• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2003년도 춘계학술대회논문집
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• pp.755-761
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• 2003

Recently, the development of mobile devices demands information storage systems to use micro drive devices and cheap media. These should have several characteristics, for example, the subminiature of size, the robustness of shock, the minimum of cost and power consumption, and the removability of multiple applications. A conventional optical disk drive is more suitable for these specifications than the others. The optical storage system of the new generation to use a blue laser and a high numerical aperture (NA) is the perfect candidate for micro optical disk drives. In this paper, the micro actuator that can be applied to a micro optical disk drive is designed by response surface methodology to use a structural analysis and an electro-magnetic analysis. Based on above results, the coarse actuator and fine actuator are designed and improved from the point of view of the size and the power. Consequently, the designs of a micro actuator are proposed through these courses.

• 대한조선학회논문집
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• 제45권6호
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• pp.726-734
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• 2008

While the structural safety assessment of Cargo Containment System(CCS) in membrane type LNG carriers has to be carried out in consideration of sloshing impact pressure, it is very difficult to figure out its dynamic response behaviors due to its very complex structural arrangements/materials and complicated phenomena of sloshing impact loading. For the development of its original technique, it is necessary to understand the characteristics of dynamic response behavior of CCS structure under sloshing impact pressure. In this study, for the exact understanding of dynamic response behavior of CCS structure in membrane Mark III type LNG carriers under sloshing impact pressure, its wet drop impact response analyses were carried out by using Fluid-Structure Interaction(FSI) analysis technique of LS-DYNA code, and were also validated through a series of wet drop experiments for the enhancement of more accurate shock response analysis technique. It might be thought that the structural response behaviors of impact response analysis, such as impact pressure impulses and resulted strain time histories, generally showed very good agreement with experimental ones with very appropriate use of FSI analysis technique of LS-DYNA code, finite element modeling and material properties of CCS structure, finite element modeling and equation of state(EOS) of fluid domain.

• 대한의생명과학회지
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• 제21권2호
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• pp.60-68
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• 2015

NecroX-7 is a novel small compound of the NecroX series based on the indole moiety, which has potent cytoprotective and antioxidant properties. We previously detected potential immune regulatory effects of NecroX-7 in immune related diseases like Graft-versus-Host Disease. However, the function and the underlying mechanisms of immunological effects of NecroX-7 in the immune system have not been well established. In this study, we investigated the immune response characterization of differentially expressed genes of NecroX-7 administration in $CD4^+$ T cells by microarray analysis. $CD4^+$ T cells stimulated with NecroX-7 ($40{\mu}M$) or vehicle for 72 hours resulted in the identification of 337 differentially expressed genes (1.5 fold, P<0.05) by expression profiling analysis. Twenty eight of the explored NecroX-7-regulated genes were related to immune system processes. These genes were validated by quantitative real-time PCR. The most significant genes were glutathione reductase, eukaryotic translation elongation factor 1, lymphotoxin-alpha, heat shock protein 9 and chloride intracellular channel protein 4. These findings demonstrate the strongly immune response of NecroX-7 in $CD4^+$ T cells, suggesting that cytoprotection and immune regulation may underlie the critical aspects of NecroX-7 exposure.

• 한국추진공학회지
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• 제20권5호
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• pp.19-30
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• 2016

파이로테크닉 착화기의 충격파 전달에 의한 폭굉 반응을 해석하기 위하여 고폭약의 폭압 발달 및 비반응 물질의 압력 감쇠 현상을 연동하여 모사할 수 있는 하이드로다이나믹 솔버를 구성하였다. 본 연구에서는 소량의 시약으로 기폭 판단이 가능한 SSGT의 시험 및 전산모사를 수행하여 97.5% RDX로 구성된 수폭약의 충격에 대한 점화 민감도를 정량화하였다. 파이로테크닉 착화기를 형상화 한 여폭약(HNS+HMX) - 격벽(STS) - 수폭약(RDX)으로 구성된 TBI 화약 트레인을 고려하여 충격파 전달을 해석함으로써 반응 및 비반응 물질 간 상호작용에 의한 임계 격벽 두께 및 기폭 압력 간의 관계를 규명하고, 소형 파이로 착화기의 작동특성을 검증하였다.

• 유통과학연구
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• 제11권10호
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• pp.73-79
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• 2013

Purpose - This study examines the impact of oil price volatility on economic activities in Korea. The new millennium has seen a deregulation in the crude oil market, which invited immense capital inflow into Korea. It has also raised oil price levels and volatility. Drawing on the recent theoretical literature that emphasizes the role of volatility, this paper attends to the asymmetric changes in economic growth in response to the oil price movement. This study further examines several key macroeconomic variables, such as interest rate, production, and inflation. We come to the conclusion that oil price volatility can, in some part, explain the structural changes. Research design, data, and methodology - We use two methodological frameworks in this study. First, in regards to the oil price uncertainty, we use an Exponential-GARCH (Exponential Generalized Autoregressive Conditional Heteroskedasticity: EGARCH) model estimate to elucidate the asymmetric effect of oil price shock on the conditional oil price volatility. Second, along with the estimation of the conditional volatility by the EGARCH model, we use the estimates in a VECM (Vector Error Correction Model). The study thus examines the dynamic impacts of oil price volatility on industrial production, price levels, and monetary policy responses. We also approximate the monetary policy function by the yield of monetary stabilization bond. The data collected for the study ranges from 1990: M1 to 2013: M7. In the VECM analysis section, the time span is split into two sub-periods; one from 1990 to 1999, and another from 2000 to 2013, due to the U.S. CFTC (Commodity Futures Trading Commission) deregulation on the crude oil futures that became effective in 2000. This paper intends to probe the relationship between oil price uncertainty and macroeconomic variables since the structural change in the oil market became effective. Results and Conclusions - The dynamic impulse response functions obtained from the VECM show a prolonged dampening effect of oil price volatility shock on the industrial production across all sub-periods. We also find that inflation measured by CPI rises by one standard deviation shock in response to oil price uncertainty, and lasts for the ensuing period. In addition, the impulse response functions allude that South Korea practices an expansionary monetary policy in response to oil price shocks, which stems from oil price uncertainty. Moreover, a comparison of the results of the dynamic impulse response functions from the two sub-periods suggests that the dynamic relationships have strengthened since 2000. Specifically, the results are most drastic in terms of industrial production; the impact of oil price volatility shocks has more than doubled from the year 2000 onwards. These results again indicate that the relationships between crude oil price uncertainty and Korean macroeconomic activities have been strengthened since the year2000, which resulted in a structural change in the crude oil market due to the deregulation of the crude oil futures.

• 대한기계학회논문집B
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• 제40권8호
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• pp.519-525
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• 2016

펌프 성능 관점에서 바라보면 회전날개의 충격손실을 최소화하는 것은 매우 중요하다. 본 연구는 회전날개의 충격손실에 직접적으로 영향을 미치는 흡입 케이싱 내에 설치되는 안내깃의 형상 및 설치 각 변화가 축류 펌프의 성능에 미치는 효과를 수치 해석 방법을 통해 살펴보았다. 그리고 주어진 운전조건에서 흡입 케이싱 내에 설치되는 안내깃의 최적형상 및 설치 각을 최적화 기법을 사용하여 최적화하였다.

• 한국농공학회논문집
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• 제48권7호
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• pp.45-52
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• 2006

A cyclic viscoelastic-viscoplastic constitutive model for clay is incorporated into an effective stress based seismic response analysis to describe viscous effect of clay layer to sand layer during earthquake. The seismic response against main shock of 1995 Hyogoken Nambu Earthquake is analyzed in the present study. Acceleration responses in both clay layer and just upper liquefiable sand layer are damped due to viscous effect of clay. A cyclic viscoelastic-viscoplastic constitutive model for clay was implemented into a FEM code, and $Newmark{\beta}$ method was employed for the time discretization in the finite element formulation. Seismic responses were simulated by numerical method with recorded data at Port Island, Kobe, Japan. As results of this study, it was found that a cyclic viscoelastic-viscoplastic constitutive model can give good description of dynamic behavior characteristics including viscoelastic effect.

• Journal of Microbiology
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• 제44권4호
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• pp.369-374
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• 2006

To investigate the mechanism of salt tolerance of gram-positive moderately halophilic bacteria, two-dimensional gel electrophoresis (2-D PAGE) was employed to achieve high resolution maps of proteins of Halobacillus dabanensis $D-8^T$. Approximately 700 spots of proteins were identified from these 2-D PAGE maps. The majority of these proteins had molecular weights between 17.5 and 66 kDa, and most of them were distributed between the isoelectric points (pI) 4.0 and 5.9. Some protein spots were distributed in the more acidic region of the 2-D gel (pI <4.0). This pattern indicated that a number of proteins in the strain $D-8^T$ are acidic. To understand the adaptation mechanisms of moderately halophilic bacteria in response to sudden environmental changes, differential protein profiles of this strain were investigated by 2-D PAGE and $Imagemaster^{TM}$ 2D Platinum software after the cells were subjected to salt shock of 1 to 25% salinity for 5 and 50 min. Analysis showed 59 proteins with an altered level of expression as the result of the exposure to salt shock. Eighteen proteins had increased expression, S proteins were induced, and the expression of 33 proteins was down-regulated. Eight of the up-regulated proteins were identified using MALDI-TOF/MS and MASCOT, and were similar to proteins involved in signal transduction, proteins participating in energy metabolism pathways and proteins involved in stress.

• Molecules and Cells
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• 제19권3호
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• pp.328-333
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• 2005

Small heat shock proteins (sHSPs) are widely distributed, and their function and diversity of structure have been much studied in the field of molecular chaperones. In plants, which frequently have to cope with hostile environments, sHSPs are much more abundant and diverse than in other forms of life. In response to high temperature stress, sHSPs of more than twenty kinds can make up more than 1% of soluble plant proteins. We isolated a genomic clone, NtHSP18.3, from Nicotiana tabacum that encodes the complete open reading frame of a cytosolic class I small heat shock protein. To investigate the function of NtHSP18.3 in vitro, it was overproduced in Escherichia coli and purified. The purified NtHSP18.3 had typical molecular chaperone activity as it protected citrate synthase and luciferase from high temperature-induced aggregation. When E. coli celluar proteins were incubated with NtHSP18.3, a large proportion of the proteins remained soluble at temperatures as high as $70^{\circ}C$. Native gel analysis suggested that NtHSP18.3 is a dodecameric oligomer as the form present and showing molecular chaperone activity at the condition tested. Binding of bis-ANS to the oligomers of NtHSP18.3 indicated that exposure of their hydrophobic surfaces increased as the temperature was raised. Taken together, our data suggested that NtHSP18.3 is a molecular chaperone that functions as a dodecameric complex and possibly in a temperature-induced manner.

• 대한기계학회논문집B
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• 제30권7호
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• pp.622-629
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• 2006

The shape optimization of blade sweep in a transonic axial compressor rotor of NASA Rotor 37 has been performed using response surface method and the three-dimensional Wavier-Stokes analysis. Two shape variables of the rotor blade, which are used to define the rotor sweep, are introduced to increase the adiabatic efficiency of the compressor. Throughout the optimization, optimal shape having a backward sweep is obtained. Adiabatic efficiency, which is the objective function of the present optimization, is successfully increased. Separation line due to the interference between a shock and surface boundary layer on the blade suction surface is moved downstream for the optimized blade compared to the reference one. The increase in adiabatic efficiency for the optimized blade is caused by suppression of the separation due to a shock on the blade suction surface.