• Journal of the Korean Data and Information Science Society
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• v.27 no.1
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• pp.225-243
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• 2016

Thanks to recent advance of next generation sequencing techniques, RNA-seq enabled to have an unprecedented opportunity to identify transcript variants with isoform diversity and allelic imbalance (Anders et al., 2012) by different transcriptional rates. To date, it is well known that those features might be associated with the aberrant patterns of disease complexity such as tissue (Anders and Huber, 2010; Anders et al., 2012; Nariai et al., 2014) specific differential expression at isoform levels or tissue specific allelic imbalance in mal-functionality of disease processes, etc. Nevertheless, the knowledge of post-transcriptional modification and AI in transcriptomic and genomic areas has been little known in the traditional platforms due to the limitation of technology and insufficient resolution. We here stress the potential of isoform variability and allelic specific expression that are relevant to the abnormality of disease mechanisms in transcriptional genetic regulatory networks. In addition, we systematically review how robust Bayesian approaches in RNA-seq have been developed and utilized in this regard in the field.

• ETRI Journal
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• v.26 no.1
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• pp.7-13
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• 2004

To improve the characteristics of breakdown voltage and specific on-resistance, we propose a new structure for a LDMOSFET for a PDP scan driver IC based on silicon-on-insulator with a trench under the gate in the drift region. The trench reduces the electric field at the silicon surface under the gate edge in the drift region when the concentration of the drift region is high, and thereby increases the breakdown voltage and reduces the specific on-resistance. The breakdown voltage and the specific on-resistance of the fabricated device is 352 V and $18.8 m{\Omega}{\cdot}cm^2$ with a threshold voltage of 1.0 V. The breakdown voltage of the device in the on-state is over 200 V and the saturation current at $V_{gs}=5V$ and $V_{ds}$=20V is 16 mA with a gate width of $150{\mu}m$.

• The Journal of Information Systems
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• v.18 no.2
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• pp.35-59
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• 2009

The study of Information Systems(IS) is a relatively new discipline area, thus an analysis of the latest research literature could be useful to identify what the researchers are doing and what can be done to improve our discipline. With that purpose in mind, this study analyzes the total 208 articles published in "The Journal of Information Systems~ between 2001 and 2008. The classification system that comprises three key characteristics of diversity (research topic, research method, and reference discipline) was developed based on a review of prior literature. The results of this study were also compared with Kim et al.(2005)'s and Vessey et al.(2002)'s results to identify issues in current Information Systems research and 10 suggest some recommendations for future In formation Systems research. The findings identify popular research topic:s, the dominant research method, and reference discipline. The popular research topics consists of organizational concepts, problem domain-specific concepts, and systems/software management concepts. Field study was characterized as the dominant research method in the papers included in the study. Information Systems itself represents the major theoretical reference of the studies. However, many papers in this study relied on a number of reference disciplines., none of which was dominant, or they did not rely on a specific reference discipline. Finally, this study suggests more research on the disciplinary issues, more training on the research method, more accurate and specific reference discipline, and controlled diversity.

• Membrane and Water Treatment
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• v.2 no.4
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• pp.239-250
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• 2011

A photovoltaic powered ultrafiltration and reverse osmosis system was tested with a number of natural groundwaters in Australia. The objective of this study was to compare system performance at six remote field locations by assessing the impact of water composition and fluctuating energy on inorganic contaminant removal using a BW30-4040 membrane. Solar irradiance directly affected pressure and flow. Groundwater characteristics (including TDS, salts, heavy metals, and pH), impacted other performance parameters such as retention, specific energy consumption and flux. During continual system operation, retention of ions such as $Ca^{2+}$ and $Mg^{2+}$ was high (> 95%) with each groundwater which can be attributed to steric exclusion. The retention of smaller ions such as $NO_3{^-}$ was affected by weather conditions and groundwater composition, as convection/diffusion dominate retention. When solar irradiance was insufficient or fluctuations too great for system operation, performance deteriorated and retention dropped significantly (< 30% at Ti Tree). Groundwater pH affected flux and retention of smaller ions ($NO_3{^-}$ and $F^-$) because charge repulsion increases with pH. The results highlight variations in system performance (ion retention, flux, specific energy consumption) with real solar irradiance, groundwater composition, and pH conditions.

• Nuclear Medicine and Molecular Imaging
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• v.40 no.2
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• pp.74-81
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• 2006

Molecular targeting may be defined as the specific concentration of a diagnostic or therapeutic tracer by its Interaction with a molecular species that is distinctly present or absent in a disease state. Monoclonal antibody (mAb) is one of the successful agents for targeted therapy in cancer. To enhance the therapeutic effect, the concept of targeting radionuclides to tumors using radiolabeled mAbs against tumor-associated antigens, radioimmunotherapy, was proposed. The efficacy of radioimmunotherapy, however, has to be further optimized. Several strategies to improve targeting of tumors with radiolabeled mAbs have been developed, such as the use of mAb fragments, the use of high-affinity mAbs, the use of labeling techniques that are stable in vivo, active removal of the radiolabeled mAb from the circulation, and pretargeting strategies. Until now, however, there are many kinds of obstacles to be solved in the use of mAb for the targeted therapy. Major technical challenges to molecular targeting are related to the rapid and specific delivery of tracers to the target, the elimination of unwanted background activity, and the development of more specific targets to create a cytocidal effect. further development of this field will be determined by success in solving these challenges.

• International Journal of Contents
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• v.14 no.4
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• pp.70-75
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• 2018

The purpose of this corpus-based study was to find 4-word lexical bundles in computer science research articles. As the demand for research articles (RAs) for international publication increases, the need for acquiring field-specific writing conventions for this academic genre has become a burning issue. Particularly, one area of burgeoning interest in the examination of rhetorical structures and linguistic features of RAs is the use of lexical bundles, the indispensable building blocks that make up an academic discourse. To illustrate, different academic discourses rely on distinctive repertoires of lexical bundles. Because lexical bundles are often acquired as a whole, the recurring multi-word sequences can be retrieved automatically to make written discourse more fluent and natural. Therefore, the proper use of rhetorical devices specific to a particular discipline can be a vital indicator of success within the discourse communities. Hence, to identify linguistic features that make up specific registers, this corpus-based study examines the types and usage frequency of lexical bundles in the discipline of CS, one of the most in-demand fields world over. Given that lexical bundles are empirically-derived formulaic multi-word units, identifying core lexical bundles used in RAs, they may provide insights into the specificity of particular CS text types. This will in turn provide empirical evidence of register specificity and technicality within the academic discourse of computer science. As in the results, pedagogical implications and suggestions for future research are discussed.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.2
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• pp.79-83
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• 2000

A han transfers her serum immunoglobulin G to the agg (IgY) and gives immunity to her offspring. Therefore, The hen agg can be an effective supplier of a large amount of antigen specific antibody that accumulates in the egg yolk. Antigen specific antibody has been widely used for immunological analysis in the field of diagnosis as well as pure scientific research. The production and separation technology of IgY is demonstrated in the present study.

• ETRI Journal
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• v.36 no.5
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• pp.829-834
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• 2014

In this paper, a lateral power metal-oxide-semiconductor field-effect transistor with ultra-low specific on-resistance is proposed to be applied to a high-voltage (up to 200 V) integrated chip. The proposed structure has two characteristics. Firstly, a high level of drift doping concentration can be kept because a tilt-implanted p-drift layer assists in the full depletion of the n-drift region. Secondly, charge imbalance is avoided by an extended trench gate, which suppresses the trench corner effect occurring in the n-drift region and helps achieve a high breakdown voltage (BV). Compared to a conventional trench gate, the simulation result shows a 37.5% decrease in $R_{on.sp}$ and a 16% improvement in BV.

• Journal of the Korea Institute of Building Construction
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• v.3 no.1
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• pp.139-146
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• 2003

The special requirements of high-performance concrete(HPC) could be enhanced property over others such as compressive strength, durability, and construction practices. In order to satisfy these requirements a series of laboratory trial mixes and following mock-up test of reinforced concrete wall at field were performed in this study. The objective of this study was to quantitatively evaluate the workability, compressive strength, and the increased heat of hydration caused by the increase of the specific weight of cement according to various variables. Six example series designed about a minimum compressive strength of 500kgf/$\textrm{cm}^2$ at 28 days, and an approximately slump and slump flow of 25cm and 60cm respectively were tested. The selection process of the specific weight of water and the percentage of fly-ash transposition determined to be most suitable for the production of HPC is presented in the following paper.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.04a
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• pp.709-712
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• 1996

Generating a project network of a specific construction project is very time consuming and difficult task in the field. To effectiviely automate and support the planning process, we design a case-based project planning expert system inspired by the fact a human expert project planner uses previous cases for planning a new project. A construction project case consist of its specific characteristics and the corresponding project network (i.e. project plan). Using frame based representation. we represent the project features affecting the progress network and the entities composing the project plan such as the buildings, construction methods, WBS (work breakdown structure), activities, and resources. The project planning process runs through most similar case retrieval, case adaptation, and user requirement satisfaction. We represent the construction domain knowledge for each procedure using constraints and rules. We develop the methodology for constraint-based case adaption. Case adaptation process mainly consist of activity generation/deletion and predecence constraint satisfaction, for which we develop the dynamic constraint generation method and connect user-level requirement representation the system-level network modification knowledge. The methodology is being applied to the prototype for apartment construction project planning.