• Biomolecules & Therapeutics
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• 제19권1호
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• pp.109-117
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• 2011

In this work, we have investigated the effect of polyoxyethylene alkyl ester nonionic surfactants on percutaneous permeation enhancement of a model drug, ketoprofen. We also investigated the mechanism involved in the enhancement using impedance and solubility measurement. Three groups of nonionic surfactants with different ethylene oxide content were studied. The permeation results showed that all surfactants enhanced the percutaneous absorption, irrespective of the molecular weight. The permeation results from PEG-45 monostearate (PEGMS45) were rather unexpected. Impedance and solubility results indicate that the mechanism involved in the enhancement of permeation by PEG-10 monooleate (PEGMO10) and PEGMS45 is rather different. The results from PEGMS45 suggest that it could be a potential candidate as a skin penetration enhancer with high molecular weight, which may poses less skin irritation and systemic side effect than the smaller surfactant molecules. Overall, this work provided some useful information on percutaneous transport enhancement and the mechanistic insights involved in skin permeation for these nonionic surfactants.

• 전기학회논문지
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• 제63권10호
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• pp.1448-1454
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• 2014

In this study, a new type of electrode device is implemented to measure the capacitance energy and interpret it as the ECG (Electrocardiogram) data. The main idea of this new electrode system is to estimate the capacitance on the skin by assembling a capacitive-coupled circuits and translate into the ECG signal. To measure the coupling energy and estimate the aquired data in terms of heart activity, the capacitive-coupled electrode is garmented with fabrics in the form of a chest band or a vest jacket. To compare the ECG data from the capacitive-coupled electrode with the conventional electrode(Ag-AgCl) system, the corelation coefficient between two signals is computed as 0.9517. Thus, we can conclude the fact that capacitive-coupled electrode system can measure a person's heart activity without any contact to his or her skin and can the interpreted as the ECG data.

• 한국응용과학기술학회지
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• 제19권2호
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• pp.79-85
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• 2002

The cutaneous tolerability of detergent formulations can be improved by means of suitable additives. They complex the surfactant molecules lowering the concentration of their free monomeric species. Proteins derivatives used as additives for detergency are usually prepared by partial hydrolysis of plant reserve proteins. The main purpose of the hydrolytic cleavage is to make them water soluble and suitable for liquid products. Water solubility and stability are obtained by means of complexation with surfactants which also increase their actual hydrophobicity, an important parameter affecting cosmetic properties of proteins. Transepidermal water loss (TEWL) and electric capacitance (EC) have been adopted as investigation technigues to evaluate the skin integrity/damage in vitro tests, The performance of native wheat protein / surfactant complexes has been compared with traditional protein hydrolysates as detergent additives. The results show a noticeable reduction of skin irritation in surfactant formulations with addition of native wheat protein.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.3115-3115
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• 2001

In this study, portable near infrared (NIR) system was newly integrated with a photodiode array detector, which has no moving parts and this system has been successfully applied for evaluation of human skin moisture. The good correlation between NIR absorbance and absolute water content of separated hairless mouse skin was, in vitro, showed depending on the water content (7.42-84.94%) using this portable NIR system. Partial least squares (PLS) regression was used for the calibration with the 1100-1650 nm wavelength range. For the practical use for the evaluation of human skin based on moisture, PLS model for human skin moisture was, in vivo, developed using the portable NIR system based on the relative water content values of stratum corneum from the conventional capacitance method. The PLS model showed a good correlation. This study indicated that the portable NIR system could be a powerful tool for human skin moisture, which may be much more stable to environmental conditions such as temperature and humidity, compared to conventional methods. Furthermore, in order to confirm the performance of newly integrated portable NIR system, scanning type conventional NIR spectrometer was used in the same experiments and the results were compared.

• Transactions on Electrical and Electronic Materials
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• 제4권3호
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• pp.5-9
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• 2003

In this paper, a layout-based CMOS RF model for RFIC's including the capacitance effect, the skin effect, and the proximity effect between metal lines on the Si surface is proposed for the first time for accurately predicting the RF behavior of CMOS devices. With these RF effects, the RF equivalent circuit model based on the layout of the multi-finger gate transistor is presented. The capacitances between metal lines on the Si surface are modeled with the layout. And the skin effect is modeled to the equivalent ladder circuit of metal line. The proximity effect is modeled by adding the mutual inductance between cross-coupled inductances in the ladder circuit representation. Compared to the BSIM 3v3 and other models, the proposed RF model shows better agreements with the measured data and shows well the frequency dependent behavior of devices in GHz ranges.

• 대한화장품학회지
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• 제27권1호
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• pp.53-72
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• 2001

Dry skin is caused mainly by the perturbation of stratum corneum lipids which affected by ageing, change of season, excess use of surfactant and the effect of disease like atopic dermatitis and psoriasis. Intercellular lipid structures in stratum corneum are responsible for the barrier function of mammalian skin. The major lipd classes that can be extracted from stratum corneum are ceramides, cholesterol and fatty acid, which make up approximately 50, 25, 10 percent of the stratum corneum lipid mass, respectively. Small amount of cholesterol sulfate, phospholipids, glycosylceramide and cholesterol esters are also present. Recent studies have shown that application of one or two these lipids to the perturbed skin delays barrier recovery; only equimolar mixtures allow normal recovery. We observed that barrier recovery rate was improved in hairless mouse by topical application of single neutral lipids (ceramide, free fatty acid, cholesterol) and lipid mixtures. Whereas the application of single lipid didn’t allows a significant enhancement comparing with normal barrier repair, the equimolar mixtures of 3 components(including synthetic pseudoceramide PC104) improved barrier repair, as assessed by the transepidermal water loss. At clinical study to the volunteers aged over sixty, skin dryness recuperated by the increase of moisture(capacitance) and the reduction of scaling. Utilization of physiologic lipid mixture containing natural ceramides or synthetic pseudoceramide could lead to new forms of topical therapy for the dryness and dermatoses(e.g., psoriasis, atopic dermatitis and irritant dermatitis).

• Korean Journal of Acupuncture
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• 제26권3호
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• pp.1-11
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• 2009

Objectives : The object of this study is to investigate the balance/imbalance of skin capacitances between left and right meridians, and to analyze the change patterns of electric energy on meridians with the lapse of time. Method : Electric potential was measured on five source points (LU9, PC7, HT7, LI4, SI4) bilaterally for 4 hours. The energy balance/imbalance between left and right was investigated, and the change patterns with time were analyzed. Results and Conclusions : The amplitude of meridian energy on five source points and the energy balance/imbalance between left and right were varied in each individual. When a source point showed a balanced meridian energy bilaterally, the change patterns of meridian energy with time were similar between left and right. While, when it showed an imbalanced energy between left and right, the change patterns of meridian energy were also different between left and right. Through this study, we proposed a new diagnostic method of meridian energy.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 ITC-CSCC -1
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• pp.440-442
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• 2002

The electrical characteristics of biologically active points (BAPs) compared with those of the surrounding human skins are studied. And we confirm that BAPs have lower resistance and higher capacitance than the surrounding skins do. We also find that BAPs have higher characteristic frequency than surrounding skins and the impedance spectra of BAPs sometimes have two semicircles on the complex impedance plane. We propose the skin impedance model that is proper to the BAPs and this circuit describes our experimental results sufficiently well.

• ETRI Journal
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• 제28권1호
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• pp.115-118
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• 2006

In this letter, a simple model parameter extraction methodology for an on-chip spiral inductor is proposed based on a wide-band inductor model that incorporates parallel inductance and resistance to model skin and proximity effects, and capacitance to model the decrease in series resistance above the frequency near the peak quality factor. The wide-band inductor model does not require any frequency dependent elements, and model parameters can be extracted directly from the measured data with some curve fitting. The validity of the proposed model and parameter extraction methodology are verified with various size inductors fabricated using $0.18\;{\mu}m$ CMOS technology.

• 대한기계학회논문집B
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• 제39권2호
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• pp.147-152
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• 2015

본 논문은 감동, 두려움 등 인간의 급격한 감정이나 온도 변화에 따른 피부 입모근 수축 (소름)현상 감지를 위한 정전용량형 전도성 폴리머 센서를 제안하였다. 전도성 폴리머를 이용한 소자 제작을 통해 소자의 착용감을 향상시켰으며, 기존 정성적 소름측정 방식에 비해 정확하고 객관적인 측정을 가능케 하였다. 인공적인 소름돌기를 이용한 실험결과, $0{\sim}326{\mu}m$ 의 정적인 소름의 높이를 $-0.00252%/{\mu}m$의 민감도, 25.9 %의 비선형도로 측정하였다. 또한, 실제 인간의 피부에 부착하여 갑작스런 체온변화의 조건에서 -6.2 fF 과 -9.2 fF 의 정전용량 변화를 측정함으로써 높이 $145{\mu}m$ 와 $194{\mu}m$ 의 피부 소름을 측정하였다. 제안된 소자는 피부 입모근 수축현상에 따른 인간의 소름을 객관적이고, 정량적으로 측정함으로써 인간이 느끼는 급격한 감정변화나 환경변화 정도를 수치화 할 수 있는 방법을 제시하였다.