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Efficacy of closantel for treatment of naturally-acquired and experimentally-induced Fasciola hepatica infections in cattle (소에 자연 또는 인공감염된 간질(Fasciola hepatica)에 미치는 closantel의 구충 효과)

  • Shin, Sung-shik;Lee, Chung-gil;Cho, Shin-hyeong;Kim, Jong-taek;Wee, Sung-ha
    • Korean Journal of Veterinary Research
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    • v.35 no.2
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    • pp.347-352
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    • 1995
  • The efficacy of closantel against naturally-acquired and experimentally-induced F hepatica and param-phistomes were administered once orally with closantel at the level of 5mg/kg body weight. In a double-checked fecal examination, cows treated with closantel did not contain F hepatica eggs in their feces at second week post-treatment(PT). At the third and fourth weeks PT, however, Fasciola eggs were found in the feces of 3 treated cows, resulting in a 97.7% efficacy. Of the 41 treated cattle, 30 were at various stages of gestation. No side effects were observed in any of the treated cows and congenital defects among calves born from the treated cows were not reported. Closantel was not effective against paramphistomes. In a separate experiment, 16 Holstein caves were experimentally infected with 300 F hepatica metacercariae each. F hepatica eggs were found in the feces of all infected calves by 14 weeks post-infection(PI). Calves were then treated at 18 weeks PI once orally with 5mg/kg body weight closantel. None of the treated calves contained F hepatica eggs in their feces at 2nd, 3rd or 4th week PT. Our results indicate that oral administration of closantel at the level of 5mg/kg body weight eliminated all mature F hepatica in the liver, while some of immature flukes survived to become adult and produce eggs.

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Effects of Chronic Inflammation on Energy Metabolism and Growth Performance in Weanling Piglets

  • Moon, H.K.;Han, In K.;Gentry, J.L.;Parmentier, H.K.;Schrama, J.W.
    • Asian-Australasian Journal of Animal Sciences
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    • v.12 no.2
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    • pp.174-179
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    • 1999
  • The effect of a chronic inflammation (cell-mediated immune response) on energy metabolism and growth performance was assessed in weanling piglets. Twenty four barrows of 4 wk of age were assigned to one of two immunization treatments : Control group [CON: immunized with Incomplete Freund's Adjuvant (lFA)] or Immunization group [IMMU: immunized with Complete Freund's Adjuvant (CFA)]. On d0, piglets were weaned and subcutaneously immunized at the medial side of the femur with 2 ml of IFA or CFA, respectively. Energy and nitrogen balances were measured per group during 13-d balance period, and total $(HP_{tot})$, activity-related ($(HP_{act})$) and non-activity-related $(HP_{cor})$ heat production were determined every 9-min by indirect calorimetry. Ig total titers to Mycobacterium butyricum, which is present in CFA, were higher (p<0.01) in IMMU than in CON on d13 (2.5 vs 1.8) and d20 (2.9 vs 1.8) after immunization. There were no differences (p>0.10) between treatments in rectal temperature, performance, feed intake, and availability and partitioning of energy during the balance period. Average daily feed intake was numerically higher in IMMU than in CON (0.34 vs 0.32 kg/d), but there was no difference (p>0.10) in metabolizability of the dietary energy between treatments. $HP_{act}/HP_{tot}$ was 16.24 and 16.89%, and retained energy was 251 and 268 $268\;kJ{\cdot}kg^{0.75}{\cdot}d^{-1}$ for CON and IMMU, respectively. Numerically, maintenance requirement of IMMU was even lower than that of CON $(419\;vs\;427\;kJ{\cdot}kg^{0.75}{\cdot}d^{-1})$. The present study suggests that a chronic inflammation has no effect on energy metabolism and growth performance, in spite of the difference in systemic antibody responses. The reason was considered to be due to locally induced immune response, resulting from the possible encapsulation at the site of injection, and/or to a low systemic immune stress which is within a functionally acceptable physiological range for the piglets.

Physical Properties or Jujube (Zizyphus jujuba miller) and Jujube Branches (대추 및 대추가지의 물리적 특성)

  • 민경선;이상우;허윤근;서정덕;맹성렬
    • Journal of Biosystems Engineering
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    • v.27 no.4
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    • pp.283-292
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    • 2002
  • Mechanical and physical properties of various parts of jujube (Zizyphus jojoba Miller) such as fruits, leaves, secondary branches, and leafy stems were measured and analyzed. The physical dimensions of the fruits were measured using a digital caliper, and the detachment force of the fruit and leafy stems was measured using a force gauge. The physical characteristics of the secondary branches such as the modulus of elasticity and the torsional rigidity were tested using a universal testing machine (UTM). The physical characteristics of leafy stems such as length and weight were also measured using a digital caliper and a digital scale, respectively. The detachment force of leafy stems and the area of the leaf also measured. The terminal velocities of the jujube fruits, leaves, and leafy stems were measured using a custom made terminal velocity experiment system. Diameter of the major and minor axis of the jujube fruit, weight of the fruit, and detachment force of the fruit stem was average of 32.02 mm, 23.92 mm. 10.0 ${\times}$ 10$\^$6/ ㎥, 8.99 g, and 5.43 N. respectively. The detachment forces of the jujube fruits increased and the force-to-weight ratio of the jujube fruits decreased as the weight of the jujube fruits increased. The modulus of elasticity of the secondary branches of the jujube was average of 7.01 ${\times}$ 10$\^$8/ N/㎡ and decreased as diameter of the secondary branches increased. The average torsional rigidity of the secondary jujube branches was 5.2 ${\times}$ 10$\^$-/ N/㎡, and the torsional rigidity decreased as the secondary branch diameter increased. The distribution of the torsional rigidity data associated with the diameter of the branches, however. widely scattered and it was difficult to find any relationship between the diameter of the branches and the torsional rigidity of tile branches. The weight of the leafy stems, number of loaves attached to the leafy stems, diameter of the stem side of the leafy stems, diameter of the leafy stem end was average or 0.7 g, 6.6 ea, 12.2 cm, 4.5 mm, and 2.7 mm, respectively. The major and minor axis of the .jujube loaves, area of leaves, weight of the leaves. and detachment force of the leaves was average of 5.7 cm, 3.3 cm, 12.98 cm$^2$, 0.20 g, and 4.39 N, respectively. The terminal velocity of the .jujube fruits increased as the weight of the fruits increased. The terminal velocity of the leafy stems, however, did not show a relationship with the weight of the leafy stems and the number of leaves attached to the leafy stem. The terminal velocity, however, slightly increased as the length of the leafy stems increased.

Structural characteristics of a red ginseng acidic polysaccharide rhamnogalacturonan I with immunostimulating activity from red ginseng

  • Lee, Sue Jung;In, Gyo;Han, Sung-Tai;Lee, Mi-Hyang;Lee, Jong-Won;Shin, Kwang-Soon
    • Journal of Ginseng Research
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    • v.44 no.4
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    • pp.570-579
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    • 2020
  • Background: Many researchers reported that the various immune activities of red ginseng are due to acid polysaccharides. But, the exact structural characteristics of the acidic polysaccharide in red ginseng have not been fully elucidated. Therefore, we isolated the acidic polysaccharide from red ginseng and characterized the structural property of the active moiety of this polysaccharide, which contributes to the immunostimulatory activity of red ginseng. Methods: A polysaccharide (RGP-AP-I) was purified from red ginseng via size-exclusion chromatography using Sephadex G-100. Immunostimulatary activity of RGP-AP-I was investigated via anti-complementory and macrophage stimulatory activity. The structure of RGP-AP-I was characterized by HPLC, sugar composition, β-glucosyl Yariv reagent and methylation analysis. Results: Peritoneal macrophages stimulated using RGP-AP-I significantly augmented the production of various cytokines such as interleukin (IL)-6, IL-12, and tumor necrosis factor (TNF)-α. The primary structure of RGP-AP-I was elucidated by assessing its sugar composition and methylation analysis. RGP-AP-I is a 96 kDa acidic polysaccharide, and comprises nine different monosaccharides, which mainly include sugars such as rhamnose (Rha, 9.5%), galacturonic acid (GalA, 18.4%), galactose (Gal, 30.4%), and arabinose (Ara, 35.0%). RGP-AP-I exhibited an considerable reaction with the β-glucosyl Yariv reagent, revealing the presence of arabino-β-3,6-galactan. Methylation analysis indicated that RGP-AP-I comprises 21 different glycosyl linkages, such as 3-, 4-, 6- and 3,6-linked Galp; 5-linked Araf; 2,4-linked Rhap; and 4-linked GalAp, which are characteristics of rhamnogalacturonan I (RG-I). Conclusion: we assumed that the immunostimulatory activity of RGP-AP-I may be due to the RG-I structure, which comprises a main chain with a repeating linkage unit, [→2)-Rhap-(1→4)-GalAp-(1→] and three groups of side chains such as (1→5)-linked arabinan, (1→4)-linked galactan, and arabino-β-3,6-galactan, which branch at the C(O)4 positions of Rha residues in the main chain of RGP-AP-I.

Reticuloendothelial System Potentiating of Polysaccharide from Panax Species (Panax속 식물의 다당류가 망내계 활성에 미치는 영향)

  • Ohtani Kazuhiro;Hirose Kumi;Hatana Shunso;Mizutani Kenji;Kasai Ryoji;Tanaka Osamu;Masuda Hitoshi;Furukawa Hiromi;Fuwa Tohru
    • Proceedings of the Ginseng society Conference
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    • 1988.08a
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    • pp.147-150
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    • 1988
  • Polysaccharides which show reticuloendothelial system potentiating activity in carbon clearance tests have been examined in water extracts of Panx species. From the dried roots of P. notoginseng, an active polysaccharide called sanchinan-A was isolated. The molecular weight of sanchinan-A was estimated to be 1,500,000D and the structure was determined to be $\beta$-D-(1-3-galactan), possessing branch points at positions 0-6 at which (mainly-$\alpha$-L-arabinofuranosyl and partly $\beta$-D-galactopyranosyl)-(1-6)-$\beta$-D-galacto-pyranosyl-(1-3)-$\beta$-D-galactopyranosyl side chains are attached on average, to two of three galactosyl units. From dried rhizomes of P. japonicus, several active polysaccharides were also isolated, and these structuers were also determined. From the dried roots of P. ginseng, several polysaccharides which showed strong activity were isolated. The structures of these compounds are currently under investigation. The polysaccharide fraction (non-dialyzed fraction) of the water extract of red ginseng (steam-dried roots) did not exhibit activity, while the dialyzed fraction potentiated RES. Activity disappeared, however, during the process of separation due to the presence of a substance in the fraction which stabilizes an active substance.

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Radiation Exposure of the Hand and Chest during C-arm Fluoroscopy-Guided Procedures

  • Jung, Cheol Hee;Ryu, Jae Sung;Baek, Seung Woo;Oh, Ji Hye;Woo, Nam Sik;Kim, Hae Kyoung;Kim, Jae Hun
    • The Korean Journal of Pain
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    • v.26 no.1
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    • pp.51-56
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    • 2013
  • Background: The C-arm fluoroscope is an essential tool for the intervention of pain. The aim of this study was to investigate the radiation exposure experienced by the hand and chest of pain physicians during C-arm fluoroscopy-guided procedures. Methods: This is a prospective study about radiation exposure to physicians during transforaminal epidural steroid injection (TFESI) and medial branch block (MBB). Four pain physicians were involved in this study. Data about effective dose (ED) at each physician's right hand and left side of the chest, exposure time, radiation absorbed dose (RAD), and the distance from the center of the X-ray field to the physician during X-ray scanning were collected. Results: Three hundred and fifteen cases were included for this study. Demographic data showed no significant differences among the physicians in the TFESIs and MBBs. In the TFESI group, there was a significant difference between the ED at the hand and chest in all the physicians. In physician A, B and C, the ED at the chest was more than the ED at the hand. The distance from the center of the X-ray field to physician A was more than that of the other physicians, and for the exposure time, the ED and RAD in physician A was less than that of the other physicians. In the MBB group, there was no difference in the ED at the hand and chest, except for physician D. The distance from the center of the X-ray field to physician A was more than that of the other physicians and the exposure time in physician A was less than that of the other physicians. Conclusions: In conclusion, the distance from the radiation source, position of the hand, experience and technique can correlate with the radiation dose.

A Study on the Position and Meaning of the Back Garden in Wanggung-ri Site, Iksan (익산 왕궁리유적에서 후원의 위상과 의미에 대한 연구)

  • Jeon, Yong-Ho
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.34 no.4
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    • pp.1-13
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    • 2016
  • The Back garden in Wanggung-ri Site, Iksan clearly presents an aspect of the landscape gardening techniques of the Baekje, which are significantly unique in the landscape gardening history of East Asia as the structure connected to the main garden through a complex waterway system on a hill. The rear garden has a complex waterway system comprising a large inverted U-shape waterway and its branch waterways, sinuous waterway and water catchment system to enhance the landscape effect with a minimum amount of water on a hill, reducing damage by floods in the case of heavy rain and securing the amount of water required by the main space in the palace. A landscape element using various kinds and sizes of oddly shaped rocks decorated the water catchment area inside or around the large inverted U-shape waterway. On the top of the hill, the center in the Back garden, a building site in the size of 4 Kans each on the front and side was made on a square base surrounded by a round base stone. The building was identified on a space partially surrounded by the rectangular stonework on the left and right slope of the hill. While the functions and roles of the rectangular stonework are not accurately identified due to the poor conditions of the present site, the stonework may be related to the building inside it. The back garden in Wanggung-ri Site, Iksan has a winding pond-shaped waterway to pull or push water into or out of the garden in a rectangular pond shape, which was a conventional landscape gardening technique during the Baekje period. Since the main garden and the back garden in Wanggung-ri Site, Iksan form a systematic connection system, this paper tried to newly establish the main garden inside Iksan Wanggungseong as the 'royal garden'.

Studies on the Flowering and Maturity in Sesame(Sesamum indicum L.) V. Changes of Grain Weight and Germinability by Maturity in Different Plant Types (참깨 개화, 등숙에 관한 연구 V. 참깨의 등숙에 따른 초형별 종실중 및 발아력의 변화)

  • Kang, Chul-Whan;Lee, Jung-Il;Son, Eung-Ryong;Yoo, Chang-Yung
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.30 no.4
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    • pp.436-441
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    • 1985
  • The study was conducted to provide basic information to breeders and agronomists working with sesame. The grain weight and germinability were investigated for eight plant types classified by branching habit, capsules per axil, and carpels and loculi of a capsule. Two typical cultivars were chosen for each plant type among 527 gene pools. Dry weight of one thousand grains was increased rapidly from 25th to 35th day after flowering, and reached peak on 40th day after flowering in upper part capsules and 45th day after flowering in lower and middle part capsules, so that this period was considered to be of physiological maturity in each capsule bearing part. Side capsules on main stem and branch capsules were lighter than central ones of main stem, and upper capsules of four carpels eight loculi type decreased more seriously. BTB type demonstrated relatively better growth compared to the growth of BTQ type in one thousand grain weight. The maximum grain filling duration for germination percentage increased rapidly up to 40th day after flowering. Above 70% germinability was obtained from 40th day after flowering. Harvesting time of physiological maturity was considered to be 45th day after flowering with peaks of 2.14g of one thousand grain weight, 26% of grain water content and 90% of germinability.

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A Study on Korea Coast Guard Intelligence Centered on legal and Institutional comparison to other organizations, domestic and international (해양경비안전본부 정보활동의 법적·제도적 측면의 문제점 분석 및 개선방안 연구)

  • Soon, Gil-Tae
    • Korean Security Journal
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    • no.44
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    • pp.85-116
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    • 2015
  • Found in 23 Dec 1953 to cope with illegal fishing of foreign ships and coastal guard duty, Korea Coast Guard was re-organized as an office under Ministry of Public Safety since the outbreak of sinking of passenger ship "Sewolho". In the course of re-organization, intelligence and investigation duty were transferred to Police Department except "Cases happened on the sea". But the definition of intelligence duty is vague and there are lots of disputes over the jurisdiction and range of activities. With this situation in consideration, the object of this study is to analyse legal and institutional characteristic of KCG Intelligence, to compare them to that of Police Department, foreign agencies like Japan Coast Guard and US Coast Guard, to expose the limit and to suggest solution. To summarize the conclusion, firstly, in the legal side, there is no legal basis on intelligence in [The Government Organization Act], no regulation for mission, weak basis in application act. Secondly, in the institutional side, stated in the minor chapter of [The Government Organization Act], 'the cases happened on sea' is a quite vague definition, while guard, safety, maritime pollution duty falls under 'on the sea' category, intelligence fell to 'Cases happened on the sea' causing coast guard duty and intelligence have different range. In addition, reduced organization and it's manpower led to ineffective intelligence activities. In the case of Police Department, there is definite lines on 'administration concerning public security' in [The Government Organization Act], specified the range of intelligence activities as 'collect, make and distribute information concerning public security' which made the range of main duty and intelligence identical. Japanese and US coast guards also have intelligence branch and performing activities appropriate for the main missions of the organizations. To have superiority in the regional sea, neighboring countries Japan and China are strengthening on maritime power, China has launched new coast guard bureau, Japan has given the coast guard officers to have police authority in the regional islands, and to support the objectives, specialized intelligence is organized and under development. To secure maritime sovereignty and enhance mission capability in maritime safety duty, it is strongly recommended that the KCG intelligence should have concrete legal basis, strengthen the organization and mission, reinforce manpower, and ensure specialized training administrative system.

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Landscape Gardening Culture in Late Joseon Dynasty Depicted in 'Ahoi-do' Paintings (아회도(雅會圖)에 나타난 조선후기 원림문화)

  • Lim, Eui-Je;So, Hyun-Su
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.32 no.3
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    • pp.46-57
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    • 2014
  • This study contemplated the gardening culture from the pictures, which the scholars of late Joseon Dynasty, the aspects of garden landscapes and garden use behaviors are drawn as follows. 1. The yard by the detached house for men and guest in front of the premises(Sarang Madang) and backyard were the major places for Ahoi(social gatherings of the scholars). The mansions had interests in the management of the outer garden beyond the house wall with building structures like the pavilions on the high walls and side gates. This management and the selection of location anticipating in advance of the management are noteworthy. 2. Only house gardens had plant pots with flowers and the small flower bed(Hwa-O) at Sarang Madang occasionally had plant pots without flowers and oddly shaped stone pots and equipped pine branch eaves and traditional awnings made of plant material like a trellis. 3. The oddly shaped stones were significant landscape elements in the gardens of houses and villas. Some of them were depicted as the Taihu stone and this draws attention to the question of whether the Taihu stone was actually used in the garden of late Joseon Dynasty. 4. The gardens in villas accommodated the borrowed scenery with various materials like wooden fences, bamboo or reed fences, mud walls. They also had the artificial gardens with some odd shaped stones, old pines, bamboos, Japanese apricots, willows, paulownia trees, lotuses and plantains in the secured Madangs. 5. Gyeong Hwa Sa Jog(The scholars of the ruling class adapted to the 18th century's new historical aspect) of late Joseon Dynasty built the villas at the beautiful scenery closed to the their houses. 6. The Gardens around pavilions were located high closed to the mountain streams with nature like beautiful forests, oddly formed rocks, precipitous cliffs and viewing stones. The back side of the pavilion was enclosed by bamboo forests and the front had pines, ginkgoes and willows as shade trees. 7. The beautiful scenery which was preferred as the place for Ahoi was basically with fantastic peaks and precipitous cliffs which forms the distant view harmonized with a waterfall. Broad and flat rocks at the summit of a mountain which commands a bird's-eye view or on a mountain streamside with pine forest, willows and plum trees were chosen as the optimal places for Ahoi. 8. Pine trees were presumed to be more preferable than other species in the garden, especially an single planted old pine tree accented symbolism. 9. Portable tea braziers for boiling tea were adopted in all four types of the gardens. 10. The gardens mixed with auspicious landscape elements were the places of the arts for an unworldliness Ahoi through GeumGiSeoHwa(enjoying strings, go, writing and painting) and boiling tea.