• Journal of Veterinary Clinics
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• v.41 no.2
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• pp.101-105
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• 2024

Ehlers-Danlos syndrome (EDS) is a rare genetic disorder in dogs and cats and has been mostly reported in purebred cats. In this study, we report a case of a 1-year-old castrated male Korean shorthair cat, who presented with multiple small skin tears and bruises distributed over the entire trunk area. The cat's skin was hyperextensible and easily torn with gentle touch. The skin extensibility index of the cat was 25%, indicating the possibility of EDS. The cat exhibited no signs of pruritus or inflammation, and no underlying disease was found. However, radiography revealed hip joint subluxation and arthritis. Following this, biopsy of the lacerated skin was performed. Histopathological examination of the skin revealed that in the dermis adjacent to the lesions, the collagen fibers were irregular in size and width, with a slightly thinner epidermis, and increased interfibrillar spaces containing low numbers of scattered well-differentiated fibroblasts and mast cells. Histopathological examination of the skin confirmed EDS. The symptoms observed in the cat, including skin hyperextensibility, multiple bruising, hip joint subluxation, and arthritis, corresponded to the classical subtype of EDS in humans. Thus, this study is a rare report of a classical EDS case in a Korean shorthair cat. This study suggests that skin extensibility index and biopsy are useful diagnostic procedures for confirming EDS in animals until a more definitive genetic test is established.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.4
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• pp.208-214
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• 2015

Objectives : The purpose of this study is to present two case reports on the treatments of psoriasis who has functional gastrointestinal disorder.Methods : We administered herbal medicine to two patients who showed psoriasis with functional gastrointestinal disorder and evaluated the results by Psoriasis Area and Severity Index(PASI).Results : After the treatment two patients showed improvements in PASI. PASI of patient 1 changed from 8.8 to 0.8; patient 2 from 7.0 to 0.2Conclusions : The results suggest that herbal medicine can be an effective treatment for psoriasis who has functional gastrointestinal disorder.

• Journal of Pharmacopuncture
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• v.10 no.3
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• pp.113-119
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• 2007

Objectives Benign essential blepharospasm is a progressive neurological disorder characterized by involuntary muscle contractions and spasms of the eyelid muscles. The aim of this study is to provide evidence of differences between facial skin temperaure of the paralyzed side and normal side in Essential Blepharospasm patients. Methods The author studied 13 patients with Essential Blepharospasm. We measured skin temperature of the forehead, zygoma area of the paralyzed side and those of the normal side with The Digital Infrared thermal image. Results There were no significant facial skin temperature differences between the paralyzed side and normal side. Conclusions Thermography is a useful diagnostic tool. But we expect that it is essential to diagnose a disease correctly at an early stage and to find a prompt treatment by introducing and utilizing a simple nonivading diagnofic method other than Thermography.

• Food Science and Preservation
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• v.10 no.4
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• pp.447-453
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• 2003

Causal factors related to the skin disorder such as black stains during cold storage of 'Niitaka' pear fruit are of great importance to solve the postharvest disorder problems. The morphological and biochemical changes observe of pear skin affected by different harvest times and storage environments. Occurrence rate of black stain in 'Niitaka' pear fruit was the highest in newspaper bagging with 75% among various bagging materials at harvest time because of the high relative humidity within the double layer paper bags. During cold storage, the rate was 54～100% in 30 $\mu\textrm{m}$ polyethylene (PE) film packaging. As the harvest time was postponed, the rate increasedduring cold stoinge. The into was 1.5 to 2.4 times higher in pears harvested in late September than in those harvested in early and mid October. There was no significant difference in occurrence of black stain fruit between the 30 and 50 $\mu\textrm{m}$ PE film bags. The causal fungus of the black stain pear was assumed as Gloeodes pomigena (Schweintz, 1920). The treatment of 0.1～0.5 ppm ozone gas prevented the occurrence of the pear fruit black stain until 180 days after cold storage. The ozone treatment on the affected fruit was also effective in preventing the progress of the black stain.

• Horticultural Science & Technology
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• v.19 no.1
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• pp.48-53
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• 2001

The study was conducted to examine the storage potential of recently developed oriental pears, 'Kamchun' and 'Chuhwang'. The content of soluble solids of 'Kamchun' pears was above 13.2% but the acidity was below 0.082% at three harvest dates. Although skin browning disorder did not occur in 'Kamchun', about 40% of fruits were affected by core breakdown especially when harvested after middle of October. In contrast, flesh browning was also observed in early harvested fruit. Flesh firmness of 'Chuhwang' was higher than that of 'Kamchun' at harvest as well as after storage. The acidity of 'Chuhwang' was constantly higher than that of 'Kamchun'. Severe skin browning (approximately 80%) occurred in 'Chuhwang' pears regardless of harvest dates. Also, more flesh browning disorder was found in fruit harvested early in the season. Further research is required to determine the optimum harvest date of both cultivars and postharvest managements to inhibit the physiological disorders.

• Horticultural Science & Technology
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• v.32 no.3
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• pp.359-365
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• 2014

Oriental pear (Pyrus communis L. cv 'Niitaka') was stored at $0^{\circ}C$ for 5 months and major metabolites involved in blackening of the peel were analyzed by untargeted GC-MS and targeted HPLC methods. In this study, peels of sound and skin-blackened pears were analyzed and compared. Skin-blackened fruit was clearly characterized by a distinctive pattern in changes which included a decrease of malic acid, succinic acid, and ascorbic acid, while an increase of fumaric acid, threonine, and gluconic acid, which indicated both reduced metabolic activity and anti-oxidative capacity of the cells. Chlorogenic acid was a major phenolic compound and the peel of sound fruit showed high levels of free phenolic compounds compared than the peel of skin-blackened fruit which are believed to be related to oxidation of phenolics in skin-blackened tissue. The changes or profiling of major metabolites by targeted or untargeted analysis method could become a useful tool for understanding physiology, disorder mechanism, and identifying metabolic networks connecting primary and secondary metabolism in postharvest research.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.3
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• pp.277-284
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• 2018

Collagen peptide plays a protective role in skin by increasing the activity of antioxidant, acts like an activator of skin regeneration by positive feedback and is used as a potent candidate for cosmetics or functional food. GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors of both pre- and postsynaptic neuronal processes in vertebrates, is also involved in the synthesis of melatonin and might exert regulatory effects on sleep and reproductive functions. In this study, we investigated the beneficial effect of a mixture of collagen peptide and GABA (J85091900) on skin and sleep condition in woman experiencing sleep disorder. We found that oral supplement with J85091900 significantly decreased the value of Pittsburgh Sleep Quality Index (PSQI), increased sleeping time by 7%, and also improved skin roughness (Ra, Rz, Rt), periorbital wrinkle (Ra, Rt), and skin capacitance in human. These findings indicate that dual strategy with which skin improvement is accomplished using collagen peptide and sleeping well is acquired using GABA could be the novel solution for sleeping beauty by edible cosmetics to improve skin status.

• Korean Journal of Veterinary Research
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• v.53 no.3
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• pp.185-187
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• 2013

An 11-year-old, toy poodle dog was presented with dermatologic lesions and mammary gland tumor (MGT) evaluation. A solitary, lobulated MGT (size $2.5{\times}3.5$ cm) was affecting the 5th left mammary gland. Firm, oval plaque skin lesions were present on the left dorsal carpal area. The skin lesions were alopecic and salivary staining. The dog had historical separation anxiety and excessive licking of skin lesions were observed. Based on the clinical and histopathologic examinations, MGT was diagnosed with mammary complex adenoma and the skin lesions were diagnosed with acral lick dermatitis. Behavior modification treatment using oral clomipramine was effective.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.3 s.31
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• pp.180-188
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• 2006

Objectives : The purpose of this study is to investigate the differences of skin disease, particularly Acne between the rotating shift work nurses and the nurses on a fixed day schedule. Methods : Questionnaries were distributed to 30 rotating shift work nurses(the rotating group) and 34 nurses on a fixed day schedule(the daytime group). The questionnaris included questions on general health concepts, insomnia skin disease(particularly Acne), gastroenteric trouble, menstrual irregularity. Result : 1. There was significant difference on skin disease(particularly Acne) between two groups. 2. There was no significant relation between Gastroenteric trouble and Acne. But, in particular, there was significant relation between Constipation, Gastritis and Acne. 3. There was no significant relation between menstrual irregularity and Acne. 4. In Acne group, more than 70% felt the necessity of treatment, but only 2.5% used Korean Oriental Medical therapy. Conclusion : Disorder of circadian rhythm affects the skin disease(particularly Acne) more than Gastroenteric trouble and menstrual irregularity. But in this study, the total number of the nurse is not enough. So we need more accurate study about the aspects of skin disease. And about the Acne, publicity of Korean Oriental Medical therapy is required.

• The Korea Journal of Herbology
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• v.31 no.2
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• pp.1-5
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• 2016

Objectives : Seborrheic dermatitis is an inflammatory skin disorder affecting the scalp, face, and torso. Typically, it presents with scaly, flaky, itchy, and red skin. It may be aggravated by illness, psychological stress, fatigue, sleep deprivation, change of season. The purpose of this study was to report the clinical effects of herbal medicine on Seborrheic dermatitisMethods : We employed oriental medical treatments; herbal-medication (Bangpungtongsungsangamibang), acupuncture, moxibustion and cupping therapy. At the same time, the patient sweated out the skin poison. We treated him two times a week with oriental therapy method. He took medicine three times a day after a meal. During taking medicine, we let him avoid fatty food, flour based food, and alcohol. We took a picture the patient's body parts and compared the symptom with previous symptom. With the picture, we evaluated the patient's condition.Results : After taking treatment - 77 times' acupuncture, moxibustion and cupping therapy during 9 months and taking herbal-medicine, the skin condition of the patient was much improved. At first, he was troubled with itching and hot feeling at reddish area, time after time the itching and hot feeling was weakened. The reddish area was changed to scaly and flaky skin and changed to normal state.Conclusions : Herbal medicine (Bangpungtongsungsangamibang) with oriental medical treatments was an effective in the treatment of Seborrheic Dermatitis and it helped to improve regenerating the skin in the body.