• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.909-913
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• 2013

Purpose: The liver is the organ to which colorectal carcinomas (CRCs) most commonly metastasize, and surgical resection has been established as the most effective and potentially curative treatment for CRC with liver metastasis (LM). Therefore, surveillance of LM is vital for improvement of prognosis of CRC patients. In this study, we aimed to explore the potential value of carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA), and marker enzymes in indicating LM with CRC. Methods: Three groups of eligible patients with metastatic cancers were retrospectively included: CRC patients with LM (CRC-LM) or without LM (CRC-NLM), and non-CRC patients with LM (NCRC-LM). All metastatic lesions were identified by CT or MRI. Data on characteristics of the patients, the primary site, the locations of metastasis, CA 19-9, CEA, and biochemical parameters were collected for analysis. Results: A total of 493 patients were retrospectively included. More alcohol consumption was found in CRC-LM than CRC-NLM. Some biochemical enzymes were found to be significantly higher in groups with LM than without (CRC-LM or NCRC-LM v.s CRC-NLM). Both CEA and CA 19-9 were much higher in CRC-LM than CRC-NLM or NCRC-LM. For CRC patients, CA 19-9, ${\gamma}$-glutamyl transpeptidase, CEA and alcohol consumption were identified as independent factors associated with LM. Conclusion: Our analysis suggested the CA 19-9 might be a potential valuable indicator for LM of CRC in the clinic.

• Journal of Periodontal and Implant Science
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• v.29 no.4
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• pp.873-893
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• 1999

The ultimate goal of periodontal therapy is the regeneration of periodontal tissue and repair of function. For more than a decade there have been many efforts to develop materials and bioactive molecule(such as growth factor and differentiation factors) to promote periodontal wound healing. Among the bioactive molecules, bone morphogenetic protein(BMP) was studied for periodontal wound healing. Since Urist demonstrated that demineralized bone matrix could induce the formation of cartilage and bone in ectopic site, many studies on BMP have been reported. Among those BMPs, it was reported that rhBMP-2 enhanced the healing of bone defects in animal studies and clinical studies. However, its efficacy in periodontal regeneration, especially 1-wall intrabony defects is still unknown. The purpose of this study was to examine the effect of rhBMP-2/ACS on the epithelial migration, gingival connective tissue adhesion, cementum formation, alveolar bone regeneration in intrabony defects of dogs. Four millimeter deep and four millimeter wide 1-wall defects were surgically created in the mesial aspects of the 3rd incisors. The test group received rhBMP-2/ACS with a flap procedure and the control underwent buffer/ACS with a flap procedure. Histologic analysis after 8 weeks of healing revealed the following results: 1. The length of epithelial growth(the distance from alveolar crest to the apical end of JE) was $0.9{\pm}1.5mm$ in the control group and $1.2{\pm}1.4mm$ in the test group. There was no statistically significant difference between the two groups. 2. The length of connective tissue adhesion was $2.4{\pm}1.3mm$ in the control group and $1.2{\pm}1.1mm$ in the test group. The control group showed significantly enhanced adhesion(P<0.05). 3. The length of new cementum was $0.9{\pm}1.0mm$ in the control group and $1.7{\pm}0.8mm$ in the test group. The test group showed significantly enhanced cementum regeneration(P<0.05). 4. The length of new bone height was $1.9{\pm}0.6mm$ in the control group and $2.4{\pm}0.9mm$ in the test group. There was no statistically significant difference between the two groups. 5. The new bone area was $4.7{\pm}1.7mm^2$ in the control group and $8.0{\pm}2.0mm^2$ in the test group. The test group showed significantly enhanced bone formed area(P<0.05). 6. The new bone density was $73.0{\pm}8.6%$ in the control group and $66.6{\pm}15.3%$ in the test group. There was no statistically significant difference between the two groups. These results suggest that the use of rhBMP-2 in 1-wall intrabony defects has significant effect on new cementum and new bone formation area, but doesn't have any significant effect on the prevention of junctional epithelium migration and new bone formation height.

• Korean Journal of Heritage: History & Science
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• v.53 no.1
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• pp.52-63
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• 2020

This study was conducted in order to evaluate the characteristics of air temperature fluctuation inside the Daegeumgul, Ondaldonggul, and Seongnyugul Caves, which are the most representative limestone caves in Korea, and also to assess the effects of air temperature on cave temperature. Temperature was measured hourly at three sites in Daegeumgul, Ondaldonggul, and Seongnyugul Caves from April 13 to June 25, 2019. Additionally, air temperature data for the areas around the caves was provided by the Meteorological Administration. Using this collected data, the basic statistical measure of fluctuation characteristics over time was ascertained, and time series analyses were performed. Wide variation of temperature was exhibited in the order of the cave entrance, the cave water inflow point, and the midpoint. Cave temperature was observed to increase gradually during the study period. There was a vast range in temperature at the Daegeumgul station located approximately 150 m outside the cave, but it remained nearly constant beyond the midpoint. Although the effect of air temperature was not significant due to the influence of visitors, the effect of air temperature on cave temperature gradually decreased from the entrance to the interior. At Ondaldonggul, there was a wide range in temperature recorded at the entrance due to the influence of air temperature, but it stayed almost constant in the interior. However, at the site where cave water flows into the cave, temperature was influenced by the cave water temperature. At Seongnyugul, there was a distinct fluctuation in temperature recorded at the cave entrance, while the middle of the cave remained nearly constant. Temperature fluctuated due to the air temperature at the entrance, while at the middle of the cave, measurements were expected to be affected to a greater extent by the lake water temperature than by the air temperature. However, this pattern was not observed. According to the time series analysis results, in all caves, fluctuations of air temperature affected cave temperature after approximately one hour. Cave size and structure, water presence, the entrance's size and shape, air flow, and visitor patterns can all influence cave temperature. Therefore, consideration of these factors is very important in the pursuit to clearly understand cave temperature characteristics.

• Journal of the Mineralogical Society of Korea
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• v.28 no.3
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• pp.255-263
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• 2015

To investigate the effect of the weathering process of biotite on Cs sorption, sorption experiment of Cs with $10^{-3}M$ solution was carried out on the biotite reacted at different reaction times at pH 2 and 4, and 1 M solutions of Na, K, Ca, Mg, Rb, and Cs. Peak changes were observed for some samples by XRD, indicating that new mineral phase formed by biotite weathering. Among several factors, cations in solutions have the most significant influence on the mineralogical changes. The samples reacted with Na showed the most outstanding change with increasing peak width and appearance of $12{\AA}$ peak and $14{\AA}$ peak. This new peaks indicate the formation of hydrobiotite and vermiculite. The new peaks had stronger peak intensity for the sample reacted at pH 4 than that at pH 2, probably due to the fast dissolution of small particles and edges and resultant decrease in the formation of expandable layers. The biotite reacted at Mg solution showed small intensity at $14{\AA}$. Based on XRD results, the degree of biotite weathering was in the order of Na, Mg, and Ca. The samples reacted with K, Rb, Cs solutions did not show noticeable mineralogical changes caused by weathering. The amount of sorbed Cs on weathered biotite showed close relationship with the degree of weathering indicated by XRD. At both pH 2 and 4, the biotite reacted with Na solution showed the highest Cs sorption, and those with Mg and Ca solutions showed the next highest ones. The sorbed amounts of Cs on the bitote reacted with K, Rb, Cs solutions were relatively low. This indicates that at the Cs concentration ($10^{-3}M$) which we used for this experiment and which was much higher than the maximum Cs concentration sorbed on the frayed edge site, expandable layer plays more important role than frayed edge. In the cases of K, Rb, and Cs solutions, Cs sorption was decreased because K is the same cations as the one in the interlayer or the sorption of Rb and Cs on the frayed edge prevents the formation of expandable layers.

• Journal of Korean Society of Forest Science
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• v.69 no.1
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• pp.56-68
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• 1985

This study was conducted (1) to measure the nitrogen content of various parts of trees in a 24-year-old Pinus koraiensis plantation, providing a harvest method with the least impact on the self-serving mechanisms in the nitrogen status of the ecosystem and (2) to examine the seasonal changes in inorganic nitrogen (ammonium salt and nitrate, separately) at various soil depths and to study the self-serving mechanisms for nitrogen at the ecosystem, providing an appropriate method and season for the application of nitrogen fertilizers. The results obtained in this study were as follows; 1) Of the total nitrogen content of the total tree biomass (except for roots), nearly 61.5% was distributed in the needles, 20% in the branches, 5.5% in the stem bark, and 13% in the stem wood. Therefore, the harvest method of removing only wood parts for pulpwood production has little impact on the self-serving mechanisms of the site's nitrogen status. 2) Inorganic nitrogen concentrations decreased with increasing soil depths. The seasonal average concentration of inorganic nitrogen was highest in early spring and decreased in the following descending order; autumn, tollowed by mid-summer, and early summer. This pattern resulted from the fact that the loss of nitrate was greatly influenced by environmental factors. Thus, it was suggested that an application of active nitrogen fertilizer would be appropriate in spring.

• Journal of the Korean Geographical Society
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• v.31 no.3
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• pp.489-507
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• 1996

The purpose of this study is to examine the increasing number of unregistered manufacturing plants and related problems, and to recommend alternative solutions to the problems. Data are obtained from a field survey of randomly selected small scale manufacturing plants in Seoul and its suburban cities. A total number or respondents are 533, and 416 of them are unregistered plants. The Capital Regional Planning has had a goal during last three decades to lead a balanced regional economic development by restriction manufacturing plants in the Capital Region and by encouraging them in other regions in the nation. It was 1984 when a comprehensive planning was established to achieve this goal. Sets of various regulations, by-laws and codes have been implemented to regulate manu-facturing activities in the Capital Region to achieve the goal. The region is divided into three sub-regions, and a different degree of regulations is applied to each sub-region. Only a certain types of industries are allowed in a particular sub-region. For instance, a plant manufacturing high-technology products could be allowed in the most urbanized sub-region. All manu-facturing plant in the Capital Region which has ares size of larger than 200"\;"$m^2$ is compulsory to register to the local government office. In practice, however, it is not common or sometimes almost impossible to get approval for many applicant manufacturers because of strict regulations. There have been increasing number of plants in the Capital Region during last several decades, despite the strict regulations. Many of those newly established plants are without formal registration at the local administration office. howerver. These are so called 'unregisterd' plants. Surveyed data and many government official data show that many of unregistered plants have been established in recent years. which indicate that current regulations are no longer effective. The number of unregistered plants are increasing tin the Capital Region because of many locational advantages in the region for plants, particularly those in small scale. Unregistered plants are the source of many problems, such as local water pollution or noise pollution in residential areas. There are also many administration problems, bed\cause they are not registered. The central government has attempted to cure the problems of unregistered plants. For example, the government allowed a unregistered plant to remain at present site for three ydars, if it met certain conditions in three years. However, this program was unsuccessful because many of those plants were not able to meet the concitions. Three times the government renewed the term for those which did not meet conditions since 1989, but it was afraid to be without success. There are many evidences that current policies to control manufacturing plants are not effective. The Capital Region must face mounting problems if ploicies are not reformed soon. This study suggests that the policy of the Capital Regional Planning has to be reoriented to provide more favorable policies for manufacturing plants in the Capital Region than current regulations which is aimed to restrict manufacturing activities. It is time to improve many existing problems in the region through reforms and of current regulations to foster unregistered plants. This study also proposes many smaller-area sub-divisions instead of current three large area sub-regions which is too broad to apply single kind of regulation, or codes. Flexible regulations and codes can be applied to such a small-area sub-divivisions based on location and industrial characteristics of the individual sub-divisions. It is necessary to provide decent industrial environment in the Capital Region, which is best equipped to provide many favorable industrial locational factors in the nation, thus this nation can be further prepared to compete in an inter-national market at an era of globalization in manufacturing.

• Korean Journal of Environmental Agriculture
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• v.10 no.2
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• pp.158-166
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• 1991

This study was performed to survey the pollution levels of Pinus Thunbergii forest soil surrounding. The Onsan industrial complexes of caused by the surrounding polluted air. The results are summarized as follows. 1. The forestry soil pH in the vicinity of the industrial complex showed severe acidity in the range of pH $4.2{\sim}4.8$. And also the available Al was higher in the acidified soils. 2. The available S was in the range of $21ppm{\sim}638ppm$, and was highest within 2km of the industrial complex and difference greatly depending on distance from the source. 3. Heavy metals soil, concentrations of Fe, Zn and Cu were $0.9ppm{\sim}73.7ppm$, $0.09ppm{\sim}6.68ppm$ and $0.10ppm{\sim}62.10ppm$, respectively and there were many site difference, especially high concentrations were observed in source nearest seaside. The sites and showed that soil pollution had been progressing in these sites. 4. The concentrations of Pb and Cd generally showed low contents as $0.06ppm{\sim}0.07ppm$ and $0.06ppm{\sim}0.24ppm$ respectively and Cd contents were also high in seaside sites near sources. 5. The results of correlation between soil factors were significant between soil pH and Al(r=0.588) at 1% and soil pH and S(r=0.469), Zn(r=0.491) and Cu(r=0.475) at 5% respectively. 6. In the correlations among the heavy metals, there were significant high correlations between Fe and Zn(r=0.833), Cu(r=0.846) and Pb(r=0.583), and Zn and Cu(r=0.773), Cu and Pb(r=0.746) at 1%, whereas correlations between Zn and Pb(r=0.529), and Zn and Cd(r=0.457) were relatively low at 5%.

• Korean Journal of Environmental Biology
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• v.38 no.1
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• pp.1-15
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• 2020

This study was conducted to determine whether invasive muskrats settle in the natural ecosystem of Korea. The study also aimed to provide information on the selection of target areas, basic behavioral characteristics, and habitat use-related data, all of which are essential for effective management strategy establishment and site management. To this end, a trend in international muskrat management was identified to examine the management direction according to the settlement stage. We also secured the location of 72 domestic farmers and classified five regions in Gyeonggi-do, Chungcheongnam-do, Gyeongsangbuk-do, and Sejong Special Self-governing City into regions with high potential for natural leakage to raise the need for a quick survey. We determined that muskrats successfully settled in the natural ecosystem of Korea, based on the fact that we consistently identified a muskrat habitat at the same point for three years, from 2016 to 2018, the age of the captured population was estimated to be 1.2 years, and there had been no additional make-up factors near the habitat since 2012. The muskrats that settled in Korea showed a small home range of 0.0027 ㎢ (MCP 95%) and were estimated to show regular mobility before Spring and Autumn. Also, the areas where the muskrat habitat was observed had a high level of habitat environment disturbance and their ecological and food intake characteristics reflected that disturbance. Muskrat traces were high in hydrophyte vegetation, which can be used as a hideout in open waters and where the growth of both floating leaved plants and floating plants are prevalent. Since international invasive muskrats have already settled in the domestic ecosystem and there is concern about their proliferation in the future, the government must consider a preemptive response and scientific management.

• Radiation Oncology Journal
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• v.19 no.1
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• pp.27-33
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• 2001

Purpose : To evaluate interim results in terms of failure, cosmetic results and survival after breast conserving operation and radiation therapy in early breast cancer. Material and Methods : From January 1992 through December 1997, seventy two patients with early stage 0, I and II breast cancer were treated with conservative surgery plus radiotherapy at Keimyung University Dongsan Medical Center. Age distribution was 25 to 77 years old with median age of 43. According to TNM stage, five patients had stage 0, thirty three were stage I, twenty five were IIa, and nine were IIb. Most patients underwent excision of all gross tumor and ipsilateral axillary dissection. Breast was irradiated through medial and lateral tangential fields of 6 MV photons to 50.4 Gy in 28 fractions over 5.5 weeks. We delivered a boost irradiation dose of 10 to 16 Gy in 1 to 2 weeks to excision site. Adjuvant chemotherapy was administered in forty one patients with CMF (cyclophosphamide, methotrexate, 5-fluorouracil) regimens of 6 cycles concurrently or before radiation. Cosmetic results were assessed by questionnaire to patients grading of excellent, good, fair, poor. Follow-up periods were 22 to 91 months with median 40 months. Results : Five year disease free survival rate (5YDFS) was $95.8\%$. According to stage, 5YDFS was $100\%,\;96.9\%,\;96\%\;and\;88.9\%$ in stage 0, I, IIa and IIb, respectively. Two patients had distant metastasis and one had local and distant failure. One patient with distant failure had bone and liver metastasis at 14 months after treatment and the other had lung and both supraclavicular metastasis at 21 months after treatment. Patient with local and distant failure had local recurrence on other quadrant in same breast and then salvaged with total mastectomy and chemotherapy but she died due to brain metastasis at 55 months. Complications were radiation pneumonitis in five patients (four patients of asymptomatic, one patients of symptomatic) and hand or arm edema(4 patients). Fifty nine patients answered our cosmetic result questionnaire and cosmetic results were good to excellent in fifty one patients $(86\%)$. Conclusion : We considered that conservative surgery and radiation for the treatment of early stage invasive breast cancer was safe and had excellent survival and cosmetic results. We need to assess about prognostic factors with longer follow up and with large number of patients.

• Journal of Chest Surgery
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• v.30 no.12
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• pp.1225-1231
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• 1997

Spontaneous pneumothorax is the sudden collapse of a lung usually caused by air leakage from a subvisceral pleural blob. Responses to closed thoracostomy,thoracentesls and simple observation are usually prompt and effective. But in some cases, these are unsucceful and open thoracotomy is indicated. A clinical evaluation was performed on 242 cases(236 patients) of open thoracotomy in spontaneous pneumoth rax who were admitted and treated at department of Thoracic and Cardiovascular Surgery. Masan Samsung General Hospital during the past 9 years from January 1988 to December 1996. The results were as follows 1. The sex ratio was male predominance(M:F=11.7:1) 2. The most common age group were 2nd, 3rd decades(2nd=29.3%, 3rd=30.2%). 3. The most common chief complaints were chest pain and dyspnea(chest pain=41.7%. dryspnea= 36.8). 4. The etiologic factors of spontaneous pneumothorax were primary spontaneous pneumothorax(86.4%), tuberculosis(9.1%), COPD(3.7%) and pleuritis(0.8%). 5. The site of spontaneous pneumothorax was 52.1% in right, 45.4% in left and 2.5% in both. 6. The common indications of open thoracotomy were recurrence(44.2%), persistent air leakage(31.8%) and inadequate expansion(15.7%). 7. The operative procedures were bullectomy or mechanical pleurodesis through posterolateral thoracotomy or median sternotomy. 8. The most frequent location of bulla or blob were apical segme t oi RUL(35.1%) and apicoposterior segment of LUL(41.3 %). 9. The number of bulla or blob were mainly 1 to 5(88%), and there were no significant differences among operation indications. 10. The size of bulla or bleb were mainly below 5cm(81%)and small bulla($\leq$1cm) were predominant in recurrence group but large bulla(>5cm)were predominant in persistent air leakage and inadequate expansion group. 11. The pleural adhesion was seen in 54.5%.(Recurrence group 64.1%,Persistent air leakage group 51.9%,Inadequate expansion group 47.4%).