• 수면정신생리
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• 제1권2호
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• pp.172-181
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• 1994

Obstructive sleep apnea syndrome(OSAS) is most frequently diagnosed in the sleep laboratories and its severity is objectively estimated. In terms of treatment, the most prevalent method is the continuous positive airway pressure(CPAP) application as of now. However, in Korea, CPAP is still not sufficiently known and it is attributable to the fact that sleep study facilities have not been popularized. In this article, the authors present their own experience with CPAP in nine subjects with OSAS. In this study, CPAP was found to decrease stage 1 sleep and to increase stage 2 sleep, with increasing mean oxygen saturation and decreasing lowest oxygen saturation during nocturnal sleep. Also, it tended to increase sleep continuity and generally to improve sleep architecture. Rebound slow wave and/or REM sleep stages during CPAP were also noted in 8 out of 9 cases. The authors suggest that CPAP should be considered as the primary mode of treatment for patients with obstructive sleep apnea syndrome and related educational programs for physicians should be developed and provided by sleep specialists.

• 한국소음진동공학회논문집
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• 제22권2호
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• pp.146-155
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• 2012

The filtered-x LMS(FX-LMS) algorithm has been applied to the active noise control(ANC) system in an acoustic duct. This algorithm is designed based on the FIR(finite impulse response) filter, but it has a slow convergence problem because of a large number of zero coefficients. In order to improve the convergence performance, the step size of the LMS algorithm was modified from fixed to variable. However, this algorithm is still not suitable for the ANC system of a short acoustic duct since the reference signal is affected by the backward acoustic wave propagated from a secondary source. Therefore, the recursive filtered-u LMS algorithm(FU-LMS) based on infinite impulse response(IIR) is developed by considering the backward acoustic propagation. This algorithm, unfortunately, generally has a stability problem. The stability problem was improved by using an error smoothing filter. In this paper, the recursive LMS algorithm with variable step size and smoothing error filter is designed. This recursive LMS algorithm, called FU-VSSLMS algorithm, uses an IIR filter. With fast convergence and good stability, this algorithm is suitable for the ANC system in a short acoustic duct such as the intake system of an automotive. This algorithm is applied to the ANC system of a short acoustic duct. The disturbance signals used as primary noise source are a sinusoidal signal embedded in white noise and the chirp signal of which the instantaneous frequency is variable. Test results demonstrate that the FU-VSSLMS algorithm has superior convergence performance to the FX-LMS algorithm and FX-LMS algorithm. It is successfully applied to the ANC system in a short duct.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2000년도 The 7th International Symposium
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• pp.116-122
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• 2000

The molecular modification of antiepileptic drugs and direct synthesis of new drugs with the predetermined antiepileptic properties are perspective. New neurochemical attacking to solve the problem including prevention and inhibition of seizures seems to be related to ginsenosides and ginseng polypeptides. The main study based on the severity of febrile convulsions of rat pups has been done from the earlier investigations of antiepileptical action of ginsenosides between KGTRI and MSU (Chepurnov, Park et al., 1995) with different kinds of experimental models of epilepsy. From the cultured cell line DAN25 of ginseng root, the extracts of ginsenosides made in "BIOKHIMMASH" were studied by the project of preclinical anticonvulsant screening (Stables, Kupferberg, 1997). The inhibition of severity of convulsions, decrease of seizures threshold, decrease of audiogenic seizures in rats of different strains and normalization of cerebral blood flow (measured by hydrogen test) were demonstrated in rats after i.c.v., intraperitoneally and orally administration, respectively. The antiepileptical effects by the combination of compounds from ginseng; were compared with the iuluence of Rg1, Rb1, Rc and with the well known antiepileptical drugs such as carbamazepine, valproic acid. The base for the research is obtained by using the WAG/Rij strain (Luijtelaar, Coenen, Kuznetcova), an excellent genetic model for human generalized absence epilepsy. The improving action of gensinosides was effectively demonstrated on the model of electrical kindling of amygdala of WAG/Rij rats with genetically determined absences, and the influences of ginsenosides on the slow wave discharges have also been being investigated. The different characteristics of a kindling process exerted in the sex-different region of the amygdala and demonstrated that the level of sex steroids and content of neurosteroids in amygdaloid tissue can modify the development of seizures. The chemical structures of ginsenosides not only have some principal differences from well-known antiepileptical drugs but the Plant Pharmacology gives us unique possibility to develop new class of antiepileptic drugs and to improve its biological activity.

• 대한한방부인과학회지
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• 제31권2호
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• pp.31-48
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• 2018

Objectives: This study was performed to observe the correlations between the results of ABR-2000 and DSOM / 3D-MAC to evaluate the feasibility of ABR-2000 as a oriental medical diagnostic criteria. Methods: We studied 547 women visiting ${\bigcirc}{\bigcirc}$ hospital from December 2012 to June 2015. The subjects were categorized in two groups, 'Hypotonia' and 'Non-Hypotonia' by the result of ABR-2000 and assessed the result of DSOM, 3D-MAC for each group. The differences of pulse wave factors by group also studied. Results: 1. There was no significant difference between two groups about the output frequency of pathogenic factors in DSOM while the result showed the higher correlation in Hypotonia group in terms of the companion tendency of pathogenic factors and syndromes formed by the combination of pathogenic factors. 2. The pulse waves of Hypotonia group were mostly slow, weak, tense and stiff than Non-Hypotonia group. Conclusions: 1. In Hypotonia group, yin deficiency (陰虛) factor was frequently accompanied and consumption (虛損) of various organs based on the yin deficiency (陰虛) was observed. It means chronic and severe condition of exhaustion syndrome (虛勞). 2. The result of 3D-MAC also means pathological feature of yin syndrome (陰 證) and consumption (虛損). Besides, lower scores of Body Surface Area (BSA), body weight, and Body Mass Index (BMI) were associated with body weakness (體瘦), a symptom of exhaustion syndrome (虛勞).

• The Korean Journal of Physiology and Pharmacology
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• 제18권4호
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• pp.341-346
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• 2014

Lubiprostone is a chloride ($Cl^-$) channel activator derived from prostaglandin $E_1$ and used for managing constipation. In addition, lubiprostone affects the activity of gastrointestinal smooth muscles. Interstitial cells of Cajal (ICCs) are pacemaker cells that generate slow-wave activity in smooth muscles. We studied the effects of lubiprostone on the pacemaker potentials of colonic ICCs. We used the whole-cell patch-clamp technique to determine the pacemaker activity in cultured colonic ICCs obtained from mice. Lubiprostone hyperpolarized the membrane and inhibited the generation of pacemaker potentials. Prostanoid $EP_1$, $EP_2$, $EP_3$, and $EP_4$ antagonists (SC-19220, PF-04418948, 6-methoxypyridine-2-boronc acid N-phenyldiethanolamine ester, and GW627368, respectively) did not block the response to lubiprostone. L-NG-nitroarginine methyl ester (L-NAME, an inhibitor of nitric oxide synthase) and 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ, an inhibitor of guanylate cyclase) did not block the response to lubiprostone. In addition, tetraethylammonium (TEA, a voltage-dependent potassium [$K^+$] channel blocker) and apamin (a calcium [$Ca^{2+}$]-dependent $K^+$ channel blocker) did not block the response to lubiprostone. However, glibenclamide (an ATP-sensitive $K^+$ channel blocker) blocked the response to lubiprostone. Similar to lubiprostone, pinacidil (an opener of ATP-sensitive $K^+$ channel) hyperpolarized the membrane and inhibited the generation of pacemaker potentials, and these effects were inhibited by glibenclamide. These results suggest that lubiprostone can modulate the pacemaker potentials of colonic ICCs via activation of ATP-sensitive $K^+$ channel through a prostanoid EP receptor-independent mechanism.

• Journal of Electrochemical Science and Technology
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• 제2권3호
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• pp.146-151
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• 2011

The formation of Li-Si-O phases, $Li_4SiO_4$ and $Li_2SiO_3$ from the starting materials SiO and $Li_2O$ are analyzed using Vienna Ab-initio Simulation (VASP) package and the total energies of Li-Si-O compounds are evaluated using Projector Augmented Wave (PAW) method and correlated the structural characteristics of the binary system SiO-$Li_2O$ with experimental data from electrochemical method. Despite $Li_2SiO_3$ becomes stable phase by virtue of lowest formation energy calculated through VASP, the experimental method shows presence of $Li_4SiO_4$ as the only product formed when SiO and $Li_2O$ reacts during slow heating to reach $550^{\circ}C$ and found no evidence for the formation of $Li_2SiO_3$. Also, higher density of $Li_4SiO_4$(2.42 g $ml^{-1}$) compared to the compositional mixture $1SiO_2-2Li_2O$ (2.226 g $ml^{-1}$) and better cycle capacity observed through experiment proves that $Li_4SiO_4$ as the most stable anode supported by better cycleabilityfor lithium ion battery remains as paradox from the point of view of VASP calculations.

• 한국전자파학회논문지
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• 제23권7호
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• pp.774-783
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• 2012

본 논문에서는 주기적인 요철 모양의 구조를 이용하여 인접해 있는 선로 간의 누화(crosstalk) 감소 효과를 갖는 전송 선로를 제안한다. 요철 모양의 전송 선로는 인접한 선로 간의 유도성 커플링과 용량성 커플링의 크기를 동일하게 조절이 가능하다. 따라서 유도성과 용량성의 커플링이 서로 상쇄되기 때문에 누화 감소 효과를 갖는다. 요철 모양의 전송 선로는 비유전율이 3.38이며, 두께가 0.508 mm인 RO4003 기판 위에 설계하였다. 전산모의 실험 결과, 일반적인 전송 선로와 주기 간격이 A=1 mm인 요철 모양 전송 선로의 far-end 누화는 30 GHz까지 각각 최대 -3.6 dB와 -22 dB 값을 가진다. 측정 결과, 일반적인 전송 선로와 A=1 mm인 요철 모양 전송 선로의 far-end 누화는 30 GHz까지 각각 최대 -6.3 dB와 -20.5 dB 값을 가진다.

• 한국전기전자재료학회논문지
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• 제22권6호
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• pp.537-545
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• 2009

In this paper, new parameters were developed to estimate the depth of anesthesia during a general anesthesia using EEG. Power spectral density(PSD) analysis was used for these parameters because EEG became slow wave during anesthesia. The new parameters were DTR, ATR, TDR, ADR, BTR and BDR applied to PSD. These parameters were compared with SEF which is conventionally used at clinic and confirmed clinical value. As the results, DTR, ATR, TDR, ADR among parameters were not useful compared with SEF but BTR and BDR is valuable for clinic. 15 patents, at pre-operation BDR the value is $265.36{\pm}25.29$, at induction the value is $129.23{\pm}34.92$, at operation the value is $154.99{\pm}38.34$, at awaked the value is $283.83{\pm}39.80$ and at post-operation the value is $234.80{\pm}23.46$. Also at pre-operation BTR value is $183.38{\pm}13.59$, at induction the value is $104.09{\pm}25.11$, at operation the value is $115.38{\pm}23.42$, at awaked the value is $190.33{\pm}23.31$ and at post-operation the value is $172.38{\pm}19.08$. Trend of BDR and BTR is similar to change of SEF, so two parameters are useful. to estimate the depth of anesthesia.

• 한국광학회지
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• 제1권2호
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• pp.155-161
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• 1990

메틸알코올 레이저의 여기용으로 저속축류형의 가변파장 $CO_2$ 레이저를 제작하였다. 파장가변은 ZnSe Brewster 창과 반사 회절격자를 사용하였으며, 반사 회절격자는 Blaze wavelength 10.6$\mu\textrm{m}$, 100grooves/mm 인 평면형이다. 실험은 $CO_2$ 레이저의 연속발진 출력특을 살펴보고, $CO_2$ 레이저의 전 발진구간을 파장가변시켜 얻어진 출력분포를 $CO_2$ 레이저의 이득 곡선과 비교하였다. 연속발진 출력은 기체 혼합비 $CO_2: N_2$ : He=1:3:10, 전류 55mA, 압력 14 torr 일 때 100W를 얻었다. 가변된 파장은 10.4$\mu\textrm{m}$ 영역의 R(6)-R(38), P(6)-P(36), 9.4$\mu\textrm{m}$ 영역의 R (10)-R(32), P(10)-P(38)의 약 60여개의 회전선이 발진함을 확인하였고, 이 때의 파장은 9.3295$\mu\textrm{m}$에서 10.7648$\mu\textrm{m}$까지 변화하였다. 각 영역에서 얻어진 출력분포는 $CO_2$ 레이저의 이득곡선과 잘 일치하였고, 최대 출력은 20W 정도였다.

• 대한조선학회논문집
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• 제31권1호
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• pp.50-62
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• 1994

본 논문에서는 비대선형에서 구상선수의 형상변화가 저항성능에 미치는 영향을 조사해 보기 위하여 구상선수 계열들을 창안하고 이들의 모형시험 결과를 비교 분석한 내용이 기술되었다. 구상선수의 형상을 결정짓는 7가지의 변수를 생각하고 이들을 체계적으로 변화시켜 구상선수 형상변화의 영향을 실험적으로 조사하도록 계획하였다. 총 23개 선형의 모형선을 제작하였으며, 각 선형에 대하여 저항시험, 유선조사시험 및 선측파고 계측시험이 수행되었다. 구상선수의 형상변화와 모형시험 결과와를 상호 비교 분석하기 위하여 유사한 특성의 구상선수들을 모아서 9개 그룹으로 분류하였으며 각 그룹 별 저항성분의 변화 경향을 분석해 본 결과 비대선에서는 형상저항이 전저항에 지배적인 영향이 있음을 확인하였다. 또한 모형시험 결과 및 이의 통계적 분석 자료로부터 비대선에서는 구상선수 주위의 유선의 방향이 저항성분들과 밀접한 관계가 있으며 저항성분들 중에서도 형상저항과 더욱 밀접한 관계가 있다는 사실을 발견하였다.