• Journal of Advanced Navigation Technology
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• v.16 no.1
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• pp.41-53
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• 2012

The technologies used by the malicious codes have been being advanced and complicated through a merge of the existing techniques, while the damages by the malicious codes are moving from individuals and industries to organizations and countries. In this situation, the security experts are corresponding with the static analysis and the dynamic analysis such as signature searching and reverse engineering, respectively. However, they have had a hard time to respond against the obfuscated intelligent new zero day malicious codes. Therefore, it is required to prepare a process for a preliminary investigation and consequent detailed investigation on the infection sequence and the hiding mechanism to neutralize the malicious code. In this paper, we studied the formalization of the process against the infection sequence and the file hiding techniques with an empirical application to the Rustock malicious code that is most notorious as a spammer. Using the result, it is expected to promptly respond to newly released malicious codes.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.42 no.1
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• pp.193-204
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• 2017

The security of Internet systems critically depends on the capability to keep anti-virus (AV) software up-to-date and maintain high detection accuracy against new malware. However, malware variants evolve so quickly they cannot be detected by conventional signature-based detection. In this paper, we proposed a malware classification method based on sequence patterns generated from the network flow of malware samples. We evaluated our method with 766 malware samples and obtained a classification accuracy of approximately 40.4%. In this study, malicious codes were classified only by network behavior of malicious codes, excluding codes and other characteristics. Therefore, this study is expected to be further developed in the future. Also, we can predict the attack groups and additional attacks can be prevented.

• Journal of KIISE:Databases
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• v.32 no.3
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• pp.263-275
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• 2005

In a large DNA database, indexing techniques are widely used for rapid approximate sequence searching. However, most indexing techniques require a space larger than original databases, and also suffer from difficulties in seamless integration with DBMS. In this paper, we suggest a space-efficient and disk-based indexing and query processing algorithm for approximate DNA sequence searching, specially exact match queries, wildcard match queries, and k-mismatch queries. Our indexing method places a sliding window at every possible location of a DNA sequence and extracts its signature by considering the occurrence frequency of each nucleotide. It then stores a set of signatures using a multi-dimensional index, such as R*-tree. Especially, by assigning a weight to each position of a window, it prevents signatures from being concentrated around a few spots in index space. Our query processing algorithm converts a query sequence into a multi-dimensional rectangle and searches the index for the signatures overlapped with the rectangle. The experiments with real biological data sets revealed that the proposed method is at least three times, twice, and several orders of magnitude faster than the suffix-tree-based method in exact match, wildcard match, and k- mismatch, respectively.

• BMB Reports
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• v.45 no.3
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• pp.133-140
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• 2012

Cancers claim millions of lives each year. Early detection that can enable a higher chance of cure is of paramount importance to cancer patients. However, diagnostic tools for many forms of tumors have been lacking. Over the last few years, studies of chimeric RNAs as biomarkers have emerged. Numerous reports using bioinformatics and screening methodologies have described more than 30,000 expressed sequence tags (EST) or cDNA sequences as putative chimeric RNAs. While cancer cells have been well known to contain fusion genes derived from chromosomal translocations, rearrangements or deletions, recent studies suggest that trans-splicing in cells may be another source of chimeric RNA production. Unlike cis-splicing, trans-splicing takes place between two pre-mRNA molecules, which are in most cases derived from two different genes, generating a chimeric non-co-linear RNA. It is possible that trans-splicing occurs in normal cells at high frequencies but the resulting chimeric RNAs exist only at low levels. However the levels of certain RNA chimeras may be elevated in cancers, leading to the formation of fusion genes. In light of the fact that chimeric RNAs have been shown to be overrepresented in various tumors, studies of the mechanisms that produce chimeric RNAs and identification of signature RNA chimeras as biomarkers present an opportunity for the development of diagnoses for early tumor detection.

• Journal of fish pathology
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• v.28 no.2
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• pp.99-107
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• 2015

Despite its economic importance as an aquaculture species, the molecular and genetic information regarding physiologically important elements in rock bream (Oplegnathus fasciatus) is not completely understood. Rab proteins play a vital role in cellular mechanisms and immunity as one of the key regulators of membrane trafficking. In this investigation, a Rab gene, named as RbRab-5C-like, was identified from Oplegnathus fasciatus. RbRab-5C-like protein exhibited high homology with Rab proteins of other species and possessed signature characteristics of Rab proteins with four conserved cysteine residues. Phylogenetic analysis showed that RbRab-5C-like clustered with other fish counterparts. The RbRab-5C-like genomic sequence possesses six exons and five introns. Transcriptional analysis revealed that RbRab-5C-like was ubiquitously expressed in all examined tissues with the highest expression occurring in the liver. While the structural and homologic characteristics of RbRab-5C-like suggest a strong conservation of this element in different species, its mRNA distribution implies a wide range of biological significance in rock bream.

• Journal of KIISE:Software and Applications
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• v.30 no.5_6
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• pp.497-502
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• 2003

Content-based video copy detection is a complementary approach to watermarking. As opposed to watermarking, which relies on inserting a distinct pattern into the video stream, video copy detection techniques match content-based signatures to detect copies of video. Existing typical content-based copy detection schemes have relied on image matching which is based on key frame detection. This paper proposes a motion directional histogram, which is quantized and accumulated the direction of motion, for video copy detection. The video clip is represented by a motion directional histogram as a 1-dimensional graph. This method is suitable for real time indexing and counting the TV CF verification that is high motion video clips.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39B no.7
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• pp.433-439
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• 2014

This paper proposes an architecture of two-stage string matching engine with content-addressable memory(CAM) and parallel bit-split string matchers for deep packet inspection(DPI). Each long signature is divided into subpatterns with the same length, where subpatterns are mapped onto the CAM in the first stage. The long pattern is matched in the second stage using the sequence of the matching indexes from the CAM. By adopting CAM and bit-split string matchers, the memory requirements can be greatly reduced in the heterogeneous string matching environments.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.7A
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• pp.943-950
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• 2000

In this paper, an asynchronous multi-rate optical wireless pulse position modulation-code division multiple access (PPM-CDMA) is proposed for an indoor non-directed diffuse channel. As a signature sequence for CDMA, an optical orthogonal code (OOC) is used and an interference cancellation scheme is applied to improve the bit error rate. It is known that the optical PPM-CDMA has advantages due to its power efficiency. Moreover, it provides multi-rate services by varying the modulation level with fixed pulse duration. In the proposed multi-rate PPM-CDMA system with fixed pulse duration, chip rate and sampling time do not change for each transmission rate and this simplifies overall system structure.

• Journal of Communications and Networks
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• v.8 no.3
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• pp.290-296
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• 2006

In this paper, a generalized blind adaptive algorithm is introduced for multi-user detection of direct sequence code division multiple access (OS-COMA) wireless communication systems. The main property of the proposed algorithm is its ability to resolve the multipath fading channel resulting in inter symbol interference (ISI) as well as multiple access interference (MAI). Other remarkable properties are its low complexity and mitigation to the near-far problem as well as its insensitivity to asynchronous transmission. The proposed system is based on the minimization of the output energy and convergence to the minimum mean square error (MMSE) detector. It is blind in the sense that it needs no knowledge of the other users' signatures, only the intended user signature and timing are required. Furthermore, the convergence of the minimum output energy (MOE) detector to the MMSE detector is analytically proven in case of M-ary PSK. Depicted results show that the performance of the generalized system dominates those previously considered. Further improvements are obtained when multiple input multiple output (MIMO) technique is employed.

• The Plant Pathology Journal
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• v.30 no.4
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• pp.375-383
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• 2014

Fungi tolerate exposure to various abiotic stresses, including cytotoxic compounds and fungicides, via their ATP-driven efflux pumps belonging to ATP-binding cassette (ABC) transporters. To clarify the molecular basis of interaction between the fungus and various abiotic stresses including fungicides, we constructed a cDNA library from germinated conidia of Colletotrichum acutatum, a major anthracnose pathogen of pepper (Capsicum annum L.). Over 1,000 cDNA clones were sequenced, of which single clone exhibited significant nucleotide sequence homology to ABC transporter genes. We isolated three fosmid clones containing the C. acutatum ABC1 (CaABC1) gene in full-length from genomic DNA library screening. The CaABC1 gene consists of 4,059 bp transcript, predicting a 1,353-aa protein. The gene contains the typical ABC signature and Walker A and B motifs. The 5'-flanking region contains a CAAT motif, a TATA box, and a Kozak region. Phylogenetic and structural analysis suggested that the CaABC1 is a typical ABC transporter gene highly conserved in various fungal species, as well as in Chromista, Metazoans, and Viridiplantae. We also found that CaABC1 was up-regulated during conidiation and a minimal medium condition. Moreover, CaABC1 was induced in iprobenfos, kresoxim-methyl, thiophanate-methyl, and hygromycin B. These results demonstrate that CaABC1 is necessary for conidiation, abiotic stress, and various fungicide resistances. These results will provide the basis for further study on the function of ABC transporter genes in C. acutatum.