• Biomolecules & Therapeutics
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• v.20 no.1
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• pp.125-131
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• 2012

Impulsiveness is an important component of many psychiatric disorders including Attention-deficit/hyperactivity disorder (ADHD). Although the neurobiological basis of ADHD is unresolved, behavioral tests in animal models have become indispensable tools for improving our understanding of this disorder. In the punishment/extinction paradigm, impulsivity is shown by subjects that persevere with responding despite punishment or unrewarded responses. Exploiting this principle, we developed a new behavioral test that would evaluate impulsivity in the most validated animal model of ADHD of the Spontaneously Hypertensive rat (SHR) as compared with the normotensive "control" strain, the Wistar Kyoto rat (WKY). In this paradigm we call the Electro-Foot Shock aversive water Drinking test (EFSDT), water-deprived rats should pass over an electrified quadrant of the EFSDT apparatus to drink water. We reasoned that impulsive animals show increased frequency to drink water even with the presentation of an aversive consequence (electro-shock). Through this assay, we showed that the SHR was more impulsive than the WKY as it demonstrated more "drinking attempts" and drinking frequency. Methylphenidate, the most widely used ADHD medication, significantly reduced drinking frequency of both SHR and WKY in the EFSDT. Thus, the present assay may be considered as another behavioral tool to measure impulsivity in animal disease models, especially in the context of ADHD.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.11
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• pp.1377-1382
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• 2011

Recently, alternative and novel energy resources have been developed for use in the future because of the current environmental problems and exhaustion of fossil energy resources. Hydrogen energy has many merits, such as its environmental friendliness, easy storage, and easy production, but it also has disadvantages, in that it is highly combustible and explosive. In this study, a test procedure using a simple SP test under highly pressurized hydrogen gas conditions was established. In order to evaluate its applicability, SP tests were carried out using a stainless steel (SUS316L) sample under atmospheric, pressurized helium, and pressurized hydrogen gas conditions. The results under the pressurized hydrogen gas condition showed fissuring and produced a reduction of the elongation in the plastic instability region due to hydrogen embrittlement, showing the effectiveness of the current in-situ SP test.

• Land and Housing Review
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• v.2 no.2
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• pp.145-155
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• 2011

It is very important for successful construction to estimate the soil volume conversion factor of domestic weathered ground accurately and reasonably. However, it is very difficult to quantify the weathering degree of weathered ground at the field, so that the soil volume conversion factor used in Korea is often dependent upon the standard of foreign countries. Besides, the soil volume conversion factor of domestic weathered ground has been rarely studied and the use and accuracy of the soil volume conversion factor have been questioned persistingly. This study suggests a simple but robust method for estimating the soil volume conversion factor and measuring the weathering degree reasonably, and attempts to establish the utilization of a soil volume conversion factor measurement system based on experimental and analytical results. We made relationship between electrical resistivity and weathering degree presented from weathering index obtained through laboratory tests using field samples, and an estimation method of in-situ weathering degree for granites and a calculation method of soil volume conversion factor using electrical resistivity. And also, we suggested the photogrametry measurement-equipment system for measuring the volume of cargo box and the application plan of stand equipment and RFID for calculating the earth volume and distinguishing buggies in order to design the measurement system for soil volume conversion factor applicable to the field. Ultimately, the Weathered Earth-work Management Program (WEMP) was developed, so field managers may easily obtain the information about earth volume and soil volume conversion factor at the weathered ground.

• Geomechanics and Engineering
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• v.23 no.1
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• pp.61-69
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• 2020

The uniaxial compressive strength (UCS) of rock is a basic parameter in underground engineering design. The disadvantages of this commonly employed laboratory testing method are untimely testing, difficulty in performing core testing of broken rock mass and long and complicated onsite testing processes. Therefore, the development of a fast and simple in situ rock UCS testing method for field use is urgent. In this study, a multi-function digital rock drilling and testing system and a digital core bit dedicated to the system are independently developed and employed in digital drilling tests on rock specimens with different strengths. The energy analysis is performed during rock cutting to estimate the energy consumed by the drill bit to remove a unit volume of rock. Two quantitative relationship models of energy analysis-based core drilling parameters (ECD) and rock UCS (ECD-UCS models) are established in this manuscript by the methods of regression analysis and support vector machine (SVM). The predictive abilities of the two models are comparatively analysed. The results show that the mean value of relative difference between the predicted rock UCS values and the UCS values measured by the laboratory uniaxial compression test in the prediction set are 3.76 MPa and 4.30 MPa, respectively, and the standard deviations are 2.08 MPa and 4.14 MPa, respectively. The regression analysis-based ECD-UCS model has a more stable predictive ability. The energy analysis-based rock drilling method for the prediction of UCS is proposed. This method realized the quick and convenient in situ test of rock UCS.

• Smart Structures and Systems
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• v.26 no.4
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• pp.507-520
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• 2020

In order to achieve effective corrosion monitoring of buried metal pipelines, a Novel nondestructive Testing (NDT) methodology using ultra-long (250 mm) Polymer Optical Fiber (POF) sensors coated with the Fe-C alloy film is proposed in this study. The theoretical principle is investigated to clarify the monitoring mechanism of this method, and the detailed fabrication process of this novel POF sensor is presented. To validate the feasibility of this novel POF sensor, exploratory research of the proposed method was performed using simulated corrosion tests. For simplicity, the geometric shape of the buried pipeline was simulated as a round hot-rolled plain steel bar. A thin nickel layer was applied as the inner plated layer, and the Fe-C alloy film was coated using an electroless plating technique to precisely control the thickness of the alloy film. In the end, systematic sensitivity analysis on corrosion severity was further performed with experimental studies on three sensors fabricated with different metal layer thicknesses of 25 ㎛, 30 ㎛ and 35 ㎛. The experimental observation demonstrated that the sensor coated with 25 ㎛ Fe-C alloy film presented the highest effectiveness with the corrosion sensitivity of 0.3364 mV/g at Δm = 9.32 × 10^-4 g in Stage I and 0.0121 mV/g in Stage III. The research findings indicate that the detection accuracy of the novel POF sensor proposed in this study is satisfying. Moreover, the simple fabrication of the high-sensitivity sensor makes it cost-effective and suitable for the on-site corrosion monitoring of buried metal pipelines.

• Journal of Pharmaceutical Investigation
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• v.24 no.3
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• pp.155-165
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• 1994

Some mucoadhesive polymers such as hydroxypropylcelluose (HPC) and carbopol-934 (CP) have been employed for the preparation of mucoadhesive polymeric systems, and their physical properties including mucoadhesion, swelling, and drug release were evaluated. A new simple experimental technique that can quantitatively measure the bioadhesive properties of various polymeric systems has been developed by the methods of detachment force test. As the polymeric systems, the discs of freeze-dried HPC/CP solid dispersions were prepared. The mucosa used in these tests were upper, middle, and lower parts of small intestine of male rats weighing $300{\sim}350\;g$. Detachment forces were increased as the mole fraction of CP increased in discs of HPC/CP solid dispersions. In the points of intestinal site dependence of mucoadhesion, the solid dispersions revealed non-specific mucoadhesion to the intestine. Swelling and drug release characteristics of mucoadhesive polymeric systems were studied extensively to find out the feasibility for the oral controlled delivery systems. Swelling ratio, expressed as the final height/initial height, has been determined in various pH buffer solutions. Hydrochlorothiazide (HCT) was employed as a model drug for release study. Apparent swelling and drug release rate constants, $K_s$ and $K_r$ respectively, were obtained from the square-root time plot of either swelling ratio or released amount of drug, particularly for the time periods before reaching the equilibrium. As a result, the swelling ratio of HPC/CP solid dispersions was increased as the weight percentage of CP increased. Similarly, the release of HCT from the solid dispersions was dependent on pH changes and CP contents, resulted in the slower release of HCT with the increases of pH and CP contents.

• Health Policy and Management
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• v.26 no.4
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• pp.325-332
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• 2016

Background: Workplace violence was recognized to be social problems that might impact the health status and the job satisfaction of employee in hospitals. This study investigated the current status of violence and job stress among hospital employees working at administration and discharging department. Methods: The study subjects were 213 administrative employees working at 20 general hospitals. Data were collected by self-administered questionnaire that included information such as demographics, job-related characteristics, experience of violence, and job stress. The violence was classified as verbal violence, physical threat, and physical violence occurred by patients and caregivers. Analysis of variance, t-tests, correlation analysis, and multiple linear regression analysis were performed to examine the associated factors with job stress. Results: The levels of verbal violence, physical threat, and physical violence were $1.64{\pm}1.08$, $0.54{\pm}0.67$, and $0.04{\pm}0.17$, respectively. The score of job stress was $2.74{\pm}0.50$ and it was associated with age, existence of spouse, drinking frequency, subjective health status, disease history, night-time treatment, and public health administration career in simple analysis. In multiple linear regression analysis, the level of verbal violence experience was significantly associated with job stress (B=0.09, p=0.001). Also physical threats (B=0.18, p<0.001) and physical violence (B=0.48, p=0.008) showed positive association with job stress. Conclusion: This study attempted to examine the association between experience of violence and job stress in administrative employees at medical institutions. Levels of violence showed positive correlation with the job stress. Environment improvement to protect employee from violence and management of employees who experienced workplace violence are needed to reduce the job stress.

• Journal of KIISE:Software and Applications
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• v.28 no.10
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• pp.699-705
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• 2001

As it became possible to generate 3D sound on a PC environment due to the advances in computing performance and digital signal processing technology, 3D sound technology gains its focus in the multimedia area Specifically a two-channel based 3D sound technology is being studied by many researchers because of its space efficiency and economical structure. While the positional sound effect is simple in its implementation, the moving sound effect has many problems to be resolved as there are only discrete measured point of HRTF database. In this paper, we propose the method of generating smooth moving sound in a two-channel based 3D sound technique with respect to generating smooth trajectory, and the interpolation method of discrete measured HRTF data. We perform the tests in the PC environment and prove the utility of the proposed method.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.24 no.4
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• pp.235-246
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• 2012

Typhoon induced surge simulations are done to make an establishment of coastal disaster prevention plan. To apply efficient run-up and overtopping on vertical harbor docks, in which prevailing wet-dry scheme cannot be satisfied due to infinite steepness, an imaginary internal barrier concept introduced and analyzed. Before real application on the Mokpo harbor area, feasibility tests are done on an idealized simple geometry and as a result it is found that the moderate width of the barrier might be 1 m. The threshold value of the minimum wet depth $H_{min}$ for land area, which behaves sensitive role in inundation area and depth, depends on grid size. However it is revealed that 0.01 m is adequate value in this fine finite element with 10 m spacing. A hypothetical typhoon of 100 years return period in central pressure and maximum velocity is generated based on historical tracks. Simulation of possible inundation on Mokpo area is performed with asymmetrical vortex of hypothetical typhoon and wave coupling. Model results show general agreement in pattern compared to other's prediction, however possibility of inundation enlargement is expected in harbor area.

• Journal of Korea Society of Industrial Information Systems
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• v.19 no.2
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• pp.59-66
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• 2014

AGV is most often used for the automation of freight transportation in the manufacturing industry or the distribution warehouses. AGV is fairly costly and used in goods transport between the determined location. The main control device dedicated to AGV is often autonomously developed for simplification using PLC in industry field. However, AGV developed for simplification makes many errors in traffic because it is developed for the limited simple function. Control device dedicated to AGV has been developed to solve the problem but it is almost impossible to revise the device according to the character and structure of every manufacturing industry. The purpose of this study is to propose the design method of the control system interlocked with PLC and dedicated to AGV. The control system should be to improve the problem of traffic rolling and possible to be revised according to the character of factory. It is apparent the proposed AGV system is efficient in operation in the result of several traffic performance analysis through the tests.