• Journal of Korean Biological Nursing Science
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• 제24권3호
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• pp.141-149
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• 2022

Purpose: This study aimed to investigate the effects of grit and body composition on fatigue and burnout in shift-working nurses. Methods: A descriptive cross-sectional design using self-report questionnaires was employed. Data were collected between February and April 2021 from 192 shift-working nurses in 22 units of C tertiary hospitals. Of the 192, 175 nurses returned their completed questionnaires (return rate: 91.1%). The participants objectively measured their body composition for three consecutive days using a home body composition measurement scale. Results: Nurses with higher consistency of interest were more likely to have lower chronic fatigue (B = -5.23, p= .013), lower emotional exhaustion (B = -2.75, p< .001), and decreased depersonalization (B = -1.08, p= .014). Perseverance of effort was not statistically significant for fatigue; however, it was statistically significant for higher personal accomplishment among the subdomains of burnout (B= 2.50, p< .001). Skeletal muscle mass and body mass index had no significant effect on fatigue and burnout. Conclusion: To reduce fatigue and burnout in shift-working nurses, comprehensive efforts at the organizational and individual levels should be implemented to increase their grit. Further research is needed to determine whether body composition affects fatigue and burnout in shift-working nurses.

• Journal of Veterinary Science
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• 제23권2호
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• pp.30.1-30.6
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• 2022

This report aims to describe the first case of muscular and collagenous choristoma in a dog. A 10-yr-old female mixed-breed dog presented with lateral recumbence, vocalization, positional vertical nystagmus, divergent strabismus, anisocoria, and status epilepticus. The clinical condition evolved to stupor and ultimately, death. Necropsy revealed a white mass causing an irregular increase in the volume of the cerebellar vermis. In histological analysis, a well circumscribed, unencapsulated mass was observed in the cerebellum, consisting of fibers of striated skeletal muscle and collagen fibers, mostly mineralized. Based on the histopathological and histochemical findings, a diagnosis of muscular and collagenous cerebellar choristoma was made.

• 가정의학회지
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• 제39권6호
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• pp.347-354
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• 2018

Background: BMI alone may not serve as an index of obesity because it does not reflect body composition. The present study aimed to compare arterial stiffness as assessed by the brachial-ankle pulse wave velocity (ba-PWV) among groups defined by body fat percentage (pBF) and BMI. Methods: This cross-sectional study was based on 1,700 participants (1,044 men and 656 women) who completed a health screening examination at a national hospital between January 2011 and February 2016. Participants were divided into four groups according to BMI and pBF: normal fat and normal weight (NFNW); excessive fat and normal weight (EFNW); normal fat and obese (NFO); and excessive fat and obese (EFO). The ba-PWV and other cardiometabolic factors were compared among the four groups in men and women separately. Results: For both sexes, the NFNW group had a lower metabolic risk compared to that in the other groups (EFNW, NFO, and EFO). After adjusting for multiple variables, the NFO males had a significantly lower ba-PWV compared to those in the other groups, including NFNW males. The NFO group had significantly more skeletal muscle mass and muscle mass compared the other groups (P<0.05). Among women, the NFNW group had a significantly lower ba-PWV compared the other groups, even after adjusting for multiple variables. Conclusion: Lower pBF in obese men may be associated with improved cardiovascular risk.

• 한방비만학회지
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• 제15권1호
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• pp.33-37
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• 2015

Objectives: The purpose of this study is to report the effectiveness of Korean medicine treatment on 254 patients visited obesity clinic. Methods: Two hundred fifty-four patients, who had visited obesity clinic from May 2013 to November 2014, were analyzed by bioelectrical impedance analysis. We analyzed changes of weight, skeletal muscle mass, fat mass, body mass index (BMI) and body fat percentage after treatment, also investigated differences of weight and fat mass loss according to age, BMI and body fat percentage. Results and Conclusions: Male and female percent of the study group was 3.5% and 96.5%. All patients were constituted with 50.0% of 20~29-year-old group, 34.1% of 30~39-year-old and 15.9% of 40 and more year-old. In BMI, $21kg/m^2$, $21.0{\sim}22.9kg/m^2$, $23.0{\sim}29.9kg/m^2$, above $30kg/m^2$ were 20.5%, 30.3%, 42.1%, 7.1%, respectively. In Body fat percentage, under 25%, 25.0%~29.9%, 30.0%~34.9%, above 35% were 11.4%, 23.2%, 30.7%, 34.6%, respectively. 96.1% of patients were showed weight loss compared with baseline, the decrease of body weight was $2.96{\pm}1.86$ kg, that of BMI was $1.13{\pm}0.70kg/m^2$ and that of body fat percentage was $2.43%{\pm}2.06%$ after 1 month treatment. We observed a decline of weight and fat mass with higher BMI and body fat percentage at the baseline.

• Journal of Nutrition and Health
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• 제57권1호
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• pp.65-74
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• 2024

Purpose: Sodium is essentially required for homeostasis and physiological functions, but excessive sodium consumption increases the risk of obesity and other chronic disorders. Korean studies on the sodium-obesity relationship are limited, and thus, this study was undertaken to determine the nature of the relationship between sodium intake and obesity in Korean adults. Methods: Forty-two participants were divided into 2 groups according to body mass index (BMI, non-obese BMI < 25 kg/m², obese BMI ≥ 25 kg/m²). Dietary intakes and eating habits were analyzed using 3-day food records and a food frequency questionnaire. Anthropometric data were obtained from bioimpedance results, and fasting glucose and lipid levels were measured. Results: Mean weight, BMI, waist and hip circumferences, and body fat mass were greater in the obese group than in the non-obese group for men and women. Skeletal muscle mass and body fat mass were higher in obese women than in non-obese women. Biochemical data were no different in these two subgroups except triglycerides (TGs), which were higher in obese women. Nutrient intakes were not significantly different in obese and non-obese groups. However, obese men consumed excessive sodium, while obese women consumed slightly more than non-obese women. Obese men preferred salty foods and tended to overeat. Positive correlations were found between sodium intake and weight in men and percent body fat mass (PBFM) in women. Correlation analysis (adjusted for energy intake) of the relation between sodium intake and obesity-related factors showed sodium intake was positively correlated with PBFM and TG in women. Conclusion: This anthropometric and biochemical data analysis emphasizes the need for awareness and interventions to mitigate the health risks of elevated sodium consumption. Our findings should aid future studies on the relationship between sodium and obesity and contribute to preventing and managing this metabolic condition.

• 디지털융복합연구
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• 제12권10호
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• pp.587-595
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• 2014

본 연구의 목적은 비만흡연자의 복합운동이 당뇨발생예측률 및 신체조성, 혈관탄성에 미치는 영향을 분석하여 비만흡연자의 건강한 삶을 위한 효과적인 운동프로그램을 제시하는데 있다. 본 연구의 취지를 충분히 설명하고 자발적 참여의 동의서를 작성한 D광역시에 소재한 H기업체의 협력업체 T기업에 근무하는 40대 비만흡연 사원 20명이었으며, 과거병력과 현재 특별한 질환이 없고 규칙적인 운동경험이 없는 자들로 구성하였다. 이들은 당뇨발생률예측률 및 신체조성, 혈관탄성 검사를 실시하였으며, 실험 전과 12주간 복합운동 실시 후 평균과 표준편차를 산출하기 위하여 기술통계를 실시하였고 실험 전 후 차이 검증은 Paired t-test를 이용하여 분석하였다. 통계적 유의수준은 p<.05로 설정하여 다음과 같은 결론을 얻었다. 12주간 복합운동프로그램 참여 후 당뇨발생예측률, 체중, 체지방률, 골격근량, 복부지방률 및 혈관탄성 상지(오른손, 왼손), 하지(오른발, 왼발)에서 통계적으로 유의한 수준의 변화를 보였다(p.<05).

• 생명과학회지
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• 제29권1호
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• pp.45-51
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• 2019

본 연구는 운동과 영양 조절을 통한 남성 체 구성을 조사하였다. 훈련을 수행하는데 문제가 없는 건강한 40명을 임의로 선정하여 20명에게는 운동과 영양조절 그룹으로 선정하였고, 나머지 20명에게는 운동만 6개월간 수행하도록 하였다. 실험조건 동안 운동강도를 정확하게 측정하기 위해 최대산소 소모량($VO_2$ max)을 측정하였다. 운동과 영양조절일 실시한 20대 남자와 운동만 수행한 남자는 6개월 후 체중이 2.3 kg과 0.4 kg이 감소하였다. 0~3개월 간 실시한 결과에서 체중 측정값에 p값은 0.697이였으며, 3~6개월 측정값의 p값은 0.535로 나타났고, 0~6개월 측정 값의 p값은 0.617로 나타났다. 20대의 골격근은 약간 증가하였다. 30대의 체중은 6개월 후 운동과 영양조절 그룹이 4.0 kg, 운동만 수행한 그룹에서 1.3 kg이 감소하였다. 비록 체중의 감소는 골격근의 증가와 연관성이 있지만 유의성은 없었다. 체중의 변화는 지질 감소와 수분(세포 내 및 세포 간 수분) 감소와 연관이 있었다. 30대를 제외한 20대, 40대, 50대의 체중 감소는 있었지만 유의성은 없었다.

• Journal of Nutrition and Health
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• 제56권6호
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• pp.602-614
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• 2023

본 연구는 근생성 및 근위축 완화효능을 가진 유효소재 발굴의 필요성에 의해 polygalacin D가 근원세포 분화 및 미토콘드리아에 미치는 영향과 항암제 유도 근위축에 대한 완화효과를 각각 세포 및 동물실험을 통해 확인하고자 하였다. 그 결과, polygalacin D는 다핵을 지닌 근관세포의 수와 분화 종결인자인 MHC isoforms의 발현량을 증가시켰고 근육 내 단백질 분해 인자인 MuRF1, Smad2/3의 발현량은 유의적으로 감소시켰다. 또한 미토콘드리아 생합성 조절인자인 Pgc1α의 발현은 증가시키고 미토콘드리아 분열인자인 Drp1과 Fis1의 발현은 감소시켰다. 한편 zebrafish 동물모델을 통해 항암제 유도 근위축에 대한 개선효과를 확인한 결과, polygalacin D는 항암제에 의해 유도된 근위축과 미토콘드리아 손상을 완화시켰다. 이상의 결과들은 polygalacin D가 미토콘드리아 기능 증진을 매개로 근원세포 분화 촉진 및 근육 단백질 분해 저하 효과를 지닐 뿐만 아니라, 미토콘드리아 손상을 개선하여 항암제로 유도된 근위축에 대한 완화 효과를 나타냄을 시사한다. 따라서 본 연구를 통해 polygalacin D가 근생성 및 근위축 예방과 치료를 위한 잠재적인 유효소재로서의 가능성을 제시하였다.

• 디지털융복합연구
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• 제18권1호
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• pp.357-368
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• 2020

이 연구는 K3 리그 축구선수들의 시즌 중 체력 상태를 점검하기 위한 목적으로 종목 특이적인 체력측정을 시즌 초반과 후반에 실시하였다. 평가항목은 신체구성, 순발력, 민첩성, 지구력 및 등속성 하지근력 등으로 구성하였다. 측정 결과 시즌 초반과 비교하여 시즌 후반에 향상된 기능을 보여준 항목은 골격근량, 순발력, 민첩성 등이며, 신체조성, 지구력 및 등속성 하지근력은 차이점이 발견되지 못하였다. 시즌 후반부에 향상도를 보여준 항목은 시즌 중 반복적인 훈련과 시합 참여에 의한 학습효과 및 다양한 생리학적 기전에 의한 것으로 생각된다. 마지막으로 지구력과 하지근력은 별도의 특이적인 훈련을 시즌 중에 실시하지 못한 이유로 인하여 시즌 후반에 향상도를 보여주지 못한 것으로 판단된다. 이상의 결과를 종합한 결과, 선수들의 체력상태를 주기적으로 점검하는 연구를 통하여 시합기, 전이기 및 준비기에 적합한 체력 훈련프로그램의 개발 및 적용이 필요한 것으로 생각된다.

• Journal of Ginseng Research
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• 제44권3호
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• pp.435-441
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• 2020

Background: As a process of aging, skeletal muscle mass and function gradually decrease. It is reported that ginsenoside Rb1 and Rb2 play a role as AMP-activated protein kinase activator, resulting in regulating glucose homeostasis, and Rb1 reduces oxidative stress in aged skeletal muscles through activating the phosphatidylinositol 3-kinase/Akt/Nrf2 pathway. We examined the effects of Rb1 and Rb2 on differentiation of the muscle stem cells and myotube formation. Methods: C2C12 myoblasts treated with Rb1 and/or Rb2 were differentiated and induced to myotube formation, followed by immunoblotting for myogenic marker proteins, such as myosin heavy chain, MyoD, and myogenin, or immunostaining for myosin heavy chain or immunoprecipitation analysis for heterodimerization of MyoD/E-proteins. Results: Rb1 and Rb2 enhanced myoblast differentiation through accelerating MyoD/E-protein heterodimerization and increased myotube hypertrophy, accompanied by activation of Akt/mammalian target of rapamycin signaling. In addition, Rb1 and Rb2 induced the MyoD-mediated transdifferentiation of the rhabdomyosarcoma cells into myoblasts. Furthermore, co-treatment with Rb1 and Rb2 had synergistically enhanced myoblast differentiation through Akt activation. Conclusion: Rb1 and Rb2 upregulate myotube growth and myogenic differentiation through activating Akt/mammalian target of rapamycin signaling and inducing myogenic conversion of fibroblasts. Thus, our first finding indicates that Rb1 and Rb2 have strong potential as a helpful remedy to prevent and treat muscle atrophy, such as age-related muscular dystrophy.