• Nutrition Research and Practice
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• v.14 no.4
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• pp.334-351
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• 2020

BACKGROUND/OBJECTIVES: This study was designed to investigate the improvement effect of white ginseng extract (GS-KG9) on D-galactosamine (Ga1N)-induced oxidative stress and liver injury. SUBJECTS/METHODS: Sixty Sprague-Dawley rats were divided into 6 groups. Rats were orally administrated with GS-KG9 (300, 500, or 700 mg/kg) or silymarin (25 mg/kg) for 2 weeks. The rats of the GS-KG9- and silymarin-treated groups and a control group were then intraperitoneally injected Ga1N at a concentration of 650 mg/kg for 4 days. To investigate the protective effect of GS-KG9 against GalN-induced liver injury, blood liver function indicators, anti-oxidative stress indicators, and histopathological features were analyzed. RESULTS: Serum biochemical analysis indicated that GS-KG9 ameliorated the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in GalN-treated rats. The hepatoprotective effects of GS-KG9 involved enhancing components of the hepatic antioxidant defense system, including glutathione, glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT). In addition, GS-KG9 treatment inhibited reactive oxygen species (ROS) production induced by GalN treatment in hepatocytes and significantly increased the expression levels of nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) proteins, which are antioxidant proteins. In particular, by histological analyses bases on hematoxylin and eosin, Masson's trichrome, α-smooth muscle actin, and transforming growth factor-β1 staining, we determined that the administration of 500 mg/kg GS-KG9 inhibited hepatic inflammation and fibrosis due to the excessive accumulation of collagen. CONCLUSIONS: These findings demonstrate that GS-KG9 improves GalN-induced liver inflammation, necrosis, and fibrosis by attenuating oxidative stress. Therefore, GS-KG9 may be considered a useful candidate in the development of a natural preventive agent against liver injury.

• Journal of Korea Multimedia Society
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• v.11 no.5
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• pp.685-691
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• 2008

Recently with the rapid evolution of the mobile computing and communication technologies, mobile VOD service becomes increasingly important for wireless mobile users. The VOD service is being widely used in various areas of application, such as education, entertainment and business, because it provides users convenience in easily having access to video information at any time in any places. However, in reality, the mobile system has many difficulties in providing the smooth VOD service owing to frequent transfers and cutoffs of clients. The importance of a technique to transmit broadcasting is being stressed as a method for providing stabler mobile VOD service to a large number of clients. This paper is aimed at showing how to reduce demands for server bandwidth and delay of earlier service through performance analysis by suggesting an effective VOD broadcasting transmission technique through channel division in the mobile atmosphere. Many researches have been made about regular broadcasting techniques in particular. This study divides the methods used for assigning channels which have been decided by the size of segments into a group of regular channels and assistant channels using wireless gap-fillers to provide effective VOD services to a large number of clients at the mobile environment using small bandwidth resources. The regular channels transfer regular streams, while assistant channels repeatedly transfer the first segment to reduce early service delay time to receive regular streams. In this way, the study suggests a technique to reduce server bandwidth demand and early service delay time. Through the proposed technique, the server bandwidth demand could be reduced by more than 30 percent and the study continuously shows reduced early service delay time through conducting performance analysis.

• Journal of the Korean Institute of Landscape Architecture
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• v.41 no.5
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• pp.68-77
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• 2013

Change in the Global Climate causes flood, drought, heavy snow, and rainfall patterns in the Korean Peninsula. A variety of alternatives related to climate change are considered. The foreign researchers are interested in Low Impact Development(LID); the utilization of water resources and eco friendly development, over 10 years ago. The research and development of related technology has been advanced to apply LID techniques in order to develop several projects in the country. However, sharing of technology or system that can be used easily in the private sector is insufficient. The performance of the elements of LID Technology has not been fully agreed. LID elements of this technology are easy to apply to Apartment complex. The elements are classified technology. The infiltration of elements performs the functions of apartment complex landscaping space technology applied to the target. The water cycle simulation(SWMM 5.0) and technology the implementation of the effectiveness is also verified. For this purpose, three different places in apartment complex to target by SWMM5.0 U.S. EPA conducted utilizing simulated rainfall and applying LID techniques before and after the simulated water cycle (infiltration, surface evaporation, and surface runoff) were conducted. The importance of green space in the LID techniques of quantitative and qualitative storm water control as well as the role of Apartment Housing is to promote Amenity. Remember that the physical limitations of apartment complex and smooth water circulation system for the application of LID integrated management techniques should be applied. To this end, landscapes, architecture, civil engineering, environmental experts for technical consilience between the Low Impact Development efforts are required.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.4
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• pp.359-365
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• 2013

Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of $K^+$ channels. Because contractility of uterine muscle is regulated by extracellular pH and humoral factors, $K^+$ conductance could be connected to factors regulating uterine contractility during pregnancy. Here, we showed that TASK-2 inhibitors such as quinidine, lidocaine, and extracellular acidosis produced contraction in uterine circular muscle of mouse. Furthermore, contractility was significantly increased in pregnant uterine circular muscle than that of non-pregnant muscle. These patterns were not changed even in the presence of tetraetylammonium (TEA) and 4-aminopyridine (4-AP). Finally, TASK-2 inhibitors induced strong myometrial contraction even in the presence of L-methionine, a known inhibitor of stretch-activated channels in myometrium. When compared to non-pregnant myometrium, pregnant myometrium showed increased immunohistochemical expression of TASK-2. Therefore, TASK-2, seems to play a key role during regulation of myometrial contractility in the pregnancy and provides new insight into preventing preterm delivery.

• The Korean Journal of Physiology
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• v.18 no.1
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• pp.37-50
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• 1984

The effects of $Ca^{++}$ and its antagonists (verapamil and $La^{+++}$) upon the spontaneous contraction and the contracture induced by 60 mM K-Tyrode solution were studied in the isolated uterine muscle. Longitudinal muscle strips were prepared from the rat uteri at estrous stage. All experiments were performed in tris-buffered Tyrode solution which was aerated with 100% $O_2$ and kept at 35^{\circ}$. The results obtained were as follows: 1) In the uterine strips contracting spontaneously, both the amplitude of peak tension and the area of contraction curve increased dose-dependently in the range of $0.5${\sim}8$ mM $Ca^{++}$. The frequency of contraction increased as the concentration of $Ca^{++}$ increased up to 2 mM, but above this concentration the frequency decreased. In $Ca^{++}-free$ media, however, contraction did not develop. In the contracture induced by 60 mM K-Tyrode solution, the developed tension increased dose-dependently as the concentration of external $Ca^{++}$ increased to 8 mM. In the absence of external $Ca^{++}$ K-contracture appeared, but it was not sustained. 2) The spontaneous contraction of rat uterus was suppressed by verapamil in proportion to an increase of its concentration and totally abolished at the concentration of $3{\times}10^{-4}\;g/l$, but the spontaneous contraction re-appeared by addition of $Ca^{++}$. The amplitude of peak tension recovered completely but the recovery of frequency was incomplete. K-contracture decreased in a dose-dependent manner after the treatment with verapamil and totally disappeared at its concentration of $3{\times}10^{-4}\;g/l$. Even in this case contracture developed again by extra $Ca^{++}$. 3) The spontaneous contractile activity was inhibited by $La^{+++}$. At the concentration of $10^{-4}$M $La^{+++}$, fibrillation appeared. In the strip inhibited by $10^{-5}M\;La^{+++}$, contractility recovered completely by extra $Ca^{++}$ while in the $10^{-4}M\;La^{+++}$ treated preparation, the rhythmic spontaneous contraction did not develop even at the concentration of 16 mM $Ca^{++}$. After the initial transient depression of contracture tension by $10^{-3}M$ of $La^{+++}$, the strip stowed considerably large size of contracture, hardly influenced by external $Ca^{++}$ or verapamil. The results obtained in this experiment suggest that in the rat uterine muscle there would be some competitive actions between $Ca^{++}$ and its antagonists. It is speculated that $Ca^{++}$ plays an important role in the conduction of excitation, and $La^{+++}$ influences upon cellular $Ca^{++}$ mobilization and re-uptake process as well as transmembrane $Ca^{++}$ transport in a K-depolarized state.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.9
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• pp.1898-1905
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• 2012

This paper presents an On-board Smart Device (OSD) for moving vehicle, based on a smooth integration of Android-based devices and a Micro-control Unit (MCU). The MCU is used for the acquisition and transmission of various vehicle-borne data. The OSD has threefold functions: Record, Report and Alarm. Based on these RRA functions, the OSD is basically a safety and convenience oriented smart device, where it facilitates alert services such as accident report and rescue as well as alarm for the status of vehicle. In addition, voice activated interface is developed for the convenience of users. Vehicle data can also be uploaded to a remote server for further access and data manipulation. Therefore, unlike conventional blackboxes, the developed OSD lends itself to a user-friendly smart device for vehicle safety: It basically stores monitoring images in driving plus vehicle data collection. Also, it reports on accident and enables subsequent rescue operation. The developed OSD can thus be considered an essential safety smart device equipped with comprehensive wireless data service, image transfer and voice activated interface.

• Korean Journal of Construction Engineering and Management
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• v.19 no.6
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• pp.103-114
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• 2018

Public-Private-Partnership(PPP) is becoming a popular form of projects in construction industry worldwide. Normally, the management team of PPP project consists of various experts from different disciplines such as construction engineer, bank financier, contract manager, investors, etc. The diversity of team members causes difficulties in managing the team efficiently and furthermore for the smooth execution of the project itself. One of the solutions to this issue might be the application of citizenship behavior by the team members. This study conducts an empirical investigation of the effect of project citizenship behavior on the project performance. We have collected data by using a questionnaire from those with PPP project experiences in the domestic construction industry. The results show that project citizenship behavior has full mediating effects between PM's leadership and the project performance. This study has an academic significance in that it is the first attempt to apply the concept and to show the effect of citizenship behavior in project management discipline, particularly in construction industry, in Korea. We also expect that the project management teams for PPP projects would benefit from the findings of this study.

• Korean Chemical Engineering Research
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• v.52 no.4
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• pp.522-529
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• 2014

Circulating fluidized bed system consists of SEWGS reactor - lower loop seal - regeneration reactor - riser - cyclone - upper loop seal has been used for solid circulation between the SEWGS reactor and the regeneration reactor in a SEWGS system for pre-combustion $CO_2$ capture. A vertical type lower loop seal has been used in current system but this lower loop seal requires high gas flow rate through the lower loop seal for fluidization and smooth solid circulation, and consequently, causes slugging behavior sometimes. To overcome these disadvantages, inclined type lower loop seal was proposed by this study. Solid circulation characteristics with change of lower loop seal geometry were measured and compared in a bubbling - bubbling - riser type circulating fluidized bed using $CO_2$ absorbent (P-78) as bed material at ambient temperature and pressure. We could conclude that the inclined lower loop seal is better than the vertical type lower loop seal from the viewpoints of minimum flow rate requirement for stable solid circulation and solid height change during solid circulation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.277-283
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• 2017

In recent years, earthquakes and volcanic activity have been occurring actively in Japan, China, and Southeast Asia in the central Pacific Rim, and the cycle interval is shortening. In addition, there is Baekdu mountain, which is a large active volcano in Korea. On the other hand, the legal system and guidelines related to volcanic ash are very limited to counteract volcanic disasters. The volcano manual does not present specific countermeasures against volcanic disasters. The preparation of systematic disaster prevention measures against an eruption of Mt. Baekdu and the volcanic activity in Japan and China, which are occurring continuously, is necessary. Therefore, this study suggests an improvement to the relevant laws and regulations against volcanic disasters to analyze the aviation safety manual and relevant legal system. The problems with the current legal system are improved by modifying the legal system related to the air traffic sector when volcanic disaster occurs, and it is expected that more efficient manuals and guidelines will form the basis for the smooth operation of the manual at a disaster site.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.11
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• pp.208-213
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• 2016

In the fourth industrial revolution, customization is becoming a conversation topic in various domains. Industry 4.0 applies cyber-physical systems (CPS), the Internet of Things (IoT), and cloud computing to manufacturing businesses. One of the main phrases in Industry 4.0 is mass customization. Optimized products or services are developed and provided through customization. Therefore, the competitiveness of a product can be enhanced, and satisfaction is improved. In particular, as IoT technology spreads, customization is an essential aspect of smooth service connections between various devices or things. Customized services in mobile applications are assembled and operate in various mobile devices in the mobile environment. Therefore, this paper proposes a method for improving customized cloud server-based mobile architectures, processes, and metrics, and for measuring the performance improvement of the customized architectures operating in various mobile devices based on the Android or IOS platforms. We reduce the total time required for customization in half as a result of applying the proposed customized architectures, processes, and metrics in various devices.