• The Transactions of the Korean Institute of Electrical Engineers D
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• v.54 no.11
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• pp.643-649
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• 2005

A heart diagnosis system adopts Superconducting Quantum Interface Device(SQUD) sensors for precise MCG(MagnetoCardioGram) signal acquisitions. Such system needs to deal with hundreds of sensors, requiring fast signal sampling md precise analog-to-digital conversions(ADC). Our development of hardware board, processing 64-channel 12-bit in 1 ks/s speed, is built by using 8-channel ADC chips, 8-bit microprocessors, SPI interfaces, and specially designed parallel data transfers between microprocessors to meet the 1ks/s, i.e. 1 mili-second sampling interval. We extend the design into 256-channel hardware and analyze the speed .using the measured data from the 64-channel hardware. Since our design exploits full parallel processing, Assembly level coding, and NOP(No Operation) instruction for timing control, the design provides expandability and lowest system timing margin. Our result concludes that the data collection with 256-channel analog input signals can be done in 201.5us time-interval which is much shorter than the required 1 mili-second period.

• Proceedings of the Korea Information Processing Society Conference
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• 2017.11a
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• pp.1267-1270
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• 2017

이 논문에서는 라즈베리파이카메라를 이용하여 실내 흡연감지를 실시간으로 모니터링하는 시스템을 제안한다. 기존에 라즈베리파이에 가스센서를 SPI 통신으로 연결하여 실외 흡연감지 기능을 제공하는 시스템에 대한 연구가 진행되었다. 그러나 기존의 시스템은 부정확한 센서 값의 원인과 흡연이 감지되어도 흡연자를 조치하는 부분에 대한 문제점이 있다. 이 논문에서 제안하는 것은 연기센서, 가스센서를 시리얼통신으로 연결하여 공공장소 실내 흡연여부를 판단해 라즈베리파이카메라를 사용하여 실시간으로 흡연감지 하는 시스템을 제안한다. 이 논문에서 제안 시스템은 공공장소에서 실내흡연을 감지하고 이미지조회기능으로 보다 더 신뢰성있는 흡연감지 시스템에 대해 기대된다.

• IEMEK Journal of Embedded Systems and Applications
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• v.14 no.1
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• pp.33-41
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• 2019

We propose an embedded solution to design a high-speed and high-accuracy 16bit analog-digital signal processing interface for the control systems using various external analog signals. Choosing TMS320F28377D micro controller unit (MCU) featuring high-performance processing in the 32-bit floating point operation, low power consumption, and various I/O device supports, we design and build the proposed system that supports both 16-bit analog-digital converter (ADC) interface and high precision digital-analog converter (DAC) interface. The ADC receives voltage-level differential signals from fully differential amplifiers, and the DAC communicates with MCU through 50 MHz bandwidth high-fast serial peripheral interface (SPI). We port the boot loader and device drivers to the implemented board, and construct the firmware development environment for the application programming. The performance of the entire implemented system is demonstrated by analog-digital signal processing tests, and is verified by comparing the test results with those of existing similar systems.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.380-380
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• 2019

본 연구에서는 일반 상호보완이론(Generalized Complementary Relationship, GCR)을 활용하여 실제증발산량을 추정하고, 추정한 실제증발산량기반 가뭄지수로부터 미국 전역에 대한 가뭄을 해석하는 것이다. 월강수량, 최고 최저기온, 이슬점온도 등의 필요한 기상자료는 Parameter-elevation Relationships on Independent Slopes Model(PRISM)으로부터 수집하였으며, 1981년부터 2015년까지 총 35년의 미국 전역에 대한 실제증발산량을 추정하였다. 대상지역의 유역평균 강수량과 유출량의 차(P-Q)와 North American Land Data Assimilation System(NLDAS-2) Noah 지표모형(Land surface models)으로 산정한 실제증발산량과 비교 검증하였다. GCR로부터 증발산 부족량(ET Deficit, ETD)을 산정하고 이를 표준정규화하여 미국 전역에 대해 Standardized Evapotranspiration Deficit Index(SEDI)를 산정하였다. 본 연구로부터 GCR 기반 실제증발산량은 P-Q의 값과 상관계수가 0.94로 매우 높은 상관성을 보였으며, NLDAS-2 Noah모형의 실제증발산량보다 다소 크게 추정하는 경향을 보였다. SEDI와 Standard Precipitation Index(SPI)의 상관성은 지속시간이 클수록 더 크게 나타났다. 증발산 상호보완이론활용 실제증발산기반 SEDI이 강수자료를 사용하지 않고서도 적절한 가뭄해석에 이용될 수 있을 것으로 판단된다.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.386-386
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• 2019

가뭄은 홍수와 더불어 주요한 자연재해로 댐이나 저수지의 저수량 저하에 따른 여러 피해를 야기한다. 특히, 용수의 대부분을 댐에서 공급받는 우리나라의 특성상 용수공급중단 등의 큰 피해를 야기할 가능성이 있다. 그러나. 기상학적 가뭄이 널리 사용되고 있는 것에 비하여 댐과 저수지의 가뭄은 예측의 난해함을 이유로 상대적으로 연구되지 않고 있으며, 현재 저수량을 기준으로 하여 소극적인 가뭄대응만이 이루어지고 있다. 이에 본 연구에서는 댐과 저수지 가뭄의 대응시간을 확보하고 수자원의 효율적인 활용을 위하여 댐 저수지 가뭄예측을 위한 연구를 수행하였다. 이를 위하여 기상학적 가뭄에 사용되어진 표준강수지수(SPI)와 동일한 개념을 댐 물수지에 적용한 표준물수지지수(Standardzied Balanced Index; SBI)를 제안하였다. 또한, 산정된 물수지 현황과 현저수량과 인공신경망을 활용하여 향후 댐의 저수량을 예측하기 위한 모형을 구축하였으며, 그 적용성을 검증하였다. 연구결과에 따르면 1개월 단위로 향후 댐의 저수량 경향성을 예측할 수 있는 것으로 나타났다.

• Proceedings of the Korea Information Processing Society Conference
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• 2021.05a
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• pp.96-99
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• 2021

NVRAM(Non-volatile RAM)이란 전원을 공급하지 않아도 데이터를 유지할 수 있는 RAM 이다. 비휘발성 메모리이기 때문에 Flash 와 동일한 기능을 제공할 수 있다. 또한 Flash 에 비해 저전력으로 동작하고, 읽고 쓰는 동작도 더 빠르며 내구성까지 뛰어나다. 즉, NVRAM 은 리소스가 제한적인 사물인터넷(IoT) 장치에서 Flash 를 대신하여 전력소모 및 지연시간 측면에서 효과적으로 사용될 수 있는 메모리이다. IoT 장치는 일반적으로 배터리와 같은 독립전원 장치로 작동하거나, 최근에는 에너지 하베스터를 활용한 간헐적 컴퓨팅 방식도 활용되고 있다. 간헐적 컴퓨팅 방식에서는 전원이 꺼졌을 때도 프로그램의 상태를 유지하기 위해 비휘발성 메모리에 백업동작이 필수적이다. 그러므로 백업을 위한 메모리를 Flash 가 아닌 NVRAM 으로 대체하게 되면 효율적이고, 상대적으로 백업 및 복구에 의한 비휘발성 메모리에 접근이 많은 간헐적 컴퓨팅에서는 더 큰 효율을 볼 수 있다. 하지만 현재 NVRAM 이 내장된 개발보드가 제한적이고, NVRAM 을 외부 모듈로서 사용하기 위해 SPI 또는 I2C 통신을 사용해야 한다. 그 외에도 동시에 공유 메모리에 접근하는 등의 문제를 막아야 한다. 이러한 문제를 막고, NVRAM 을 편리하게 사용할 수 있도록 추상화 계층을 만들어 NVRAM 테스팅 환경을 제공하여 해당 분야의 연구개발을 가속화할 수 있을 것으로 기대된다. 본 논문에서는 NVRAM 의 한 종류인 FRAM 을 사용하여 추상화 계층을 구현하였다.

• Proceedings of the KSAR Conference
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• 2001.03a
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• pp.19-19
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• 2001

Mammalian urothelium undergoes unique membrane specialization by making the asymmetric unit membrane (AUM) that is covered with the apical cell surface during terminal differentiation. The AUM contains several major integral membrane proteins including uroplakin Ia, Ib, II and III. The genes for uroplakins have been cloned from humans and mice, but not from porcine. In this study, we report the cloning of the UPII genomic DNA, which codes for the full length open reading frame for the uroplakin II protein. The deduced amino acid sequence encodes of a hydrophobic NH$_2$-terminal peptide, a prosequence, and a mature protein. The prosequence contains three potential N-glycosylation sites and a RGRR cleavage site that may be involved in uroplakin II processing and maturation. Northern and immunohistochemistry analyses showed that the porcine UPII gene is only expressed in urothelium and that the protein was specifically localized in urothelial superficial cells. A 2kb of upstream in the promoter sequence contains multiple transcription factor binding sites, including GC-box, SPI, AP2, and GATA-box sites, but not for TATA or CAAT-box sequences. Comparison of the porcine UPII promoter sequence with that of the murine by MEME system presented two conserved motifs, suggesting a cis-acting regulatory role for the conserved sequences. Sequence homology between two species in motif A and B was 79% and 80% respectively, although their relative locations were different. During the gestation, mouse bladder at estrus stages and day 10 after parturition showed higher UPII expression, while showed lower expression at peri-implantation stage. Taken together, our results showed that the porcine UPII gene was expressed highly and specifically in the bladder urothelium and that steroid hormones for implantation changed the expression of UPII in the bladder, although the biological significance of UPII remains to be not determined.

• Clinical and Experimental Vaccine Research
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• v.12 no.2
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• pp.156-171
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• 2023

Purpose: The development of vaccines that confer protection against multiple avian influenza A (AIA) virus strains is necessary to prevent the emergence of highly infectious strains that may result in more severe outbreaks. Thus, this study applied reverse vaccinology approach in strategically constructing messenger RNA (mRNA) vaccine construct against avian influenza A (mVAIA) to induce cross-protection while targeting diverse AIA virulence factors. Materials and Methods: Immunoinformatics tools and databases were utilized to identify conserved experimentally validated AIA epitopes. CD8⁺ epitopes were docked with dominant chicken major histocompatibility complexes (MHCs) to evaluate complex formation. Conserved epitopes were adjoined in the optimized mVAIA sequence for efficient expression in Gallus gallus. Signal sequence for targeted secretory expression was included. Physicochemical properties, antigenicity, toxicity, and potential cross-reactivity were assessed. The tertiary structure of its protein sequence was modeled and validated in silico to investigate the accessibility of adjoined B-cell epitope. Potential immune responses were also simulated in C-ImmSim. Results: Eighteen experimentally validated epitopes were found conserved (Shannon index <2.0) in the study. These include one B-cell (SLLTEVETPIRNEWGCR) and 17 CD8⁺ epitopes, adjoined in a single mRNA construct. The CD8⁺ epitopes docked favorably with MHC peptidebinding groove, which were further supported by the acceptable ∆G_bind (-28.45 to -40.59 kJ/mol) and Kd (<1.00) values. The incorporated Sec/SPI (secretory/signal peptidase I) cleavage site was also recognized with a high probability (0.964814). Adjoined B-cell epitope was found within the disordered and accessible regions of the vaccine. Immune simulation results projected cytokine production, lymphocyte activation, and memory cell generation after the 1st dose of mVAIA. Conclusion: Results suggest that mVAIA possesses stability, safety, and immunogenicity. In vitro and in vivo confirmation in subsequent studies are anticipated.

• Speech Sciences
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• v.10 no.4
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• pp.201-219
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• 2003

Background: The perceptual assessment is generally performed by the voice specialist. The objective evaluation is performed in a voice laboratory. Research in voice laboratories has generated a variety of different objective tests and parameters. The perceptual evaluation is one of the most controversial topics in voice research. Review of literature reveals a wide variety of rating scales and reliability data fluctuating from study to study. Unfortunately, there is no widely accepted valid method for classifying voice disorders and assessing outcome after voice treatment. Objectives: The goals of this research were to identify important objective acoustic parameters of vocal quality, and to establish an objective and quantitative correlate of the perceived vocal quality. Materials and Methods : We evaluated the voice analyzed data from 122 dysphonic patients and 20 normal volunteers. A computerized speech lab. 4300B(CSL) was used to carry out the analysis of each voice sample. Results: Three dysphonia severity indices(DSI) were created using discriminant analysis. DSI is based on the weighted combination of the following selected set of acoustic parameters: absolute jitter(Jita in us), smoothed pitch period perturbation (sPPQ in %), amplitude perturbation quotient(APQ in %), soft phonation index(SPI), average fundamental frequency(Fo in Hz), lowest fundamental frequency(Flo in Hz), and smoothed amplitude perturbation quotient(sAPQ in %). The DSI, being the discriminating rule calculated by the logistic regression, consists of three equation based on statistically significant acoustic parameters. Three DSI were created to reflects best the degree of hoarseness as expressed by G from the GRBAS scale. The more positive this DSI is for a patient, the worse the vocal quality. The more it is negative, the better it is. The effect of sex is included implicitly in the DSI-1 and DSI-2, so that a separate DSI-1 and DSI-2 for males and females need not be used. The DSI is objective because no perceptual input is required for its calculation. Conculsion : This research demonstrates that the voice function values calculated from three different multivariate objective dysphonia severity indices are significantly associated with subjective voice assessments. These multivariate objective dysphonia severity indices may be appropriate for use in clinical trials and outcomes research on treatment effectiveness for voice disorders.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2007.11a
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• pp.77-82
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• 2007

This paper discusses on implementation methods for providing data exchange capability of the Construction Project Lifecycle Management System (CPLM). Because most information media currently used in the construction industry are computer files, the system must be capable of handling various file types; however, The goals of PLM cannot be achieved if the contents of the files are communicated freely, which can only be achieved using a standardized information model that has comprehensive coverage of all information produced within the projects (i.e., a BlM). Several methods of adopting the model are investigated here, and a transitional implementation method for K-IFC is suggested, in which a file-based exchange backed by the BlM can evolve into object-level transactions of the BIM with not only advanced data integrity and security, but also improved communications between the project participants.