• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.4125-4128
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• 2012

Background: Soft tissue sarcomas (STS) must be managed with a team involving pathologists, radiologists, surgeons, radiation therapists and medical oncologists. Treatment modalities and demographic charasteristics of Turkish STS were analysed in the current study. Material-Methods: Primary adult STS followed between 1999-2010 in Cukurova University Medical Faculty Department of Medical Oncology were analzied retrospectively Results: Of the total of 498 patients, 238 were male and 260 female. The most seen adult sarcomas were leomyosarcoma (23%). Localization of disease was upper extremity (8.8%), lower extremity (24.7%), head-neck 8.2%, thoracic 8%, retroperitoneal 5.6%, uterine 12.4%, abdominal 10%, pelvic region 3.6 and other regions 10%. Some 13.1% were early stage, 10.2% locally advanced, 8.2% metastatic and 12.2% recurrent disease. Patients were treated with neoadjuvant/adjuvant (12%) or palliative chemotherapy (7.2%) and 11.4% patients did not receive chemotherapy. Surgery was performed as radical or conservative. The most preferred regimen was MAID combination chemotherapy in the rate of 17.6%. The most common metastatic site was lung (18.1%). The overall survival was 45 months (95%CI 30-59), 36 months in men and 55 months in women, with no statistically significant difference (p=0.5). The survival rates were not different between the group of adjuvant and palliative chemotherapy (respectively 28 versus 18 months) (p=0.06), but radical surgery at 37 months was better than 22 months for conservative surgery (p=0.0001). No differences were evident for localization (p=0.152). Locally advanced group had higher overall survival rates (72 months) than other stages (p=0.0001). Conclusion: STS can be treated successfully with surgery, chemotherapy and radiotherapy. The survival rates of Turkish people were higher in locally advanced group; these results show the importance of multimodality treatment approach and radical surgery.

• 한국임상보건과학회지
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• 제6권1호
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• pp.1065-1073
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• 2018

Purpose. In this study, we aim to clarify the correlation between happiness, appearance, and happiness index among many happiness factors based on the influence of quality of life on the quality of life and the affect of appearance on the happiness index. Methods. We conducted a self - filling questionnaire survey for college students in Busan from March 30 to May 10, 2017, and analyzed 392 copies of the 412 questionnaires, excluding 20 inappropriate copies. In the questionnaire, categorical data were analyzed by frequency and percentage (%) using the SPSS program (ver. 23.0, Chicago, Illinois, USA) by examining 11 items of general characteristics, successive data are presented as mean standard deviation. Results. The higher the grades, the better the dating. Women(3.32) are more likely than men(2.74) at the appearance interest(p>0.001) and the higher the grades, the better. If it's dating someone else, higher than not to do at the appearance interest and all of the questions showed higher interest in appearance. Also there was a high percentage of thought'My life is ideal in all aspects'If it's dating someone else, higher than not to do (p=0.007) Conclusion. At present, There is a high interest in the appearance of dating. In addition, the happiness index according to the current resentment status was higher in both the single item happiness index and the 5 item happiness index, and was significant in the item "My life is ideal in all aspects". Therefore, it is related to the happiness index as well as the appearance interest. Finally, whether or not dating and appearance interest play a role in raising the happiness of the individual.

• 한국산학기술학회논문지
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• 제21권1호
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• pp.208-215
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• 2020

본 연구는 65세에서 85세 사이의 남녀 노인 200명을 대상으로 노인 체력 측정과 보행 검사를 실시하여 노인의 체력 변인과 보행 특성 간의 관계를 조사하고자 하였다. 연구 대상자는 65세에서 85세 사이의 노인 200명으로 노인 체력 검사(Senior Fitness Test) 항목 6개와 추가 체력검사 3개(수직점프, 외발서기, 악력) 및 보행 측정을 수행하였다. 보행은 신발에 장착된 가속도계 기반 보행 측정 장비를 사용하였다. 이원분산분석, 주요인분석, 상관관계 분석을 실시하여 연령에 따른 영향과 변인들 간의 관계성을 파악하였다. 실험 결과 나이에 따라 보행 능력(보장, 6분 걷기), 제지방량, 체력(아령 들기)의 유의한 감소가 있었다(p<.05). 33개의 체력 및 보행 변인을 대상으로 주성분 분석을 실시한 결과 5개의 주성분(보행 특성, 신체 특성, 보행 가변성, 체지방 요인, 체력 요인)이 나타났으며 전체 가변성의 64.7% 설명력을 나타냈다. 보행 시 편한 보속은 보폭, 외발지지 시간과는 정적 상관, 양발지지 시간, 보행 가변성 변인들과는 부적 상관을 나타냈다(p<.05). 노인들의 삶의 질을 유지하려면 보행 능력이 매우 중요하며 이것은 근력운동을 통해 유지 또는 개선되어야 한다.

• 지능정보연구
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• 제29권2호
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• pp.219-240
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• 2023

사용자가 만족감을 느끼며 상호작용할 수 있는 대화형 인공지능을 개발하기 위한 노력이 이어지고 있다. 대화형 인공지능 개발을 위해서는 사람들의 실제 대화를 반영한 학습 데이터를 구축하는 것이 필요하지만, 기존 데이터셋은 질문-답변 형식이 아니거나 존대어를 사용하여 사용자가 친근감을 느끼기 어려운 문체로 구성되어 있다. 이에 본 논문은 온라인 커뮤니티에서 수집한 30,767개의 질문-답변 문장 쌍으로 구성된 대화 데이터셋(KOMUChat)을 구축하여 제안한다. 본 데이터셋은 각각 남성, 여성이 주로 이용하는 연애상담 게시판의 게시물 제목과 첫 번째 댓글을 질문-답변으로 수집하였다. 또한, 자동 및 수동 정제 과정을 통해 혐오 데이터 등을 제거하여 양질의 데이터셋을 구축하였다. KOMUChat의 타당성을 검증하기 위해 언어 모델에 본 데이터셋과 벤치마크 데이터셋을 각각 학습시켜 비교분석하였다. 그 결과 답변의 적절성, 사용자의 만족감, 대화형 인공지능의 목적 달성 여부에서 KOMUChat이 벤치마크 데이터셋의 평가 점수를 상회했다. 본 연구는 지금까지 제시된 오픈소스 싱글턴 대화형 텍스트 데이터셋 중 가장 대규모의 데이터이며 커뮤니티 별 텍스트 특성을 반영하여 보다 친근감있는 한국어 데이터셋을 구축하였다는 의의를 가진다.

• 한국안광학회지
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• 제10권4호
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• pp.313-321
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• 2005

소프트 콘택트렌즈에서의 미생물 오염에 의한 정도를 알아보기 위해 각기 다른 방법의 2가지 실험이 실시되었다. 첫 번째 실험에서는, 소프트 콘택트렌즈 착용 시 각막염의 주된 원인균이 될 수 있는 Staphylococcus aureus, Pseudomonas aeruginosa 그리고 Enterobacter aerogenes의 현탁액을 이용하여 소프트 콘택트렌즈를 오염시킨 후, 렌즈표면을 주사전자현미경으로 관찰하였다. S. aureus로 소프트 콘택트렌즈를 오염시킨 지 1시간 경과 후에 다수의 세균이 렌즈에 유착되어 있는 것이 관찰되었으며, 시간의 경과(2, 4, 6, 12, 그리고 24 시간)에 따라 오염양상은 더욱 증가하였다. P. aeruginosa의 경우, 12시간 경과 후에 세균이 렌즈에 유착되어 있는 것이 관찰되었으며 또한, E. aerogenes는 24시간 경과 후에 세균이 렌즈에 유착되어 있었으며 무정형의 물질이 렌즈 표면 일부에서 관찰되었다. 두 번째 실험에서는, 안질환이 없는 20대 남녀 21명을 대상으로 소프트 콘택트렌즈를 4시간 착용시켜 봄으로써 소프트 콘택트렌즈에서의 미생물 오염양상 정도를 살펴보았다. 그 결과 다수의 세균류와 진균류가 관찰되었으며, 특히 세균류는 균의 색과 콜로니의 형태로 판별하여 단일종, 2종, 그리고 3종이 렌즈에 유착되어 있는 것이 관찰되었다.

• 대한지리학회지
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• 제40권5호
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• pp.514-532
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• 2005

본 연구는 시간지리학 개념을 도입한 새로운 접근성 개념을 통해 공간적 근접성과 단일한 이동 행태를 전제하는 기존의 방법을 비판적으로 검토해보고자 한다. 이를 위해, 미국 Portland Metro 지역의 개인통행자료를 이용해 시공간적 접근성의 공간적 패턴과 근접성의 관계를 비교${\cdot}$분석하였다. 시간지리학의 시공간 프리즘 개념에 기반한 시공간적 접근성은 근접성 외에도 시공간 제약에 따른 다양한 이동성을 고려한 대안적 방법으로 최근 새롭게 주목받고 있다. 기존 방법은 접근성이 도시의 기능 중심성과 유사한 공간패턴을 보일 것으로 예상하지만, 연구결과는 접근성이 근접성보다는 개인의 시공간적 속성에 더 많은 영향을 받는다는 사실을 보여준다. 접근성은 CBD나 도시기회의 고밀도지역을 멀리 벗어난 지역에서 오히려 높게 나타났으며, 같은 지리적 특성을 공유하는 동일 지역이라 할지라도 성별에 따라 다르게 드러났다. 이는 접근성이 거주지뿐만 아니라 다른 공간적 축들(직장, 자녀의 탁아시설등)을 중심으로도 형성되며, 이에 따라 집에서 멀리 떨어진 곳의 도시 기회들이 집 주변의 도시기 회들보다 개인의 접근성에 더 큰 기여를 할 수 있다는 점을 시사한다.

• 대한두경부종양학회지
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• 제17권2호
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• pp.174-178
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• 2001

Background and Objective: Percutaneous ethanol injection therapy has been used in the treatment of the benign thyroid diseases. Although the reported side-effects of the therapy was mild and transient, some side-effects including local or radiating pain are troublesome to the patients. Radioactive iodine-131($Ra-^{131}I$) also has been effectively and safely used for management of the benign thyroid diseases. So we developed the percutaneous intranodular injection therapy of $Ra-^{131}I$ as an alternative of percutaneous ethanol injection therapy. Materials and Methods: From December 1998 to October 1999, we treated 29 outpatients (25 women and 4 men, mean age: $47{\pm}12$ years). Inclusion criteria were follows; age >30 years, cytologically benign, with normal thyroid function, cold nodule on thyroid scintigram, solid or mixed natured nodules in sonographical evaluation. Nodular volume was estimated by sonography according to the ellipsoid formula. $Ra-^{131}I$(0.1mCi/ml) was administered in a single dose injection. Follow-up studies every 3 months consisted of full history, thyroid function test, and sonography. We determined the therapeutic response is effective if the volume reduction of the nodule occurred above 30%. Results: After at least 3 months follow-up, 11 patients showed effective response, 12 patients showed minimal or unchanged response and 6 patients showed progression. Although side-effects such as injection pain, febrile reaction, and hormonal changes were absent, an infectious complication in injection site was developed from 1 case. Conclusion: Although we need a more prolonged follow-up to evaluate the delayed sequelae, we can suggest that percutaneous intranodular injection therapy of $Ra-^{131}I$ may be an attractive non-surgical treatment in selected cases of benign thyroid nodules.

• Archives of Plastic Surgery
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• 제35권6호
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• pp.698-702
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• 2008

Purpose: Basal cell carcinoma is one of the most common cancers in the western population and the annual incidence rate is still on an increasing course. In Asian countries such as Korea, the incidence of basal cell carcinoma is reported to be remarkably low but is estimated to be in a steep increase nowadays. This study was to analyze the recent clinical trends of basal cell carcinoma in Korea by reviewing a single institution's experience. Methods: Throughout an 11-year period, the surgical excision of 143 cases of basal cell carcinoma was performed in our department. General data of these cases such as the primary site of cancer, age and sex of the patient, operative methods, recurrence rate were reviewed retrospectively. Results: Among the 143 patients included in this study, 82 patients were men and 61 patients were women. The ages ranged from 27 to 89 years with a mean age of 64.0 years. The head and neck region was the most frequently involved primary site for the cancer as 95.1% of the total cases occurred in this area. Especially the nose and perinasal area were the most frequent region, which was followed by the periorbital area, cheek, and perioral area. During this study period, 9 cases showed recurrence of the cancer as the overall recurrence rate was 6.3%. Conclusion: Gradual increase in the incidence of basal cell carcinoma was demonstrated in this study. Basal cell carcinoma showed high incidence in the old-age population as 68.5% of the total patients were more than 60 years of age. High recurrence rate was noted in the nasal region especially after local flap reconstruction. A more cautious approach is to be required when handing such high risk lesions. Multiple factors such as extended life span, increased outdoor leisure activity and exposure to sunlight, higher accessibility to medical services and increased understanding of the public about skin cancer are assumed to be the main reasons for this increase of basal cell carcinoma.

• Nutrition Research and Practice
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• 제12권3호
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• pp.258-264
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• 2018

BACKGROUND/OBJECTIVES: Diet quality scores or indices, based on dietary guidelines, are used to summarize dietary intake into a single numeric variable. The aim of this study was to examine the association between the modified diet quality index for Koreans (DQI-K) and mortality among Health Examinees-Gem (HEXA-G) study participants. SUBJECTS/METHODS: The DQI-K was modified from the original diet quality index. A total of 134,547 participants (45,207 men and 89,340 women) from the HEXA-G study (2004 and 2013) were included. The DQI-K is based on eight components: 1) daily protein intake, 2) percent of energy from fat, 3) percent of energy from saturated fat, 4) daily cholesterol intake, 5) daily whole-grain intake, 6) daily fruit intake, 7) daily vegetable intake, and 8) daily sodium intake. The association between all-cause mortality and the DQI-K was examined using Cox proportional hazard regression models. Hazard ratios and confidence intervals were estimated after adjusting for age, gender, income, smoking status, alcohol drinking, body mass index, and total energy intake. RESULTS: The total DQI-K score was calculated by summing the scores of the eight components (range 0-9). In the multivariable adjusted models, with good diet quality (score 0-4) as a reference, poor diet quality (score 5-9) was associated with an increased risk of all-cause mortality (hazard ratios = 1.23, 95% confidence intervals = 1.06-1.43). Moreover, a one-unit increase in DQI-K score resulted in a 6% higher mortality risk. CONCLUSIONS: A poor diet quality DQI-K score was associated with an increased risk of mortality. The DQI-K in the present study may be used to assess the diet quality of Korean adults.

• Journal of Korean Neurosurgical Society
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• 제67권4호
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• pp.442-450
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• 2024

Objective : Cerebral hyperperfusion syndrome (CHS) manifests as a collection of symptoms brought on by heightened focal cerebral blood flow (CBF), afflicting nearly 30% of patients who have undergone superficial temporal artery (STA)-middle cerebral artery (MCA) anastomosis. The aim of this study was to investigate whether the amalgamation of magnetic resonance imaging (MRI) fluid-attenuated inversion recovery (FLAIR) and apparent diffusion coefficient (ADC) imaging via MRI can discern cerebral hyperemia after STA-MCA anastomosis surgery. Methods : A retrospective study was performed of patients who underwent STA-MCA anastomosis due to Moyamoya disease or atherosclerotic steno-occlusive disease. A protocol aimed at preventing CHS was instituted, leveraging the use of MRI FLAIR. Patients underwent MRI diffusion with FLAIR imaging 24 hours after STA-MCA anastomosis. A high signal on FLAIR images signified the presence of hyperemia at the bypass site, triggering a protocol of hyperemia care. All patients underwent hemodynamic evaluations, including perfusion MRI, single-photon emission computed tomography (SPECT), and digital subtraction angiography, both before and after the surgery. If a high signal intensity is observed on MRI FLAIR within 24 hours of the surgery, a repeat MRI is performed to confirm the presence of hyperemia. Patients with confirmed hyperemia are managed according to a protocol aimed at preventing further progression. Results : Out of a total of 162 patients, 24 individuals (comprising 16 women and 8 men) exhibited hyperemia on their MRI FLAIR scans following the procedure. SPECT was conducted on 23 patients, and 11 of them yielded positive results. All 24 patients underwent perfusion MRI, but nine of them showed no significant findings. Among the patients, 10 displayed elevations in both CBF and cerebral blood volume (CBV), three only showed elevation in CBF, and two only showed elevation in CBV. Follow-up MRI FLAIR scans conducted 6 months later on these patients revealed complete normalization of the previously observed high signal intensity, with no evidence of ischemic injury. Conclusion : The study determined that the use of MRI FLAIR and ADC mapping is a competent means of early detection of hyperemia after STA-MCA anastomosis surgery. The protocol established can be adopted by other neurosurgical institutions to enhance patient outcomes and mitigate the hazard of permanent cerebral injury caused by cerebral hyperemia.