• 대한한방내과학회지
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• 제42권5호
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• pp.1094-1101
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• 2021

Objectives: This study examined a case of chronic intestinal pseudo-obstruction (CIPO) in an adult with unspecified abdominal pain.Methods: The patient was treated with herbal medicine, acupuncture, and moxa. Treatment progress was evaluated by follow-up monitoring of the intensity, frequency, and duration (in hours) of abdominal pain and body weight. Results: The average abdominal pain level on the Numerical Rating Scale (NRS) and its incidence decreased. The duration of pain was 15 hours maximum and 2.5 hours minimum. The body weight repeatedly increased and decreased but increased overall. Despite no remarkable findings from X-rays, air-fluid levels and coil-shaped folds of the small bowel were observed. Conclusions: Korean medical treatment based on a dialectic effectively relieved chronic abdominal pain and suspected CIPO-a disease that requires continuous management and therapeutic intervention.

• Tribology and Lubricants
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• 제37권2호
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• pp.77-80
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• 2021

In this study, we investigated the effect of the spring constant on frictional behavior at a nanoscale through molecular dynamics simulation. A small cube-shaped tip was modeled and placed on a flat substrate. We did not apply the normal force to the tip but applied adhesive force between the tip and the substrate. The tip was horizontally pulled by a virtual spring to generate relative motion against the substrate. The controlled spring constant of the virtual spring ranged from 0.3 to 70 N/m to reveal its effect on frictional behavior. During the sliding simulation, we monitored the frictional force and the position of the tip. As the spring constant decreased from 70 to 0.3 N/m, the frictional force increased from 0.1 to 0.25 nN. A logarithmic relationship between the frictional force and spring constant was established. The stick-slip instability and potential energy slope increased with a decreasing spring constant. Based on the results, an increase in the spring constant reduces the probability of trapping in the local minima on the potential energy surface. Thus, the energy loss of escaping the potential well is minimized as the spring constant increases.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 춘계학술대회
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• pp.93-93
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• 2019

In this study, we evaluated the anti-cancer activity and potential molecular mechanism of 70% ethanol extracts of branches from Taxillus yadoriki parasitic to Neolitsea sericea (TN-NS-B) against human lung cancer cells, A549. TY-NS-B dose-dependently suppressed the growth of A549 cells. TY-NS-B decreased ${\beta}$-catenin protein level, but not mRNA level in A549 cells. The downregulation of ${\beta}$-catenin protein level by TY-NS-B was attenuated in the presence of MG132. Although TY-NS-B phosphorylated ${\beta}$-catenin protein, the inhibition of $GSK3{\beta}$ by LiCl did not blocked the reduction of ${\beta}$-catenin by TY-NS-B. In addition, TY-NS-B decreased ${\beta}$-catenin protein in A549 cells transfected with Flag-tagged wild type ${\beta}$-catenin or Flag-tagged S33/S37/T41 mutant ${\beta}$-catenin construct. Our results suggested that TN-NS-B may downregulate ${\beta}$-catenin protein level independent on GSK3${\beta}$-induced ${\beta}$-catenin phosphorylation. Based on these findings, TY-NS-B may be a potential candidate for the development of chemopreventive or therapeutic agents for human lung cancer.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권12호
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• pp.6000-6017
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• 2018

This paper presents a new descriptor, named Histograms of Prominent Edge Directions (HPED), for the recognition of facial expressions in a person-independent environment. In this paper, we raise the issue of sampling error in generating the code-histogram from spatial regions of the face image, as observed in the existing descriptors. HPED describes facial appearance changes based on the statistical distribution of the top two prominent edge directions (i.e., primary and secondary direction) captured over small spatial regions of the face. Compared to existing descriptors, HPED uses a smaller number of code-bins to describe the spatial regions, which helps avoid sampling error despite having fewer samples while preserving the valuable spatial information. In contrast to the existing Histogram of Oriented Gradients (HOG) that uses the histogram of the primary edge direction (i.e., gradient orientation) only, we additionally consider the histogram of the secondary edge direction, which provides more meaningful shape information related to the local texture. Experiments on popular facial expression datasets demonstrate the superior performance of the proposed HPED against existing descriptors in a person-independent environment.

• Smart Structures and Systems
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• 제26권6호
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• pp.809-817
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• 2020

In cells, the microtubules are surrounded by viscoelastic medium. Microtubules, though very small in size, perform a vital role in transportation of protein and in maintaining the cell shape. During performing these functions waves propagate and this propagation of waves has been investigated using nonlocal elastic theory. But the effect of surrounding medium was not taken into account. To fill this gap, this study considers the viscoelastic medium along with nonlocal elastic theory. The analytical formulas of the velocity of waves, and the results reveal that the presence of medium reduces the velocity. The axisymmetric and nonaxisymmetric waves are separately discussed. Furthermore, the results are compared with the results gained from the studies of free microtubules. The presence of medium around microtubules results in the increase of the flexural rigidity causing a significant decrease in radial wave velocity as compared to axial and circumferential wave velocities. The effect of viscoelastic medium is more obvious on radial wave velocity, to a lesser extent on torsional wave velocity and least on longitudinal wave velocity.

• 대한조선학회논문집
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• 제57권5호
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• pp.271-277
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• 2020

Recoverability and vulnerability of navy ships under underwater explosion are critical verification factors in the acquisition phase of navy ships. This paper aims to establish numerical analysis techniques for the underwater explosion of navy ships. Doubly Asymptotic Approach (DAA) Equation of Motion (EOM) of primary shock wave and secondary bubble pulse proposed by Geers-Hunter was introduced. Assuming a non-compressive fluid, reference solution of the DAA EOM of Geers-Hunter using Runge-Kutta method was derived for the secondary bubble pulse phase with an assumed charge conditions. Convergence analyses to determine fluid element size were performed, suggesting that the minimum fluid element size for underwater explosion analysis was 0.1 m. The spherical and cylindrical fluid domains were found to be appropriate for the underwater explosion analyses from the fluid domain shape study. Because the element size of 0.1 m was too small to be applied to the actual navy ships, a very slender beam with the square solid section was selected for the study of fluid domain existence effect. The two underwater explosion models with/without fluid domain provided very similar results in terms of the displacement and stress processes.

• 한국기계가공학회지
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• 제20권3호
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• pp.107-112
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• 2021

Pressure, which is a dynamic characteristic of a floodgate, is predicted using an FSI analysis method. A fluid analysis model and a hydrology analysis model were used as analysis models. As a result of the analysis, we found that a warped model has smaller acceleration than a square model. Additionally, this numerical analysis technique was applied to the actual hydrology, and the analysis results were compared with the results of the vibration tests. As a result, we confirmed that there is a small difference between the results of the vibration tests and the results of the FSI analysis. Through this analysis, the applicability and reliability of the FSI analysis method were verified. We concluded that the pressure of a floodgate can be measured through an FSI analysis method.

• 대한약침학회지
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• 제25권1호
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• pp.52-62
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• 2022

Objectives: Snake venom is a complex mixture of various pharmacologically active substances, such as small proteins, peptides, and organic and mineral components. This paper aims to identify and analyse the proteins in common venomous snakes, such as Gloydius blomhoffii (G. blomhoffii) and Agkistrodon acutus (A. acutus), in Korea. Methods: We used mass spectrometry, electrophoresis, N-terminal sequencing and in-gel digestion to analyse the proteins in these two snake venoms. Results: We identified eight proteins in G. blomhoffii venom and four proteins in A. acutus venom. The proteins detected in G. blomhoffii and A. acutus venoms were phospholipase A₂, snake venom metalloproteinase and cysteine-rich secretory protein. Snake C-type lectin (snaclec) was unique to A. acutus venom. Conclusion: These data will contribute to the current knowledge of proteins present in the venoms of viper snakes and provide useful information for investigating their therapeutic potential.

• Journal of Information Processing Systems
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• 제18권3호
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• pp.411-427
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• 2022

Digging historical and cultural information from seals in ancient books is of great significance. However, ancient Chinese seal samples are scarce and carving methods are diverse, and traditional digital image processing methods based on greyscale have difficulty achieving superior segmentation and recognition performance. Recently, some deep learning algorithms have been proposed to address this problem; however, current neural networks are difficult to train owing to the lack of datasets. To solve the afore-mentioned problems, we proposed an SEL-RefineMask which combines selector of feature pyramid network (SEL-FPN) with RefineMask to segment and recognize seals. We designed an SEL-FPN to intelligently select a specific layer which represents different scales in the FPN and reduces the number of anchor frames. We performed experiments on some instance segmentation networks as the baseline method, and the top-1 segmentation result of 64.93% is 5.73% higher than that of humans. The top-1 result of the SEL-RefineMask network reached 67.96% which surpassed the baseline results. After segmentation, a vision transformer was used to recognize the segmentation output, and the accuracy reached 91%. Furthermore, a dataset of seals in ancient Chinese books (SACB) for segmentation and small seal font (SSF) for recognition were established which are publicly available on the website.

• Steel and Composite Structures
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• 제44권3호
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• pp.371-388
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• 2022

The present study tackles the problem of forced vibration of imperfect axially functionally graded shell structure with truncated conical geometry. The linear and nonlinear large-deflection of the structure are considered in the mathematical formulation using von-Kármán models. Modified coupled stress method and principle of minimum virtual work are employed in the modeling to obtain the final governing equations. In addition, formulations of classical elasticity theory are also presented. Different functions, including the linear, convex, and exponential cross-section shapes, are considered in the grading material modeling along the thickness direction. The grading properties of the material are a direct result of the porosity change in the thickness direction. Vibration responses of the structure are calculated using the semi-analytical method of a couple of homotopy perturbation methods (HPM) and the generalized differential quadrature method (GDQM). Contradicting effects of small-scale, porosity, and volume fraction parameters on the nonlinear amplitude, frequency ratio, dynamic deflection, resonance frequency, and natural frequency are observed for shell structure under various boundary conditions.