• Mass Spectrometry Letters
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• v.3 no.3
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• pp.68-73
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• 2012

Fat malabsorption is an important cause of poor growth in infancy and childhood. Steatorrhea tests have been developed using various methods. Traditional measurements of stool fat, however, require large samples and it often takes as a week to complete the analysis. In this paper, a liquid chromatography-electrospray ionization/mass spectrometry (LC-ESI/MS) method was developed for simultaneous quantitative analysis of triacylglycerols, triolein, diolein and monoolein, in mouse feces. Moreover, the procedure was rapid, simple as well as compatible with LC-ESI/MS. Chloroform-isopropyl alcohol solution was used for fat-soluble sample extraction. After centrifugation and filtration, an analytical solution was prepared. Triolein, diolein and monoolein were separated using non-aqueous reversed-phase column with the mobile phase consisting of A (methanol) and B (acetone-isopropyl alcohol). The precision (% CV) and accuracy (% bias) of the assay were 3.8-14.7% and 85.2-114.9%, respectively. This method has been successfully applied to simultaneous determination of triolein, diolein and monoolein in feces from 30 mice. This method can therefore be applied to measure triacylglycerols in mouse feces accurately and precisely by LC-ESI/MS, thereby helping to predictive biomarker in fat malabsorption and diagnostic research.

• Journal of the Korea Concrete Institute
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• v.24 no.5
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• pp.535-542
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• 2012

Adiabatic temperature rise test for predicting heat of hydration in mass concrete is especially inconvenient in the field. In order to overcome the problem, the equipment to effectively and conveniently measure semi-adiabatic temperature change was developed. The main objective of this paper is to propose a new and simple equipment for measuring semi-adiabatic temperature rise by using insulation bottles. In order to predict exact heat loss of concrete using this device, it is required to assume the specific heat loss coefficient of the device by water temperature change inside the experimental device. According to experimental and analytical results, the adiabatic temperature rise does not have significant differences in changes of temperature and humidity of air, as well as initial temperature of water. By comparing adiabatic temperature rise tests, the equipment for measuring semi-adiabatic temperature change can be used to predict the hydration heat of concrete within sufficient accuracy.

• Journal of the Korean Geotechnical Society
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• v.20 no.8
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• pp.5-14
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• 2004

The settlement of foundations under working load conditions is an important design consideration. Well-designed foundations induce stress-strain states in the soil that are neither in the linear elastic range nor in the range usually associated with perfect plasticity. Thus, in order to accurately predict working settlements, analyses that are more realistic than simple elastic analyses are required. The settlements of footings in sand are often estimated based on the results of in-situ tests, particularly the standard penetration test (SPT) and the cone penetration test (CPT). In this paper, we analyze the load-settlement response of vertically loaded footings placed in sands using both the finite element method with a non-linear stress-strain model and the conventional elastic approach. Based on these analyses, we propose a procedure for the estimation of footing settlement in sands based on CPT results.

• Journal of The Korean Association For Science Education
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• v.13 no.1
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• pp.100-120
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• 1993

Middle school students' conceptual changes on physics, chemistry, biology and earth science concepts which were intentionally selected by researchers had been investigated through traditional teaching and learning by paper and pencil tests and P.O.E. The weak points had been studied by individual interviews about the problems of traditional science classroom teaching after students' testing and learning about science concepts. As results, students' conceptual changes could be hardly found through traditional teaching and learning except several concepts in biology, The weak points of traditional science classroom teaching and learning were as follows: 1) Teachers teach science as finding answers. 2) The conventional science test is not performed to find students' concepts out but to recall simple knowledge or calculus. 3) Students hesitate to ask teacher Questions in science class because of their colleagues' or teachers' blame. These mean that science teachers need specially designed teaching methods on the students' concepts and reseachers had to study about science classroom socialogy, what happened in science classrooms.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.4971-4975
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• 2015

Background: Several methods have been presented for the evaluation of the endometrium in patients with abnormal uterine bleeding, which include minimal invasive and invasive approaches such as diagnostic curettage or endometrial biopsy by Pipelle. Many studies have been performed in order to compare two methods; diagnostic curettage and outpatient endometrial biopsy. This investigation compared sampling adequacy, endometrial histopathology, failure rates, duration and costs between diagnostic curettage in a hospital and endometrial biopsy. Materials and Methods: This single blind clinical trial was performed on 130 patients older than 35 years who was referred to Amir training hospital in 2013 for elective diagnostic curettage because of abnormal uterine bleeding. For all patients eligible for the study, an endometrial sample by Pipelle was taken without anesthesia or dilatation. Then under general anesthesia diagnostic curettage was performed by sharp curette. Sampling duration was calculated and both samples were sent to the same pathologist. The diagnostic values of two methods in the diagnosis of normal endometrium, endometrial hyperplasia and carcinoma were compared. The costs of these two methods were also compared. Data analysis was performed by SPSS (version 16.0) software. Chi-Square, Fisher, and Pearson tests were used and were considered statistically significant at P values less than 0.05. Results: Two methods were agreed upon 88% of sampling adequacy and 94% of pathological results. Specificity of 100% and sensitivity of 90% for detection of proliferative endometrium, secretory endometrium, simple hyperplasia without atypia and 100% for cancer were recorded. Pipelle diagnostic accuracy in comparison with curettage, have been reported over 97%, so the failure rate in this study was below 5%. Sensitivity of Pipelle for detection of atrophic endometrium was reported below 50%. Duration and cost was lower in Pipelle versus curettage. Conclusions: It is concluded that due to high agreement and cohesion coefficient between curettage and Pipelle on the issue of sampling adequacy, histopathology finding (except atrophic endometrium), low failure rate, duration of sampling and cost, Pipelle can be introduced as a suitable alternative of diagnostic curettage.

• Biomedical Science Letters
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• v.21 no.1
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• pp.1-8
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• 2015

Alzheimer's disease is a common form of dementia occurring among the elderly population and can be identified by symptoms such as cognition impairments, memory loss and neuronal dysfunction. Alzheimer's disease was found to be caused by the deposition of $\beta$-amyloid plaques and neurofibrillary tangles. In addition, mutation in the APP (Amyloid precursor protein), Presenilin 1 (PSEN1) and Presenilin 2 (PSEN2) genes were also found to contribute to Alzheimer's disease. Since the potential conformational diagnosis of Alzheimer's disease requires histopathological tests on brain through autopsy, potential early diagnosis still remains challenging. In recent years, several researches have proposed the use of biomarkers for early diagnosis. In cerebrospinal fluid (CSF), $\beta$-amyloid(1-42), phosphorylated-tau and total tau were suggested to be effective biomarkers for Alzheimer's disease diagnosis. However, a single biomarker might not be sufficient for potential diagnosis of Alzheimer's disease. Thus, the use of RNA interference (RNAi) through microRNAs (miRNAs) has been proposed by several researchers for simultaneous analysis of several biomarkers using microarray technology. These miRNA based biomarkers can be analysed from both blood and CSF, but miRNAs from blood are advantageous over CSF as they are non-invasive and simple for collection. Moreover, the RNAi based therapeutics by siRNA (short interference RNA) or shRNA (short hairpin RNA) have also been proposed to be effective in the treatment of Alzheimer's disease. This review describes the promising application of RNAi technology in therapeutics and as a biomarker for both Alzheimer's disease diagnosis and treatment.

• The Korean Journal of Nuclear Medicine
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• v.3 no.1
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• pp.1-12
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• 1969

Liver functions in diffuse parenchymal liver disease such as cirrhosis of the liver depend largely on the effective hepatic blood flow rather than on the individual cell functions. Clinical methods of measuring the hepatic blood flow were developed recently by the application of colloidal disappearance rate. In order to correlate the radiogold disappearance rate to conventional biochemical liver function tests, 21 normal subjects and 80 cases of cirrhosis of the liver were studied with both methods. The results are summarized as following: 1. The validity of external counting method to measure the blood disappearance rate of colloidal radiogold was confirmed by in vitro counting of the serial blood samples. 2. The blood disappearance rate of collidal radiogold was essentially the same. as the liver uptake rate of colloidal radiogold in normal and cirrhotic subjects with various degrees of functional disturbance. And it seemed there was no serious extrahepatic removal of the colloidal radiogold. 3. The disappearance rate of colloidal radiogold was not significantly changed by the posture change, but was enhanced by ingestion of 500 ml of water. 4. The disappearance rate of colloidal radiogold was not influenced by single dose of Telepaque, while BSP retention was increased after Telepaque. 5. The mean disappearance half time of colloidal radiogold in normal subjects was $2.49{\pm}0.391$(S.D.) minutes. The mean normal disappearance rate constant (K value) was $0.285{\pm}0.0428$(S.D.)/minute. 6. The colloidal radiogold disappearance half time was abnormally prolonged (over 3.2 min.) in $87.7{\pm}3.68$(S.D.) % of cirrhotic subjects. 7. In patients of liver cirrhosis the blood disappearance rate of colloidal radiogold correlated well to serum albumin and globulin levels and BSP retention which were considered to reflect functions of hepatic parenchymal cells. There was, however, no correlation between colloidal disappearance rate and thymol turbidity test, serum glutamic pyruvic transaminase, and serm alkaline phosphatase activities. The latters were considered to be associated with the activity of liver disease.

• The Journal of the Acoustical Society of Korea
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• v.20 no.5
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• pp.35-47
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• 2001

This paper describes an efficient harmonic-CELP speech coder by taking advantages of harmonic and CELP coders into account. According to frame voicing decision, the proposed harmonic-CELP coder adopts the RP-VSELP coder as a fast CELP in case of an unvoiced frame, or an improved harmonic coder in case of a voiced frame. The proposed coder has main features as follows: simple pitch detection, fast harmonic estimation, variable dimension harmonic vector quantization, perceptual weighting reflecting frequency resolution, fast harmonic synthesis, naturalness control using band voicing, and multi-mode. These features make the proposed coder require very low complexity, compared with HVXC coder To demonstrate the performance of the proposed coder, a 2.4 kbps coder has been implemented and compared with reference coders. From results of informal listening tests, the proposed coder showed good quality while requiring low delay and complexity.

• Journal of computational fluids engineering
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• v.18 no.1
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• pp.83-90
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• 2013

OpenMP is becoming more and more useful as a simple parallel processing paradigm on SMP (Shared Memory Multi-Processors) computing environment with the development of multi-core processors. However, very few data is available publically regarding the OpenMP performance in CFD (Computational Fluid Dynamics). In the present study a CFD test suite is prepared for the performance evaluation of OpenMP on various multi-core systems. The test suite is composed of two-dimensional numerical simulations for inviscid/viscous and reacting/non-reacting flows using three different levels of grid systems. One to five test runs were carried out on various systems from dual-core dual threads to 16-core 32-threads systems by changing the number of threads engaged for each test up to 80. The results exhibit some interesting results and the lessons learned from the tests would be quite helpful for the further use of OpenMP for CFD studies using multi-core processor systems.

• Transactions of the Korean Society of Mechanical Engineers
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• v.9 no.4
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• pp.395-402
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• 1985

The apparent activation energy Q$_{c}$ and the applied stress exponent n have been determined during creep of Al 7075 alloy over the temperature range of 90.deg. C to 320.deg. C (0.4-0.65T$_{m}$) and stress range of 1.85 kgf/mm$^{2}$ to 21 kgf/mm$^{2}$, respectively in order to investigate the creep behavior. Constant load creep tests were carried out in the experiment. At round the temperature of 200.deg. C-240.deg. C and under the stress level 8.13-9.55kgf/mm$^{2}$ and again at around the temperature of 280.deg. C-320.deg. C and under the stress level of 1.85-2.55kgf/mm$^{2}$, the creep behavior obeyed for the creep deformation was nearly equal to that of the volume self diffusion of pure aluminum (34kcal/mole). But at around the temperature of 90.deg. C and under the stress level of 10-21kgf/mm$^{2}$, the creep behavior did not obey a simple power-law relation and the apparent activation enrgy, Q$_{c}$ was 26.01 kcal/mole. From the above facts, at around the temperature of 200.deg. C-240.deg. C and 280.deg. C-320.deg. C, the creep deformation for Al 7075 alloy seemed to be controlled by dislocation climb but at 90.deg. C, by cross slip over the range of experimental stress conditions.tions.