• Journal of Pharmaceutical Investigation
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• v.31 no.1
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• pp.7-12
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• 2001

Amphotericin B (AmB) is a drug of choice for the treatment of systemic fungal diseases, but its use is considerably limited due to a high incidence of toxicity, particularly nephrotoxicity. It has been demonstrated that the toxicity of AmB is caused by self-aggregated species of the drug and that unaggregated (monomeric) drug is nontoxic but still expresses antifungal activity. Poly (ethylene oxide) (PEO) is a water-soluble polymer, which may impact the aggregation state of AmB. We have studied the aggregation state of AmB as a function of PEO molecular weight and concentration. At 3,000 and 8,000 g/mole, there was minimal or no change of critical aggregation concentration (CAC) of AmB regardless of the concentration of polymer. By contrast at 20,000 g/mole, the CAC of AmB strikingly increased to 24.3 and $37.5\;{\mu}M$ at 5.0% and 10 % w/v of polymer, respectively. The critical overlap concentration (COC) of PEO 20,000 g/mole was 5.5%. It appears that an interaction between monomeric AmB and polymer coil increases above the COC, competing with self-aggregation of the drug. Accordingly, the degree of aggregation of AmB stayed low and the toxicity became less. There was no such effect at 3,000 and 8,000 g/mole of PEO, owing perhaps to small dimensions in comparison to AmB. Based upon these findings, less toxic AmB formulation may be developed by a pharmaceutical technique such as solid dispersion system containing both AmB and PEO 20,000 g/mole.

• Journal of the Korean Society for Marine Environment & Energy
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• v.12 no.1
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• pp.55-59
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• 2009

As one of the methods for recycling the FRP from the small and medium waste ships, separation of roving layer from the mat has some merits in a sense of the recycling energy and the environmental effects. Similar characteristics, however, between the roving and the mat even with different ratio of the resin and the glass and the thickness of the roving, much thinner than the mat, make the mechanically automatic differentiation difficult. In this study spectrochemical differentiation between the two layers has been made using (1) boiling concentrated sulfuric acid which can dissolve the resin in the FRP layer, (2) methanol and isopropanol solution saturated with KOH which can dissolve the glass, or (3) hydrogen fluoride(HF) solution which can reacts with $SiO_2$ fragments of the glass. Furthermore coloring water-soluble dye following the HF treatment makes the roving layer more distinguishable photo-physically.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1996.06c
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• pp.957-966
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• 1996

An attempt was made to measure the availability of waste heat, released from the cooling system of a small engine, which can be utilized for grain drying. An engine powered flat-bed rough rice dryer was constructed and the performance of the dryer with available engine-waste heat was analyzed for 10 , 20, 30 and 40 cm rough rice bulk depths with a constant dryer base area of 0.81$m^2$/min. The waste heat was sufficient to increase the drying air temperature 7 to 12$^{\circ}C$ at an air flow rate of 8.8 to 5.7㎥/min, while the average ambient temperature and relative humidity were 24$^{\circ}C$ and 70%. The minimum energy requirement was 3.26 MJ/kg of water removed in drying a 40 cm deep grain bed in 14h. A forty to fifty centimeter deep grained seems to be optimum in order to avoid over-drying in the top layers. On the basis of minimum energy requirement (3.26 MJ/kg ) , an estimation was made that the waste heat harvest from an engine of a power range of 1 to 10.5PS can dry about 0.1 to 1 metric on of rough rice from 23% to 15% m.c. (w.b) in 12 h at an average ambient temperature and relative humidity of $25^{\circ}C$ and 80%, respectively. The engine-waste heated grain dryer can be used in the rural areas of non industrialized countries where electricity is not available.

• Journal of the Korean Society of School Health
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• v.10 no.2
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• pp.193-211
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• 1997

The study was designed to gain necessary basic data in order to grasp the health knowledge, attitude, and practice level of students and teachers of elementary, middle and high schools. This study was conducted through interviews of 3,400 students and 1,022 teachers attending 14 different schools large, middle and small cities and rural towns during a period of nine months (from Oct. 2 1995 to Jun. 30 1996). By the results of this study, the recommendations can be summarized as follows: 1. A school health development committee should be established of 10 members: school health related teachers (physical trainers, nurses, and teachers in charge of health), parents, persons related to health administration, local medical doctors, and student reprensentatives in order to support and immplement school health development plans. 2. Like advanced countries, a health class of 2~4 hours should beplaced in middle and high schools. A nurse majoring in health from a university should be the teacher. 3. A curriculum of health should contain the following: education on health, sex, alcohol, tabacco, the misuse of the drugs, the structure and function of human body, the growth of the body, mental health, safety and emergency care, the prevention of disease, proper eating habits and nutrition, daily health life, family health education, society health, community health, environmental pollution and individual responsibility. 4. Create a school health promotion center, with a nurse's office, and a sports center which has health machines (bars, aerobics, training, twist machine, belt massage, running machine, bench press, chest waist, hack hip extension machine) as well as a physical strength measuring machine (muscular strength, alertness, flexibility, endurance, lung functions and so on), so that the teaching staff and students can use them and train their bodies. 5. Through a refresher education program, urge teachers to understand school health promotion services. 6. Regulate a standard and establish a system of monitoring the physical enviroment of the school (the height of desks and chairs, illumination facilities, ventilation facilities, safe drinking water). 7. Create a check list of health to evaluate improvement.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.26 no.2
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• pp.103-111
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• 2014

The wave power, extracted from a circular array of small power buoys, is investigated under the potential theory. It is assumed that the buoy's radius, the draft, and the separation distance are much smaller than the water depth, the wave length, and the radius of a circular deployment area. The boundary value problem involving the macro-scale boundary condition on the mean surface covered by buoys is solved using the eigenfunction expansion method. The capture width, which is defined as the ratio of the extracted power to the wave power per unit length of the incident wave crest, is assessed for various combinations of packing ratio, radius of a circular array, and PTO damping coefficient. It is found that the circular array deployment is more effective in the viewpoint of efficiency than the single large buoy of the same total displaced volume.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.19 no.1
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• pp.95-106
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• 2001

The aim of this study was to find out and confirm the project formulation, feasibility, scale and locations on the farmland development projects such as planned and ongoing tideland reclamation and irrigation facilities along the western coast of North Korea using satellite image data, Landsat TM, JERS OPS and SPOT PAN and aged maps. In order to apply to the study, remote sensing technologies such as geometric correction. digital mosaicking, image merging, linear extraction and land cover classification were studied. As the results of the study, the reclaimable tidal flats are recognized at about 178, 000 ha equivalent to 59% of announced 300, 000ha. and 16, 000 ha of completed, 17, 000 ha of ongoing project areas although 27, 000 ha were revealed to be completed during 1987-1993. Almost planned projects are appeared to be shortage of water supply due to their small watersheds, however, most projects are connected with 2000 mile canal system.

• Journal of Energy Engineering
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• v.2 no.1
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• pp.95-103
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• 1993

A conceptual thermoelectric heat pump(cooling mode) of small capacity is designed. Its performance is investigated through parametric analysis. COP and cooling capacity decease as the ambient temperature increases with ${\mu}$, J, T$\sub$wi/, fixed. To design a system of fixed capacity comes to calculate ${\mu}$ and J when T$\sub$wi/, and T$\sub$a/ are given. As v is fixed by semi-conductor manufacturers, optimum combination of n and I should be searched for ν. Optimum current could be calculated using ${\mu}$-J curve and optimum value of ${\mu}$. COR$\sub$R/ increases as water flow rate increases and T$\sub$a/ decreases. The effect of heat transfer coefficient at hot(heat releasing) side is more significant than that at cold(heat absorbing) side.

• Carbon letters
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• v.11 no.1
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• pp.28-33
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• 2010

In this study, $TiO_2$-Activated carbon (AC) complex fibers were prepared by electrospinning for the synergetic effect of adsorption and degradation of organic pollutant. The average diameter of these fibers increased with increasing the amount of AC added, except for 1AC-TOF (AC$/TiO_2$ =1/40 mass ratio). After calcinations at $500^{\circ}C$, long as-spun fibers were broken and their average diameter was slightly decreased. The resultant fibers after calcination had rough surface and sphere shapes like a peanut. From XRD results, it was confirmed that as-spun fibers were changed to anatase $Ti_O2$ fiber after calcinations at $500^{\circ}C$. The prepared $TiO_2$-AC complex fibers could remove procian blue dyes by solar light irradiation with high removal property of 94~99%. The PB dye was rapidly removed by adsorption during the initial 5 minutes. But after 5 minutes, dye removal was occurred by photodegradation. In this study, the most efficient AC/$TiO_2$ ratio of $TiO_2$-AC complex fibers was 5/40, showing the synergetic effect of adsorption and photodegradation. It is expected that the $TiO_2$-AC complex fibers can be used to remove of organic pollutants in water system.

• Restorative Dentistry and Endodontics
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• v.26 no.2
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• pp.134-140
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• 2001

The polymerization shrinkage of composite resins is an important drawback although the composites have many advantages-more esthetic and conservative than metallic restoratives etc. The purposes of this research were to develop a new measurement method and to manufacture an instrument that can measure the initial dynamic volumetric shrinkage of composite resins during polymerization. The instrument was basically an electromagnetic balance that constructed with a force transducer using position sensitive photo detector(PSPD) and a negative feedback servo amplifier of proportional-derivative(PD) controller. The volumetric change of composites during polymerization was detected continuously as buoyancy change in distilled water by means of Archimedes's principle. It was converted to continuous electrical voltage signal in real time. The signal was properly conditioned and filtered and then it was stored in computer by a data acquisition(DAQ) board. By using this electronic instrument. the dynamic patterns of the polymerization shrinkage of eight commercial(Z-100, DenFil, AeliteFil, Z-250, P-60, SureFil, Synergy compact, and Tetric ceram) composite resins were measured and compared. The results were as follows. 1. From this project of developing instrument, the ability has been achieved that can acquire and process data of electrical signal transformed from various physical phenomenon by using temperature, displacement. photo. and force transducer. As a consequence, the instrumentation and measurement system used to analyze the physical characteristics of various dental materials in dental research field can be designed, manufactured and implemented in lab. 2. This instrument has some advantages. It was insensible to temperature change and could measure true dynamic volumetric shrinkage in real time without complicated process. It showed accuracy and high precision results with small standard deviation. 3. The polymerization shrinkage of composites was significantly different between brands and ranged from 2.47％ to 3.89％, The order of polymerization shrinkage was as follows, in order of increasing shrinkage, SureFil, P60, Z250, Z100, Synergy compact. DenFil, Tetric ceram, and AeliteFil. 4. The polymerization shrinkage rate per unit time, dVol％/dt, showed that the instrument can provide an indirect research method for polymerization reaction kinetics.

• Magazine of the Korean Society of Agricultural Engineers
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• v.39 no.1
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• pp.102-111
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• 1997

Experiments both in laboratory and field were performed to compare and analyze the characteristics of alluvial clay. The alluvial clay was sampled in test site in which large-scaled tests for the part of the site are under process to suggest the rational method for alluvial clay and the criterion for ground settlement monitoring system. The followings were observed through the experiments : 1. Natural water content, plastic limit, and liquid limit of alluvial clay composed of highly fine grains were 40~80%, 10~20%, and 30~55%, respectively. The values of these properties were relatively small at the ground surface, while the values showed maximum at G.L.- l0m and gradually decreased below the level. 2. Shear strength of alluvial clay was proportionally increased to the depth. Unconfined and triaxial compressive strengths were 0.2~0.6kgf/$cm^2$ and 0.1~0.3kgf/$cm^2$, respectively. 3. Compression index and secondary compression index showed maximum values at G.L.-l0m and gradually decreased below the level. The value of consolidation coefficient was relatively large at the ground surface, constant with decreasing the depth, and incresed when G.L. was below -20m. 4. Piezocone test appeared that alluvial clay with N value of 2~4 was uniformly distributed with 20~ 30m thickness from the ground surface, sand seam was nonuniformly distributed, and penetration pore pressure was 0.8 ~ 1 times of the hydrostatic pressure. Undrained shear strength and consolidation coefficient were 0.04 ~ 0.76kgf / $cm^2$ and $2.88{\times} 10{^-4}~1.3{\times} 10{^-2} cm^2/s$ respectively.