• Asian Pacific Journal of Cancer Prevention
• /
• 제13권9호
• /
• pp.4505-4510
• /
• 2012

Purpose: To determine the efficacy of post-operative chemotherapy with cisplatin plus vinorelbine (NP) in Chinese patients with non-small cell lung cancer (NSCLC). Methods: A total of 451 patients with NSCLCs at stages I, II, and IIIA after surgical resection were treated with cisplatin plus vinorelbine for 4 cycles or volunteers observed between January 2002 and November 2004 and were followed for five years. The therapeutic efficacy was evaluated with reference to overall survival (OS) and disease-free survival (DFS), and adverse effects were also recorded. Potential factors affecting the lengths of OS and DFS were analyzed by multivariate analysis. Results: Most patients (86.7%) completed at least 4 cycles of treatment. Patients with chemotherapy survived significantly longer than those in the observation group (p<0.001). The absolute improvements in the 2 and 5-year OS were 3.8% [hazard ratio (HR) =0.674, 95% confidence interval (CI): 0.554-0.820, P<0.0001] and 13.0% (HR=0.732, 95% CI: 0.579-0.926, P=0.009), respectively. The improvement at 4-year DFS was 2.1% (HR=0.327, 95% CI: 0.214-0.500, P<0.0001). Stratification analysis revealed that older age, histological type, pathological degree, but not the gender and smoking status, are independent factors affecting the length of survival in this population. Many patients (63.3%) had grade 1-III tolerable adverse effects, and there was no treatment-related death. Conclusions: Post-operative chemotherapy with NP regimen is effective and tolerable in Chinese patients with NSCLC.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권3호
• /
• pp.965-971
• /
• 2016

Aims: To investigate the distribution of epidermal growth factor receptor (EGFR) mutations, and explore any relationships with clinical characteristics in non-small-cell lung carcinoma (NSCLC) patients. Materials and Methods: EGFR mutations were assessed by ADx-ARMS in 261 NSCLC patients from West China Hospital of Sichuan University. Relationships between EGFR mutation and clinical characteristics were analyzed by SPSS. Results: The EGFR mutation rate was 48.7% (127/261), 19-del and L858R mutations occurred predominantly, accounting for 33.1% and 40.9%, respectively, in mutated cases. Moreover, 10.2% patients were found to carry double mutations. EGFR mutations occurred more frequently in women (57.5%) than in men (41.8%) (P=0.01), and were more frequent in non-smokers (61.2%) than in former or current smokers (31.2%) (P<0.00). In addition, they were more common in adenocarcinomas (52.8%) and adenosquamous carcinomas (42.8%) than in squamous cell carcinomas (14.8%) (p<0.00). However, only smoking history and pathological types, rather than gender, proved to be associated with EGFR mutations on multivariate logistic regression analysis. No significant differences in pathological stage and metastasis status were found between EGFR wild-type and mutated cases, although EGFR mutation type was related to pathological type (p=0.00) - 19-del, L858R and other mutation types respectively occurred in 34.2%, 42.5% and 23.3% of adenocarcinomas, but in 14.3%, 0% and 85.7% of non-adenocarcinomas. Conclusions: The EGFR mutation rate was 48.7% in NSCLCs in Southwest China, so that nearly 40% patients might benefit from targeted therapies. Smoking status and pathological types were independent predictors of EGFR mutation, while EGFR mutation type was related to only pathological type, rather than smoking status.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권5호
• /
• pp.2987-2990
• /
• 2013

Background: To explore mRNA expression and clinical significance of ERCC1, BRCA1, RRM1, TYMS and TUBB3 genes in tumor tissue of postoperative patients with non-small cell lung cancer (NSCLC). Materials and Methods: Sixty NSCLC patients undergoing radical operation in our hospital from Nov., 2011 to Jun., 2012 were selected. Plasmid standards of ERCC1, BRCA1, RRM1, TYMS and TUBB3 were established and standard curves were prepared by SYBR fluorescent real-time quantitative PCR analysis. Samples from tumor centers were taken to detect mRNA expression of ERCC1, BRCA1, RRM1, TYMS and TUBB3 genes in cancerous tissue during operation. The total mRNA expression quantities were compared according to different clinical characteristics. Results: The total expression quantities of 5 genotypes from high to low were ERCC1>RRM1>TUBB3>TYMS>BRCA1 in turn. By pairwise comparisons, other differences showed statistical significance (p<0.05 or p<0.01) except for TYMS and TUBB3 (p>0.05); the low expression rates from high to low were ERCC1>TYMS>TUBB3>TUBB3>RRM1>BRCA1 in turn. The expression quantities of BRCA1, RRM1 and TYMS in males, smokers and patients without adenocarcinoma were all significantly higher than that in females, non-smokers and patients with adenocarcinoma, and significant differences were present (p<0.05 or p<0.01). In terms of pathological staging, the expression quantities of BRCA1, RRM1 and TYMS in phases IIa~IIb and IIIa~IIIb had a tendency to be greater than in phases I and IV. Conclusions: Resistance to chemotherapy and sensitivity to targeted therapy differ among patients with NSCLC. Differences in gene expression in different individuals were also revealed. Only according to personalized detection results can individualized therapeutic regimens be worked out, which is a new direction for oncotherapy.

• Journal of Astronomy and Space Sciences
• /
• 제19권3호
• /
• pp.215-224
• /
• 2002

This paper describes EGSE design for the small satellite such like KOMPSAT-2 satellite. Recent design trend of small satellite and EGSE is to take short development time and less cost. For this purpose, the design for KOMPSAT-2 satellite and EGSE are not much modified from KOMPSAT-1 heritage. It means that it is able to be accommodated the verified hardware and software modules used in KOMPSAT-1 satellite program if possible. The objective of EGSE is to provide hardware and software for efficient electrical testing of integrated KOMPSAT-2 satellite in three general categories. (1) Simulators for ground testing (e.g. solar-simulation power, earth scenes, horizons and sun sensor). (2) Ground station type satellite data acquisition and processing test sets. (3) Overall control of satellite using hardline datum. In KOMPSAT (KOrea Multi-Purpose SATellite) program, KOMPSAT-2 EGSE was developed to support satellite integration and test activities. The KOMPSAT-2 EGSE was designed in parallel with satellite design. Consequently, the KOMPSAT-2 EGSE was based on the KOMPSAT-1 heritage since the spacecraft design followed the heritage. The KOMPSAT-2 baseline was elaborated by taking advantage of experience from KOMPSAT-1 program. The EGSE of KOMPSAT-2 design concept is generic modular design with preference in part selection with commercial off-the-shelf which were proven from KOMPSAT-1 programs, flexible/user friendly operational environment (graphical interface preferred), minimized new design and self test capability.

• 한국항해항만학회지
• /
• 제35권10호
• /
• pp.785-791
• /
• 2011

본 논문에서는 소형 선박용 관성측정장치(Inertial Measurement Unit, IMU) 개발에 적합한 MEMS(Micro-Electro Mechanical System) 기반의 관성 센서 평가와 선정에 관하여 기술했다. 먼저, 오일러 공식에 기초한 관성 센서의 오차 모델과 잡음 모델을 정의하고, 앨런 분산(Allan Variance) 기법과 몬테카르로(Monte Carlo) 시뮬레이션 기법을 도입하여 관성 센서를 평가하였다. ADIS16405, SAR10Z, SAR100Grade100, LIS344ALH, ADXL103 등 다섯 가지 관성 센서에 대한 평가결과, ADIS16405의 자이로와 가속도계를 조합한 경우 오차가 가장 작게 나타났는데, 600 초 경과시 속도 오차의 표준편차가 약 160 m/s, 위치 오차의 표준편차가 약 35 km로 나타났다. 평가를 통해 ADIS16405 관성 센서가 IMU 구축에 최적임을 알았고, 이러한 오차 감소 방법에 대해서 참고문헌을 조사하여 검토하였다.

• The Plant Pathology Journal
• /
• 제38권5호
• /
• pp.533-540
• /
• 2022

Thunberg fritillary (Fritillaria thunbergii), a perennial used in traditional Chinese herbal medicine, is a members of the family Liliaceae. The degeneration of germplasm is a severe problem in the production of Fritillaria thunbergii var. chekiangensis. However, no information about viral infections of F. thunbergii var. chekiangensis has been reported. In this study, we sequenced the small RNAs of F. thunbergii var. chekiangensis from leaves and bulbs, and viruses were identified using a phylogenetic analysis and BLAST search for sequence. In addition, multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) was used to rapidly detect viruses in this variety. Our study first reported that five viruses infected F. thunbergii var. chekiangensis. Among them, fritillary virus Y (FVY), lily mottle virus (LMoV), Thunberg fritillary mosaic virus (TFMV), and hop yellow virus (HYV) had been reported in F. thunbergii, while apple stem grooving virus was first reported in the genus Fritillaria. A multiplex RT-PCR method was developed to rapidly test the four viruses FVY, LMoV, TFMV, and HYV in F. thunbergii var. chekiangensis. Our results provide a better understanding of the infection of F. thunbergii var. chekiangensis by viruses and a basic reference for the better design of suitable control measures.

• Journal of Biosystems Engineering
• /
• 제7권2호
• /
• pp.1-7
• /
• 1983

경운시(耕耘時) 토양조건(土壤條件) 및 절삭조건(切削條件)에 따른 역토내의 응력분포(應力分布)를 파악(把握)한 목적(目的)으로 토양응력계(土壤應力計)를 시작(詩作)하여 소형토양조(小型土壤槽)을 사용(使用)한 실험(實驗)에서 얻어진 결과(結果)를 요약(要約)하면 다음과 같다. 가. 절삭조건(切削條件) 및 토양조건(土壤條件)은 주응력(主應力)의 방향(方向)에 영향(影響)을 미치지 않는다. 나. 절삭조건(切削條件)에 따른 주응력(主應力)의 크기는 경심(耕深)이 클수록 최대(最大) 주응력(主應力)이 증대(增大)하는 경향(傾向)이 있으나 절삭각(切削角)의 변화(變化)에는 그 영향(影響)이 나타나지 않았다. 다. 토양조건(土壤條件)에 따른 주응력(主應力)의 크기는 토양수분(土壤水分) 함량(含量)이 많아질수록, 점토분(粘土分)이 많을수록 최대(最大) 주응력(主應力)이 증대(增大)하는 경향(傾向)이 있다. 라. 전단면상(剪斷面上)에서의 응력분포(應力分布)는 모래 성분(成分)이 많은 토양(土壤)일수록 상층(上層)의 응력(應力)이 0에 접근(接近)하고 점토성분(粘土成分)이 많은 토양(土壤)일수록 상층(上層)의 응력(應力)이 증가(增加)하여 상하층(上下層)의 응력(應力)이 같아진다.

• Steel and Composite Structures
• /
• 제41권5호
• /
• pp.761-773
• /
• 2021

This study presents a 3D non-linear finite element (FE) assessment of dynamic soil-structure interaction (SSI). The numerical investigation has been performed on the time domain through a Finite Element (FE) system, while considering the nonlinear behavior of soil and the multi-directional nature of genuine seismic events. Later, the FE outcomes are analyzed to the recorded in-situ free-field and structural movements, emphasizing the numerical model's great result in duplicating the observed response. In this work, the soil response is simulated using an isotropic hardening elastic-plastic hysteretic model utilizing HSsmall. It is feasible to define the non-linear cycle response from small to large strain amplitudes through this model as well as for the shift in beginning stiffness with depth that happens during cyclic loading. One of the most difficult and unexpected tasks in resolving soil-structure interaction concerns is picking an appropriate ground motion predicted across an earthquake or assessing the geometrical abnormalities in the soil waves. Furthermore, an artificial neural network (ANN) has been utilized to properly forecast the non-linear behavior of soil and its multi-directional character, which demonstrated the accuracy of the ANN based on the RMSE and R² values. The total result of this research demonstrates that complicated dynamic soil-structure interaction processes may be addressed directly by passing the significant simplifications of well-established substructure techniques.

• 한국전자통신학회논문지
• /
• 제17권4호
• /
• pp.687-694
• /
• 2022

본 논문에서는 Visual 동시적 위치추정 및 지도작성(SLAM : Simultaneous Localization and Mapping)기술을 응용하여 실내에서 생성된 SLAM 맵을 기반으로 지정된 목적지에 물건을 배달하는 자율주행 차량 플랫폼을 제안하였다. 실내에서 SLAM 맵을 생성하기 위해 소형 자율주행 차량 플랫폼의 상단에 SLAM 맵 생성을 위한 심도 카메라를 설치하고 SLAM 맵 속에서의 정확한 위치추정을 하기 위해 추적 카메라를 장착하여 구현하였다. 또한, 목적지의 표찰을 인식하기 위해 합성곱 신경망(CNN : Convolutional neural network)을 사용하여 목적지에 정확하게 도착할 수 있도록 주행 알고리즘을 적용하여 설계하였다. 실내 배송 자율주행 차량을 실제로 제작하였고 SLAM 맵의 정확도 확인과 CNN을 통한 목적지 표찰 인식 실험을 수행하였다. 결과적으로 표찰 인식의 성공률을 향상시켜 구현한 실내 배송용 자율주행 차량의 활용 적합성 여부를 확인하였다.

• 유기물자원화
• /
• 제8권3호
• /
• pp.131-140
• /
• 2000

가정에서 발생되는 퇴비화 가능한 폐기물 중 폐지 및 폐골탄지를 제외한 폐기물을 매일 1kg 정도씩 소형 퇴비화 3개의 소형 퇴비화용기 중 하나는 퇴비만, 또 하나에는 퇴비와 퇴비화 가능한 가정 폐기물 그리고 다른 하나에는 퇴비와 질석 그리고 퇴비화 가능한 가정 폐기물을 넣어 퇴비화하면서 정확한 매일의 무게 감소율, 분해 율(유기물감소비율)과 퇴비화 혼합물질의 각종 이 화학성 변화를 조사하였다. 30일 후 총 무게 감소율은 퇴비를 첨가제로 사용하였을 경우 57.32% 그리고 퇴비와 질석을 함께 첨가제로 사용하였을 때 64.71%이었다. 퇴비만을 첨가제로 사용하였을 경우 퇴비화 혼합물(퇴비+퇴비화 가능한 가정 폐기물)의 총 무게 감소율은 6.81% 그리고 분해율은 7.76%로 큰 차이가 없었다. 그러나 투입된 퇴비화 가능한 폐기물만을 기준으로 계산한 결과 매일 무게 감소율은 첨가제로 퇴비와 질석을 함께 사용하였을 경우 퇴비화 혼합물(퇴비+질석+퇴비화 가능한 가정 폐기물)의 매일 총무게 감소율은 64.99% 그리고 분해율은 1.48%이었으나 투입된 퇴비화 가능한 가정 폐기물만을 기준으로 매일 총무게 감소율은 4.36% 그리고 분해율은 35.46%이었다. 따라서 투입된 퇴비화 가능한 가정 폐기물만을 기준으로 계산된 매일의 분해율은 퇴비만을 첨가제로 사용하였을 경우 6.79% 그리고 퇴비와 질석을 같이 사용하였을 경우 35.46%로 질석의 첨가가 퇴비화 가능한 가정 폐기물의 분해 속도를 크게 증가시켰다. 퇴비화 혼합물 중의 MgO, $K_2O$ 및 Cr 함량은 질석을 첨가제로 사용하였을 경우가 사용하지 않았을 경우보다 퇴비화 초기에 높았다. 반면에 유기물, CaO, NaCl 및 $P_2O_5$ 함량은 질석을 첨가하였을 경우 낮아졌다.