• Journal of the Korean Magnetic Resonance Society
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• v.25 no.4
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• pp.58-63
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• 2021

Apolipoprotein B-100 (apo B-100), the main protein component that makes up LDL (Low density lipoprotein), consists of 4,536 amino acids and serves to combine with the LDL receptor. The oxidized LDL peptides by malondialdehyde (MDA) or acetylation in vivo act as immunoglobulin (Ig) antigens and peptide groups were classified into 7 peptide groups with subsequent 20 amino acids (P1-P302). The biomimetic peptide P143 (IALDD AKINF NEKLS QLQTY) out of C-group peptides carrying the highest value of IgG antigens were selected for structural studies that may provide antigen specificity. Experimental results show that P143 has β-sheet in Ile[1]-Asn[9] and α-helice in Gln[16]-Tyr[20] structure. Homonuclear 2D-NMR (COSY, TOCSY, NOESY) experiments were carried out for NMR signal assignments and structure determination for P143. On the basis of these completely assigned NMR spectra and proton distance information, distance geometry (DG) and molecular dynamic (MD) were carried out to determine the structures of P143. The proposed structure was selected by comparisons between experimental NOE spectra and back-calculated 2D NOE results from determined structure showing acceptable agreement. The total Root-Mean-Square-Deviation (RMSD) value of P143 obtained upon superposition of all atoms were in the set range. The solution state P143 has a mixed structure of pseudo α-helix and β-turn(Phe[10] to Glu[12]). These results are well consistent with calculated structure from experimental data of NOE spectra. Structural studies based on NMR may contribute to the prevent oxidation studies of atherosclerosis and observed conformational characteristics of apo B-100 in LDL using monoclonal antibodies.

• Smart Structures and Systems
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• v.29 no.1
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• pp.195-206
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• 2022

Crack detection is essential for inspection of existing structures and crack segmentation based on deep learning is a significant solution. However, datasets are usually one of the key issues. When building a new dataset for deep learning, laborious and time-consuming annotation of a large number of crack images is an obstacle. The aim of this study is to develop an approach that can automatically select a small portion of the most informative crack images from a large pool in order to annotate them, not to label all crack images. An active learning method with difficulty learning mechanism for crack segmentation tasks is proposed. Experiments are carried out on a crack image dataset of a steel box girder, which contains 500 images of 320×320 size for training, 100 for validation, and 190 for testing. In active learning experiments, the 500 images for training are acted as unlabeled image. The acquisition function in our method is compared with traditional acquisition functions, i.e., Query-By-Committee (QBC), Entropy, and Core-set. Further, comparisons are made on four common segmentation networks: U-Net, DeepLabV3, Feature Pyramid Network (FPN), and PSPNet. The results show that when training occurs with 200 (40%) of the most informative crack images that are selected by our method, the four segmentation networks can achieve 92%-95% of the obtained performance when training takes place with 500 (100%) crack images. The acquisition function in our method shows more accurate measurements of informativeness for unlabeled crack images compared to the four traditional acquisition functions at most active learning stages. Our method can select the most informative images for annotation from many unlabeled crack images automatically and accurately. Additionally, the dataset built after selecting 40% of all crack images can support crack segmentation networks that perform more than 92% when all the images are used.

• Journal of Internet Computing and Services
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• v.24 no.1
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• pp.49-59
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• 2023

Recently, attention to the pandemic situation represented by COVID-19 emerged problems caused by unexpected shortage of medical personnel. In this paper, we present a method for diagnosing the presence or absence of lesional sign on PA chest X-ray images as computer vision solution to support diagnosis tasks. Method for visual anomaly detection based on feature modeling can be also applied to X-ray images. With extracting feature vectors from PA chest X-ray images and divide to patch unit, region-specific abnormality can be detected. As preliminary experiment, we created simulation data set containing multiple objects and present results of the comparative experiments in this paper. We present method to improve both efficiency and performance of the process through hard masking of patch features to aligned images. By summing up regional specificity and global anomaly detection results, it shows improved performance by 0.069 AUROC compared to previous studies. By aggregating region-specific and global anomaly detection results, it shows improved performance by 0.069 AUROC compared to our last study.

• Structural Engineering and Mechanics
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• v.85 no.1
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• pp.105-118
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• 2023

The present work is an attempt to develop a simple and accurate finite element formulation for the assessment of thermal shock/thermally induced vibrations in pretwisted and tapered functionally graded material thin (FGM) blades obtained from Voigt and local representative volume elements (LRVE) homogenization models, based on neutral surface approach. The neutral surface of the FGM blade does not coincide with its mid-surface. A finite element model (FEM) is developed using first-order shear deformation theory (FSDT) and the FGM turbine blade is modelled according to the shallow shell theory. The top and the bottom layers of the FGM blade are made of pure ceramic and pure metal, respectively and temperature-dependent material properties are functionally graded in the thickness direction, the position of the neutral surface also depends on the temperature. The material properties are estimated according to two different homogenization models viz., Voigt or LRVE. The top layer of the FGM blade is subjected to high temperature and the bottom surface is either thermally insulated or kept at room temperature. The solution of the nonlinear profile of the temperature in the thickness direction is obtained from the Fourier law of heat conduction in the unsteady state. The results obtained from the present FEM are compared with the benchmark examples. Next, the effect of angle of twist, intensity of thermal shock, variable chord and span and volume fraction index on the transient response due to thermal shock obtained from the two homogenization models viz., Voigt and LRVE scheme is investigated. It is shown that there can be a significant difference in the transient response calculated by the two homogenization models for a particular set of material and geometric parameters.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.2
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• pp.133-146
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• 2023

Traffic states in urban areas are essential to implement effective traffic operation and traffic control. However, installing traffic sensors on numerous road sections is extremely expensive. Accordingly, estimating the traffic state using a vehicle-mounted camera, which shows a high penetration rate, is a more effective solution. However, the previously proposed methodology using object tracking or optical flow has a high computational cost and requires consecutive frames to obtain traffic states. Accordingly, we propose a method to detect vehicles and lanes by object detection networks and set the region between lanes as a region of interest to estimate the traffic density of the corresponding area. The proposed method only uses less computationally expensive object detection models and can estimate traffic states from sampled frames rather than consecutive frames. In addition, the traffic density estimation accuracy was over 90% on the black box videos collected from two buses having different characteristics.

• Journal of Veterinary Clinics
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• v.39 no.6
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• pp.302-310
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• 2022

Recently, in human medicine and veterinary medicine, interest in synthetic bone graft is increasing. Among them, bone morphogenic protein (BMP) is currently being actively researched and applied to clinical trials. However, BMP has the disadvantage of being expensive and easily absorbed into surrounding tissues. Therefore, BMP requires the use of small amounts and rhBMP (recombinant human bone morphogenetic protein)-2 carriers that can be released slowly. Hydrogel has the property of swelling a large amount of water inside when it is aqueous solution, and when it is, it consists of more than 90 percent water. Using these properties, hydrogels are often used as rhBMP-2 carrier. The scaffold used in this study is a hydrogel made from which keratin is extracted using human hair and based on it. In this study, we wanted to see the effect of bone formation in the calvarial defect model by using keratin-based hydrogel made with human hair as a scaffold. The experiment was conducted by dividing 3 groups a total of 12 mice. Calvarial bone defect is set to all 4 mm diameters. Bone formation was evaluated by using gross evaluation, micro-computed tomography (micro-CT), immunohistochemistry. Groups using keratin-based hydrogel were significantly observed compared to Group 1s, and the most bone formations were found when rhBMP-2 and hydrogel were used. This represents the superiority of the functions of the rhBMP-2 carrier by a new material, keratin-based hydrogel. Through gross evaluation, micro-CT, and immunohistochemistry, we can confirm that keratin-based hydrogel is a useful rhBMP-2 carrier.

• Journal of the Korea Institute of Building Construction
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• v.23 no.2
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• pp.113-121
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• 2023

In this study, the applicability and reproducibility of laser induced breakdown spectroscopy(LIBS) for heavy metal analysis in clinker and 5 types of by-products(crushed stone sludge, blast furnace slag, steel slag, waste concrete sludge, bottom ash) were experimentally reviewed. As a result of ICP-MS, XRF, and LIBS analysis of the six samples, the difference between ICP and XRF was confirmed in the quantitative analysis, but the LIBS analysis showed a difference by element from the standard analysis, and only qualitative analysis of the sample was possible. LIBS analysis wavelength was set for three types of heavy metals(Cd - 214.44nm, Pb - 405.78nm, Hg - 253.65nm). As a result of laser irradiation on the surface of the membrane impregnated with a solution of each concentration(1~1000ppm) and dried, the correlation between the spectral intensity and the concentration was confirmed.

• Design Convergence Study
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• v.15 no.6
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• pp.243-253
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• 2016

In this study, crutch and crutch gait for the handicapped in the lower extremity were discussed, and the study was conducted as a part of long-term research that suggests a practical solution for a crutch design. Three axillary crutches were evaluated in the study by a set of design guidelines for crutches delivered from the advanced research. In this comparative study with axillary crutch design variations, 31 healthy subjects were participated and three crutches were evaluated by ten guidelines. The result showed that Mobilegs-ultra and In-motion Pro were significantly greater than KM Crutch. However, no statistically significant difference was found between Mobilegs-ultra and In-motion Pro. While analyzing with guidelines, Mobilegs-ultra and In-motion Pro were significantly greater than KM Crutch for 6-guideline, but no significant difference was found among three crutches for the guidelines related with Lightweight and Economical feasibility and marketability. The result of the study is expected to be used for a solid foundation to evaluate for the reasonableness of the guidelines with comprehensive analysis for crutch gait evaluation in the further study.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.52.4-53
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• 2020

It is less well known that the properties, especially the mass accretion rate, of accretion flow are affected by the angular momentum of accreting gas. Park (2009) found that the mass accretion rate \dot{m}, mass accretion rate in units of Bondi accretion rate, is inversely proportional to the angular momentum of gas λ, at the Bondi radius where gas sound speed is equal to the free-fall velocity and proportional to the viscosity parameter α, and also Narayan & Fabian (2011) found a similar relation, but the dependence of the mass accretion rate of the gas angular momentum is much weaker. In this work, we investigate the global solutions for the rotating Bondi flow, i.e., polytropic flow accreting via viscosity, for various accretion parameters and the dependence of the mass accretion rate on the physical characteristics of gas. We set the outer boundary at various radius r_{out}=10^3~10^5 r_{Sch}, where r_{Sch} is the Schwarzschild radius of the black hole. For a small Bondi radius, the mass accretion rate changes steeply, as the angular momentum changes, and for a large Bondi radius, the mass accretion rate changes gradually. When the accreting gas has a near or super Keplerian rotation, we confirm that the relation between the mass accretion rate and angular momentum is roughly independent of Bondi radius as shown in Park (2009). We find that \dot{m} is determined by the gas angular momentum at the Bondi radius in units of r_{Sch}c. We also investigate the solution for the rotating Bondi flow with the outflow. The outflow affects the determination of the mass accretion rate at the outer boundary. We find that the relation between the mass accretion and the gas angular momentum becomes shallower as the outflow strengthens.

• Progress in Medical Physics
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• v.34 no.1
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• pp.10-13
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• 2023

Patients with breast cancer can be positioned with their head turned to the contra lateral side or with their head straight during the radiation therapy treatment set-up. In our hospital, patients with locally advanced breast cancer who were receiving radiation therapy have experienced swallowing difficulty after 2 weeks of irradiation. In this pilot study, the impact of head position on reducing dysphagia occurrence was dosimetrically evaluated. Patients were divided into two groups viz., HT (head turned to the contra lateral side of the breast) and HS (head straight) with 10 members in each. Treatment planning was performed, and the dosimetric parameters such as Dmin, Dmax, Dmean, V₅, V₁₀, V₂₀, V₃₀, V₄₀, and V₅₀ of both groups were extracted from the dose volume histogram (DVH) of esophagus. The target coverage in the supraclavicular fossa (SCF) region was analyzed using D₉₅ and D₉₈; moreover, the dose heterogeneity was assessed with D₂ from the DVHs. The average values of the dose volume parameters were 27.6%, 58.6%, 35.4%, 19%, 13.8%, 14.1%, 11.8%, 8.4%, and 8.1% higher in the HT group compared with those in the HS group. Furthermore, for the SCF, the mean values of D₉₈, D₉₅, and D₂ were 42.4, 47.5, and 54 Gy, respectively, in the HS group and 38.9, 45.35, and 55.5 Gy, respectively, in the HT group. This pilot study attempts to give a solution for the poor quality of life of patients after breast radiotherapy due to dysphagia. The findings confirm that the head position could play a significant role in alleviating esophageal toxicity without compromising tumor control.