• The Korean Journal of Physiology and Pharmacology
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• v.15 no.3
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• pp.171-177
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• 2011

Tonic smooth muscle exhibit the latch phenomenon: high force at low myosin regulatory light chains (MRLC) phosphorylation, shortening velocity (Vo), and energy consumption. However, the kinetics of MRLC phosphorylation and cellular activation in phasic smooth muscle are unknown. The present study was to determine whether $Ca^{2+}$-stimulated MRLC phosphorylation could suffice to explain the agonist- or high $K^+$-induced contraction in a fast, phasic smooth muscle. We measured myoplasmic [$Ca^{2+}$], MRLC phosphorylation, half-time after step-shortening (a measure of Vo) and contractile stress in rabbit urinary bladder strips. High $K^+$-induced contractions were phasic at both $22^{\circ}C$ and $37^{\circ}C$: myoplasmic [$Ca^{2+}$], MRLC phosphorylation, 1/half-time, and contractile stress increased transiently and then all decreased to intermediate values. Carbachol (CCh)-induced contractions exhibited latch at $37^{\circ}C$: stress was maintained at high levels despite decreasing myoplasmic [$Ca^{2+}$], MRLC phosphorylation, and 1/half-time. At $22^{\circ}C$ CCh induced sustained elevations in all parameters. 1/half-time depended on both myoplasmic [$Ca^{2+}$] and MRLC phosphorylation. The steady-state dependence of stress on MRLC phosphorylation was very steep at $37^{\circ}C$ in the CCh- or $K^+$-depolarized tissue and reduced temperature flattend the dependence of stress on MRLC phosphorylation compared to $37^{\circ}C$. These data suggest that phasic smooth muscle also exhibits latch behavior and latch is less prominent at lower temperature.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2010.07a
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• pp.435-437
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• 2010

렌즈의 피사계심도 (Depth of Field)가 낮은 카메라로 영상을 획득 했을 때, 한 영상 내에도 in-focus 영역과 out of-focus 영역이 동시에 존재하게 된다. 따라서 영상을 복원하기 위해 in-focus 영역과 out-of-focus 영역을 구분하는 focus measure가 필요하게 된다. 기존 focus measure 알고리즘은 획득된 영상의 intensity 값의 절대적인 변화나 고주파수 성분 값에 따라 in-focus와 out-of-focus를 결정하기 때문에 out-of-focus 영역이 smooth 하지 않을 경우에는 in-focus 영역이라 잘못 판단할 수 있을 뿐만 아니라 잡음에 민감한 단점을 가진다. 본 논문에서는 기존 알고리즘의 한계점을 보완하는 연구 방향을 제시한다.

• Journal of Korean Academy of Dental Administration
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• v.11 no.1
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• pp.38-46
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• 2023

Composite resins, commonly used in clinical practice, have been developed to improve aesthetics to obtain smooth surfaces. Although the restored composite resin has a smooth surface, it gradually becomes rough over time. Therefore, this study measured glossiness to evaluate the surface of various composite resins and attempted to evaluate the maintenance of glossiness of composite resins by observing surfaces that change to roughness. Specimens were produced using resin used in clinical practice: Gradia direct anterior (GA), Tetric N-Ceram (TN), Ceram.X Sphere TEC one (CX), Filtek Z350XT (FT), Estelite sigma quick (ES). After creating a smooth surface with slide glass, five locations were randomly selected to measure surface gloss, and the average was the representative value of the specimen. Roughness was applied to the specimen under water pouring at the same speed and pressure using SiC paper #2400, 1200, and 400. The gloss unit of different SiC papers was measured. To evaluate the gloss unit and gloss retention between composite resins, one-way analysis of variance and Tukey multiple comparisons test were used. As a result of the study, there was a difference in gloss unit of specimens produced under the same conditions. Although the degree differed depending on the composite resin, there was also a difference in gloss retention. Based on the findings, composite resins show differences in gloss due to their different characteristics. Ceram.X Sphere TEC one (CX) showing the lowest gloss retention and Estelite sigma quick (ES) showing the highest.

• The KSFM Journal of Fluid Machinery
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• v.14 no.6
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• pp.76-84
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• 2011

The effect of inlet velocity profile on the heat transfer coefficient in a rotating smooth channel was investigated experimentally. Three simulated inlet flow conditions of fully developed, uniform, and distorted inlet conditions were tested. The Reynolds number based on the channel hydraulic diameter was ranged from 10,000 to 30,000 and the transient liquid crystal technique was used to measure the distribution of the heat transfer coefficient in the rotating channel. Results showed that the overall heat transfer coefficient increased as the Reynolds number increased. Also, the distribution of the heat transfer coefficient was strongly affected by the inlet flow condition. Generally, the fully developed flow simulated condition showed the highest heat transfer coefficient.

• Journal of Information Processing Systems
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• v.15 no.5
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• pp.1108-1118
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• 2019

Non-local means (NLM) algorithm is an effective and successful denoising method, but it is computationally heavy. To deal with this obstacle, we propose a novel NLM algorithm with fuzzy metric (FM-NLM) for image denoising in this paper. A new feature metric of visual features with fuzzy metric is utilized to measure the similarity between image pixels in the presence of Gaussian noise. Similarity measures of luminance and structure information are calculated using a fuzzy metric. A smooth kernel is constructed with the proposed fuzzy metric instead of the Gaussian weighted L2 norm kernel. The fuzzy metric and smooth kernel computationally simplify the NLM algorithm and avoid the filter parameters. Meanwhile, the proposed FM-NLM using visual structure preferably preserves the original undistorted image structures. The performance of the improved method is visually and quantitatively comparable with or better than that of the current state-of-the-art NLM-based denoising algorithms.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.43.2-43.2
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• 2019

In many astrophysical systems, smooth large-scale variations coexist with small-scale fluctuations. For example, a large-scale velocity or density gradient can exist in molecular clouds that have small-scale fluctuations by turbulence. In redshifted 21cm observations, we also have two types of signals - the Galactic foreground emissions that change smoothly and the redshifted 21cm signals that fluctuate fast in frequency space. In many cases, the large-scale variations make it difficult to extract information on small-scale fluctuations. We propose a simple technique to remove smooth large-scale variations. Our technique relies on multi-point structure functions and can obtain the magnitudes of small-scale fluctuations. It can also be used to design filters that can remove large-scale variations and retrieve small-scale data. We discuss how to apply our technique to irregularly spaced data, such as rotation measure observations toward extragalactic radio point sources.

• Journal of the Korean Mathematical Society
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• v.34 no.3
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• pp.731-770
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• 1997

We study Diriclet forms and related subjects for the Gibbs measures of classical unbounded sping systems interacting via potentials which are superstable and regular. For any Gibbs measure $\mu$, we construct a Dirichlet form and the associated diffusion process on $L^2(\Omega, d\mu), where \Omega = (R^d)^Z^\nu$. Under appropriate conditions on the potential we show that the Dirichlet operator associated to a Gibbs measure $\mu$ is essentially self-adjoint on the space of smooth bounded cylinder functions. Under the condition of uniform log-concavity, the Gibbs measure exists uniquely and there exists a mass gap in the lower end of the spectrum of the Dirichlet operator. We also show that under the condition of uniform log-concavity, the unique Gibbs measure satisfies the log-Sobolev inequality. We utilize the general scheme of the previous works on the theory in infinite dimensional spaces developed by e.g., Albeverio, Antonjuk, Hoegh-Krohn, Kondratiev, Rockner, and Kusuoka, etc, and also use the equilibrium condition and the regularity of Gibbs measures extensively.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.2
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• pp.139-147
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• 2013

Lysolipids such as LPA, S1P and SPC have diverse biological activities including cell proliferation, differentiation, and migration. We investigated signaling pathways of LPA-induced contraction in feline esophageal smooth muscle cells. We used freshly isolated smooth muscle cells and permeabilized cells from cat esophagus to measure the length of cells. Maximal contraction occurred at $10^{-6}M$ and the response peaked at 30s. To identify LPA receptor subtypes in cells, western blot analysis was performed with antibodies to LPA receptor subtypes. LPA1 and LPA3 receptor were detected at 50 kDa and 44 kDa. LPA-induced contraction was almost completely blocked by LPA receptor (1/3) antagonist KI16425. Pertussis toxin (PTX) inhibited the contraction induced by LPA, suggesting that the contraction is mediated by a PTX-sensitive G protein. Phospholipase C (PLC) inhibitors U73122 and neomycin, and protein kinase C (PKC) inhibitor GF109203X also reduced the contraction. The PKC-mediated contraction may be isozyme-specific since only $PKC{\varepsilon}$ antibody inhibited the contraction. MEK inhibitor PD98059 and JNK inhibitor SP600125 blocked the contraction. However, there is no synergistic effect of PKC and MAPK on the LPA-induced contraction. In addition, RhoA inhibitor C3 exoenzyme and ROCK inhibitor Y27632 significantly, but not completely, reduced the contraction. The present study demonstrated that LPA-induced contraction seems to be mediated by LPA receptors (1/3), coupled to PTX-sensitive G protein, resulting in activation of PLC, PKC-${\varepsilon}$ pathway, which subsequently mediates activation of ERK and JNK. The data also suggest that RhoA/ROCK are involved in the LPA-induced contraction.

• Geotechnical Engineering
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• v.12 no.2
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• pp.107-114
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• 1996

A series of shear tests is performed to measure friction coefficients of the interface between different reinforcements and weathered granite soils. The reinforcements tested are smooth steel strip, Paraweb(friction tie) and geotextile with rough surface, while the weathered granite soils are composed of different, grain size distribution. Soils are compacted with the energy of 95% modified AASHTO and fully saturated before testing to simulate the worst site condition. Because of characteristics of the direct shear apparatus, shear strength is obtained in terms of drained condition. Test results show that the more fines the soils contain, the larger ratio of friction coefficient ($\mu=\frac{tan{\delta}}{tan{\Psi}}$) is obtained. Also the ratios are much higher for the Friction tie and the geotextile compared to the smooth steel strip. Those suggest that even weathered granite soils with 36% fines are possible to use as backfill of reinforced earth structures for the two reinforcements when a drainage system is provided.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.32 no.8
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• pp.612-620
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• 2008

New alternative refrigerants have been developed due to the ozone layer depletion and global warming. For this reason, carbon dioxide is believed to be a promising refrigerant for use in air conditioners and heat pumps. Evaporative heat transfer characteristics and pressure drop of $CO_2$ with outer diameter of 5 mm in inclined ($45^{\circ}$) smooth and micro-fin tubes have been investigated by the experiments with respect to several test conditions such as mass fluxes, heat fluxes, evaporation temperatures in this study. The inclined ($45^{\circ}$) smooth and micro-fin tubes with length of 1.44 m were installed to measure the evaporative heat transfer coefficients of $CO_2$ and heat was supplied to the refrigerant by direct heating method where the test tube was uniformly heated by electricity. The tests were conducted at mass fluxes from 212 to $656\;kg/m^2s$, heat fluxes from 15 to $60\;kW/m^2$ and evaporation temperatures from -10 to $20^{\circ}C$. The heat transfer coefficients of $CO_2$ are slightly increased with increasing mass flux, and the heat transfer characteristics in the inclined ($45^{\circ}$) tubes are enhanced about $5{\sim}10%$ compared with those in horizontal or vertical tubes.