• Journal of Applied Biological Chemistry
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• 제57권3호
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• pp.251-254
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• 2014

$\small{L}$-arginine ($\small{L}$-Arg)을 짠맛 증강소재로 활용하기 위하여 전자혀 분석으로 $\small{L}$-Arg의 맛 특성을 조사하고, $\small{L}$-Arg의 강한 쓴맛을 억제하기 위하여 $\small{L}$-aspartic acid ($\small{L}$-Asp)을 혼합하였다. 0.4% NaCl 용액에 $\small{L}$-Arg과 $\small{L}$-Asp를 혼합하여 전자혀 시스템으로 분석한 결과 $\small{L}$-Arg과 $\small{L}$-Asp의 혼합을 다르게 한 경우, 동일한 $\small{L}$-Arg 농도에서 $\small{L}$-Asp의 비율이 감소함에 따라 NaCl의 짠맛 상승효과는 증가하였다. 관능평가에서 짠맛은 동일한 경향이었으며, $\small{L}$-Asp의 첨가로 $\small{L}$-Arg의 쓴맛이 억제되는 것을 확인하였다. 즉, $\small{L}$-Arg과 $\small{L}$-Asp 혼합물은 짠맛 증강소재로 활용될 수 있으며, $\small{L}$-Arg의 쓴맛을 상쇄하기 위한 최적의 혼합비율은 $\small{L}$-Arg : $\small{L}$-Asp =1.00:0.98-1.00 범위가 적합하였다.

• 천문학회보
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• 제44권2호
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• pp.59.4-59.4
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• 2019

In this talk, we will give an overview of the small telescope network project in Korea. The small telescope network is a project in planning that would gather 0.4m-1.0m telescopes in Korea together for a common use in research and education, and the project is being led by the Optical/IR Astronomy Division of KAS. Even in the era of giant telescopes, small telescopes are still competitive for various research topics that require rapid response or long-term, steady monitoring. There are quite a few small telescopes in Korea, but the research use of these telescope has been very limited. By organizing these telescopes together, the small telescope network hopes to bring these telescopes in full operation and offer Korean astronomers competitive observational resources. In this talk, we will outline the project, describe potential resources, and several science cases such as multi-messenger astronomy, supernovae, and AGN. We will also introduce how this project might be run, with the expected operation of the small network starting at 2020.

• Journal of Microbiology and Biotechnology
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• 제23권8호
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• pp.1070-1075
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• 2013

Streptococcus mutans is the primary etiological agent of dental caries. The antimicrobial peptide $\small{D}$-Nal-Pac-525 was designed by replacing the tryptophans of the Trp-rich peptide Pac-525 with $\small{D}$-${\beta}$-naphthyalanines. To assess the effect of $\small{D}$-Nal-Pac-525 on cariogenic bacteria, the activity of $\small{D}$-Nal-Pac-525 on the growth of S. mutans and its biofilm formation were examined. $\small{D}$-Nal-Pac-525 showed robust antimicrobial activity against S. mutans (minimum inhibitory concentration of 4 ${\mu}g/ml$). Using scanning electron microscopy and transmission electron microscopy, it was shown that $\small{D}$-Nal-Pac-525 caused morphological changes and damaged the cell membrane of S. mutans. $\small{D}$-Nal-Pac-525 inhibited biofilm formation of S. mutans at 2 ${\mu}g/ml$. The results of this study suggest that $\small{D}$-Nal-Pac-525 has great potential for clinical application as a dental caries-preventing agent.

• 대한두경부종양학회지
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• 제16권2호
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• pp.216-219
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• 2000

Small cell carcinoma usually occurs in lung, but extrapulmonary small cell carcinomas can occur in any sites of body. Most sites of extrapulmonary small cell carcinoma reported were esophagus. And small cell carcinomas occurred in head and neck area were reported rarely. Extrapulmonary small cell carcinoma could be diagnosed when there is no evidence of primary lung lesion on chest X-ray, CT scan of chest and bronchoscopy. The authors experienced a case of small cell carcinoma of left submandibular lymph node in 64-year-old male patient. Biopsy specimen showed poorly differentiated carcinoma but immunohistochemical study showed small cell carcinoma. The chest X-ray and CT scan of chest showed no evidence of primary lung lesion. The patient received chemotherapy(etoposide plus cisplatin) and concurrent chemoradiotherapy using weekly taxol which resulted in good clinical remission. He is still alive 8 months after diagnosis without evidence of lung disease. We report our case with a brief review of literatures.

• Journal of Microbiology and Biotechnology
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• 제24권12호
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• pp.1664-1672
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• 2014

In this study, a fibrous bed bioreactor (FBB) was used for $\small{D}$-lactic acid ($\small{D}$-LA) production by Sporolactobacillus inulinus Y2-8. Corn flour hydrolyzed with ${\alpha}$-amylase and saccharifying enzyme was used as a cost-efficient and nutrient-rich substrate for $\small{D}$-LA production. A maximal starch conversion rate of 93.78% was obtained. The optimum pH for $\small{D}$-LA production was determined to be 6.5. Ammonia water was determined to be an ideal neutralizing agent, which improved the $\small{D}$-LA production and purification processes. Batch fermentation and fed-batch fermentation, with both free cells and immobilized cells, were compared to highlight the advantages of FBB fermentation. In batch mode, the $\small{D}$-LA production rate of FBB fermentation was 1.62 g/l/h, which was 37.29% higher than that of free-cell fermentation, and the $\small{D}$-LA optical purities of the two fermentation methods were above 99.00%. In fe$\small{D}$-batch mode, the maximum $\small{D}$-LA concentration attained by FBB fermentation was 218.8 g/l, which was 37.67% higher than that of free-cell fermentation. Repeate$\small{D}$-batch fermentation was performed to determine the long-term performance of the FBB system, and the data indicated that the average $\small{D}$-LA production rate was 1.62 g/l/h and the average yield was 0.98 g/g. Thus, hydrolyzed corn flour fermented by S. inulinus Y2-8 in a FBB may be used for improving $\small{D}$-LA fermentation by using ammonia water as the neutralizing agent.

• 한국전자거래학회지
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• 제19권4호
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• pp.195-204
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• 2014

최근 지능화 고도화 되고 있는 사이버 위협으로부터 중소기업을 보호하기 위해서는 24시간 예방 탐지 분석 대응 해 주는 보안관제가 필수적이다. 이러한 중소기업의 보안관제를 지원하기 위해 정부로부터 예산지원을 받아 중소기업기술지킴센터가 구축되어 운영 중이며, 현재 900여 개 중소기업에 대해 보안관제서비스를 지원하고 있다. 본 논문에서는 중소기업 기술지킴센터에서 보안관제서비스를 지원하고 있는 중소기업들의 이상트래픽에 대해 살펴보고 중소기업의 보안관제 개선방안을 제시하였다.

• Biomolecules & Therapeutics
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• 제31권1호
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• pp.48-58
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• 2023

Interferon regulatory factor 3 (IRF3) integrates both immunological and non-immunological inputs to control cell survival and death. Small GTPases are versatile functional switches that lie on the very upstream in signal transduction pathways, of which duration of activation is very transient. The large number of homologous proteins and the requirement for site-directed mutagenesis have hindered attempts to investigate the link between small GTPases and IRF3. Here, we constructed a constitutively active mutant expression library for small GTPase expression using Gibson assembly cloning. Small-scale screening identified multiple GTPases capable of promoting IRF3 phosphorylation. Intriguingly, 27 of 152 GTPases, including ARF1, RHEB, RHEBL1, and RAN, were found to increase IRF3 phosphorylation. Unbiased screening enabled us to investigate the sequence-activity relationship between the GTPases and IRF3. We found that the regulation of IRF3 by small GTPases was dependent on TBK1. Our work reveals the significant contribution of GTPases in IRF3 signaling and the potential role of IRF3 in GTPase function, providing a novel therapeutic approach against diseases with GTPase overexpression or active mutations, such as cancer.

• 한국항해항만학회지
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• 제48권2호
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• pp.116-124
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• 2024

Automatic docking of small planing ship is a critical aspect of maritime operations, requiring accurate prediction of motion states to ensure safe and efficient maneuvers. This study investigates the use of Artificial Neural Network (ANN) to predict motion state of a small planing ship to enhance navigation automation in port environments. To achieve this, simulation tests were conducted to control a small planing ship while docking at various heading angles in calm water and in waves. Comprehensive analysis of the ANN-based predictive model was conducted by training and validation using data from various docking situations to improve its ability to accurately capture motion characteristics of a small planing ship. The trained ANN model was used to predict the motion state of the small planning ship based on any initial motion state. Results showed that the small planing ship could dock smoothly in both calm water and waves conditions, confirming the accuracy and reliability of the proposed method for prediction. Moreover, the ANN-based prediction model can adjust the dynamic model of the small planing ship to adapt in real-time and enhance the robustness of an automatic positioning system. This study contributes to the ongoing development of automated navigation systems and facilitates safer and more efficient maritime transport operations.

• KIEAE Journal
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• 제12권1호
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• pp.127-132
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• 2012

The energy consumption in the world is growing rapidly. And the environmental issues of climate become a important task. The interest in renewable energy like wind and solar is increasing now. Especially, by reducing power transmission loss, a small wind power is getting attention at the residential areas and campus of university. In this study, we attempted to estimate and compare the wind energy density using wind data of AWS (Automatic Weather Station) of H University. In this case of a campus, the weibull distribution parameter C is 2.27, and K is 0.88. According to the data, the energy density of the small wind power is 12.7 W/m2. We did CFD(Computational Fluid Dynamics) simulations at H University campus by 7 wind directions(ENE, ESE, SE, NW, WNW, W, WSW). In the results, we suggest 4 small wind powers. The small wind power generating system can produce 4,514kWh annually.

• Animal cells and systems
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• 제8권2호
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• pp.81-87
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• 2004

Male red-spotted newts, Notophthalmus viridescens, use chemical cues to locate and select potential mates. To investigate whether large and small males respond differentially to chemical cues from conspecifics, we conducted a series of two-choice Y-maze tests with odorant stimuli from two large females (LF/LF), one large versus one small female (LF/SF), and one large female placed with four males versus one small female (LF+4M/SF). We found that males responded more rapidly in a LF/LF choice situation than in those involving LF/SF or LF+4M/SF. In addition, small males chose more quickly than did large males. These results suggest that both body size and odorant context affect the speed of odorant responses. By responding differentially to conspecific chemical cues, small males may arrive earlier at a courting area, increasing their chances of successfully guarding and mating with a female.