• Journal of Preventive Medicine and Public Health
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• 제29권4호
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• pp.785-799
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• 1996

절삭유의 사용과 피부질환의 관계를 알아보기 위하여 한 자동차공장의 엔진 및 구동부서 근로자 1,004명을 대상으로 피부 이상 증세에 대한 기초설문조사를 실시하여 응답을 해준 근로자 667명을 대상으로 분석 및 피부과적 검진을 실시하였다. 또한 절삭유의 노출 정도를 알기 위한 방법으로 공기 중 오일 미스트를 측정하였다. 이 조사의 결과를 요약하면 다음과 같다. 1. 공기 중 오일미스트는 3개 부서로 나누어서 측정 하였는데, 전체 52건의 측정건수 중에서 8시간가중 평균 기준치인 $5mg/m^3$을 넘는 건수는 9건(17.3%)이었고, 로그정규분포상에서 95% 신뢰한계의 전체 상한치는 기준치 미만이었다. 2. 조사한 부서는 엔진가공부(258명), 가솔린 엔진조립부(210명), 디젤엔진조립부(96명), 구동부 가공반(86명), 구동부 조립반(17명)의 5개 부서였으며, 조사한 667명의 평균 나이는 34.5세였고, 근무연수의 중앙값은 7년 7개월이었다. 3. 이들 부서 중 엔진가공부와 구동부 가공반(A군)은 절삭유를 공정상 많이 사용하는 부서로 근로자 344명 중 298명 (86.6%)이 한 가지 이상의 절삭유를 사용하고 있는 반면, 가솔린엔진 조립부, 디젤엔진 조립부, 구동부 조립반의 근로자 323명(B군) 중에는 31명 (9.1%)만이 절삭유를 사용하고 있었다. 4. 피부 이상 증세의 경험자 227명 중 213명에 대하여 피부과전문의의 진찰을 시행하였는데, 이중에 172명이 검진당시 증세를 호소했는데, 1인당 평균 호소증세 건수가 1.5건 정도였다. 가장 많은 증세는 가려움증(32.5%), 구진(21.6%), 인설(15.7%), 소수포(12.5%), 반점(9.4%)의 순서였다. 5. 검진을 받은 근로자 231명 중 정상소견이나 뚜렷한 병변이 없는 사람으로 분류된 경우는 53명이었고, 나머지 160명에서 피부과적 질환이 발견되었다. 가장 많은 것은 접촉 피부염으로 전체 질환자 중 92명 (57.5%)을 차지하였고, 이들 중에는 여드름이나 낭포염 등 기타 다른 피부질환을 동반한 경우가 23명 (25%) 이었다. 기타 낭포염, 여드름만 있는 경우도 각각 9명(5.6%), 8명(5.0%)이었으며 , 각질화와 색소 이상도 1명 씩 발견되었다. 기타의 수부 습진은 비특이성 수부습진으로 분류되었는데 이들은 47명이었다. 6.피부질환이 있다고 진단받은 160명에서 발견된 피부과적 이상부위는 1인당 1.3부위였다. 이상이 발견된 부위는 손바닥(27.6%), 손가락과 손톱(22.7%), 상박부(16.0%), 손등(11.8%), 손가락 사이(10.3%)의 순이었고, 이들 수부 및 상박부위의 이상이 전체 이상의 약 88.7%였다. 7. 전체 피부질환의 유병상태는 각 부서별로 차이가 많았는데, 특히 접촉 피부염의 경우 엔진가공부는 1,000명당 213명, 가솔린엔진 조립부는 1,000명당 29명, 디젤엔진 조립부는 1,000명당 73명이었고, 구동부 가공반은 1,000명당 267명, 구동부 조립반은 1,000명당 59명으로 부서별로 차이가 매우 켰다. 이러한 경향은 절삭유 사용에 따라서 특히 수용성 절삭유만 사용하는 군과 두 종류의 절삭유를 모두 사용하는 근로자에서 마찬가지로 높게 관찰되었다. 8. 감별진단이 필요하다고 판단된 접촉 피부염 환자 49명은 첩포 검사를 시행하였다. 첩포 검사 결과, 기본 표준시료에 양성이 나타난사람이 12명, 기본표준시료와 오일시료에 모두 양성이 나타난 사람 3명, 그리고 오일 시료에만 양성이 나타난 사람 3명이 있었고, 기본 표준시료와 유기용제시료에 양성이 나타난 사람, 유기용제 시료에만 양성이 나타난 사람이 각각 1명 있었다. 9. 전체 피부질환의 유무에 대하여, 근로자의 나이와 근무기간의 영향을 통제한 후 근로자들이 사용하는 절삭유의 종류에 따른 위험도를 알아보기 위하여 다변량 분석을 하였다. 분석결과 절삭유를 전혀 사용하지 않는 군과 비수용성 절삭유만을 사용하는 군과는 유의한 차이가 없었으며 수용성 절삭유만 사용하는 사람은 $1.4\sim3.3$배(교차비의 95%신뢰한계), 두 종류의 절삭유를 모두 사용하는 사람은 $1.9\sim4.1$배 정도로 위험도가 높았다. 10. 알레르기성 접촉 피부염을 종속변수로 같은 분석을 했을 때도 결과는 같았으나, 수용성 절삭유만 사용하는 군이 $2.7\sim9.7$배, 두 종류를 모두 사용하는 군에서는 $3.7\sim12.6$배 정도로 위험도가 증가한 것을 관찰할 수 있었다.

• 대한골관절종양학회지
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• 제2권1호
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• pp.78-87
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• 1996

The results of treatment of eighteen lesions of fibrous dysplasia which of them seventeen lesions were treated with surgery were reviewed at the Department of Orthopedic Surgery, College of Medicine, Hanyang University Hospital. We studied to evaluate the functional clinical results and the recurrence according to the type of disease, grafted bone, methods of treatment and location of lesion. We treated sixteen patients(five males and eleven females) and their mean age was 22.6 years. There was no association with skin pigmentation or dysfunction of endocrine system. Twelve patients had a monostotic pattern and four patients had a polyostotic pattern. Twelve lesions were treated with curettage and bone grafting and four lesions in the proximal femur were treated by internal fixation with curettage and bone grafting. One lesion was treated by en-bloc resection. There were eleven satisfactory results in twelve monostotic lesions and there were four satisfactory results in five polyostotic lesions, but the recurrence were four cases, respectively. The two unsatisfactory results were seen in two patients treated by autografting, but there were three recurrence of four lesions in autografting only, one of five in autografting and allografting, four of eight in allgrafting or xenografting. Four of six lesions in upper extremity were recurred after curettage and bone grafting and five of them showed satisfactory results. In pelvic and lower extremity lesions, the recurrence were occurred in two lesions after curettage and bone grafting and in two lesions after internal fixation and bone grafting. The recurrence does not always provide an unsatisfactory functional results and the recurrence showed higher rate in radiologic pattern of ground glass appearance with-out marginal sclerotic rim, but the recurrence according to grafted bone showed similar rates. Curettage and bone grafting is adequate for a symptomatic lesion and firm internal fixation is needed for a lesion in proximal femur. In use of grafted bone, xenograft or allograft may be preferable to autograft because of the disadvantage of autografting like a increased blood loss, prolonged operation times, etc.

• 대한한의학원전학회지
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• 제27권3호
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• pp.101-122
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• 2014

Objectives : The comparison of symptoms of hypoadrenocorticism with symptoms according to spleen and kidney show how many points of similarity they are. And by analysis of symptoms of hypoadrenocorticism it was examined that Kidney Jeonggyeok help to cure many different symptoms including symptoms of hypoadrenocorticism. Methods : The symptoms of hypoadrenocorticism were compared and analyzed according to standards of the book of korean traditional medical pathology. First, this study was designed to show to found out how many symptoms of hypoadrenocorticism belong to symptoms of kidney qi-deficiency and slpeen qi-deficiency and how similar they are. Second, the symptoms of kidney qi deficiency were compared with the indicant of kidney Jeonggyeok suggested by two of korean traditional doctors to find out kidney Jeonggyeok can help to cure symptoms of kidney qi deficiency. And then on the basis of those, the symptoms of hypoadrenocorticism were compared with the symptoms of kidney qi deficiency. Results : The hypoadrenocorticism seems to be kidney yang(陽) deficiency. But because hypoadrenocorticism doesn't have body temperature decline, symptoms of hypoadrenocorticism are more similar symptoms of kidney qi deficiency than symptoms of kidney yang deficiency. The symptoms of hypoadrenocorticism seems to be correlated with the functions of spleen. But because of vomiting and pigmentation(skin and mucous membrane), they seem to have less to do with the functions of spleen than the functions of kidney. The comparison analysis of indicant of Kidney Jeonggyeok and symptoms of kidney qi deficiency shows that acupuncture stimulation help to cure kidney qi deficiency and hypoadrenocorticism. Conclusions : Symptoms of hypoadrenocorticism are expected to be more similar symptoms of kidney qi deficiency. And Kidney Jeonggyeok is helpful for treatment of Kidney qi deficiency and hypoadrenocorticism.

• Journal of Microbiology and Biotechnology
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• 제25권12호
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• pp.2011-2015
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• 2015

Ginsenoside Rb2 (Gin-Rb2) was purified from the fruit extract of Panax ginseng. Its chemical structure was measured by spectroscopic analysis, including HR-FAB-MS, ¹H-NMR, and IR spectroscopy. Gin-Rb2 decreased potent melanogenesis in melan-a cells, with 23.4% at 80 μM without cytotoxicity. Gin-Rb2 also decreased tyrosinase and MITF protein expression in melan-a cells. Furthermore, Gin-Rb2 presented inhibition of the body pigmentation in the zebrafish in vivo system and reduced melanin contents and tyrosinase activity. These results show that Gin-Rb2 isolated from P. ginseng may be an effective skin-whitening agent via the in vitro and in vivo systems.

• 약학회지
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• 제48권6호
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• pp.323-327
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• 2004

Whitening effect, which decreases the skin pigmentation, is the one of important targets in cosmetics. This study was investigated the effects of Scirpi rhizoma on ant ioxidation and melanogenesis. S.rhizoma is a rhizome of Scirpus fluviatilis G. a perennial Cyperaceae species of wide occurrence in Asia, Europe, Africa and North America. S.rhizoma shown scavenging activities of free radicals and reactive oxygen species (ROS) with the IC50 of 638${\mu}g/ml$ against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 21.7${\mu}g/ml$ against superoxide radicals in the xanthine/xanthine oxidase system, respectively. S.rhizoma treatment (48 h) suppressed the biosynthesis of melanin up to 27% and reduced tyrosinase activity up to 31% at 100${\mu}g/ml$ in B16 melanoma cells. S.rhizoma was also able to significantly inhibit tyrosinase and TRP-1 expres- sion in protein level. These results suggest that S.rhizoma inhibited melanin biosynthesis by regulating tyrosinase activity and expression in B16 melanoma cells. Therefore S.rhizoma may be useful as new whitening agent due to the antioxidant effect and the inhibitory effect against melanogenesis.

• 대한유전성대사질환학회지
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• 제4권1호
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• pp.13-17
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• 2004

저자들은 생후 28일된 발열, 간종대, 출혈성 경향, 구토, 잦은 보챔, 전신의 황달 증상을 보이던 환아를 MS-MS 이용한 신생아 대사 이상 검사와 혈중 아미노산 분석, 뇨중 유기산 분석을 통하여 hereditary tyrosinemia type I으로 진단하였다. 저 페닐알라닌/타이로신 식이와 NTBC 사용으로 국내 첫 타이로신혈증 I 치료 성공례를 경험하였다.

• 한방안이비인후피부과학회지
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• 제26권1호
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• pp.1-18
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• 2013

Objective: Recently the demands for the effective and safe depigmentative and anti-aging agents of the skin have increased due to the medical, pharmaceutical and cosmetic reasons. The purpose of this study is to investigate the MKG(Methanol Extract of Kaempferia galanga) and their dermal bioactivity properties related to cosmeceuticals such as depigmentation. Methods: We assessed inhibitory effects of MKG on melanin production in B16/F10 melanoma cells, on mushroom tyrosinase activity, effects of MKG on the expression tyrosinase, TRP-1, TRP-2, GSK-$3{\beta}$, CREB, MITF in B16/F10 melanoma cells without cytotoxicity range. Cell viability was measured by MTT assay and tyrosinase activity was assessed using by DOPA staining, western-blot analysis. We measured inhibition of melanin synthesis and tyrosinase activity by down-regulation of melanogenic enzyme expressions in ${\alpha}$-MSH induced melanogenesis B16/F10 melanoma cells. Results: MKG inhibited tyrosinase-activity, total melanin contents and dendrite out-growth. MKG inhibited melanogenesis by down-regulation of tyorsinase, TRP-1, TRP-2, CREB, and MITF in B16/F10 cells. The treatment with MKG at the 12.5, $25{\mu}g/ml$ level significantly inhibited the melanin synthesis induced ${\alpha}$-MSH in B16/F10 melanoma cells compared with untreated control. Conclusion: These results suggest that MKG inhibit melanin biosynthesis which is involved in hyper-pigmentation. So MKG is considered to be used as a whitening components reducing cytotoxicity.

• Radiation Oncology Journal
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• 제35권1호
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• pp.32-38
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• 2017

Purpose: Several accelerated partial breast radiation (APBR) techniques have been investigated in patients with early-stage breast cancer (BC); however, the optimal treatment delivery techniques remain unclear. We evaluated the feasibility and toxicity of APBR delivered using intensity-modulated radiation therapy (IMRT) in elderly patients with stage I BC, using a novel fractionation schedule. Materials and Methods: Forty-two patients aged ${\geq}65$ years, with stage I BC who underwent breast conserving surgery were enrolled in a phase I/II study evaluating APBR using IMRT. Forty eligible patients received 40 Gy in 4 Gy daily fractions. Patients were assessed for treatment related toxicities, and cosmesis, before APBR, during, and after completion of the treatment. Results: The median age was 73 years, median tumor size 0.8 cm and the median follow-up was 54 months. The 5-year locoregional control was 97.5% and overall survival 90%. Erythema and skin pigmentation was the most common acute adverse event, reported by 27 patients (69%). Twenty-six patients (65%) reported mild pain, rated 1-4/10. This improved at last follow-up to only 2 (15%). Overall the patient and physician reported worst late toxicities were lower than the baseline and at last follow-up, patients and physicians rated cosmesis as excellent/good in 93% and 86 %, respectively. Conclusion: In this prospective trial, we observed an excellent rate of tumor control with daily APBR. The acceptable toxicity profile and cosmetic results of this study support the use of IMRT planned APBR with daily schedule in elderly patients with early stage BC.

• Archives of Plastic Surgery
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• 제39권1호
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• pp.18-24
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• 2012

Background : Infection caused by rapidly growing mycobacteria (RGM) is not uncommon, and the prevalence of RGM infection has been increasing. Clinical diagnosis is difficult because there are no characteristic clinical features. There is also no standard antibiotic regimen for treating RGM infection. A small series of patients with RGM infections was studied to examine their treatments and outcomes. Methods : A total of 5 patients who had developed postoperative infections from January 2009 to December 2010 were retrospectively reviewed. Patients were initially screened using a mycobacteria rapid screening test (polymerase chain reaction [PCR]-reverse blot hybridization assay). To confirm mycobacterial infection, specimens were cultured for nontuberculous mycobacteria and analyzed by 16 S ribosomal RNA and rpoB gene PCR. Results : The patients were treated with intravenous antibiotics during hospitalization, and oral antibiotics were administered after discharge. The mean duration of follow-up was 9 months, and all patients were completely cured of infection with a regimen of a combination of antibiotics plus surgical treatment. Although none of the patients developed recurrence, there were complications at the site of infection, including hypertrophic scarring, pigmentation, and disfigurement. Conclusions : Combination antibiotic therapy plus drainage of surgical abscesses appeared to be effective for the RGM infections seen in our patients. Although neither the exact dosage nor a standardized regimen has been firmly established, we propose that our treatment can provide an option for the management of rapidly growing mycobacterial infection.

• 한국임상수의학회지
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• 제22권2호
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• pp.153-156
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• 2005

5살과 2살의 푸들 견이 미용 직후, 등 부위의 털의 변색과 전신적 탈모증세로 건국대학교 부속 동물 병원에 내원하였다 병변 부위에서는 육안적으로 약간의 피부 발적과 소농포가 발견되었지만 총 혈구 계산, 혈액 화학 검사에서는 특이한 소견이 발견되지 않았다. 아울러 최근 약물투여 병력도 없었다. 병변부의 trichogram에서는 모근 쪽과 모간에 멜라닌 과립이 착색되어 있었고, 병변 이외의 부위에서는 멜라닌 착색이 관찰되지 않았다. 그리고 병변부 피부 생검에서는 약한 부전 각화증이 관찰되었으며 아주 미약한 진피층의 호중구 침윤이 관찰되었다. 본 케이스에서는 melanotrichia가 미용 직후에 피부에 가해지는 각종 자극에 의해 발생할 수 있음을 보여주고 있다. 그러나, 미용 후 멜라닌 신생의 정도와 델라닌 세포의 증식 기전은 본 증례로서는 현재까지 명확하게 밝혀지지는 않았다.