• Transactions of the Korean Society of Machine Tool Engineers
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• v.16 no.1
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• pp.92-97
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• 2007

This study was carried out to minimize the lifting force and to design the slim sized frame of a height adjustment mechanism. This unit is designed for the display devices in order to enhance the ergonomics for effective height adjustment as well as to achieve much slimmer frame for the pedestal. A tolerance analysis of 6 sigma was applied to achieve smooth lift at design stage not to change the tolerance specification of gap several times in a roller type of lifting mechanism at mass production stage. The specification of minimum gap and the target of production yield ratio were agreed with a quality team before tooling. A DFSS simulation on drawings had been done with reasonable tolerance and achievable standard deviation(${\sigma}$) several times until the target specification of gap and yield ratio was met. Once tolerance and deviation(${\sigma}$) were fixed tooling start was done successfully. A CAE method was applied to achieve a slim design. Design parameters were frozen when those parameters matched the reference strength data of standard model. Through those tolerance analysis and CAE simulation the number of tool modification was reduced and production yield ratio was raised up without arguing quality specification at production stage in the end.

• Journal of computational fluids engineering
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• v.12 no.2
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• pp.21-25
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• 2007

A general purpose program NUFLEX has been extended for two-phase flows with topologically complex interface and cavitation flows with liquid-vapor phase change caused by large pressure drop. In analysis of two-phase flow, the phase interfaces are tracked by employing a LS(Level Set) method. Compared with the VOF(Volume-of-Fluid) method based on a non-smooth volume-fraction function, the LS method can calculate an interfacial curvature more accurately by using a smooth distance function. Also, it is quite straightforward to implement for 3-D irregular meshes compared with the VOF method requiring much more complicated geometric calculations. Also, the cavitation process is computed by including the effects of evaporation and condensation for bubble formation and collapse as well as turbulence in flows. The volume-faction and continuity equations are adapted for cavitation models with phase change. The LS and cavitation formulation are implemented into a general purpose program for 3-D flows and verified through several test problems.

• Biomolecules & Therapeutics
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• v.3 no.2
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• pp.149-153
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• 1995

Nitric oxide (NO) has been regarded as one of the neurotransmitters of nonadrenergic, noncholinergic (NANC) nerve stimulation in rabbit corpus cavernosum, rat gastric fundus and human intestine. PIANO (photo-induced adequate nitric oxide) is a very useful tool to investige the role of NO in various smooth muscles where NO is a mediator. The present study was undertaken to compare the physiological responses of the rat gastric smooth muscle in response to NANC nerve stimulation and to PIANO. Photolysis of L-NAME, D-NAME and streptozotocin (572) by UV light in the bathing medium caused relaxation of rat gastric fungus that contracted with carbachol, but was resistant to tetrodotoxin (TTX, 1 $\mu$M). Electrical stimulation (20 V, 2~32 Hz, 0.2 msec, 10s) of the gastric fundus, in the presence of atropine and guanethidine, induced frequency-dependent, TTX-sensitive relaxation. Sodium nitroprusside (1 nM-10 $\mu$M), a NO donor, mimicked the relaxations observed after NANC-stimulation or PIANO. Furthermore, PIANO caused UV light exposure time-dependent increase of CGMP in rat gastric fungus strips. These results provide another evidence indirectly that NO is one of the mediators of the NANC inhibitory nerve stimulation in the rat gastric fundus.

• Biomolecules & Therapeutics
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• v.24 no.5
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• pp.523-528
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• 2016

Urotensin II (UII) is a potent vasoactive peptide and mitogenic agent to induce proliferation of various cells including vascular smooth muscle cells (VSMCs). In this study, we examined the effects of a novel UII receptor (UT) antagonist, KR-36676, on vasoconstriction of aorta and proliferation of aortic SMCs. In rat aorta, UII-induced vasoconstriction was significantly inhibited by KR-36676 in a concentration-dependent manner. In primary human aortic SMCs (hAoSMCs), UII-induced cell proliferation was significantly inhibited by KR-36676 in a concentration-dependent manner. In addition, KR-36676 decreased UII-induced phosphorylation of ERK, and UII-induced cell proliferation was also significantly inhibited by a known ERK inhibitor U0126. In mouse carotid ligation model, intimal thickening of carotid artery was dramatically suppressed by oral treatment with KR-36676 (30 mg/kg/day) for 4 weeks compared to vehicle-treated group. From these results, it is indicated that KR-36676 suppress UII-induced proliferation of VSMCs at least partially through inhibition of ERK activation, and that it also attenuates UII-induced vasoconstriction and vascular neointima formation. Our study suggest that KR-36676 may be an attractive candidate for the pharmacological management of vascular dysfunction.

• The Pure and Applied Mathematics
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• v.11 no.4
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• pp.293-308
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• 2004

Let K be a nonempty convex subset of an arbitrary Banach space X and $T\;:\;K\;{\rightarrow}\;K$ be a uniformly continuous strictly hemi-contractive operator with bounded range. We prove that certain Ishikawa iteration scheme with errors both converges strongly to a unique fixed point of T and is almost T-stable on K. We also establish similar convergence and almost stability results for strictly hemi-contractive operator $T\;:\;K\;{\rightarrow}\;K$, where K is a nonempty convex subset of arbitrary uniformly smooth Banach space X. The convergence results presented in this paper extend, improve and unify the corresponding results in Chang [1], Chang, Cho, Lee & Kang [2], Chidume [3, 4, 5, 6, 7, 8], Chidume & Osilike [9, 10, 11, 12], Liu [19], Schu [25], Tan & Xu [26], Xu [28], Zhou [29], Zhou & Jia [30] and others.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.479-482
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• 2002

Riblets with longitudinal grooves along the streamwise direction have been used as an effective flow control technique for drag reduction. A flexible micro-riblet with v-grooves of peak-to-peak spacing of $300{\mu}m$ was made using a MEMS fabrication process of PDMS replica. The flexible micro-riblet was attached on the whole surface of a NACA0012 airfoil with which grooves are aligned with the streamwise direction. The riblet surface reduces drag coefficient about $7.9{\%}\;at\;U_o=3.3m/s$, however, it increases drag about $8{\%}\;at\;U_o=7.0m/s$, compared with the smooth airfoil without riblets. The near wake has been investigated experimentally far the cases of drag reduction ($U_o\;=\;3.3 m/s$) and drag increase ($U_o\;=\;7 m/s$). Five hundred instantaneous velocity fields were measured for each experimental condition using the cross-correlation PIV velocity field measurement technique. The instantaneous velocity fields were ensemble averaged to get spatial distribution of turbulent statistics such as turbulent kinetic energy. The experimental results were compared with those of a smooth airfoil under the same flow condition. The micro-riblet surface influences the near wake flow structure largely, especially in the region near the body surface

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.11
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• pp.1233-1238
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• 2009

This study analyzed the characterization of high temperature strength of $Si_3N_4$ composite ceramics additive based on variations in the amount of nano colloidal $SiO_2$ added. Semi-elliptical cracks about 100 ${\mu}m$ length were obtained from a Vickers indenter using a load of 24.5 N. The results showed that the heat-treated smooth specimens with $SiO_2$ nano colloidal coating exhibited the highest bending strength at 0.0 wt% $SiO_2$ nano colloidal added, which is amounted to a 187 % increase over that of smooth specimen. Limiting temperature for bending strength of crack-healed zone for bending strength was about 1273 K. However, the bending strength of SSTS-3 and SSTS-4 was considerably increased while that of SSTS-1 and SSTS-2 was decreased at a temperature of 1,573K.

• The Korean Journal of Food And Nutrition
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• v.22 no.1
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• pp.97-102
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• 2009

In order to obtain a non-toxic and more active and stable microorganism-produced tyrosinase inhibitor, we isolated actinomycetes F-97, a producer of tyrosinase inhibitor, from soil. The aerial hyphae of this strain were gray in color with tree types. Under the microscopic examination, the isolate formed a spiral aerial spore mass with a smooth surface. The analysis of cell wall acid hydrolysate of the isolate revealed the presence of LL-diaminopimelic acid(LL-DAP). No specific sugar was detected. From these results and the cultural and physiological characteristics described in the Bergey's Manual, actinomycetes F-97 was identificated as, or best-matched to, Streptomyces aburaviensis.

• International Journal of CAD/CAM
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• v.6 no.1
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• pp.139-148
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• 2006

Catmull-Clark subdivision scheme provides a powerful method for building smooth and complex surfaces. But the number of faces in the uniformly refined meshes increases exponentially with respect to subdivision depth. Adaptive tessellation reduces the number of faces needed to yield a smooth approximation to the limit surface and, consequently, makes the rendering process more efficient. In this paper, we present a new adaptive tessellation method for general Catmull-Clark subdivision surfaces. Different from previous control mesh refinement based approaches, which generate approximate meshes that usually do not interpolate the limit surface, the new method is based on direct evaluation of the limit surface to generate an inscribed polyhedron of the limit surface. With explicit evaluation of general Catmull-Clark subdivision surfaces becoming available, the new adaptive tessellation method can precisely measure error for every point of the limit surface. Hence, it has complete control of the accuracy of the tessellation result. Cracks are avoided by using a recursive color marking process to ensure that adjacent patches or subpatches use the same limit surface points in the construction of the shared boundary. The new method performs limit surface evaluation only at points that are needed for the final rendering process. Therefore it is very fast and memory efficient. The new method is presented for the general Catmull-Clark subdivision scheme. But it can be used for any subdivision scheme that has an explicit evaluation method for its limit surface.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.46 no.4
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• pp.1-6
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• 2009

In this paper, we design a dynamic state feedback smooth stabilizer for a nonlinear system whose Jacobian linearization may have uncontrollable mode because its eigenvalues are on the right half-plane. After designing an augmented system, a dynamic exponent scaling and backstepping enable one to explicitly design a smooth stabilizer and a continuously differentiable Lyapunov function which is positive definite and proper. The convergence of the designed controller is proved by the new notion 'degree indicator'.