• 대한본초학회지
• /
• 제38권1호
• /
• pp.45-53
• /
• 2023

Objectives : Network pharmacology-based research is one of useful tool to predict the possible efficacy and molecular mechanisms of natural materials with multi compounds-multi targeting effects. In this study, we investigated the functional underlying mechanisms of Astragalus membranaceus Bunge (AM) on its anti-obesity effects using a network pharmacology analysis. Methods : The constituents of AM were collected from public databases and its target genes were gathered from PubChem database. The target genes of AM were compared with the gene set of obesity to find the correlation. Then, the network was constructed by Cytoscape 3.9.1. and functional enrichment analysis was conducted to predict the most relevant pathway of AM. Results : The result showed that AM network contained the 707 nodes and 6867 edges, and 525 intersecting genes were exhibited between AM and obesity gene set, indicating that high correlation with the effects of AM on obesity. Based on GO biological process and KEGG Pathway, 'Response to lipid', 'Cellular response to lipid', 'Lipid metabolic process', 'Regulation of chemokine production', 'Regulation of lipase activity', 'Chemokine signaling pathway', 'Regulation of lipolysis in adipocytes' and 'PPAR signaling pathway' were predicted as functional pathways of AM on obesity. Conclusions : AM showed high relevance with the lipid metabolism related with the chemokine production and lipolysis pathways. This study could be a basis that AM has promising effects on obesity via network pharmacology analysis.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 1991년도 한국자동제어학술회의논문집(국내학술편); KOEX, Seoul; 22-24 Oct. 1991
• /
• pp.332-336
• /
• 1991

Network management is responsible for gathering information on the usage of the network media by the network devices, ensuring the correct operation of the network, and providing reports. MAP network management must provide the high reliability of the media and signaling method, even in very harsh environments, providing a very low bit error rate and minimum number of retransmission. In this paper, we analysed the framework of OSI management and MAP network management and discussed the implementation method of fault management and remote management mechanism in the Mini-MAP controller developed for IBM-PC.

• Journal of Communications and Networks
• /
• 제2권1호
• /
• pp.35-45
• /
• 2000

this paper presents the concept of "mobile ATM', a proposal for third-generation (3G) mobile communication network infrastructure capable of supporting flexible evolution of radio technologies from today's cellular and data services towards future wireless multimedia services. Mobile ATM provides generic mobility management and QoS-based transport capabilities suitable for integration of multiple radio access technologies including cellular voice. wireless data, and future broadband wireless services. The architecture of a mobile ATM network is outlined in terms of the newly-defined "W-UNI" interface at the radio link and "M-UNI"and "M-UNI" interface which supports unified access for WATM and non-ATM mobile terminals through corresponding interworking functions (IWF) is explained. leading to an understanding of how different radio access technologies are supported by the same ATM-based core network infrastructure. Generic mechanisms for handoff and location management within the core mobile network are discussed. and related protocol extensions over the "W-UNI" and "M-UNI/NNI"interfaces are proposed. the issue of "crossover switch (COS)" selection in mobile ATM is considered, and a unified handoff signaling syntax which supports flexibility in COS selection is described. Typical signaling sequences for call connection and handoff using the proposed protocols are outlined. Experimental results form a proof-of-concept mobile ATM network prototype are presented in conclusion.

• Genomics & Informatics
• /
• 제21권1호
• /
• pp.6.1-6.8
• /
• 2023

Glaucoma is the second leading cause of irreversible blindness, and primary open-angle glaucoma (POAG) is the most common type. Due to inadequate diagnosis, treatment is often not administered until symptoms occur. Hence, approaches enabling earlier prediction or diagnosis of POAG are necessary. We aimed to identify novel drugs for glaucoma through bioinformatics and network analysis. Data from 36 samples, obtained from the trabecular meshwork of healthy individuals and patients with POAG, were acquired from a dataset. Next, differentially expressed genes (DEGs) were identified to construct a protein-protein interaction (PPI) network. In both stages, the genes were enriched by studying the critical biological processes and pathways related to POAG. Finally, a drug-gene network was constructed, and novel drugs for POAG treatment were proposed. Genes with p < 0.01 and |log fold change| > 0.3 (1,350 genes) were considered DEGs and utilized to construct a PPI network. Enrichment analysis yielded several key pathways that were upregulated or downregulated. For example, extracellular matrix organization, the immune system, neutrophil degranulation, and cytokine signaling were upregulated among immune pathways, while signal transduction, the immune system, extracellular matrix organization, and receptor tyrosine kinase signaling were downregulated. Finally, novel drugs including metformin hydrochloride, ixazomib citrate, and cisplatin warrant further analysis of their potential roles in POAG treatment. The candidate drugs identified in this computational analysis require in vitro and in vivo validation to confirm their effectiveness in POAG treatment. This may pave the way for understanding life-threatening disorders such as cancer.

• 한국자원식물학회:학술대회논문집
• /
• 한국자원식물학회 2019년도 춘계학술대회
• /
• pp.33-33
• /
• 2019

The AKT signaling pathway is a highly regulated cell signaling system that forms a network with other cell signaling pathways. Hence, the AKT signaling pathway mediates several important cellular functions that include cell survival, proliferation, cell migration, and et cetera. Irregularities that led overactive AKT signaling have been linked to many diseases such as cancer and metabolic-associated diseases. Hence, modulating the overactive AKT signaling pathway via inhibitor is a tantalizing prospect for treatment of cancer and metabolic-associated diseases. Two inhibitors of the AKT signaling pathway will be presented in this symposium: 1) Bisleuconothine A (BisA), a bisindole alkaloid that inhibit autophagy and 2) Ceramicine B (CerB), a limonoid that inhibit adipogenesis. The first topic is on a bisindole alkaloid, BisA and its mechanism in inducing autophagosome formation in lung cancer cell line, A549.(1) Since most autophagy inducing agents generally induce apoptosis, we found that BisA does not induce apoptosis even in high dose. BisA up-regulation of LC3 lipidation is achieved through mTOR inactivation. The phosphorylation of PRAS40, a mTOR repressor was suppressed by BisA. This observation suggested that BisA inactivates mTOR via suppression of PRAS40 phosphorylation. Interestingly, the phosphorylation of AKT, an upstream regulator of PRAS40 phosphorylation was also down-regulated by BisA. These findings suggested that Bis-A induces autophagosomes formation by interfering with the AKT-mTOR signaling pathway. The second topic is on CerB and its mechanism in inhibiting adipogenesis in preadipocytes cell line, MC3T3-G2/PA6.(2,3) CerB inhibits the phosphorylation of protein kinase B (AKT) at the Thr308 position but not the Ser473. Consequently, the phosphorylation of FOXO3 which is located downstream of AKT is also inhibited. Considering that FOXO3 is an important regulator of PPARγ which is a key factor in adipogenesis, CerB may inhibit adipogenesis via the AKT-FOXO3 signaling pathway. Taken together, both BisA and CerB highlighted the potential of AKT signaling pathway modulation as an approach to induce autophagy and inhibit the formation of fat cells, respectively.

• 정보처리학회논문지C
• /
• 제15C권1호
• /
• pp.37-44
• /
• 2008

이동 네트워크 환경에서 MN(Mobile Node)의 핸드오버 후 새로운 경로 상에 자원을 예약할 때 시그널링 지연을 최소화하기 위해서는 이전 경로와 새로운 경로가 만나는 지점에 있는 노드인 크로스오버 노드(Crossover Node:CRN)를 발견하는 것이 중요하다. 일반적으로 크로스오버 노드의 발견은 MN과 CN(Correspondent Node)간 설립된 종단간 SID(Session ID)를 주요키로 사용하여 이루어지지만, HMIPv6(Hierarchical Mobile IPv6) 네트워크에서 MAP(Mobility Anchor Point)과 HA(Home Agent)간 군집(Aggregate) 세션 단위로 자원예약을 하는 경우에는 이와 같은 일반적인 방법의 적용이 어렵다. 군집 예약을 할 때에는 종단간 SID와는 별도로 군집 SID를 사용하는데, MN의 핸드오버 후 이전 MAP과 HA간 설립된 세션의 군집 SID가 새로운 MAP과 HA간 설립된 세션의 군집 SID와 달라서 SID를 이용하여 크로스오버 노드를 발견할 수 없기 때문이다. 이에, 본 논문에서는 HMIPv6 네트워크에서 차세대 네트워크 시그널링 프로토콜인 NSIS(Next Step in Signaling)를 이용하여 자원을 예약하는 경우 군집 예약이 이루어진 MAP과 HA간 터널상에서 크로스오버 노드를 발견하고, 크로스오버 노드를 발견한 즉시, 군집 예약된 자원의 갱신이 지역적으로 이루어지도록 하는 방안을 제안한다. 시뮬레이션을 통해, 시그널링 메시지가 항상 터널의 끝 노드까지 전달되는 기존 방안에 비해 제안하는 방안이 자원 예약을 위한 시그널링 지연을 단축시키고, 핸드오버 동안의 평균 처리율을 향상시킴을 알 수 있었다.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1987년도 전기.전자공학 학술대회 논문집(II)
• /
• pp.898-902
• /
• 1987

An end-to-end connect ion between customers on a network such as the PSTN (Public Switched Telephone Network) requires a number of internal connection ammong pieces of transmission, switching and signaling equipment. New switching, transmission, and station systems, as well as new features for existing systems, are continually being developed. and the complexities are such that ensuring compatibility of signaling arrange.ent is a major concern. In this paper, we propose that new signal interface using features of SPC(Stored Program Control) and digital transmission has to be introduced into the domestic telecommunications network in the near future.

• 한국정보과학회:학술대회논문집
• /
• 한국정보과학회 2000년도 봄 학술발표논문집 Vol.27 No.1 (A)
• /
• pp.322-324
• /
• 2000

본 논문에서는 이동 컴퓨팅 환경에서 이동 호스트에게 실시간 서비스의 Quality of Service(QoS)를 제공하기 위한 자원 예약 프로토콜을 제시, 설명한다. 실시간 서비스를 제공하는데 있어 이동성은 통신 경로의 변경으로 인해 QoS에 심각한 영향을 끼치게 된다. 그러나 현재 QoS를 위한 signaling 프로토콜인 자원 예약 프로토콜(Resource ReServation Protocol , RSVP)은 고정 호스트만을 가정하고 있으므로 이동 컴퓨팅 환경에서 그대로 사용하기에는 적합하지 않다. 이에 본 논문에서는 이동 호스트를 지원하는 Integrated Network에서 RSVP Agent를 사용하여 Mobile IP와 연동하는 새로운 signaling프로토콜을 제안한다. RSVP Agent는 RSVP tunnel을 사용하여 이동호스트를 대신해서 주위의 ？들에 미리 자원을 예약해 주는 역할을 하게 된다. 이 후 이동 호스트는 RSVP Agent가 미리 예약해준 자원을 사용하게 됨으로써 고정 호스트에게 상대 노드의 이동성을 고려하여 자원을 예약하지 않아도 되도록 지원해주며, 경로 마다 관리해야 하는 soft-state 유지비용의 감소를 가져오고, 불필요한 bandwidth의 예약을 막고, 패킷 지연을 줄여 주는 효과를 가져오게 되며 그 결과를 시뮬레이션을 통하여 확인해 본다.

• 한국정보통신학회논문지
• /
• 제3권1호
• /
• pp.175-183
• /
• 1999

본 논문에서는 이동전화 망에서 제공되는 다양한 부가 서비스 중에서 원격 기능제어(RFC: Remote Feature Control) 서비스를 위한 망 구성 및 RFC 서비스에 사용되는 이동전화 망의 프로토콜인 No. 7 신호 방식의 IS-41.A 규격과 RFC 기본 동작에 대해서 분석하고, RFC 서비스를 제공함에 있어서 일부 아날로그 시스템에서 발생하는 신호처리 절차의 오류를 추출하여 이를 해결하기 위한 세 가지 방안을 제안한다 또한 제안한 방법들에 대해 상세한 신호의 알고리즘을 분석하고, 시뮬레이션을 통하여 자각의 방안들 중에서 발생하는 문제점을 살펴봄으로서 효과적인 방안을 제시하도록 한다.

• 한국정보처리학회:학술대회논문집
• /
• 한국정보처리학회 2004년도 추계학술발표논문집(상)
• /
• pp.765-768
• /
• 2004

IEEE 802.110e는 실시간 트래픽의 QoS를 보장하기 위해 제안되었으나 cellular ip network 망에서 발생하는 route update packet과 같은 signaling traffic에 대해서는 아무런 언급을 하고 있지 않다. 따라서 본 논문에서는 IEEE 802.11e draft가 제안하고 있는 4가지의 AC(Access Category)에 따라 signaling traffic 에 대해서도 높은 우선 순위를 할당 함으로서 handoff시 발생하는 packet drop 이 얼마 만큼 줄어드는지를 분석하였다.