• 제목/요약/키워드: side chain

검색결과 657건 처리시간 0.028초

Acridine orange-induced changes in the O-side chain lengths of lipopolysaccharides of Salmonella pullorum (Salmonella pullorum lipopolysaccharide의 acridine organe에 의한 O-side chain 길이의 변화)

  • Kim, Jong-bae;Kim, Tae-ue;Lee, Won-yong;Yang, Se-whan
    • Korean Journal of Veterinary Research
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    • 제33권1호
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    • pp.87-91
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    • 1993
  • The morphological hetergeneity of lipopolysaccharides(LPSs) and variation in the O-side chain lengths of LPSs of Salmonella pullorum, which was serially subcultured on the brain heart infusion agar containing $100{\mu}g/m{\ell}$ of acridine orange, was analyzed in Sephadex G-50 column chromatography and silver-stained polyacrylamide gels. The biochemical differences in LPS W and LPS A0150 were identified. Increases in the contents of O-polysaccharides of LPS A0150 than those of LPS W were reflected in the profiles of chromatography and silver-stained polyacrylamide gels. In summary, LPS molecules of S pullorum A0150 appeared to be enriched in the molecules with long O-polysaccharide chains than those of LPS W.

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Designing of Surface Comparison Method on Active Site of Enzyme (Enzyme의 활성 사이트 표면 비교기법 설계)

  • Nam Hee Yu;Kwang Su Jung;Keun Ho Ryu;Yong Je Chung
    • Proceedings of the Korea Information Processing Society Conference
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    • 한국정보처리학회 2008년도 추계학술발표대회
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    • pp.279-282
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    • 2008
  • 단백질의 구조는 그 기능과 밀접히 연관되어 있기 때문에 구조에 조금이라도 변화가 생기면 바로 생체기능에 이상이 생긴다. 그래서 단백질 구조연구는 필수적이고 구조의 유사성 검색을 이용하여 단백질 기능을 예측한다. 그러나 전체적인 구조가 유사한 단백질이라도 기능에 중요한 특정구조가 다르게 되면 다른 기능을 수행 할 수 있고 구조가 다른 단백질이라도 핵심 영역의 구조가 유사하다면 유사한 기능을 수행할 수 있다. 이는 단백질의 기능이 특정 하위구조의 잘 보존된 활성 사이트에 따라 결정되기 때문이다. 이 논문은 단백질의 3차원 공간정보를 matrix로 표현 할 수 있는 가장 작은 평면도형인 삼각형을 이용하여 단백질 표면에 대한 상세한 형태비교를 제공한다. 단백질 표면에서 활성 사이트 아미노산 잔기의 side chain은 일반적으로 바깥을 향하여 표면의 형태를 결정짓기 때문에 단백질 표면을 비교하기 위해 side chain 정보가 필수적이다. 우리는 아미노산 잔기의 Cα원자에 side chain을 포함하여 Cα삼각형과 side chain 삼각형 2개를 하나의 특정하위구조 set으로 정의하고 이 하위구조로 distance matrix를 구축한다. 만들어진 distance matrix에 RMSD를 이용하여 활성 사이트의 표면을 비교한다. 제시한 기법은 단백질의 전체적인 서열과 구조 정보를 이용하지 않고, 활성 사이트의 특정하위 영역만을 고려함으로써 더욱 효과적이고 빠른 시간 내에 상세한 비교를 수행할 수 있다.

The Conversion of Lithocholic Acid into 5$\beta$-Androstan-3, 17-dione in the Cell-free System of Mycobacterium sp. NRRL B-3805

  • Lee, Kang-Man;Park, Hye-Kyung
    • Archives of Pharmacal Research
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    • 제14권3호
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    • pp.261-265
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    • 1991
  • In a microbial cell-free extract system, side chain cleavage on various sterols and steroids was tested. The cell-free extracts of Mycobacterium sp. NRRL B-3805 showed the side chain cleavage activity on lithocholic acid to form 5$\beta$-androstan-3.17-dione. The properties of the activity were examined.

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Synthesis and Preliminary Biological Studies of Novel Retinamide Derivatives

  • Sin, Hong-S.;Kwon, Youn-J.;Han, Hye-S.;Park, Si-H.;Park, Moong-S.;Rho, Young-S.;Um, Soo-J.
    • Bulletin of the Korean Chemical Society
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    • 제23권12호
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    • pp.1806-1810
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    • 2002
  • We have described the synthesis and biological activity of novel retinamide . The retinamide derivatives were synthesized by introducing functional side chains into the 4-hydroxy group of 4-HPR. The activities could be dependent on the side chain length, functional group, and hetero atom. The antiprolife-rative potential of the derivatives was assessed by MTT assay in HCT116 cancer cell lines.

The Strategic Performance Measurement of Sea Port: Supply Chain Management Perspectives (공급사슬관리 관점에서의 전략적 항만성과측정)

  • Pak, Myong-Sop
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
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    • 제38권
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    • pp.229-262
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    • 2008
  • With the introduction of supply chain management concept, the nature of a firm is fundamentally changed. Control is no longer based on direct control of the business processes, but rather based on integration across member organizations in the supply chain. Firms are trying to achieve a competitive edge by managing their supply chain performance to gain advantages in cost and service differentiation. The supply chain elements of a sea port involves ILSP (Inbound Logistics Service Provider) at the input side and OLSP (Outbound Logistics Service Provider) at the output side. The goal of sea port is to satisfy the needs of different parties, both upstream and downstream, in the chain with greater effectiveness and efficiency than it's competitors. In this context, the purpose of this paper is to derive conceptualization of the SCP (Supply Chain Performance) in the sea port from literature review on the previous researches and to tackle their theoretical and practical implications. The paper deals with conceptualizing SCP in sea port using the SCOR (Supply Chain Operation Reference) model. It incorporates both the effectiveness and efficiency aspects of performance measurement. And it also recognizes customer related reasons for measuring performance.

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Synthese and Anti-wear Properties of Diol Derivatives Containing Dithiophosphate Group-effect on Main Alkyl Chain and Side Alkyl Chain (Dithiophosphate Group을 함유한 디올유도체의 합성 및 내마모성-말단 알킬기 및 몸체 알킬기의 탄소사슬에 따른 영향)

  • Ko, Kyung-Min;Han, Hye-Rim;Kim, Young-Wun;Kang, Ho-Cheol;Jeong, Noh-Hee
    • Applied Chemistry for Engineering
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    • 제29권4호
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    • pp.405-412
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    • 2018
  • Three types of bis[3-(dialkyloxylphosphorothionyl) thio-2-methylpropanyloxy]alkane (BAPA) drived from alkane diol were synthesized. The principal chain of each BAPA had a different carbon number, i.e., 6, 9, and 11. The three types of synthesized BAPA were compared to zinc dialkyl dithiophosphates (ZDDPs) in terms of abrasion resistance. A four-ball test was conducted to evaluate the anti-abrasion performance of the synthesized BAPA according to the length of the principal carbon chain. Each product was added to an additive at a concentration of 1% of the base oil weight, and the wear scar diameter (WSD) was measured as 0.472, 0.459, and 0.480 mm, respectively. Among the BAPA compounds, dialkyl dithiophosphoric acid (DDP), which is the side chain of bis[methacryloyloxy] nonane (BMOO9), was synthesized by varying the carbon number, i.e., 4, 8, and 12, and subsequently the 4-ball test was carried out. The WSD was determined as 0.537, 0.459, and 0.531 mm, respectively. As a result, it was found that when a side chain is short, a thin film is formed. In contrast, a long side chain hindered the formation of a film, and hence the best result was achieved when the carbon number was 8. As for the ZDDPs, the WSD was determined to be 0.563 mm, when measured under the same conditions. The measurements confirm that the synthesized BAPA compounds are superior to the ZDDPs as abrasion resistance additives.

Facile Synthesis and Characterization of Poly(dialkoxy-p-phenylene 1,3,4-oxadiazole-alt-phenylene 1,3,4-oxadiazole)s

  • Kim, Hoon-Seok;Kang, Soon-Min;Do, Jung-Yun
    • Macromolecular Research
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    • 제16권4호
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    • pp.360-366
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    • 2008
  • Poly(dialkoxyphenylene 1,3,4-oxadiazole)s were conveniently synthesized to compare their material properties of solvent solubility, thermal stability and molecular alignment with respect to alkyl chain length and meta/para-phenylene structure. All prepared polymers exhibited good solubility in co-solvents containing various volume levels of chloroform to trifluoroacetic acid. Meta-polymers showed slightly better solubility than para-polymers. All polymers produced were thermally stable up to $320^{\circ}C$. Photoluminescence of polymer films was observed with blue light emission at around 450 nm. X-ray diffraction patterns of all polymers indicated that they were composed of stacked molecular sheets with the same layer-to-layer distance of $3.4\;{\AA}$. However, side chain-to-side chain and main chain-to-main distances within the layers increased with increasing alkyl chain lengths. The meta-polymer chains were separated more than the para-polymer chains.

Osteoma of the stylohyoid chain: A rare presentation in a CBCT study

  • Sai Mi Kim ;Dev Patel ;Ali Zakir Syed
    • Imaging Science in Dentistry
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    • 제54권1호
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    • pp.109-113
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    • 2024
  • A 54-year-old male patient presented for a periodic check-up at the dental clinic. A panoramic radiograph showed bilateral ossification of the stylohyoid ligament with an oval radiopacity on the right side. Cone-beam computed tomography revealed a well-defined, homogenous hyperdense entity from the lower third of the ossified stylohyoid ligament on the right side. The differential diagnosis of osteoma on the stylohyoid chain includes Eagle syndrome and benign tumors of the stylohyoid chain and adjacent structures. Osteoma rarely manifests in the neck. Even more infrequent are tumors originating from the stylohyoid chain, with only a single documented case of osteoma reported in the literature in 1993. Due to the asymptomatic status, no surgical intervention was advised, and the case would be monitored periodically. This case report describes the details of an osteoma that emerged from the stylohyoid chain, marking it as the second recorded occurrence of this highly rare condition.

Investigation of the Effect of new alignment in NLC by using Dipping Effect (침지효과를 이용한 신액정배향효과에 관한 연구)

  • Lee, Jeong-Ho;Park, Tae-Kyu;Seo, Dae-Shik
    • Proceedings of the KIEE Conference
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    • 대한전기학회 1999년도 하계학술대회 논문집 D
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    • pp.1815-1817
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    • 1999
  • In this paper, the generation of high pretilt angle in nematic liquid crystal (NLC) by dipping effect on three kinds of the rubbed polyimide (PI) surface was investigated. The generated pretilt angle of NLC increases due to dipping effect before rubbing treatment on two kinds of the rubbed PI surface with side chain. The generated pretit angle in NLC by using dipping effect after rubbing treatment on PI surface with short side chain is high compared to the PI surface with long side chain. The generated pretit angle of the positive type NLC $(\Delta{\varepsilon}>0)$ is higher as than that of the negative type NLC $({\Delta}{\varepsilon}<0)$ by using dipping effect before rubbing treatment on homeotropic layer. The generated pretilt angle of NLC is attributed to perpendicular component of permittivity ${\varepsilon}_{\perp}$ of NLC on rubbed PI surface.

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