• Journal of the Earthquake Engineering Society of Korea
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• v.6 no.3
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• pp.53-62
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• 2002

Site soil condition affects significantly on the seismic response of a structure and is a critical factor for the performance based seismic design of a structure. In this paper, the effects of nonlinear soil properties on the elastic response spectra of a structure including the nonlinearity of a soil due to the earthquake excitation is investigated using one step finite element approach for the entire soil structure system and approximate linear iterative procedure to simulate the nonlinear soil behavior with the Ramberg-Osgood soil model. Studies were carried out for a linear SDOF system of a variable period with and without a pile group for the 1940 CI Centro earthquake recorded on ground rather than rock. The study results showed clearly that the effect of the nonlinear behavior of soft soil is very important on the elastic seismic response of a structure suggesting the necessity of the performance based seismic design.

• Tuberculosis and Respiratory Diseases
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• v.43 no.6
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• pp.903-915
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• 1996

Background: Combination chemotherapy is now considered to be the cornerstone of small cell lung cancer (SCLC). management but the optimal management of limited SCLC is not well defined. The role of thoracic radiotherapy (TRT) is less well established. Recent meta-analyses reports revealed that TRT combined with chemotherapy produce "good" local control and prolonged survival. But other reports that survival was not changed. The liming, dose, volume and fractionation for TRT with the combined chemotherapy of SCLC remains unsettled. In this study, we analyzed the effects according to the timing of thoracic radiotherapy in limited SCLC. Method: All fifty one patients received cytoxan, adriamycin and vincristine(CAV) alternating with etoposide and cisplatin(VPP) every 3 weeks for 6 cycles were randomized prospectively into two groups: concurrent and sequential. 27 patients received 4500cGy in 30 fractions(twice daily 150cGy fractional dose) over 3 weeks 10 the primary site concurrent with the first cycle of VPP(concurrent gorup). 24 patients received 4000 to 5000cGy over 5 or 6 weeks after completion of sixth cycles of chemotherapy(sequential group). Results: 1. Response rates and response duration : Response rates were not significantly different between two groups(p=0.13). But response duration was superior in the concurrent group(p=0.03). 2. Survival duration was nor different between two groups(p=0.33). 3. Local control rate was superior in the concurrent group(p=0.00). 4. Side effects and toxicities: Hematologic toxicities, especially leukopenia, infection and frequency of radiation esophagitis were higher in the concurrent group (p=0.00, 0.03, 0.03). Conclusion: The concurrent use of TRT with chemotherapy failed to improve the survival of limited stage SCLC patients compared with the sequential use of TRT but response duration and local control rate were superior in the concurrent group. Frequency of radiation esophagitis, life threatening hematologic toxicities and infection were more frequent in the concurrent group than sequential group. So, the selection of an optimal schedule of chemotherapy combined with TRT that would lead to a major increase in survival with minimal toxicity is remained to be validated in large scale study in the future.

• Journal of the Earthquake Engineering Society of Korea
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• v.3 no.1
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• pp.113-122
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• 1999

The importance of the vertical response of a structure was well recognized after the Hyogoken-Nanbu earthquake of Japan. However, most of the seismic design codes does not specified the site sail profiles, and the sail and foundations conditions were mostly neglected in the vertical seismic analyses of a structure. In this paper, the effects of foundation size, sail layer depth under the foundation, foundation embedment and pile foundation on the vertical seismic response spectra for both surface and embedded mat foundation were studied to investigate the effects of the soft soil layer on the vertical response of a structure excited with the vertical components of Taft and El Centro earthquakes, considering the sail profile types of $S_A,S_C,S_E$ in UBC-97, the medium and large size foundations, the soil layer depth under the foundation of 30 and 60m, the foundation embedment of 0 and 15m, and the precast reinforced concrete bearing piles installed in the soft soil deposit. According to the study results, the foundation size has a little effect on the vertical seismic response, However, the soil layer depth under the foundation of 60m has to be considered for the vertical seismic analysis of a structure as for the horizontal one. The embedded pile foundations as well as the surface ones built on the soft soil layer amplified the vertical seismic response of a structure very much.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.5
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• pp.423-431
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• 2001

Some recent investigations revealed that vasodilatory action of adenosine is mainly not mediated by surface A2 receptor and suggested the existence of an intracellular action site. In the present study, we tried to differentiate intracellular from extracellular site of adenosine action in the regulation of coronary flow. In perfused rabbit hearts, concentration-response curve of coronary flow to exogenous adenosine was constructed in the presence or absence of dipyridamole, an inhibitor of transmembrane purine transport. Inhibition of cellular adenosine uptake by dipyridamole suppressed the increase of flow rate while enhancing the decrease in heart rate induced by exogenous adenosine. In another series of experiments, perfused rabbit hearts were subjected to energy deprivation in order to increase the production of endogenous adenosine. Energy deprivation along with dipyridamole administration resulted in higher coronary flow rate. Lower perfusate adenosine concentration was observed along with higher tissue adenosine content in this group. These results implied that coronary flow rate is determined not by interstitial adenosine concentration but by intracellular activity of adenosine. To confirm the effects of dypiridamole in vivo, direct measurement of interstitial adenosine concentration by mycrodialysis along with the assay of intracellular adenosine content was performed after intranenous dipyridamole administration. After dipyridamole infusion, intracellular adenosine content was markedly increased while interstitial adenosine concentration was not altered. In another series of experiments, the right shift of concentration-response curve of adenosine-induced vasodilation by 8-phenyltheophilline, a representative adenosine receptor antagonist, was mostly abolished by prior administration of prazosin, indicating that the influence of 8-PT on the adenosine action is not attributed to the inhibition of A2 receptor but related to the suppression of ${\alpha}-adrenoceptor$ activation. From these results, we concluded that adenosine acts intracellularly to regulate the coronary blood flow.

• Journal of the Korean Geotechnical Society
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• v.34 no.8
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• pp.51-64
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• 2018

Korean peninsula is known to be far from the plate boundary and not to generate large-scale earthquakes. However, earthquakes recently occurred in Gyeongju (2016/09/12, $M_L=5.8$) and Pohang (2017/11/15, $M_L=5.4$). The interest in earthquake engineering has increased, and various studies are actively underway by recently events. However, the seismic station network in Korea is less dense than that of the western U.S., resulting in the lack of data for detailed analyses of earthquakes. Therefore, KMA (Korea Meteorological Administration) set up temporary seismic stations and recorded ground motions from aftershocks. In this study, characteristics of Pohang seismic propagation and generation of bedrock motion are analyzed through the aftershock ground motion records at both permanent and temporary stations, as well as through the collected geological structure and site information. As a result, the response at Mangcheon-Li shows evidences of basin effects from both geology structures and measured aftershock motions.

• International Journal of High-Rise Buildings
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• v.11 no.4
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• pp.347-362
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• 2022

Current vibration serviceability assessment criteria for wind-induced vibrations in tall buildings are based largely on human 'perception' thresholds which are shown not to be directly translatable to human 'acceptability' of vibrations. There is also a considerable debate about both the metrics and criteria for vibration acceptability, such as frequency of occurrence or peak vs mean vibration, and how these might vary with the nature of the vibration. Furthermore, the design criteria are necessarily simplified for ease of application so cannot account for a range of environmental, situational and human factors that may enhance or diminish the impact of vibrations on serviceability. The dual-site VSimulators facility was created specifically to provide an experimental platform to address gaps in understanding of human response to building vibration. This paper considers how VSimulators can be used to inform general design guidance and support design of specific buildings for habitability, in terms of vibration, which allow engineers and clients to make informed decisions with regard to sustainable design, in terms of energy and financial cost. This paper first provides a brief overview of current vibration serviceability assessment guidelines, and the current understanding and limitations of occupants' acceptability of wind-induced motion in tall buildings. It then describes how the dual-site VSimulators facility at the Universities of Bath and Exeter can be used to assess the effects of motion and environment on human comfort, wellbeing and productivity with examples of how the facility capabilities have been used to provide new, human experience based experimental research approaches.

• Korean Journal of Ecology and Environment
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• v.56 no.4
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• pp.303-319
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• 2023

Pitfall traps that use ethylene glycol as a preservative solution are commonly used in arthropod research. However, a recent surge in cases involving damage to these traps by roe deer or wild boars owing to the sweet taste of ethylene glycol has prompted the addition of quinone sulfate, a substance with a pungent taste, to deter such wildlife interference. This study aimed to assess the effects of quinone sulfate on arthropods collected from pitfall traps containing ethylene glycol. We strategically positioned 50 traps using ethylene glycol alone and 50 traps containing a small amount of quinone sulfate mixed with ethylene glycol in a grid pattern for systematic sampling at the Gwangneung Forest long-term ecological research (LTER) site. Traps were collected 10 days later. The results revealed a notable effect on ants when quinone sulfate was introduced. Specifically, it decreased the number of ants. In a species-specific analysis of ants, only Nylanderia flavipes showed a significant decline in response to quinone sulfate, whereas other ant species remained unaffected. Additionally, among the arthropod samples obtained in this survey, we identified species or morpho-species of spiders, beetles, and ants and assessed species diversity. Consequently, the utilization of quinone sulfate should be undertaken judiciously, taking into account the specific species composition and environmental characteristics of the monitoring site. Our study also highlighted the significant response of various arthropod groups to variations in leaf litter depth, underscoring the crucial role of the leaf litter layer in providing sustenance and shelter for ground-foraging arthropods. Furthermore, we have compiled comprehensive species lists of both spiders and ants in Gwangneung forest by amalgamating data from this investigation with findings from previous studies.

• Journal of the Earthquake Engineering Society of Korea
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• v.25 no.6
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• pp.293-303
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• 2021

Seismic fragility functions for unreinforced masonry buildings were derived based on the incremental dynamic analysis of eight representative inelastic numerical models for application to Korea's earthquake damage estimation system. The effects of panel zones formed between piers and spandrels around openings were taken into account explicitly or implicitly regarding stiffness and inelastic deformation capacity. The site response of ground motion records measured at the rock site was used as input ground motion. Limit states were proposed based on the fraction of structural components that do not meet the required performance from the nonlinear static analysis of each model. In addition to the randomness of ground motion considered in the incremental dynamic analysis explicitly, supplementary standard deviation due to uncertainty that was not reflected in the fragility assessment procedure was added. The proposed seismic fragility functions were verified by applying them to the damage estimation of masonry buildings located around the epicenter of the 2017 Pohang earthquake and comparing the result with actual damage statistics.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2021.05a
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• pp.265-266
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• 2021

Recently, the importance of disaster prevention has emerged as serious accidents have occurred frequently, in which workers died or seriously injured at industrial sites. In response, the government enacted the 'Act on the Punishment of Major Disasters' to strengthen the responsibility, punishment intensity, and regulation of business owners for accidents at the site. In particular, the construction industry accounts for a large proportion of serious accidents, so safety levels need to be raised through on-site management. This study aims to reduce the occurrence of disasters at construction sites and to improve the work efficiency of safety managers. To derive detailed elements of the safety manager's work, domestic and overseas cases were investigated. The derived items were analyzed for the difficulty and preventive effects of the work through a survey of experts, and they will contribute to disaster prevention by presenting tasks to be focused and suggesting ways to improve inefficient tasks.

• The Journal of the Acoustical Society of Korea
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• v.43 no.4
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• pp.414-421
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• 2024

In this paper, we design and verify a system that can detect piping leakage noise in an environment with significant reverberation and reflection using a multi-channel acoustic sensor module as a technology to prevent major plant accidents caused by leakage. Four-channel microphones arranged in a tetrahedron are designed as a single sensor module to measure three-dimensional sound intensity vectors. In an environment with large effects of reverberation and reflection, the measurement error of each sensor module increases on average, so after placing multiple sensor modules in the field, measurement results showing locations with large errors due to effects such as reflection are excluded. Using the intersection between three-dimensional vectors obtained from several pairs of sensor modules, the coordinates where the sound source is located are estimated, and outliers (e.g., positions estimated to be outside the site, positions estimated to be far from the average position) are detected and excluded among the points. For achieving aforementioned goal, an excluding algorithm by deciding the outliers among the estimated positions was proposed. By visualizing the estimated location coordinates of the leakage sound on the site drawing within 1 second, we construct and verify a system that can detect the location of the leakage sound in real time and enable immediate response. This study is expected to contribute to improving accident response capabilities and ensuring safety in large plants.