• 산업경영시스템학회지
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• 제33권1호
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• pp.59-70
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• 2010

This paper reorganized five service qualities dimensions of ski-resorts, then derived the improvement priority order of the service quality through a satisfaction measure considering the importance. There're more competitive situations to guarantee customers using the skies and snowboards is a major sports in winter season. In these competitive environments, this paper's going to propose a predominant-competitive strategies for improving the service quality of ski-resorts. This study measured the satisfaction considering the importance of service quality target on customers has an experience ski resort service quality to improve ski resort service quality. This study using Performance Model decide a priority order about a particular item improvement, then is going to present a guideline that can improve the service quality more exactly. As a result of the study the factors that is important to the customer were prime physical factor, access, assistance physical factor, staff service and assistant service, an improvement priority order were accommodation and eating-drinking facilities, waiting time of a slope and lift/gondola, entertainment/shopping facilities in the resorts, equipment rental and lift fare.

• 약학회지
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• 제39권4호
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• pp.385-394
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• 1995

Antiinflammatory activities of the solvent fractionates of several herbal medicines were investigated and SKI306X was prepared from the active principles of three herbal medicines, Prunella vulgaris, Trichosantlies kirilowii and Clematis mandshurica. SK1306X was shown to have strong inhibitory effects on acetic acid-induced pain, carrageenan-induced paw edema and adjuvant induced arthritis. LD50 of SKI306X was more than 5 g/kg in rat, so generally nontoxic. Chemical analysis revealed that oleanolic acid and rutin, which are known to have various antiinflammatory activities, were contained in it. These results suggest SK1306-X may become a useful drug for the treatment of inflammatory diseases such as rheumatoid arthritis.

• Journal of the Korean Statistical Society
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• 제35권4호
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• pp.397-407
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• 2006

A new stochastic process is introduced for describing a mechanism of viruses. The process generalizes the $Bartoszy\'{n}ski's$ process ($Bartoszy\'{n}ski$, 1975a, 1975b, 1976) by allowing the stochastic perturbation between consecutive jumps to take into account the persistent infection (the infection without breaking infected cells). It is shown that the new process can be obtained by a weak limit of a sequence of Markov branching processes. Along with the construction of the new process, we study how the stochastic perturbation influences the risk of a symptom in an infected host. For this purpose, the quantal response model and the threshold model are investigated and compared through their induced survival functions.

• 한국조경학회지
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• 제33권1호
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• pp.19-32
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• 2005

The role of emotional responses is an important subject of study in consumer behavior. Although the perceived performance and satisfaction related emotions have been studied with increasing quantities in leisure studies or fields of outdoor recreation and tourism, issues concerning the appropriate way to measure these emotional responses remains unresolved. This article reviews the emotion measuring scales, and testify the usefulness of PAD scale based upon 349 questionnaires by users of Phoenix Park(Ski Resort) and Seoul Land(Theme Park) in Korea. It was found that, users' emotional response was closely related with satisfaction in Phoenix Park(Ski Resort); however, users' perceived performance was closely related with satisfaction in Seoul Land (Theme Park). This article argues that the meanings of these findings is due to different characteristics of consumption typology between ski resort and theme park. In conclusion, users' emotional experience may be more useful in understanding skiing activities and in formulating management strategies for ski resorts than theme parks.

• 한국항공우주학회지
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• 제40권3호
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• pp.193-200
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• 2012

스키점프 공력 특성에 관한 자료 획득을 목적으로 전산 수치 해석을 수행하였다. 한국인의 체형을 고려한 인체 모델링 기법을 적용하였으며 해석 결과의 검증을 위해 기존 풍동실험 연구 결과를 비교 분석하였다. 다양한 비행 조건에서 공력 계수를 분석하여 최대 양항비를 나타내는 비행 자세를 발견하였다. 본 연구가 대한민국 스키점프 선수들의 비행 자세 교정과 국내 스포츠 과학 발전에 기여할 수 있을 것으로 기대한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2447-2451
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• 2014

Human papillomavirus (HPV) is the primary etiologic agent of cervical cancer. Consideration of safety and non human leukocyte antigen restriction, protein vaccine has become the most likely form of HPV therapeutic vaccine, although none have so far been reported as effective. Since tumor cells consistently express the two proteins E6 and E7, most therapeutic vaccines target one or both of them. In this study, we fabricated DC vaccines by transducing replication-defective recombinant adenoviruses expressing E6/E7 fusion gene of HPV-16, to investigate the lethal effects of specific cytotoxic T lymphocytes (CTL) against CaSki cells in vitro. Mouse immature dendritic cells (DC) were generated from bone marrow, and transfected with pAd-E6/E7 to prepare a DC vaccine and to induce specific CTL. The surface expression of CD40, CD68, MHC II and CD11c was assessed by flow cytometry (FCM), and the lethal effects of CTL against CaSki cells were determined by DAPI, FCM and CCK-8 methods. Immature mouse DC was successfully transfected by pAd-E6/E7 in vitro, and the transfecting efficiency was 40%-50%. A DC vaccine was successfully prepared and was used to induce specific CTL. Experimental results showed that the percentage of apoptosis and killing rate of CaSki cells were significantly increased by coculturing with the specific CTL (p <0.05). These results illustrated that a DC vaccine modified by HPV-16 E6/E7 gene can induce apoptosis of CaSki cells by inducing CTL, which may be used as a new strategy for biological treatment of cervical cancer.

• 한국운동역학회지
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• 제30권1호
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• pp.17-25
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• 2020

Objective: The purpose of this study is to provide a better understanding of long turn mechanism by describing long turns after kinematic analysis and provide skiers and winter sports instructors with data through which they are able to analyze right postures for turns in skiing in a systematic, rational and scientific manner. Method: For this, a mean difference of kinematic variables (the center of gravity (CG) displacement of distance, trajectory, velocity, angle) was verified against a total of 12 skiers (skilled and unskilled, 6 persons each), regarding motions from the up-start to down-end points for long turns. Results: First, concerning the horizontal displacement of CG during a turn in skiing, skilled skiers were positioned on the right side at the upstart and edge-change points at a long turn. There was no difference in anteroposterior and vertical displacements. Second, in terms of CG-trajectory differences, skilled skiers revealed a significant difference during a long turn. Third, regarding skiing velocity, skilled skiers were fast at the edge-change and maximum inclination points in long turns. Fourth, there was no difference in a hip joint in terms of a lower limb joint angle. In a knee joint, a large angle was found at the up-start point among skilled skiers when they made a long turn. Conclusion: In overall, when skilled and unskilled skiers were compared, to make a good turn, it is required to turn according to the radius of turn by reducing weight, concerning the CG displacement. Regarding the CG-trajectory differences, the edge angle should be adjusted via proper inclination angulation. In addition, a skier should be more leaned toward the inside of a turn when they make a long turn. In terms of skiing velocity, it is needed to reduce friction on snow through the edging and pivoting of the radius or turn according to curvature and controlling ski pressure. Regarding a lower limb joint angle, it is important to make an up move by increasing ankle and knee angles instead of keeping the upper body straight during an up motion.

• 한국콘텐츠학회논문지
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• 제16권7호
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• pp.587-597
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• 2016

본 연구는 스키리조트를 바탕으로 체험형태를 스키형과 비스키형으로 구분하고, 자기 자신에 대한 신념과 기대감의 반영인 자기효능감을 독립변인으로 적용하고 체험형태와의 조절효과 규명과 두 변인들 사이의 상호작용효과를 고찰하고자 하였다. 또한 체험을 통해 형성된 주관적 안녕감이 서비스에 대한 고객만족의 표현인 추천의도에 미치는 영향을 규명하고자 하였다. 연구결과, 자기효능감은 주관적 안녕감(여가의 만족, 긍정적 정서)에 긍정적인 영향을 미치는 것으로 나타났다. 스키형 체험의 경우 자기효능감이 높은 사람들은 상대적으로 자기효능감이 낮은 사람들보다 주관적 안녕감(여가의 만족, 긍정적 정서)을 높게 느끼는 것으로 나타났다. 반면, 비스키형 체험의 경우 자기효능감이 낮은 사람들이 상대적으로 자기효능감이 높은 사람들보다 주관적 안녕감(여가의 만족, 긍정적 정서)을 높게 느끼는 것으로 나타났다. 이러한 주관적 안녕감(여가의 만족, 긍정적 정서)은 자기효능감과 추천의도 사이에 매개역할로 작용하였다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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• pp.73-73
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• 1993

As part of a research program to develope 3rd generation anti tumor platinum complexes, a series of platinum complexes which have 4, 5-bis-(aminomethyl)- 1, 3-dioxolane derivatives as bidenate amine ligands, represented by the general structual formula was prepared. The R$_1$ and/or R$_2$ substituents in this series of platinum complexes can be hydrogen. alkyl, of jointly formed cyclohexane. Two Xs can be a bidenate leaving ligand such as 1, 1-cyclobutanedicarboxylate, malonate, dimethylmalonate, ethylmalonate, glycolate, L-lactate, or N-methyliminodiacetate. From based on the pharmacological and toxicological studies, we have chosen SKI 2053R, cis-malonato[(4R, 5R)-4, 5-bis(aminomethyl)-2-isopropyl-1, 3-dioxolane] platinum(II) complex (NSC D644591) as a candidate for clinical evaluation. The antitumor activity of a new anti tumor platinum complex, cis-malonato [(4R, 5R)-4, 5-bis(aminomethyl)-2-isopropyl-1, 3-dioxolane] platinum(II) (SKI 2053R, NSC D644591), was compared with those of cisplatin and carboplatin using murine tumors. We evaluated three platinum complexes against L1210/CPR, a subline of L1210 leukemia resistant to cisplatin for their abilities to overcome tumor resistance to cisplatin. The in vitro cytotoxicity of SKI 2053R to L1210 cell line was 2.5-fold less potent thann that of cisplatin, and was 10-fold more cytotoxic than that of carboplatin. SKI 2053R retained similar cytotoxic effect and anti tumor activity to L1210/CPR cell line, like the cytotoxicity of SKI 2053R to L1210 cell line, while either cisplatin or carboplatin had not property to overcome the acquired cisplatin-resistance. SKI 2053R exhibited greater or comparable antitumor activity than cisplatin or carboplatin in murine tumor models.

• Food Quality and Culture
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• 제3권1호
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• pp.20-26
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• 2009

The purpose of this study was to investigate the characteristics of dining-out customers by their behaviors based on geographical regions and visiting days in relation to restaurant attraction at ski resorts in Korea. The data were collected from six ski resorts. Three of the ski resorts were located in Kyunggi Province close to a metropolitan area, namely Seoul. The other three resorts were located in Kangwon Province, which is considered to be distant from the Seoul metropolitan area. A total of 599 usable questionnaires were utilized in the data analysis. Descriptive statistics and a cross tabulation analysis with chi square were used to examine the demographic characteristics of the respondents and the significant differences between geographical regions as well as between weekdays and weekends. The responding customers consisted of 57.3% (n=343) males and 42.7% (n=256) females. With respect to age, 15.5% were less than 20 yr., 44.6% were $20{\sim}30$ yr., and 28.0% were $30{\sim}40$ yr. The most recognizable occupations were student (32.9%) followed by office worker (33.2%). Twenty-seven percent of the respondents had less than one year of skiing experience and the majority (32.9%) had more than $1{\sim}3$ yr of experience. The major findings obtained from this study include statistically significant differences in the customers' demographical characteristics of age, occupation, skiing experience, and residential area according to the geographical regions of Kyunggi Province and Kangwon Province (p<0.05). All six of the customers' behavioral attributes, including transportation, reason to visit, staying days, purpose of visit, spending expenses, and usage of discount programs, showed significant differences between geographical groups (p<0.05). Finally, restaurant attraction was associated with the purpose of visiting and spending expenses by customers at the ski resorts (p<0.001).