• The Korean Journal of Pharmacology
• /
• v.5 no.1
• /
• pp.57-64
• /
• 1969

Acetylsalicylic acid, administered intravenously in a dose of 120 mg+250 mg/h, markedly decreased the urinary excretion of sodium and chloride, and slightly depressed potassium excretion, so that the ratio of urinary concentrations of potassium to sodium increased after ASA. Osmolar and free water clearances also diminished during water diuresis, and free water reabsorption $(T^cH_2O)$ decreased after ASA during mannitol diuresis. Glomerular filtration rate and urine flow rate changed little. When infused directly into a renal artery, ASA exhibited identical action on both kidneys, indicating that the renotropic action is mediated by some endogenous humoral agents or by some metabolites of ASA. A dose of 100 mg i.v. of spironolactone, a aldosterone antagonist, slightly reversed the renal reflect when given during maximum action of ASA. Ethacrynic acid could display its full diuretic action unhindered during maximum ASA action. Above observations lead to the suggestion that acetylsalicylic acid might release aldosterone and the action on electrolyte excretion may be mediated by the mineralocorticoid.

• YAKHAK HOEJI
• /
• v.23 no.1
• /
• pp.31-39
• /
• 1979

Bethanidine was administered into the lateral ventricle of the rabbit brain for the investigation of the effect on the renal function in doses ranging from 0.1 to 1.0mg/kg. In a dose of 0.1 mg/kg, bethanidine did not exhibit significant changes on the renal function of the rabbit, on the other hand, in the doses of 0.3 and 1.0mg/kg bethanidine elicited the reduction of renal plasma flow and glomerular filtration rate with a marked antidiuresis, at the same time bethanidine produced the decrement of urinary sodium and potassium excretion. After intravenous pretreatment of phentolamine, intraventricular bethanidine in a dose of 0.3mg/kg did not produced the antidiuresis and the decrement of urinary sodium and potassium excretion, wherease renal plasma flow and glomerular filtration rate reduced as before of phentolamine pretreatment although the durations of their reduction were shortened. These observations suggest that bethanidine induces the antidiuresis through the centrally mediated mechanism which interposed other factors in addition to sympathetic stimulation affected by phentolamine, alpha adrenergic blocking agent.

• YAKHAK HOEJI
• /
• v.43 no.5
• /
• pp.665-673
• /
• 1999

This study was performed in order to investigate the effect of ketanserin, a specific antagonist of 5-HT2 receptor, on renal function in dogs. Ketanserin (50.0 and $150.0{\;}\mu\textrm{g}/kg$), when given intravenously, produced antidiuretic action accompanied with the decreased amounts of sodium and potassium excreted in urine (ENa, EK) and the increased reabsorption rates of sodium and potassium in renal tubules (RNa, RK). Ketanserin (50.0 and $50.0{\;}\mu\textrm{g}/kg$), when administered into a renal artery, elicited antidiuretic action in both experimental and control kidney, this time changes of renal function showed the same aspect as when given intravenously. Ketanserin (15.0 and $50.0{\;}\mu\textrm{g}/kg$) injected into the carotid artery exhibited also antidiuretic action and this antidiuretic action was not affected by renal denervation. Above results suggest that ketanserin elicits antidiuretic through central function, this central antidiuretic action is not mediated by renal nerves.

• Korean Journal of Pharmacognosy
• /
• v.6 no.2
• /
• pp.101-110
• /
• 1975

In this study attempts were made to explore effects of the water and alcohol extracts of Junci Herba on the renal function of dogs. The water extract (in a dose 15 mg/kg, i.v.) and alcohol extract (in a dose 1.5 mg/kg, i.v.) elicited a diuretic response and produced a marked diuresis during bicarbonate infusion whereas no diuresis ensues during infusion of hydrochloric acid. The ratios of potassium and sodium excreted in urine $(K^+/Na^+)$, pH of urine, Cosm (osmolar clearance) and $C_{H_2O}$ (free water clearance) increased but hemodynamic states changed little with both extracts. All the observed facts can be best explained on the assumption that Junci Herba inhibits the carbonic anhydrase in the tubule. Thus it produces the effect by increasing urinary potassium and sodium.

• Korean journal of food and cookery science
• /
• v.15 no.4
• /
• pp.382-387
• /
• 1999

This study was conducted to investigate the changes of mineral contents in radish leaves, soybean sprout and chwi namul by cooking method(boiling, steaming, sauting) and cooking time(1, 3, 5 min.). The residual rate of minerals(such as Calcium, Sodium, Potassium, Iron and Magnesium) in radish leaves, soybean sprout and chwi namul by 1 minute sauting was the range of 83.2 to 99.1%. It was shown that sauting was desirable method for all three vegetables. The residual rate by the cooking method was sauting, steaming, boiling, in that order, but boiling in radish leaves and chwi namul were more desirable method than steaming for Calcium use. At the cooking method and cooking time, Potassium content in soybean sprout was reduced remarkably in 5 minutes boiling. Boiling of radish leaves and soybean sprout showed that Sodium was reduced remarkably after 5 minutes of boiling, 54.4% for radish leaves and 19.9% for soybean sprout, respectively.

• The Journal of Natural Sciences
• /
• v.12 no.1
• /
• pp.81-84
• /
• 2002

We developed new process for the large scale preparation of pyrazole sulfonyl urea and pyrazole sulfonyl urea carboalkoxyl benzene sulfonyl urea 1) in high yields and convenience. As compound with know procedure this procedure have found to be far large scale preparation. During the preparation we obtains two new sulfonyl urea 5a and 5b in 70% and 74% ( purified by crystallization).

• YAKHAK HOEJI
• /
• v.38 no.5
• /
• pp.568-578
• /
• 1994

This study was performed in order to investigate the effect of diltiazem, which is a $Ca^{2+}$ channel blocker of benzothiazepine derivatives, on renal function in the dog. Diltiazem, when infused into the vein or carotid artery, produced the antidiuresis accompanied with the decreased excretion rates of sodium and potassium in urine$(E_{Na},\;E_K)$ and the increased reabsorption rates of sodium and potassium in renal tubules$(R_{Na},\;R_K)$. Diltiazem, when infused into a renal artery, exhibited the diuresis along with the increased renal plasma flow(RPF), osmolar clearance$(C_{osm})$, $E_{Na}$ and $E_K$, and decreased $R_{Na}$ and $R_K$ in only infused kidney. Above results suggest that diltiazem possess both antidiuretic action through central action and diuretic action by direct inhibition of electrolytes reabsorption rates in renal tubules, mainly distal tubule.

• Journal of Nutrition and Health
• /
• v.24 no.4
• /
• pp.344-349
• /
• 1991

This study was undertaken to evaluate the potassium consumption and excretion in forty healthy male workers of a tire company in Seoul. Mean postassium intake for three days in the subject was $54.5\pm16.7mEq/day(2.13\pm0.64g)$ and urinary excretion of potassium in 24 hours was $45.9\pm10.5mEq(1.77\pm0.41g)$. Thus 83% of dietary potassium was excreted in the form of urine. Dietary ratio of Na to K was $4.15\pm0.58$ while urinary ratio of Na to K was $5.20\pm1.11$. The main food source of potassium was cooked rice with soybean in the rice group, potato with soybean paste soup in the part of soup group. and seasoned Spanish mackerel with raddish in the side dish group. There was a strong correlation between dietary protein and dietary potassium(r=0.694, p<0.001). Urinary sodium and potassium were also strongly associated with each other(r=0.647, p<0.001).

• The Korean Journal of Food And Nutrition
• /
• v.3 no.1
• /
• pp.39-56
• /
• 1990

The effects of six kinds of phosphate complex on the water holding capacity (W.H.C) and protein solubility of hair tail, yellow tail runner and dried pollack meat paste were investigated and animal meat(pork, chicken and hare meat complex) The formulation of six kind of phosphate complex employed to this experiment were made by mixing several phosphate such as sodium polyphosphate, sodium pyrophosphate, sodium acid pyrophosphate, potassim pyrophosphate, sodium ultra-meta-phosphate, sodium-tetra-phosphate and monoglyceride at different mixture ratio Among the six kinds of phosphate complex, phosphate B complex which was formulated by mixing sodium polyphosphate 40%, sodium pyrophosphate 30%, sodium tetra mata phosphate 10%, sodium ultra meta phosphate 10% was most effective on enchanging the W H. C, and protein solubility of hair tail, yellow tail runner dried pollack meat past and in case of pork, chicken and hare meat paste. Phosphate C complex which was formulated by mixing sodium polyphosphate 50%. sodium pyrophosphate 30%, sodium tetra meta phosphate 10%, potassium pyrophosphate 10%, was more effective them other phosphate complex, and thief optimum addition level was 0.5% respectively in weight of fish meat paste. Texture characteristics such as hardness, cohesiveness and springiness value of Kamaboko(fish meat and pork, chicken, hare meat complex past meat product) were evaluted as best when 0.5% of Phosphate B complex was added The optimum cooking condition of Kamaboko to get good texture was heating for 20 minutes at 12$0^{\circ}C$.

• The Journal of Internal Korean Medicine
• /
• v.19 no.2
• /
• pp.317-332
• /
• 1998

The purpose of this study is to find out the effects of Poria extract on rat's nephrotoxicity induced by CsA. The experimental animals were divided into 3 groups and treated as follows; Nothing was given to Sample A, Sample B was given normal saline after IV injection of CsA and Sample C was given Poria extract after CsA injection. After precription of medicine, serum BUN, creatinine, total protein, sodium, potassium, chloride ions were measured. 1. Changes in serum level. ALT, BUN, chloride ion were significantly reduced in experimental group as compaired to control group, and total protein showed significant elevation in experimental group. AST was reduced, but not significant and creatine level was below the normal range. K level showed mild elevation initially and later showed mild decrease, but no significance is noted. There were no significant differance in the sodium level. 2. Changes in Urine level. Urinary specific gravity showed significant increase in experimental group compaired to control group. Urinary creatinine level initially increased, and later decreased but showed no significance. To conclude, it can be inferred that Poria may improve nephrotoxicity and hepatotoxicity in rat induced by Cyclosporin A.