• Interdisciplinary Bio Central
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• v.2 no.3
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• pp.8.1-8.5
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• 2010

Introduction: Recently identified human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Bioinformatics study of hABH2 and hABH3 had led to the discovery of a novel DNA repair mechanism. Very little is known about structure and function of hABH4, one of the members of this superfamily. Therefore, in present study we are intended to predict its structure and function through various bioinformatics tools. Materials and Methods: Modeling was done with modeler 9v7 to predict the 3D structure of the hABH4 protein. This model was validated with the program Procheck using Ramachandran plot statistics and was submitted to PMDB with ID PM0076284. The 3d2GO server was used to predict the functions. Residues at protein ligand and protein RNA binding sites were predicted with 3dLigandSite and KYG programs respectively. Results and Discussion: 3-D model of hABH4, ALKBH4.B99990003.pdb was predicted and evaluated. Validation result showed that 96.4 % residues lies in favored and additional allowed region of Ramachandran plot. Ligand binding residues prediction showed four Ligand clusters, having 24 ligands in cluster 1. Importantly, conserved pattern of Glu196-X-Pro198- Xn-His254 in the functional domain was detected. DNA and RNA binding sites were also predicted in the model. Conclusion and Prospects: The predicted and validated model of human homologue hABH4 resulted from this study may unveil the mechanism of DNA damage repair in human and accelerate the research on designing of appropriate inhibitors aiding in chemotherapy and cancer related diseases.

• Journal of the Korean Society of Safety
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• v.25 no.3
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• pp.40-44
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• 2010

North Korea's discharge of water from a dam into the Imjin River that flows through the inter-Korean border swept away a riverside camping site early Sunday morning, killing six people. This tragic incident might have been prevented if the North had given prior notice of the release from its Hwanggang Dam to the South. Investigations are under way to determine the reasons behind the unexpected act. This incident was a man-made disaster not least death of six people. A water level monitoring system(WLMS) of the Imjin River was installed the bridge of Pilseung that operate three public institutions. The WLMS of the A institution set up warning siren and broadcasting as the water level has been rising the bridge of Pilseung in the Imjin River. But the A institution's system was already out of side before discharged of water a dam into the Imjin River and the operators were culpable negligence. The B institution's office employee on charges of negligence that might have contributed to the tragedy and one of the A institution's employees ignored 26 warning messages on the WLMS. This tragic incident was a man-made disaster not least death of six people and might have been prevented if the WLMS was normally operated and the system operators must be worked a tight.

• Journal of Korean Library and Information Science Society
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• v.45 no.4
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• pp.409-428
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• 2014

The purpose of this study is to analyze the economic feasibility of Busan Regional Central Library. The four candidate sites were included for the analysis. To achieve the purpose of this study, we applied three types of indices such as Benefit-Cost analysis, Net Present Value, and Internal Rate of Return. We used CVM(Contingent Valuation Method) to calculate the benefit; we conducted two investigations to calculate WTP, which are for pretest and for main survey. From results of pretest, we designed five optimal prices. On the basis of them, main survey was accomplished to figure out WTPs for four candidate sites. The results show that four candidate sites were all feasible from an economic point of view. Of these, the Busan Citizen Park site got the highest point of B/C ratio.

• The Korean Journal of Quaternary Research
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• v.17 no.2
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• pp.55-61
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• 2003

In the year 2000 we culminated a successful five year investigation of climate change by completing a preliminary east-west transect across Mongolia. An earlier tree-ring study at Tarvagatay Pass, Mongolia indicated unusual warming during the 20th century similar to other paleo-investigations of the northern hemisphere. This record had represented one of the few tree-ring records for central Asia. New data from several sites in western Mongolia confirmed the preliminary temperature. The highest twenty-year growth period for the composite record is from 1973-1994. The western Mongolian record was significantly correlated with the Taimyr Peninsula and two northern hemisphere temperature reconstructions reflecting large-scale temperature patterns while showing some important regional differences. These differences should prove useful for climate models. We have also developed a millennial length temperature-sensitive record at the Solongotyin Davaa site (formerly Tarvagatay Pass) using relict wood and living trees. Conspicuous features over the last 1000 years are a century scale temperature decline punctuated by the end of the Little Ice Age in the late-1800s and 20th century warming. The record also shows a cold period early in the 12th century and warm intervals late in the 10th, early in the 15th and at end of the 18th centuries. Despite a limited sample size before 900 AD, the long Solongotyin Davaa record is useful in indicating severe cold events and suggests some cold intervals nearly as severe. These tree ring series, spanning much of the circumpolar northern treeline, have been compiled to create a long-term reconstruction of the Earth's temperature over centuries. The new chronology, in addition to its value as a detailed record of Mongolian climate, provides independent corroboration for such hemispheric and global reconstructions and their indications of unusual warming during the 20th century.

• Korean Journal of Cognitive Science
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• v.7 no.3
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• pp.37-60
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• 1996

From the biopsychological point of view,learning could be defined as the processes to transfer the information that we obtain from environment to the neural circuits in the brain.In the studies to determine the biological substrates of learning and memory,there was a remarkable effort to identify neural circuits related with a specific type of learning and to describe the mechanixm of neural plasticity of learning and memory,under the assumption that the memory orinformation may be stored as a modificationof neural synapes in the central nerviys system.On the other hand,there was a different kind of tendency to analyze the mechanism of interactions between neural substrates involved in learning and memory,under the assumption that a specific information may be represented in the patterns of comples neural network of the central nervous system.The present review,in the former position.focused on the research methods and the chracteristics and finding of the investigations employing animal model systems to indentify the essential site of engram for learning and memory.Specifically,the review presents major advances in ourunderstanding of the memory trace circuit for a specific type of learning,with the use of animal model system,the detemination of the critical lodi of neuaral plastic chabges In learing abd memory,and the neurophysiological an biocemical mechanixms of the neural modifia by learint.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.03a
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• pp.1148-1155
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• 2010

To suggest a modified shallow foundation design method which can be considered the scale effect of foundation on IGM(intermediate geomaterial) soil layer, the weathered soil layer that is uniformly formed up to 8m(2B) with over 50 N-value is selected and 3 times field loading tests are performed on several sized square-shaped shallow foundations with 30, 75, 150, 240 and 400cm in width respectively. Because the soil modulus of elasticity(Es) calculated by soil investigation and 1st field test(PBT) results showed an underestimated tendency, a modified correlation is required for the reasonable estimation of Es on the weathered soil. Also, the N-value was increased with an increasing in depth. However, the N-values around the test foundations showed the different values even though the foundations on the same level because the test site was arranged by excavation. Therefore, the more detail soil investigations are required for the each test foundations respectively. Since Es based on elasticity theory is determined by the stress distribution shape of the foundation and elasticity modulus of the soil, the scale effect considered pressure-settlement curve can be clearly derived from the correlation on stress distribution shape and the variation of soil elasticity modulus with depth. Therefore, the modified correlation will be suggested to estimate a reasonable Es on the weathered soil, and the scale effect considered shallow foundation design method is also developed based on the elastic theory and field tests in this research.

• Journal of the Korean GEO-environmental Society
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• v.16 no.4
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• pp.23-32
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• 2015

This paper addresses the effects of extreme rainfall on the stability of cut slopes in Yen Bai city, Northern Viet Nam. In this area, natural slopes are excavated to create places for infrastructures and buildings. Cut slopes are usually made without proper site investigations; the design is mostly based on experience. In recent years, many slope failures have occurred along these cuts especially in rainy seasons, resulting in properties damaged and loss of lives. To explain the reason that slope failure often happens during rainy seasons, this research analyzed the influence of extreme rainfalls, initial ground conditions, and soil permeability on the changes of pore water pressure within the typical slope, thereafter determining the impact of these changes on the slope stability factor of safety. The extreme rainfalls were selected based on all of the rainfalls triggering landslide events that have occurred over the period from 1960 to 2009. The factor of safety (FS) was calculated using Bishop's simplified method. The results show that when the maximum infiltration capacity of the slope top soil is less than the rainfall intensity, slope failures may occur 14 hours after the rain starts. And when this happens, the rainfall duration is the deciding factor that affects the slope FS values. In short, cut slopes in Yen Bai may be stable in normal conditions after the excavation, but under the influence of tropical rain storms, their stability is always questionable.

• Fire Science and Engineering
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• v.30 no.6
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• pp.84-91
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• 2016

In case of fire, vertically and intensively loaded rack warehouses are faced with a severe status due to the rapid increase in fires. In this regard, there have been trials to prevent fires from spreading by applying fire extinguishing systems, such as ESFR and In-Rack Sprinklers, vertical and horizontal barriers, etc.; however, it is difficult to calculate and design proper fire extinguishing systems caused by various composition conditions, such as the size and loading density of the rack, types of loading commodities, etc. Therefore, in this study, a standard rack was manufactured, incorporating a rack warehouse in Korea by site investigations, surveys, etc. In addition, a full scale fire test was executed to check the fire characteristics depending on the conditions of the ignition points. As a result, the extracted fire spread speed is expected to be utilized as a reference for performance comparisons of the fire extinguishing systems to be developed and applied in the future.

• Journal of Korean Society of Rural Planning
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• v.11 no.2 s.27
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• pp.21-34
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• 2005

The objective of this study is to suggest a planning direction for the management and conservation of a rural landscape. For suggesting the planning direction, this study was classified rural landscape resources based on spatial type to understand the assessment of rural landscape. This study examined literature reviews and site investigations for collecting the data on the resources of a rural landscape to maintain rurality. First above all, it was classified into physical and non-physical resources. Non-Physical resources include elements such as inhabitants' will, leaders' will and the software. It is also to reflect all these factors on the planning. Next, this study classified the resources of a landscape into artificial and natural resources and applied these resources to rural areas which were divided into five types: industry area, life area, natural landscape area, program area and human behavior area. The pictures obtained from this field survey were used for a questionnaire survey to understand the value of a rural landscape. The contents of questionnaire survey were divided into two parts: the presentation condition of a rural land-scape and assessment of a rural landscape. Especially, the value of a rural landscape was divided into the ecological value, socio-cultural value and holistic value.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.51 no.4
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• pp.624-629
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• 2015

To estimate the movement of Pacific cod Gadus macrocephalus in the Korean Southeast Sea, three type tags were used. A total of 97 Pacific cod were tagged and released with either archival tags or conventional tags. Of these releases, commercial fishermen recovered thirteen conventional tags, and five of seven pop-up tags transmitted data to Argos satellites. Pacific cod began to move towards East Sea after release, and they spent most of their time at depths of 100 to 300m, water temperatures of 0.8 to $14.0^{\circ}C$. However, geographical ranges of their movement limited to area around the southern East Sea. Pacific cod attached conventional tag were recaptured near the release site(Jinhae Bay: main spawning ground) about one or two year after release. Data obtained from tagging investigations suggest that they migrated annually from spawning ground to habtat of the Korean Southeast Sea.