• Journal of the Institute of Electronics Engineers of Korea TC
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• v.41 no.4
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• pp.25-34
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• 2004

UMTS network, evolved from GSM, includes packet core network that consists of SGSNS and GGSNs. Service providers should consider subscriber mobility, location registration, and subscriber distribution when designing packet core networks and network elements. Since one of the major traffic sources for IMT-2000 will be data which has bursty characteristics, new design guidelines for dimensioning of SGSN and GGSN should be proposed under various constraints of system parameters. In this paper, we first evaluate the performance of signaling traffic for packet call subscribers. After that, we also obtain the impact of bursty data traffic on the SGSN and GGSN by simulation, and suggest new dimensioning guidelines for packet core network of UMTS under various environments.

• Herbal Formula Science
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• v.32 no.1
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• pp.39-49
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• 2024

Objectives : The purpose of this study was to investigate the molecular targets and pathways of anti-inflammatory effects of Jakyakgamchotang with corydalis tuber (JC) using network pharmacology. Methods : The compounds in constituent herbal medicines of JC were searched in TCM systems pharmacology (TCMSP). Target gene informations of the components were collected using chemical-target interactions database provided by Pubchem. Afterwards, network analysis between compounds and inflammation-related target genes was performed using cytoscape. Go enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed on inflammation-related targets using DAVID database. Results : 70 active compounds related to inflammation were identified, and 295 target genes related to the anti-inflammatory activity of the compound of JC were identified. In the Go biological process DB and KEGG pathway DB, "inflammatory response", "cellular response to lipopolysaccharide", "positive regulation of interleukin-6 production", and "positive regulation of protein kinase B. signaling", "positive regulation of ERK1 and ERK2 cascade", "positive regulation of I-kappaB kinase/NF-kappaB signaling", "negative regulation of apoptotic process", and "PI3K-Akt signaling pathway" were found to be mechanisms related to the anti-inflammatory effects related to the target genes of JC. The main compounds predicted to be involved in the anti-inflammatory effect of JC were quercetin, licochalcone B, (+)-catechin, kaempferol, and emodin. Conclusions : This study provides the molecular targets and potential pathways of JC on inflammation. It can be used as a basic data for using JC for various inflammatory disease in traditional korean medicine clinic.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2002.11a
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• pp.355-361
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• 2002

There are many economic and operational reasons to integrate fire alarm signaling system with other building automation system. Integration of this requires open network with for the standard communication protocol and careful design practices. The important point for this is also the development of intelligent control modules for replacing the conventional zone adapter in fire system. Therefore, this paper proposes an new conceptual design of the open distributed fire alarm signaling system for the integration of BAS, a new intelligent control modules with LonTalk protocol and a new control modules for power line communication. Newly proposed additions to LonWorks network make it very well suited for integrating fire systems with other building automation sub-systems and another BAS with low cost. Additionally, it is very important that best design practices, test procedures and building codes need to be modernized to accommodate integrated building systems.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1731-1735
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• 2013

Objective: We aimed to identify key genes, pathways and function modules in the development of diffuse large B-cell lymphoma (DLBCL) with microarray data and interaction network analysis. Methods: Microarray data sets for 7 DLBCL samples and 7 normal controls was downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified with Student's t-test. KEGG functional enrichment analysis was performed to uncover their biological functions. Three global networks were established for immune system, signaling molecules and interactions and cancer genes. The DEGs were compared with the networks to observe their distributions and determine important key genes, pathways and modules. Results: A total of 945 DEGs were obtained, 272 up-regulated and 673 down-regulated. KEGG analysis revealed that two groups of pathways were significantly enriched: immune function and signaling molecules and interactions. Following interaction network analysis further confirmed the association of DEGs in immune system, signaling molecules and interactions and cancer genes. Conclusions: Our study could systemically characterize gene expression changes in DLBCL with microarray technology. A range of key genes, pathways and function modules were revealed. Utility in diagnosis and treatment may be expected with further focused research.

• Microbiology and Biotechnology Letters
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• v.38 no.1
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• pp.13-18
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• 2010

Past decade systemic mycoses caused by opportunistic human fungal pathogens, including Candida, Aspergillus, and Cryptococcus, have been a growing problem for both immunocompromised and immunocompetent individuals. Particularly, Cryptococcus neoformans has recently emerged as a major fungal pathogen, which can cause fungal pneumonia and meningitis that are lethal if not timely medicated. However, treatment for cryptococcosis has been difficult due to a lack of proper anti-cryptococcal drugs with fungicidal activity and less toxicity. In this review we introduced novel therapeutic methods for treating cryptococcosis by exploring pathogenomic signa1ing networks of C. neoformans with genome-wide transcriptome approaches as well as diverse molecular/genetic tools.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.7
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• pp.1524-1528
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• 2005

In this paper, we analyses of a traffic for authentication signaling in third generation mobile sensor network. In universal mobile telecommunication system, authentication functions are utilized to identify and authentication a mobile station and validate the service request network services. The authenticating parties are the authentication the serving general packet radio service support node access the authentication center to obtain the authentication with the mobile station. In this paper, we propose that the automatic cost-effective solution size of the authentication vector array.

• Proceedings of the KIEE Conference
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• 2001.11c
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• pp.387-389
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• 2001

The railway signaling systems are computerized vital equipments for safety guarantee of train running. And also it is important to prepare the reliable communication link between signalling equipments. In this paper the review of network technology for railway signalling is presented and reliable network technology for network is represented. And also the direction for our further study on these is discussed.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.4
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• pp.772-776
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• 2005

To support abruptly increasing data traffic in these days, network management is needed. And also to maintain the steady infra, there is MPLS need which can support traffic engineering. It's necessary that MPLS doesn't only manage network to support recently booming data traffic, but has capacity to support traffic engineering to keep static infrastructure. Traffic engineering, method that a large-scale user shifts traffic to the beforehand designated routes that pass through specific nodes on network, is operation that is mapping traffic flow to the physical network topology. In this paper, we supplement the defect of the traditional RSVP traffic engineering and to construct far more steady infra, we suggest the way of its development of ERSVP signaling protocol.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.1A
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• pp.46-54
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• 2005

This paper presents an effcient mobile multicast method using the user pattern. We exploit the repetitive movement pattern of mobile node to reduce the total number of experience of graft and join procedure. We defined the locality scope by a movement pattern. While the network is included in the locality scope, the network should maintain a multicast tree even when the mobile node moves to the other network. In this way, the mobile host can receive a multicast service without a delay when it moves to the network in the locality scope later. We compare our scheme with existing schemes under the total signaling cost and the service delay time by using a discrete analytical model for cost analysis. Analytical results demonstrated that the total signaling cost and service delay time was significantly reduced through our proposed scheme.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.1
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• pp.105-108
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• 2005

To support abruptly increasing data traffic in these days. network management is needed. And also to maintain the steady infra, there is MPLS need which can support traffic engineering. It's necessary that MPLS doesn't only manage network to support recently booming data traffic, but has capacity to support traffic engineering to keep static infrastructure. Traffic engineering, method that a large-scale user shifts traffic to the beforehand designated routes that pass through specific nodes on network, is operation that is mapping traffic flow to the physical network topology. In this paper, we supplement the defect of the traditional RSVP traffic engineering and to construct far more steady infra, we suggest the way of its development of ERSVP signaling protocol.