• Sleep Medicine and Psychophysiology
• /
• v.1 no.2
• /
• pp.172-181
• /
• 1994

Obstructive sleep apnea syndrome(OSAS) is most frequently diagnosed in the sleep laboratories and its severity is objectively estimated. In terms of treatment, the most prevalent method is the continuous positive airway pressure(CPAP) application as of now. However, in Korea, CPAP is still not sufficiently known and it is attributable to the fact that sleep study facilities have not been popularized. In this article, the authors present their own experience with CPAP in nine subjects with OSAS. In this study, CPAP was found to decrease stage 1 sleep and to increase stage 2 sleep, with increasing mean oxygen saturation and decreasing lowest oxygen saturation during nocturnal sleep. Also, it tended to increase sleep continuity and generally to improve sleep architecture. Rebound slow wave and/or REM sleep stages during CPAP were also noted in 8 out of 9 cases. The authors suggest that CPAP should be considered as the primary mode of treatment for patients with obstructive sleep apnea syndrome and related educational programs for physicians should be developed and provided by sleep specialists.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.22 no.2
• /
• pp.146-155
• /
• 2012

The filtered-x LMS(FX-LMS) algorithm has been applied to the active noise control(ANC) system in an acoustic duct. This algorithm is designed based on the FIR(finite impulse response) filter, but it has a slow convergence problem because of a large number of zero coefficients. In order to improve the convergence performance, the step size of the LMS algorithm was modified from fixed to variable. However, this algorithm is still not suitable for the ANC system of a short acoustic duct since the reference signal is affected by the backward acoustic wave propagated from a secondary source. Therefore, the recursive filtered-u LMS algorithm(FU-LMS) based on infinite impulse response(IIR) is developed by considering the backward acoustic propagation. This algorithm, unfortunately, generally has a stability problem. The stability problem was improved by using an error smoothing filter. In this paper, the recursive LMS algorithm with variable step size and smoothing error filter is designed. This recursive LMS algorithm, called FU-VSSLMS algorithm, uses an IIR filter. With fast convergence and good stability, this algorithm is suitable for the ANC system in a short acoustic duct such as the intake system of an automotive. This algorithm is applied to the ANC system of a short acoustic duct. The disturbance signals used as primary noise source are a sinusoidal signal embedded in white noise and the chirp signal of which the instantaneous frequency is variable. Test results demonstrate that the FU-VSSLMS algorithm has superior convergence performance to the FX-LMS algorithm and FX-LMS algorithm. It is successfully applied to the ANC system in a short duct.

• Proceedings of the Plant Resources Society of Korea Conference
• /
• 2000.10a
• /
• pp.116-122
• /
• 2000

The molecular modification of antiepileptic drugs and direct synthesis of new drugs with the predetermined antiepileptic properties are perspective. New neurochemical attacking to solve the problem including prevention and inhibition of seizures seems to be related to ginsenosides and ginseng polypeptides. The main study based on the severity of febrile convulsions of rat pups has been done from the earlier investigations of antiepileptical action of ginsenosides between KGTRI and MSU (Chepurnov, Park et al., 1995) with different kinds of experimental models of epilepsy. From the cultured cell line DAN25 of ginseng root, the extracts of ginsenosides made in "BIOKHIMMASH" were studied by the project of preclinical anticonvulsant screening (Stables, Kupferberg, 1997). The inhibition of severity of convulsions, decrease of seizures threshold, decrease of audiogenic seizures in rats of different strains and normalization of cerebral blood flow (measured by hydrogen test) were demonstrated in rats after i.c.v., intraperitoneally and orally administration, respectively. The antiepileptical effects by the combination of compounds from ginseng; were compared with the iuluence of Rg1, Rb1, Rc and with the well known antiepileptical drugs such as carbamazepine, valproic acid. The base for the research is obtained by using the WAG/Rij strain (Luijtelaar, Coenen, Kuznetcova), an excellent genetic model for human generalized absence epilepsy. The improving action of gensinosides was effectively demonstrated on the model of electrical kindling of amygdala of WAG/Rij rats with genetically determined absences, and the influences of ginsenosides on the slow wave discharges have also been being investigated. The different characteristics of a kindling process exerted in the sex-different region of the amygdala and demonstrated that the level of sex steroids and content of neurosteroids in amygdaloid tissue can modify the development of seizures. The chemical structures of ginsenosides not only have some principal differences from well-known antiepileptical drugs but the Plant Pharmacology gives us unique possibility to develop new class of antiepileptic drugs and to improve its biological activity.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.31 no.2
• /
• pp.31-48
• /
• 2018

Objectives: This study was performed to observe the correlations between the results of ABR-2000 and DSOM / 3D-MAC to evaluate the feasibility of ABR-2000 as a oriental medical diagnostic criteria. Methods: We studied 547 women visiting ${\bigcirc}{\bigcirc}$ hospital from December 2012 to June 2015. The subjects were categorized in two groups, 'Hypotonia' and 'Non-Hypotonia' by the result of ABR-2000 and assessed the result of DSOM, 3D-MAC for each group. The differences of pulse wave factors by group also studied. Results: 1. There was no significant difference between two groups about the output frequency of pathogenic factors in DSOM while the result showed the higher correlation in Hypotonia group in terms of the companion tendency of pathogenic factors and syndromes formed by the combination of pathogenic factors. 2. The pulse waves of Hypotonia group were mostly slow, weak, tense and stiff than Non-Hypotonia group. Conclusions: 1. In Hypotonia group, yin deficiency (陰虛) factor was frequently accompanied and consumption (虛損) of various organs based on the yin deficiency (陰虛) was observed. It means chronic and severe condition of exhaustion syndrome (虛勞). 2. The result of 3D-MAC also means pathological feature of yin syndrome (陰 證) and consumption (虛損). Besides, lower scores of Body Surface Area (BSA), body weight, and Body Mass Index (BMI) were associated with body weakness (體瘦), a symptom of exhaustion syndrome (虛勞).

• The Korean Journal of Physiology and Pharmacology
• /
• v.18 no.4
• /
• pp.341-346
• /
• 2014

Lubiprostone is a chloride ($Cl^-$) channel activator derived from prostaglandin $E_1$ and used for managing constipation. In addition, lubiprostone affects the activity of gastrointestinal smooth muscles. Interstitial cells of Cajal (ICCs) are pacemaker cells that generate slow-wave activity in smooth muscles. We studied the effects of lubiprostone on the pacemaker potentials of colonic ICCs. We used the whole-cell patch-clamp technique to determine the pacemaker activity in cultured colonic ICCs obtained from mice. Lubiprostone hyperpolarized the membrane and inhibited the generation of pacemaker potentials. Prostanoid $EP_1$, $EP_2$, $EP_3$, and $EP_4$ antagonists (SC-19220, PF-04418948, 6-methoxypyridine-2-boronc acid N-phenyldiethanolamine ester, and GW627368, respectively) did not block the response to lubiprostone. L-NG-nitroarginine methyl ester (L-NAME, an inhibitor of nitric oxide synthase) and 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ, an inhibitor of guanylate cyclase) did not block the response to lubiprostone. In addition, tetraethylammonium (TEA, a voltage-dependent potassium [$K^+$] channel blocker) and apamin (a calcium [$Ca^{2+}$]-dependent $K^+$ channel blocker) did not block the response to lubiprostone. However, glibenclamide (an ATP-sensitive $K^+$ channel blocker) blocked the response to lubiprostone. Similar to lubiprostone, pinacidil (an opener of ATP-sensitive $K^+$ channel) hyperpolarized the membrane and inhibited the generation of pacemaker potentials, and these effects were inhibited by glibenclamide. These results suggest that lubiprostone can modulate the pacemaker potentials of colonic ICCs via activation of ATP-sensitive $K^+$ channel through a prostanoid EP receptor-independent mechanism.

• Journal of Electrochemical Science and Technology
• /
• v.2 no.3
• /
• pp.146-151
• /
• 2011

The formation of Li-Si-O phases, $Li_4SiO_4$ and $Li_2SiO_3$ from the starting materials SiO and $Li_2O$ are analyzed using Vienna Ab-initio Simulation (VASP) package and the total energies of Li-Si-O compounds are evaluated using Projector Augmented Wave (PAW) method and correlated the structural characteristics of the binary system SiO-$Li_2O$ with experimental data from electrochemical method. Despite $Li_2SiO_3$ becomes stable phase by virtue of lowest formation energy calculated through VASP, the experimental method shows presence of $Li_4SiO_4$ as the only product formed when SiO and $Li_2O$ reacts during slow heating to reach $550^{\circ}C$ and found no evidence for the formation of $Li_2SiO_3$. Also, higher density of $Li_4SiO_4$(2.42 g $ml^{-1}$) compared to the compositional mixture $1SiO_2-2Li_2O$ (2.226 g $ml^{-1}$) and better cycle capacity observed through experiment proves that $Li_4SiO_4$ as the most stable anode supported by better cycleabilityfor lithium ion battery remains as paradox from the point of view of VASP calculations.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.23 no.7
• /
• pp.774-783
• /
• 2012

In this paper, a periodically corrugated transmission line is proposed. The proposed transmission line can reduce crosstalk between transmission lines. The corrugated transmission line can adjust the amount of inductive coupling and capacitive coupling equally. Thus, the crosstalk is effectively reduced because the inductive coupling and capacitive coupling cancel each other. The corrugated transmission line is fabricated on RO4003 substrate with a dielectric constant of 3.38 and a thickness of 0.508 mm. The simulated far-end crosstalks of conventional transmission line and corrugated transmission line with a period of A=1 mm have maximum values of -3.6 dB and -22 dB, respectively, up to 30 GHz. Measurement results showed that far-end crosstalks of the conventional and corrugated transmission line have maximum values of -6.3 dB and -20.5 dB, respectively, up to 30 GHz.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.22 no.6
• /
• pp.537-545
• /
• 2009

In this paper, new parameters were developed to estimate the depth of anesthesia during a general anesthesia using EEG. Power spectral density(PSD) analysis was used for these parameters because EEG became slow wave during anesthesia. The new parameters were DTR, ATR, TDR, ADR, BTR and BDR applied to PSD. These parameters were compared with SEF which is conventionally used at clinic and confirmed clinical value. As the results, DTR, ATR, TDR, ADR among parameters were not useful compared with SEF but BTR and BDR is valuable for clinic. 15 patents, at pre-operation BDR the value is $265.36{\pm}25.29$, at induction the value is $129.23{\pm}34.92$, at operation the value is $154.99{\pm}38.34$, at awaked the value is $283.83{\pm}39.80$ and at post-operation the value is $234.80{\pm}23.46$. Also at pre-operation BTR value is $183.38{\pm}13.59$, at induction the value is $104.09{\pm}25.11$, at operation the value is $115.38{\pm}23.42$, at awaked the value is $190.33{\pm}23.31$ and at post-operation the value is $172.38{\pm}19.08$. Trend of BDR and BTR is similar to change of SEF, so two parameters are useful. to estimate the depth of anesthesia.

• Korean Journal of Optics and Photonics
• /
• v.1 no.2
• /
• pp.155-161
• /
• 1990

A Continous wave tunable $CO_2$ laser which is the slow axial flow type was construccted for the optical pumping of methyl alcohol ($CH_3OH$) laser. The reflective grating of 100 grooveslmm and 10.6$\mu\textrm{m}$ blaze wavelength was used to select wavelength. We have investigated continous outpu: power characteristics, and then have compared tuned output power profile with the gain curve of $CO_2$ laser. The optimum condition for maxium power was found at the gas mixing ratio 1 : 3 : 10 for $CO_2: N_2$ and He. under this condition the flow rate, pressure of lasing gas and discharge current are 9.5 llmin. 14 torr, and 55 mA respectively. The maxium output power was 55 Wlm. Output power of single wavelength operation was measured on 60 individual rotation vibration transitions in the P and K branches of the 9.5$\mu\textrm{m}$ band and 10.4$\mu\textrm{m}$ band in $CO_2$. The output power profile obtained from each band is well consistent with the gain curve of $CO_2$ laser and maxium tuned output power was 20 watt.

• Journal of the Society of Naval Architects of Korea
• /
• v.31 no.1
• /
• pp.50-62
• /
• 1994

This paper presents the results of a comparative analysis of the model test results to investigate the effect of bulbous bow installed on a large full form ship to the ship resistance performance. Seven parameters related to the shape of bulbous bow were selected and varied systematically to inquire their effects experimentally. A total number of twenty-three ship models with different bulbous bow were manufactured, and resistance tests. flow visualization test, and wave profile measurement were carried out for each model. For the comparative analysis between the various bulb forms and their model test results, bulbous bow forms are classified into nine groups according to their form characteristics. From the analysis of the trend of the resistance components, it was verified that form resistance has dominant effect on the total resistance of a slow full form ship. The model test and its statistical analysis showed that the direction of streamlines around bulbous bow has close relationship with resistance components. especially with form resistance