• 한국정보통신학회논문지
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• 제7권5호
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• pp.925-933
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• 2003

네트워크는 IP 계층과 광 계층이 수렴되는 광인터넷 네트워크로 진화할 것으로 예상되나, 현재의 기술수준으로 인해 과도적인 진화단계로서 GMPLS가 대두되었다. MPLS가 확장되고 일반화된 GMPLS는 패킷 교환 장치뿐만 아니라 시간, 파장 및 공간 영역에서 교환을 수행하는 장치까지 지원할 수 있도록 하고 있다. 이런 다양한 스위칭 타입에 공통적인 제어 평면을 구현하기 위해 GMPLS에서는 기존의 MPLS 신호 및 라우팅 프로토콜을 확장하게된다. 본 논문에서는 GMPLS 기술의 개요와 MPLS에서 링크의 상태 정보를 교환하기 위해 사용되었던 OSPF(Open shortest Path First) 프로토콜을 광 네트워크에서 다양한 링크 타입, 대역폭, 링크 보호 타입 등의 정보를 주고받기 위한 라우팅 확장 방안에 대하여 알아보고, 두 노드간의 수백, 수천개의 링크를 관리하는 복잡한 문제를 해결하기 위한 신호 프로토콜로 LMP라는 새로운 프로토콜의 정의를 기술한다. 그리고 MPLS에서 트래픽 엔지니어링을 위한 신호 프로토콜인 RSVP-TE를 GMPLS에 적용하기 위한 신호 프로토콜의 확장 방안과 수정된 RSVP 관련 메시지들을 검토분석 한다.

• Journal of Ginseng Research
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• 제32권4호
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• pp.315-323
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• 2008

In the previous studies, we isolated the compound K rich fractions (CKRF) and showed that CKRF inhibited Toll-like receptor (TLR) 4- or TLR9-induced inflammatory signaling. To extend our previous studies,1) we investigated the molecular mechanisms of CKRF in the TLR4-associated signaling via nuclear factor (NF)-${\kappa}B$, and in vivo role of CKRF for induction of tolerance in lipopolysaccharide (LPS)-induced septic shock. In murine bone marrow-dervied macrophages, CKRF significantly inhibited the induction of mRNA expression of proinflammatory mediators such as tumor necrosis factor-${\alpha}$, interleukin-6, cyclooxygenase-2, and inducible nitric oxide synthase. In addition, CKRF significantly attenuated the transcriptional activities of TLR4/LPS-induced NF-${\kappa}B$. Nuclear translocation of NF-${\kappa}B$ in response to LPS stimulation was significantly abrogated by pre-treatment with CKRF. Furthermore, CKRF inhibited the recruitment of p65 to the interferon-sensitive response element flanking region in response to LPS. Finally, oral administration of CKRF significantly protected mice from Gram-negative bacterial LPS-induced lethal shock and inhibited systemic inflammatory cytokine levels. Together, these results demonstrate that CKRF modulates the TLR4-dependent NF-${\kappa}B$ activation, and suggest a therapeutic role for Gram-negative septic shock.

• BMB Reports
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• 제54권6호
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• pp.323-328
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• 2021

Periodontal diseases have been reported to have a multidirectional association with metabolic disorders. We sought to investigate the correlation between periodontitis and diabetes or fatty liver disease using HFD-fed obese mice inoculated with P. gingivalis. Body weight, alveolar bone loss, serological biochemistry, and glucose level were determined to evaluate the pathophysiology of periodontitis and diabetes. For the evaluation of fatty liver disease, hepatic nonalcoholic steatohepatitis (NASH) was assessed by scoring steatosis, inflammation, hepatocyte ballooning and the crucial signaling pathways involved in liver metabolism were analyzed. The C-reactive protein (CRP) level and NASH score in P. gingivalis-infected obese mice were significantly elevated. Particularly, the extensive lobular inflammation was observed in the liver of obese mice infected with P. gingivalis. Moreover, the expression of metabolic regulatory factors, including peroxisome proliferator-activated receptor γ (Pparγ) and the fatty acid transporter Cd36, was up-regulated in the liver of P. gingivalis-infected obese mice. However, inoculation of P. gingivalis had no significant influence on glucose homeostasis, insulin resistance, and hepatic mTOR/AMPK signaling. In conclusion, our results indicate that P. gingivalis can induce the progression of fatty liver disease in HFD-fed mice through the upregulation of CD36-PPARγ axis.

• Genomics & Informatics
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• 제13권3호
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• pp.76-80
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• 2015

Type 2 diabetes mellitus is a complex metabolic disorder associated with multiple genetic, developmental and environmental factors. The recent advances in gene expression microarray technologies as well as network-based analysis methodologies provide groundbreaking opportunities to study type 2 diabetes mellitus. In the present study, we used previously published gene expression microarray datasets of human skeletal muscle samples collected from 20 insulin sensitive individuals before and after insulin treatment in order to construct insulin-mediated regulatory network. Based on a motif discovery method implemented by iRegulon, a Cytoscape app, we identified 25 candidate regulons, motifs of which were enriched among the promoters of 478 up-regulated genes and 82 down-regulated genes. We then looked for a hierarchical network of the candidate regulators, in such a way that the conditional combination of their expression changes may explain those of their target genes. Using Genomica, a software tool for regulatory network construction, we obtained a hierarchical network of eight regulons that were used to map insulin downstream signaling network. Taken together, the results illustrate the benefits of combining completely different methods such as motif-based regulatory factor discovery and expression level-based construction of regulatory network of their target genes in understanding insulin induced biological processes and signaling pathways.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제11권4호
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• pp.9-17
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• 2007

Network Mobility basic support protocol (NEMO Basic) extends the operation of Mobile IPv6 to provide uninterrupted Internet connectivity to the communicating nodes of mobile networks. The protocol uses a mobile router (MR) in the mobile network to perform prefix scope binding updates with its home agent (HA) to establish a bi-directional tunnel between the HA and MR. This solution reduces location-update signaling by making network movements transparent to the mobile nodes (MNs) behind the MR. However, delays in data delivery and higher overheads are likely to occur because of sub-optimal routing and multiple encapsulation of data packets. To manage the mobility of the mobile network, it is important to minimize packet overhead, to optimize routing, and to reduce the volume of handoff signals over the nested mobile network. This paper proposes en aggregate router-assisted route optimization (ARARO) scheme for nested mobile networks support which introduces a local anchor router in order to localize handoff and to optimize routing. With ARARO, a mobile network node (MNN) behind a MR performs route optimization with a correspondent node (CN) as the MR sends a binding update message (BU) to aggregate router (AGR) via root-MR on behalf of all active MNNs when the mobile network moves. This paper describes the new architecture and mechanisms and provides simulation results which indicate that our proposal reduces transmission delay, handoff latency and signaling overhead. To evaluate the scheme, we present the results of simulation.

• Nutrition Research and Practice
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• 제7권1호
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• pp.9-14
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• 2013

Bamboo leaves (Phyllostachys pubescens Mazel ex J. Houz (Poacea)) have a long history of food and medical applications in Asia, including Japan and Korea. They have been used as a traditional medicine for centuries. We investigated the mechanism of anti-inflammatory activity of a bamboo leaf extract (BLE) on tumor necrosis factor-alpha (TNF-${\alpha}$)-induced monocyte adhesion in human umbilical vein endothelial cells (HUVECs). Exposure of HUVECs to BLE did not inhibit cell viability or cause morphological changes at concentrations ranging from 1 ${\mu}g/ml$ to 1 mg/ml. Treatment with 0.1 mg/ml BLE caused 63% inhibition of monocyte adhesion in TNF-${\alpha}$-activated HUVECs, which was associated with 38.4% suppression of vascular cell adhesion molecule-1 expression. Furthermore, TNF-${\alpha}$-induced reactive oxygen species generation was decreased to 47.9% in BLE treated TNF-${\alpha}$-activated HUVECs. BLE (0.05 mg/ml) also caused about 50% inhibition of interleukin-6 secretion from lipopolysaccharide-stimulated monocyte. The results indicate that BLE may be clinically useful as an anti-inflammatory or anti-oxidant for human cardiovascular disease including atherosclerosis.

• 대한전자공학회논문지TC
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• 제41권9호
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• pp.55-65
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• 2004

ATM기술은 ITU나 ATM Forum과 같은 표준화 기관에서 B-ISDN서비스를 전송하기 위한 기술로 표준화 되어 왔다. 현재는 ATM기술이 복잡하여 인터넷 트래픽을 전송하도록 MPLS와 같은 백본기술로 채택되고 있다. 그러나 ATM프로토콜은 BcN망등에서 많이 채택될 것이다. 본 논문은 ATM기반 시스템에서 네트워크의 정보를 이용하여 HTR코드를 기법을 적용하여, 코드를 검출하고, 등록하는 기법에 대해 논하고 자 한다. 고속의 circuit switching시스템에서 HTR코드 제어는 필수적이며, 본 논문에서는 HTR코드검출 및 Fuzzy제어방식을 통해 실험결과를 보인다. 본 방법에 의해 제시된 실험결과는 체증상태를 신속히 제어하며 시스템 자원을 최대한 활용하고, 적은 부하로서도 효율적으로 제어함을 보인다.

• Journal of information and communication convergence engineering
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• 제8권2호
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• pp.168-172
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• 2010

The Network-based handover still has problems such as the transmission delays and the packet losses in the case of macro mobility, though technological advances have been made in the wireless and mobile communication. For end-to-end handover, the link bandwidth has been reduced in the wireless network due to its burst errors and congestion control. To overcome such problems, we propose a new scheme of the macro handover according to the protocol layer. The proposed macro handover is implemented on the network layer to partially substitute wired signaling for wireless signaling, to flexibly employ buffers, and on the transport layer to postpone its retransmission time. We have performed extensive simulation using ns-2 and the result shows that our proposed scheme outperforms the other existing schemes in terms of transmission delay, packet loss, and data transfer rate during the handovers.

• Journal of information and communication convergence engineering
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• 제17권2호
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• pp.97-104
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• 2019

Distributed mobility management (DMM) does not use a centralized device. Its mobility functions are distributed among routers; therefore, the mobility services are not limited to the performance and reliability of specific mobility management equipment. The DMM scheme has been studied as a partially distributed architecture, which distributes only a packet delivery domain in combination with the software defined network (SDN) technology that separates the packet delivery and control areas. Particularly, a separated control area is advantageous in introducing a new service, thereby optimizing the network by recognizing the entire network situation and taking an optimal decision. The SDN-based mobility management scheme is studied as a method to optimize the packet delivery path whenever a mobile node moves; however, it results in excessive signaling processing cost. To reduce the high signaling cost, we propose a hybrid distributed mobility management method and analyze its performance mathematically.

• Journal of Microbiology and Biotechnology
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• 제31권6호
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• pp.765-774
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• 2021

Although research on the osteal signaling pathway has progressed, understanding of gut microbial-dependent signaling pathways for metabolic and immune bone homeostasis remains elusive. In recent years, the study of gut microbiota has shed light on our understanding of bone homeostasis. Here, we review microbiota-mediated gut-bone crosstalk via bone morphogenetic protein/SMADs, Wnt and OPG/receptor activator of nuclear factor-kappa B ligand signaling pathways in direct (translocation) and indirect (metabolite) manners. The mechanisms underlying gut microbiota involvement in these signaling pathways are relevant in immune responses, secretion of hormones, fate of osteoblasts and osteoclasts and absorption of calcium. Collectively, we propose a signaling network for maintaining a dynamic homeostasis between the skeletal system and the gut ecosystem. Additionally, the role of gut microbial improvement by dietary intervention in osteal signaling pathways has also been elucidated. This review provides unique resources from the gut microbial perspective for the discovery of new strategies for further improving treatment of bone diseases by increasing the abundance of targeted gut microbiota.