• Nutrition Research and Practice
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• v.14 no.5
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• pp.438-452
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• 2020

BACKGROUND/OBJECTIVES: Brain senescence causes cognitive impairment and neurodegeneration. It has also been demonstrated that curcumin (Cur) and hesperetin (Hes), both antioxidant polyphenolic compounds, mediate anti-aging and neuroprotective effects. Therefore, the objective of this study was to investigate whether Cur, Hes, and/or their combination exert anti-aging effects in D-galactose (Dg)-induced aged neuronal cells and rats. MATERIALS/METHODS: SH-SY5Y cells differentiated in response to retinoic acid were treated with Cur (1 μM), Hes (1 μM), or a combination of both, followed by 300 mM Dg. Neuronal loss was subsequently evaluated by measuring average neurite length and analyzing expression of β-tubulin III, phosphorylated extracellular signal-regulated kinases, and neurofilament heavy polypeptide. Cellular senescence and related proteins, p16 and p21, were also investigated, including their regulation of antioxidant enzymes. In vivo, brain aging was induced by injecting 250 mg/kg body weight (b.w.) Dg. The effects of supplementing this model with 50 mg/kg b.w. Cur, 50 mg/kg b.w. Hes, or a combination of both for 3 months were subsequently evaluated. Brain aging was examined with a step-through passive avoidance test and apoptosis markers were analyzed in brain cortex tissues. RESULTS: Cur, Hes, and their combination improved neuron length and cellular senescence by decreasing the number of β-gal stained cells, down-regulated expression of p16 and p21, and up-regulated expression of antioxidant enzymes, including superoxide dismutase 1, glutathione peroxidase 1, and catalase. Administration of Cur, Hes, or their combination also tended to ameliorate cognitive impairment and suppress apoptosis in the cerebral cortex by down-regulating Bax and poly (ADP-ribose) polymerase expression and increasing Bcl-2 expression. CONCLUSIONS: Cur and Hes appear to attenuate Dg-induced brain aging via regulation of antioxidant enzymes and apoptosis. These results suggest that Cur and Hes may mediate neuroprotective effects in the aging process, and further study of these antioxidant polyphenolic compounds is warranted.

• Journal of Advanced Navigation Technology
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• v.20 no.1
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• pp.8-14
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• 2016

High-level conceptual design analysis results of satellite communication system for Korea augmentation satellite system (KASS) satellite communication system, which is a part of KASS and consisted of KASS uplink Stations and two leased GEO is presented in this paper. We present major functions such as receiving correction and integrity message from central processing system, taking forward error correction for the message, modulating and up converting signal and conceptual design analysis for concepts for design process, GEO precise orbit determination for GEO ranging that is additional function, and clock steering for synchronization of clocks between GEO and GPS satellites. In addition to these, KASS requires 2.2 MHz for SBAS Augmentation service and 18.5 MHz for Geo-ranging service as minimum bandwidths as a results of service performance analysis of GEO ranging with respect to navigation payload(transponder) RF bandwidth is presented. These analysis results will be fed into KASS communication system design by carrying out final analysis after determining two GEOs and sites of KASS uplink stations.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.5A
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• pp.490-496
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• 2007

This paper describes the design and implementation of an integrated LTCC front-end module for the IEEE802.11a WLAN applications by performing the behavioral-level simulation using measurement-based behavioral model. To meet the IEEE802.11a WLAN standard, a system transmitting 1024 symbols through 64-QAM process at the rate of 54Mbps should be implemented and nonlinear properties are confirmed by simulations of ACPR and EVM in this circumstance. The right offsets of ACPR which are 30MHz, 20MHz, and 11MHz distant from the center frequency of 5.8GHz are 49.36dBc, 36.90dBc, and 24.58dBc, respectively. The left offsets are 50.14dBc, 30.04dBc, and 28.85dBc, respectively and EVM is 2.94%. The size of the module implemented with LTCC five-layer substrates is $13.4mm{\times}14.2mm$. The measured characteristics of the transmitter show P1dB of 16.2dBm and power gain of 16.73dB. Those of the receiver exhibit the small signal gain of 16.24dB and noise figure of 7.83dB.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.8C
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• pp.575-582
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• 2008

In this paper we described the process and the results of real-time implementation of G.729.1 wideband speech codec which is standardized in SG15 of ITU-T. To apply the codec on ARM926EJ-S(R) processor core. we transformed some parts of the codec C program including basic operations and arithmetic functions into assembly language to operate the codec in real-time. G.729.1 is the standard wideband speech codec of ITU-T having variable bit rates of $8{\sim}32kbps$ and inputs quantized 16 bits PCM signal per sample at the rate of 8kHz or 16kHz sampling. This codec is interoperable with the G.729 and G.729A and the bandwidth extended wideband($50{\sim}7,000Hz$) version of existing narrowband($300{\sim}3,400Hz$) codec to enhance voice quality. The implemented G.729.1 wideband speech codec has the complexity of 31.2 MCPS for encoder and 22.8 MCPS for decoder and the execution time of the codec takes 11.5ms total on the target with 6.75ms and 4.76ms respectively. Also this codec was tested bit by bit exactly against all set of test vectors provided by ITU-T and passed all the test vectors. Besides the codec operated well on the Internet phone in real-time.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.42 no.1
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• pp.1-7
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• 2016

Highly porous polymethyl methacrylate (PMMA) microspheres impregnated by $TiO_2$ powder were prepared by spray drying method. The particle size and the porosity were controlled by optimizing the co-solvent ratio and the polymer concentration. $TiO_2$ powder was impregnated into the microspheres upto 74.6 wt% content based on the weight of the resultant $PMMA/TiO_2$ microspheres. SEM images showed that $TiO_2$ powder was well distributed throughout the inside of the microsphere. EDX mapping showed that the Ti signal was well detected from every part of the microspheres, which was the evidence of the formation of the $PMMA/TiO_2$ composite. Hg porosimetry result showed that the porosity was found to be over 50% regardless of the $TiO_2$ contents. The final product was found to have high oil-absorbing capacity and great hiding power, both of which are key properties in designing the microsphere materials for make-up cosmetics application.

• The Journal of the Acoustical Society of Korea
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• v.14 no.2
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• pp.101-112
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• 1995

In order to construct a feature map-based phoneme classification system for speech recognition, two procedures are usually required. One is clustering and the other is labeling. In this paper, we present a phoneme classification system based on the Kohonen's Self-Organizing Feature Map (SOFM) for clusterer and labeler. It is known that the SOFM performs self-organizing process by which optimal local topographical mapping of the signal space and yields a reasonably high accuracy in recognition tasks. Consequently, SOFM can effectively be applied to the recognition of phonemes. Besides to improve the performance of the phoneme classification system, we propose the learning algorithm combined with the classical K-mans clustering algorithm in fine-tuning stage. In order to evaluate the performance of the proposed phoneme classification algorithm, we first use totaly 43 phonemes which construct six intra-class feature maps for six different phoneme classes. From the speaker-dependent phoneme classification tests using these six feature maps, we obtain recognition rate of $87.2\%$ and confirm that the proposed algorithm is an efficient method for improvement of recognition performance and convergence speed.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.3
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• pp.181-187
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• 2020

In this paper, we proposed a register allocation algorithm and resource allocation algorithm in the high level synthesis process for the SoC design synthesis system of high performance vehicles We have analyzed to the operator characteristics and structure of datapath in the most important high-level synthesis. We also introduced the concept of virtual operator for the scheduling of multi-cycle operations. Thus, we demonstrated the complexity to implement a multi-cycle operation of the operator, regardless of the type of operation that can be applied for commonly use in the resources allocation algorithm. The algorithm assigns the functional operators so that the number of connecting signal lines which are repeatedly used between the operators would be minimum. This algorithm provides regional graphs with priority depending on connected structure when the registers are allocated. The registers with connecting structure are allocated to the maximum cluster which is generated by the minimum cluster partition algorithm. Also, it minimize the connecting structure by removing the duplicate inputs for the multiplexor in connecting structure and arranging the inputs for the multiplexor which is connected to the operators. In order to evaluate the scheduling performance of the described algorithm, we demonstrate the utility of the proposed algorithm by executing scheduling on the fifth digital wave filter, a standard bench mark model.

• Journal of the Korean Magnetics Society
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• v.7 no.3
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• pp.152-158
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• 1997

NiFeCo/ Cu /Co trilayers were formed on 4$^{\circ}$ tilt-cut Si(111) substrates with a Cu(50$\AA$) underlayer and large-scaled test magnetoresistive RAM (MRAM) cells were fabricated using a conventional lithographic process. NiFeCo / Cu /Co trilayers deposited on the same templates without any applied magnetic field showed strong in plane uniaxial magnetic anisotropy and excellent magnetoresistive (MR) properties such as high MR ration and sensitivity within a low external magnetic field, which are suitable properties for a MRAM application. In order to obtain optimized MR results in NiFeCo /Cu /Co trilayers, the thickness of Cu spacer was varied. Interlayer coupling between two magnetic layers was observed and it was found that the MR properties were strongly dependent on the coupling force, especially near 20 $\AA$ of Cu spacer thickness. Test MRAM cells were fabricated using the optimized NiFeCo (60$\AA$)/ Cu (25$\AA$)/ Co (30$\AA$) trilayer thin films. With a 10 mA of sense current and 5$\times$$10^5$ of word current, 10 mV of signal output was obtained, which implies the strong potentials of NiFeCo/ Cu /Co trilayer thin films for a MRAM application.

• Journal of the Korean Magnetics Society
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• v.21 no.3
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• pp.83-87
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• 2011

We have analyzed the torque signals measured in synthetic antiferromagnetic (SAF) coupled CoFeB/Ru/CoFeB thin film, which signals were drastically changed at flopping field ($H_F$) and saturation field ($H_s$). The minimum value of negative uniaxial anisotropy constant ($-\;K_1$) was appeared at HF. The $-\;K_1$ was due to the zero net magnetization by the antiferromagnetic coupling between two ferromagnetic layers. Whereas, the biaxial anisotropy constant (K2) was induced in the field range of $H_F$ < H < $H_s$. The induced $K_2$ was originated from deviation angles between magnetization directions of two ferromagnetic layers. And at H > $H_s$, intrinsic uniaxial anisotropy constant of CoFeB layer was observed. These change of the anisotropy constant with magnetic field was explained by the magnetization process of two ferromagnetic layers based on Stoner-Wohlfarth model calculation for SAF thin film.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.48 no.3
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• pp.62-70
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• 2011

Nowadays image sensor is an essential component in many multimedia devices, and it is covered by a color filter array to filter out specific color components at each pixel. We need a certain algorithm to combine those color components reconstructed a full color image from incomplete color samples output from an image sensor, which is called a demosaicking process. Most existing demosaicking algorithms are developed for ideal image sensors, but they do not work well for the practical cases because of dissimilar characteristics of each sensor. In this paper, we propose a new demosaicking algorithm in which the color filter characteristics are fully utilized to generate a good image. To demonstrate significance of our algorithm, we used a commerically available sensor, CBN385B, which is a sort of Honeycomb-style CFA(Color Filter Array) CCD image sensor. As a performance metric of the algorithm, PSNR(Peak Signal to Noise Ratio) and RGB distribution of the output image are used. We first implemented our algorithm in C-language for simulation on various input images. As a result, we could obtain much enhanced images whose PSNR was improved by 4~8 dB compared to the commonly idealized approaches, and we also could remove the inclined red property which was an unique characteristics of the image sensor(CBN385B).Then we implemented it in hardware to overcome its problem of computational complexity which made it operate slow in software. The hardware was verified on Spartan-3E FPGA(Field Programable Gate Array) to give almost the same performance as software, but in much faster execution time. The total logic gate count is 45K, and it handles 25 image frmaes per second.