• YAKHAK HOEJI
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• v.41 no.1
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• pp.117-125
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• 1997

The pharmacological effects of benzopyran potassium channel openers (lemakalim, KR-30450 and KR-30818) on the occlusion/reperfusion-induced myocardial infarction were investigat ed. In anesthetized rats, subjected to 45-min occlusion of the left anterior descending coronary artery (LAD) followed by 90-min reperfusion, the infarct size was measured by calculating the ratio of infarct zone to area at risk (IZ/AAR) with the Evans blue/TTC technique. Rats were intravenously given vehicle (1% DMSO), lemakalim, KR-30450, and KR-30818 alone or in combination with a selective K$_{ATP}$ blacker glibenclamide, 30 min prior to coronary occlusion. Compared to vehicle, lemakalim (30 ${\mu}$g/kg i.v.), the active enantiomer of cromakalim, had a tendancy to decrease infarct size. KR-30450(30 ${\mu}$g/kg, i.v.). the newly synthetized potassium channel openers (PCOs), caused a reduction of infarct size (from 70${\pm}$4%to 57${\pm}$5%). but KR-30818 (30 ${\mu}$g/kg, i.v.), a metabolite of KR-30450. did not modify infarct size. It seem ed likely that glibenclamide (0.3mg/kg, i.v.), given in combination, reduced the effects of these PCOs, especially KR-30450 (30 ${\mu}$g/kg, i.v.) on the infarct size. These results indicate that. in the coronary occluded rat model of ischemia, lemakalim and KR-30450 may exert cardioprotective activity through a reduction of infarct size, the effect being considered related to the opening of K$_{ATP}$ channel.

• Korean Journal of Acupuncture
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• v.35 no.1
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• pp.41-45
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• 2018

Objectives : To investigate minimum pressure by verifying changes in pressure due to bleeding amount during bloodletting-cupping therapy. Methods : (1) We compared adhesion performance of four different cupping cups of same size: two disposable cupping cups(A, B) and two reusable cupping cups(A, B) each were vacuumed three times and kept in place for 10 minutes. (2) We vacuumed two different sized disposable cupping cups(A), size.1(InnerDiameter 48.8 mm) and size.3(InnerDiameter 39.1 mm), twice each(-200 mmHg) on silicon plate. We injected water and air at regular intervals in cupping cups by using a syringe, and then measured change of pressure in cupping cups and pressure at the time of dropout. Results : (1) Pressure reduction was $4.75{\pm}2.78%$ on average in the order of 'Disposable[A]>reusable[B]>Disposable[B]>reusable[A]', so that pressure retention performance of disposable cups can't be regarded as inferior to that of reusable cups. (2) Pressure of disposable cupping B(size.1) decreased by an average of -40.08 mmHg per 5 ml of water. At -24.8 mmHg, when 22 ml of water has been injected, cup has come off. Pressure of disposable cupping B(size. 3) decreased by an average of -99.4 mmHg per 5 ml of water. At -48.6 mmHg, when 13 ml of water was injected, cupping came off. Conclusions : Considering reduction rate of pressure due to water injection, in case of bleeding more than 15 ml, size.3 cup always comes off, therefore it needs to be re-operated at least once. Meanwhile, size.1 cup does not always come off in the same condition, depending on the initial pressure and therefore, re-operation may be considered.

• Journal of Korea Water Resources Association
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• v.48 no.3
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• pp.221-231
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• 2015

This is a continuous study on the dam effects for the spatial extension of flood data. In this study, flood reduction rates of dams and their influences on downstream using the spatially extended flood data were implemented. Nam-Han River was selected for measuring the impacts of ChoongJu and HoangSung dams. In the evaluations of flood reduction rate at dams, the larger flood events have the lower flood reduction rates for both dams. At the YeoJoo water level station, the analyses of the relations between flood reduction rates and the sizes of watersheds dams located were performed. the sizes of watersheds having a functional dam have highly influenced on the reduction rates of flood. The average of flood reduction rates was smaller than the area rate. For instances, area rates of HoangSung (0.02) and ChoongJu dams (0.6) are larger than the average flood reduction rates for HoangSung (0.01) and ChoongJu dams (0.51), respectively. However, the water level station follows the dam flood reduction characteristics of dams themselves. The spatial effects of dam flood reductions are analyzed based on the three water level stations (GangChun, YeoJoo, YangPyung). The distance of flood reduction rates lower than 0.1 as average flood reduction rate was the area 7 times of watershed having a dam with 0.02 as a minimum reduction rate.

• Wind and Structures
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• v.16 no.3
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• pp.263-278
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• 2013

The fatigue load of a turbine blade has become more important because the size of commercial wind turbines has increased dramatically in the past 30 years. The reduction of the fatigue load can result in an increase in operational efficiency. This paper numerically investigates the load reduction of large wind turbine blades using active aerodynamic load control devices, namely trailing edge flaps. The PD and LQG controllers are used to determine the trailing edge flap angle; the difference between the root bending moment and its mean value during turbulent wind conditions is used as the error signal of the controllers. By numerically analyzing the effect of the trailing edge flaps on the wind turbines, a reduction of 30-50% in the standard deviation of the root bending moment was achieved. This result implies a reduction in the fatigue damage on the wind turbines, which allows the turbine blade lengths to be increased without exceeding the designed fatigue damage limit.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.15 no.6
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• pp.97-104
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• 2006

The geometric configuration in the weight reduction designis very required to be started from the conceptual design with low cost, high performance and quality. In this point, a structural-topological shape concerned with conceptual design of structure is important. The method used in this paper combines three optimization techniques, where the shape and physical dimensions of the structure and material distribution are hierachically optimized, with the maximum rigidity of structure and lightweight. As the results, the technology of weight reduction design is considered in designs of aluminum control arm and inner panel of door.

• Coupled systems mechanics
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• v.9 no.3
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• pp.281-287
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• 2020

Nanotechnology is an upcoming technology that can provide solution for combating pollution by controlling shape and size of materials at the nanoscale. This review provides comprehensive information regarding the role of nanotechnology in pollution control at concrete structures. Titanium dioxide (TiO2) nanoparticles are a good item for concrete structures for diminishing the air polluting affect by gasses of exhaust. In this article, the mixture rule is presented for the effect of nanoparticles in environmental pollution reduction in concrete structures. The compressive strength, elastic modulus and reduction of steel bars in the concrete structures are studied. The Results show that TiO2 nanoparticles have significant effect on the reduction of environmental pollution and increase of stiffness in the concrete structures. In addition, the nanoparticles can reduce the use of steel bars in the concrete structure.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09a
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• pp.482-483
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• 2006

Synthesis of iron nanopowder by room-temperature electrochemical reduction process of ${\alpha}-Fe_2O_3$ nanopowder was investigated in terms of phase evolution and microstructure. As process variables, reduction time and applied voltage were changed in the range of $1{\sim}20$ h and $30{\sim}40$ V, respectively. From XRD analyses, it was found that volume of Fe phase increased with increasing reduction time and applied voltage, respectively. The crystallite size of Fe phase in all powder samples was less than 30 nm, implying that particle growth was inhibited by the reaction at room temperature. Based on the distinct equilibrium shape of crystalline particle, phase composition of nanoparticles was identified by TEM observation.

• IE interfaces
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• v.13 no.2
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• pp.217-224
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• 2000

This paper analyzes the effects of setup cost reduction in a dynamic lot-sizing model for a single-facility multi-product problem. In the model, demands for each product are known, no backlogging is allowed, and a single resource is employed. Also, setup cost is defined as a function of capital expenditure to invest in setup cost reduction. Furthermore, in each production period the facility (or plant) produces many products, each representing a fixed part of the involved production activity (or input resource quantity). In this paper, the structure of the optimal solution is characterized and an efficient algorithm is proposed for simultaneously determining the optimal lot size with reduced setup cost and the optimal investment in setup cost reduction. Also, the proposed algorithm is illustrated by a numerical example with a linear and an exponential setup reduction functions.

• Korean Journal of Materials Research
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• v.27 no.8
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• pp.438-444
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• 2017

In this work, the effects of hydrogen reduction on the microstructure and thermoelectric properties of $(GeTe)_{0.85}(AgSbTe_2)_{0.15}$ (TAGS-85) were studied by a combination of gas atomization and spark plasma sintering. The crystal structure and microstructure of TAGS-85 were characterized by X-ray diffraction(XRD) and scanning electron microscopy (SEM). The oxygen content of both powders and bulk samples were found to decrease with increasing reduction temperature. The grain size gradually increased with increasing reduction temperature due to adhesion of fine grains in a temperature range of 350 to $450^{\circ}C$. The electrical resistivity was found to increase with reduction temperature due to a decrease in carrier concentration. The Seebeck coefficient decreased with increasing reduction temperature and was in good agreement with the carrier concentration and carrier mobility. The maximum power factor, $3.3{\times}10^{-3}W/mK^2$, was measured for the non-reduction bulk TAGS-85 at $450^{\circ}C$.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.48 no.1
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• pp.82-92
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• 2016

The reduction of carbon dioxide emission is hot issue in the world because we are confronted with serious global warming and climate change. As a part of carbon dioxide reduction efforts, various approaches for increasing filler loading have been carried out in order to decrease the energy consumption in papermaking processes. Effects of the pretreatment of GCC with cationic starch and MFC on the flocculation behaviour of GCC were investigated in this study. Pretreatment of GCC with cationic starch caused the change of electric charge of suspension and flocculation behaviour of GCC. Largest flocculation size was obtained near the isoelectric point in the case of cationic starch treatment. When MFC (30 times grinded) was added after preflocculation of GCC with cationic starch, the flocculation size was increased, but largest flocculation size was obtained at -150 mV of electric charge of suspension in this study. However the addition of highly grinded MFC (60 times grinded) caused smaller flocculation size of GCC than those of MFC (30 times grinded). When GCC and MFC were mixed first, and then cationic starch was added, the characteristics of MFC and the change of electric charge which could be brought by cationic starch did not affect the flocculation size of GCC at all. The flocculation size obtained by the combination of cationic starch and MFC was smaller than those of cationic starch. These results show that flocculation behaviour could be controlled by the change of electric charge of suspension and the combination methods of cationic starch and MFC.