• Journal of the Korea Convergence Society
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• v.8 no.2
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• pp.121-126
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• 2017

In this study, we measured the bioelectrical impedance of whole body in various frequency bands by non-invasive method by four electrode method using a portable small impedance measurement system developed to understand the bioimpedance characteristics of intracellular fluid and extracellular fluid components through a skin equivalent model. The measurements were performed on 10 male subjects (mean age $24{\pm}3.0$, body mass index(BMI) $20.3kg/m^2$) for four weeks and the bioimpedances were measured at multi-frequencies (1 kHz, 5 kHz, 50 kHz, 70 kHz, 100 kHz and 500 kHz). Experimental results show that the impedance is the highest in the low frequency range of 1 kHz and the lowest in the high frequency range of 500 MHz. Especially, it was confirmed through experiments that the impedance is rapidly lowered above 50 kHz band. In addition, it was confirmed that similar characteristics to the measured values of the bioimpedance measuring system were obtained in the simulations for understanding the impedance characteristics of the intracellular fluid and the extracellular fluid through the skin equivalent circuit model.

• JSTS:Journal of Semiconductor Technology and Science
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• v.10 no.4
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• pp.300-308
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• 2010

This paper describes the development of a low-power electrocardiogram (ECG) touch sensor intended for the use with two dry metal electrodes. An equivalent ECG extraction circuit model encountered in a ground-free two-electrode configuration is investigated for an optimal sensor read-out circuit design criteria. From the equivalent circuit model, (1) maximum sensor resolution is derived based on the electrode's background thermal noise, which originates from high electrode-skin contact impedance, together with the input referred noise of instrumentation amplifier (IA), (2) 60 Hz electrostatic coupling from mains and motion artifact are also considered to determine minimum requirement of common mode rejection ratio (CMRR) and input impedance of IA. A dedicated ECG read-out front end incorporating chopping scheme is introduced to provide an input referred circuit noise of 1.3 ${\mu}V_{rms}$ over 0.5 Hz ~ 200 Hz, CMRR of IA > 100 dB, sensor resolution of 7 bits, and dissipating only 36 ${\mu}W$. Together with 8 bits synchronous successive approximation register (SAR) ADC, the sensor IC chip is implemented in 0.18 ${\mu}m$ CMOS technology and integrated on a 5 cm $\times$ 8 cm PCB with two copper patterned electrodes. With the help of proposed touch sensor, ECG signal containing QRS complex and P, T waves are successfully extracted by simply touching the electrodes with two thumbs.

• Natural Product Sciences
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• v.25 no.4
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• pp.341-347
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• 2019

Luffa cylindrica (LC) is a very fast-growing climber and its fruit have been considered as agricultural wastes. We conducted to check the comparative qualities of ethanol solvent extraction (LCE) and supercritical carbon dioxide extraction (LCS) of L. cylindrica fruit and seed. LCS had higher antioxidant and polyphenol contents than LCE. LCS were significantly increased peroxisome proliferator-activated receptor (PPAR)-a and involucrin expression as epidermal differentiation marker in 3D skin equivalent model. LCS also showed antimicrobial activity against Staphylococcus aureus, a causative bacteria in atopic dermatitis. In addition, LCS inhibited the adipocyte differentiation of 3T3-L1 cells. When treated with the extract at a concentration of 100 ㎍/mL, the Wnt/β-catenin pathway reporter luciferase activity of HEK 293-TOP cells was increased approximately by 2-folds compared to that of the untreated control group. These results indicate that L. cylindrica supercritical carbon dioxide extract may serve as a cosmeceutical for improving skin barrier function and the treatment of obesity.

• Radiation Oncology Journal
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• v.10 no.1
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• pp.107-113
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• 1992

Increasing frequency of skin cancer, mycosis fungoides, Kaposi's sarcoma etc, it need to treatment dose planning for total skin electron beam (TSEB) therapy. Appropriate treatment planning for TSEB therapy is needed to give homogeneous dose distribution throughout the entire skin surface. The energy of 6 MeV electron from the 18 MeV medical linear accelerator was adapted for superficial total skin electron beam therapy. The energy of the electron beam was reduced to 4.2 MeV by a $0.5\;cm\times90\;cm{\times}180\;cm$ acryl screen placed in a feet front of the patient. Six dual field beam was adapted for total skin irradiation to encompass the entire body surface from head to toe simultaneously. The patients were treated behind the acryl screen plate acted as a beam scatterer and contained a parallel-plate shallow ion chamber for dosimetry and beam monitoring. During treatment, the patient was placed in six different positions due to be homogeneous dose distribution for whole skin around the body. One treatment session delivered 400 cGy to the entire skin surface and patients were treated twice a week for eight consecutive weeks, which is equivalent to TDF value 57. instrumentation and techniques developed in determining the depth dose, dose distribution and bremsstrahlung dose are discussed.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.13-34
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• 2003

Fructose-1, 6-diphosphate (FOP), a glycolytic metabolite is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FOP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart. In this study, we examined whether FDP has protective effects on UV-induced oxidative damage in skin cell culture system and human skin in vivo. FDP had a protective role in UVB-induced LDH release and ROS accumulation in HaCaT although it did not show direct radical scavenging effect in the experiment using 1, 1-diphenyl-2-picrylhydrazyl (DPPH). FDP also preserved cellular GSH content after UV irradiation in HaCaT and normal human fibroblast culture system. Cellular oxidative stress induces multiple downstream signaling pathways that regulate expression of multiple gene including MMP-1 and collagen, we examined the effects of FDP on UV-induced alteration of these protein expression in fibroblast culture and human skin in vivo. The increased MMP-1 expression in fibroblast and human skin by UV irradiation was significantly decreased by FDP. FDP also prevented the UV-induced decrease of collagen expression in fibroblast and human skin. Moreover, the decreasing the intracellular levels of reducing equivalents in human fibroblast by glutathione (GSH) depletion lowered the UVA dose threshold for reduction of procollagen expression, indicating that the differences of glutathione contents define the susceptibility of fibroblasts towards UV-induced reduction of procollagen expression. FDP also preserved cellular GSH content after UV irradiation, indicating that FDP has protective effects on UV-induced reduction of procollagen expression, which are possibly through maintaining intracellular reducing equivalent. Based on these premises, we examined the effect of daily use of a moisturizer containing FDP on facial wrinkle in comparison with vehicle moisturizer lacking FDP. In the clinical study, FDP significantly decreased facial wrinkle compared with vehicle alone after 6 months of use. Our results suggest that FDP has anti-aging effects in skin by increasing cellular antioxidant system and preventing oxidative signal and inflammatory reaction. Therefore FDP may be useful anti-aging agent for cosmetic purpose.

• Journal of Korea Multimedia Society
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• v.20 no.3
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• pp.482-490
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• 2017

Early detection of infiltration is one of the most important tasks of nurses to minimize skin damage due to infiltration. For subjects receiving invasive intravenous treatment, the bioelectrical impedance (impedance) were measured in the frequency range of 5 to 500 kHz using bioelectrical impedance spectroscopy (BIS). After attaching electrodes at both ends of a transparent dressing mounted on the skin in which IV solution was infused into the vein, the change in impedance was measured as a function of time and frequency before and after infiltration. The experimental results are described as follows. When IV solution was properly infused into the vein, the impedance was nearly constant over time and decreased with increasing frequency. However, when infiltration occurred, the impedance decreased significantly and thereafter gradually decreased with time. In addition, impedance decreased with time for all applied frequencies. In this study, when IV solution penetrated into the surrounding skin and subcutaneous tissue by infiltration, impedance was quantitatively analyzed for as a function of time and frequency. This suggests a method for early detection of infiltration using BIS.

• Steel and Composite Structures
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• v.14 no.2
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• pp.191-204
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• 2013

A hybrid double skin concrete filled (HDSCF) circular steel tube column is proposed in this study. The yield strength of the outer steel tube is larger than 690MPa and the inner tube has less strength. In order to achieve efficiency with the high strength outer tube, a feasibility study on reducing the thickness of the tube below the specified design codes for CFTs was conducted based on an experimental approach. The experiment also took variables such as thickness of the inner tube, hollow ratio, and strength of concrete into consideration to investigate the behavior of the HDSCF column. In order to estimate the applicability of design equations for CFTs to the HDSCF column, test results from CFT and HDSCF columns with design codes were compared. It was found that the axial compressive performance of the proposed HDSCF column is equivalent to that of the conventional CFT member irrespective of design variables. Furthermore, the design equation for a circular CFT given by EC4 is applicable to estimate the ultimate strength of the HDSCF circular steel tube column.

• ALGAE
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• v.24 no.3
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• pp.179-184
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• 2009

Methanol crude extract of the sea grass Zostera marina L. and organic solvent fractions (n-hexane, chloroform, ethyl acetate, n-butanol, and water) were screened for antioxidant activity (total phenolic contents, DPPH scavenging activity, and reducing power) and antimicrobial activity against three human skin pathogens, two bacteria and a yeast; Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans. Total phenolic contents and 2, 2- diphenyl-1-picrylhydrazyl (DPPH) scavenging activity were highest in the ethyl acetate fraction with 968.50 $\mu$g gallic acid equivalent per milligram of extract, and ca. 95% scavenging activity on the DPPH radicals at 10 mg $ml^{-1}$. In antimicrobial activity tests, MICs (Minimum Inhibitory Concentration) of each Zostera marina extract partitioned ranged from 1mg to 8 mg $ml^{-1}$ (extract/ 10% DMSO) against all three human skin pathogens. The MICs of the ethyl acetate and n-butanol fractions were the same with 1 mg $ml^{-1}$ against S. aureus and C. albicans. The ethyl acetate fraction of Z. marina does protect against free radicals and may be used to inhibit the growth of human skin pathogens.

• Research in Community and Public Health Nursing
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• v.22 no.4
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• pp.409-419
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• 2011

Purpose: The purpose of this study was to examine the effects of foot reflexology on sleep, depression and skin temperature of the female elderly at home. Methods: This research used the non-equivalent control group pretest-posttest design. The participants were 45 elders residing at home: 23 in the experimental group and 22 in the control group. The experimental group received 30-minute foot reflexology 8 times for 2 weeks. The results were analyzed using ${\chi}^2$ test, t-test with the SPSS/WIN 12.0 program. Results: The results showed that foot reflexology was significantly effective in improving the quality of sleep, reducing depression, and raising the temperature of both feet. However, the temperature of both palms was not statistically significantly different between the two groups. Conclusion: The results of this study indicated that foot reflexology is an effective nursing intervention in improving the quality of sleep, reducing depression, and raising the temperature of both feet. Therefore, it is recommended to use foot reflexology as a complementary nursing intervention for elderly women at home in community.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.11a
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• pp.853-856
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• 2004

This study presents a prediction method for sound insulation of sandwich plate which consists of orthotropic plates as skin and mineral wool as core. Prediction by classic theory, which considers orthotropic effects, requires considerably complex and cumbersome process and moreover many assumption. However, experimental results of the sandwich plate with orthotropic plates as skin show that the orthotropic effects are disappeared or fade out. Hence, predictions by using sandwich model are conducted by a simple modelling that substitutes an orthotropic plate into an equivalent flat plate. Comparative results show that sandwich model gives a good agreements with theoretical prediction.