propagation through or in the ionosphere is affected by ionospheric condition so that one needs to consider its effects on operating communication systems normally. For examples, sporadic E may form at any time. It occurs at altitudes between 90 to 140 km (in the E region), and may be spread over a large area or be confined to a small region. Sometimes the sporadic E layer works as a mirror so that the communication signal does not reach the receiver. And radiation from the Sun during large solar flares causes increased ionization in the D region which results in greater absorption of HF radio waves. This phenomenon is called short wave fade-outs. If the flare is large enough, the whole of the HF spectrum can be rendered unusable for a period of time. Due to events on the Sun, sometimes the Earth's magnetic field becomes disturbed. The geomagnetic field and the ionosphere are linked in complex ways and a disturbance in the geomagnetic field can often cause a disturbance in the F region of the ionosphere. An enhancement will not usually concern the HF communicator, but the depression may cause frequencies normally used for communication to be too high with the result that the wave penetrates the ionosphere. Ionospheric storms can occur throughout the solar cycle and are related to coronal mass ejections (CMEs) and coronal holes on the Sun. Except the above mentioned phenomena, there are a lot of things to affect the radio communication. Nowadays, radio technique for probing the terrestrial ionosphere has a tendency to use satellite system such as GPS. To get more accurate information about the variation of the ionospheric electron density, a TEC measurement system is necessary so RRL will operate the system in the near future.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6403-6409
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• 2013

Purpose: Biallelic germline variants of the 8-hydroxyguanine (8-OG) repair gene MYH have been associated with colorectal neoplasms that display somatic $G:C{\rightarrow}T:A$ transversions. However, the effect of single germline variants has not been widely studied, prompting the present investigation of monoallelic MYH variants and susceptibility to sporadic colorectal cancer (CRC) in a Chinese population. Patients and Methods: Between January 2006 and December 2012, 400 cases of sporadic CRC and 600 age- and sex-matched normal blood donors were screened randomly for 7 potentially pathogenic germline MYH exons using genetic testing technology. Variants of heterozygosity at the MYH locus were assessed in both sporadic cancer patients and healthy controls. Univariate and multivariate analyses were performed to determine risk factors for cancer onset. Results: Five monoallelic single nucleotide polymorphisms (SNPs) were identified in the 7 exon regions of MYH, which were detected in 75 (18.75%) of 400 CRC patients as well as 42 (7%) of 600 normal controls. The region of exon 1 proved to be a linked polymorphic region for the first time, a triple linked variant including exon 1-316 $G{\rightarrow}A$, exon 1-292 $G{\rightarrow}A$ and intron 1+11 $C{\rightarrow}T$, being identified in 13 CRC patients and 2 normal blood donors. A variant of base replacement, intron 10-2 $A{\rightarrow}G$, was identified in the exon 10 region in 21 cases and 7 controls, while a similar type of variant in the exon 13 region, intron 13+12 $C{\rightarrow}T$, was identified in 8 cases and 6 controls. Not the only but a newly missense variant in the present study, p. V463E (Exon 14+74 $T{\rightarrow}A$), was identified in exon 14 in 6 patients and 1 normal control. In exon 16, nt. 1678-80 del GTT with loss of heterozygosity (LOH) was identified in 27 CRC cases and 26 controls. There was no Y165C in exon 7 or G382D in exon 14, the hot-spot variants which have been reported most frequently in Caucasian studies. After univariate analysis and multivariate analysis, the linked variant in exon 1 region (p=0.002), intron 10-2 $A{\rightarrow}G$ (p=0.004) and p. V463E (p=0.036) in the MYH gene were selected as 3 independent risk factors for CRC. Conclusions: According to these results, the linked variant in Exon 1 region, Intron 10-2 $A{\rightarrow}G$ of base replacement and p. V463E of missense variant, the 3 heterozygosity variants of MYH gene in a Chinese population, may relate to the susceptibility to sporadic CRC. Lack of the hot-spot variants of Caucasians in the present study may due to the ethnic difference in MYH gene.

• Korean Journal of Clinical Laboratory Science
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• v.38 no.3
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• pp.179-183
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• 2006

Alzheimer's disease (AD) is characterised neuropathologically by the accumulation of neuritic plaques and neurofibrillary tangles as well as by cerebrovascular amyloid deposition and neuronal cell loss. Current advances have shown the apolipoproteinE-epsilon 4 (ApoE4) allele to be highly associated with late-onset familial and sporadic Alzheimer's disease (AD) in Western populations. The association of ApoE allele frequencies and dementia remains unknown in populations from many countries. We recently initiated a project to examine ApoE frequencies in non-demented healthy Koreans. Genomic DNA in hair root from a thousand persons was collected and ApoE gene type was investigated with the methods of polymerase chain reaction (PCR) and restriction fragment length polymorphism. A group of a thousand non-demented Koreans over the age of 40 years were found to be positive in 15.7% of the cases for ApoE4. AD and ApoE4 were closely related. ApoE epsilon 4 was a dangerous factor of AD and ApoE 4 allele made a contribution to the heterogenicity of AD.

• Journal of Microbiology and Biotechnology
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• v.27 no.10
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• pp.1727-1735
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• 2017

Hepatitis E virus (HEV) infections cause epidemic or sporadic acute hepatitis, which are mostly self-limiting. However, viral infection in immunocompromised patients and pregnant women may result in serious consequences, such as chronic hepatitis and liver damage, mortality of the latter of which reaches up to 20-30%. Type I interferon (IFN)-induced antiviral immunity is known to be the first-line defense against virus infection. Upon HEV infection in the cell, the virus genome is recognized by pathogen recognition receptors, leading to rapid activation of intracellular signaling cascades. Expression of type I IFN triggers induction of a barrage of IFN-stimulated genes, helping the cells cope with viral infection. Interestingly, some of the HEV-encoded genes seem to be involved in disrupting signaling cascades for antiviral immune responses, and thus crippling cytokine/chemokine production. Antagonistic mechanisms of type I IFN responses by HEV have only recently begun to emerge, and in this review, we summarize known HEV evasion strategies and compare them with those of other hepatitis viruses.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2003.10a
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• pp.28-28
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• 2003

Hepatitis E virus (HEV), previously referred to as enterically transmitted non-A, non-B hepatitis, is responsible for sporadic infections as well as large epidemics of acute viral hepatitis in developing countries. The disease generally affects young adults and reportedly has a mortality rate of up to 20％ in infected pregnant women. HEV was once considered to be a member of the family Caliciviridae, but the unique genomic organization of HEV has led to the removal of HEV from the family and it was provisionally classified in an unassigned family of HEV-like viruses. In situ hybridization provides any cellular detail and histological architecture.[1] However, use of in situ hybridization is largely restricted to the laboratories because this technique is the greater technical complexity and expense compared with immunohistochemistry. Therefore, the objective of this study is to develop the immunohistochemistry for the detection of swine HEV from formalin-fixed, paraffin-embedded hepatic tissues. (omitted)

• Journal of Genetic Medicine
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• v.3 no.1
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• pp.29-32
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• 1999

The Apolipoprotein E type 4 allele (ApoE ${\varepsilon}4$) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease. The BchE-k variant, which is the common variant of the BchE gene, has been reported to show allelic association with AD in subjects who are also carriers of the ${\varepsilon}4$ allele of the ApoE, especially in subjects over the age of 75. This study was performed to evaluate the distribution of the ApoE and the BchE genotypes in the healthy and AD groups and to evaluate the synergy between the BchE-k variant and the ApoE ${\varepsilon}4$ in AD. The ApoE and the BchE genotypes were determined in DNA samples from 610 healthy people and 60 LOAD patients by using ARMS by standard agarose gel electrophoresis. The effect of the ApoE ${\varepsilon}4$ was closely related to AD(p<0.05). A comparison between the AD patients and the healthy individuals, both with the ${\varepsilon}4$ allele, indicated an interaction between the BchE-k and the ApoE ${\varepsilon}4$(p<0.05). The association of the BchE-k with AD was limited to carriers of the ApoE ${\varepsilon}4$ allele, among whom the presence of the BchE-k gave an odds ratio of AD 3.48 (95% C.I. 1.3-9.2). Therefore, these results suggested that further evidence of an association between the ApoE ${\varepsilon}4$ and LOAD, and the BchE-k acts in synergy with the ApoE ${\varepsilon}4$ as a susceptibility gene for AD.