• Journal of the Korea Institute of Military Science and Technology
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• v.22 no.5
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• pp.581-589
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• 2019

Guided missiles assembled with the bolted joint are subjected to various shock loading conditions while flying in the air and operating on the ground or platform. Especially, It is important to analyze the effect of the shock load on the structure because it affects the structure for a short duration time while its acceleration magnitude is quite large. In this study, mechanical shock tests on the structure with the bolted joint have been carried out to measure the acceleration changes of the structure against external shock loads by electrical exciter. Variation of dynamic characteristics of a structure with fastening methods and fastening forces has been investigated through Shock Response Spectrum analysis.

• Animal cells and systems
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• v.4 no.2
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• pp.181-186
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• 2000

The expression of $p21^{WAF1/ClP1/SDl1}$, one of the cyclin-dependent kinase inhibitors, is regulated by a variety of transcription factors including p53 and STAT. Heat shock induces the expression of p21 in a temperature- and time-dependent manner. Although the p21 induction by heat shock has been reported to be controlled by p53, a p53-independent mechanism Is also involved. To understand the p53-independent regulation of heat shock-induced p21 expression, we searched the promoter region of p21 gene and found one or two heat shock element (HSE)-like sequences in human, rat, and mouse. Electromobility shift assay (EMSA) showed that heat shock factor (HSF) could bind to these HSE-like sequences In response to heat shock, even though to a lesser extent than to HSE. In addition, p21 promoter deletion analysis revealed that heat shock activated a p21 deletion promoter construct containing the HSE-like sequences but lacking p53-binding sites, but not a promoter construct containing neither HSE-like sequences nor the p53-responsive element. Furthermore, the p21 induction by heat shook was significantly inhibited in confluent cells in which heat shock-induced HSF activation was reduced. These results suggest that the transcriptional regulation of p21 by heat shock may be mediated through activation and binding to HSE-like sequences of HSF.

• Microbiology and Biotechnology Letters
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• v.38 no.3
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• pp.273-277
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• 2010

Undecylprodiginine and streptorubin B are red-pigmented antibiotics produced by Streptomyces coelicolor A3(2). In this study, we investigated the correlation between productivity of these red-pigmented antibiotics and stress of pH shock. Biosynthesis of these red-pigmented antibiotics is enhanced at acidic pH shock on solid R2YE medium. The optimal pH shock is pH 4 which led to 1.6 fold and two-fold increase in the production of undecylprodiginine and streptorubin B as compared with control, respectively. In addition, the extract of pH 4 shocked cells exhibited a remarkable activity against Trichophyton mentagrophytes. However, neutral and basic pH shock did not give raise to promote a production of these red-pigmented antibiotics as well as antifungal activity. Thus, although the acidic pH shock is simple and easy method, it should be extremely effective approach to enhance a productivity of these red-pigmented antibiotics and other secondary metabolites.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.39 no.5
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• pp.385-390
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• 2015

The flow characteristics in micro shock tube are investigated experimentally. Studies were carried out using a stainless steel micro shock tube. Shock and expansion wave was measured using 8 pressure sensors. The initial pressure ratio was varied from 4.3 to 30.5, and the diameter of tube was also changed from 3mm to 6mm. Diaphragm conditions were varied using two types of diaphragms. The results obtained show that the shock strength in the tube becomes stronger for an increase in the initial pressure ratio and diameter of tube. For the thinner diaphragm, the highest shock strength was found among varied diaphragm condition. Shock attenuation was highly influenced by the diameter of tube.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.1
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• pp.61-66
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• 2012

In this study, to find the effect of nonequilibrium condensation on the oscillation of the terminating shock wave in transonic flows, an NACA0014 airfoil flow with nonequilibrium condensation is analyzed using the total variation diminishing (TVD) numerical scheme. Transonic free stream Mach numbers of 0.81-0.87 are tested with variations in the stagnation relative humidity. For the same free stream Mach number and attack angle of ${\alpha}=0^{\circ}$, an increase in the stagnation relative humidity attenuates the strength of the terminating shock and reduces the oscillation of the terminating shock wave. Furthermore, for the same stagnation relative humidity, the larger the free stream Mach number becomes, the shorter the period of the oscillation shock wave is. The excursion distance of the oscillation shock increases with the free stream Mach numbers for the same stagnation relative humidity. Finally, it is found that for the same shock location, the strength of the oscillating shock facing upstream is stronger than that facing downstream.

• Journal of The Korean Society of Clinical Toxicology
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• v.7 no.2
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• pp.137-142
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• 2009

Purpose: This study was conducted to investigate the characteristics of drug induced anaphylactis and anaphylactic shock in patients who were admitted to the emergency department Methods: We retrospectively collected the data on patients with drug induced anaphylaxis and who were admitted to the emergency department from January 2001 to June 2009. The study group was divided into the non-shock and shock groups according to whether the systolic blood pressure more than 90mmHg. The initial demographic data, the causes of drug-induced anaphylaxis, the clinical manifestations, the treatment and the prognosis were reviewed for 72 patients. Results: The mean age of the study subjects was $47.9P{\pm}14.2$ years old and there were 40 male patients and 32 female patients. There were 26 patients in the non-shock group and 46 in the shock group. The mean age was older in the shock group than in the non-shock group ($51.5{\pm}15.1$ vs $42.5{\pm}10.6$, p-0.002). A history of drug allergy was more common in the shock group, but no difference was found for the comorbid chronic diseases between the two groups. Radio-contrast media was the most common cause, followed non-steroidal anti inflammatory drugs and antibiotics, but there is no difference in the causes between the two groups. The symptoms of cyanosis, syncope, sweating and dizziness were more frequently manifested in the shock group. The administration of intravenous fluid and injection of subcutaneous epinephrine at the emergency department were more frequent in the shock group than in the non-shock group. Conclusion: For the patients who were admitted to the emergency department with drug induced anaphylaxis, the mean age was older and the symptoms of cyanosis, syncope, sweating, dizziness were more frequent in the anaphylactic shock patients than in the non-shock group. More treatments were given at the emergency department to the anaphylactic shock patients.

• Journal of Ocean Engineering and Technology
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• v.27 no.5
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• pp.22-27
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• 2013

The present work dealt with the high temperature thermal shock properties of 316 stainless steels, in conjunction with a detailed analysis of their microstructures. In particular, the effects of the thermal shock temperature difference and thermal shock cycle number on the properties of 316 stainless steels were investigated. A thermal shock test for 316 stainless steel was carried out at thermal shock temperature differences from $300^{\circ}C$ to $1000^{\circ}C$. The cyclic thermal shock test for the 316 stainless steel was performed at a thermal shock temperature difference of $700^{\circ}C$ up to 100 cycles. The characterization of 316 stainless steels was evaluated using an optical microscope and a three-point bending test. Both the microstructure and flexural strength of 316 stainless steels were affected by the high-temperature thermal shock. The flexural strength of 316 stainless steels gradually increased with an increase in the thermal shock temperature difference, accompanied by a growth in the grain size of the microstructure. However, a thermal shock temperature difference of $800^{\circ}C$ produced a decrease in the flexural strength of the 316 stainless steel because of damage to the material surface. The properties of 316 stainless steels greatly depended on the thermal shock cycle number. In other words, the flexural strength of 316 stainless steels decreased with an increase in the thermal shock cycle number, accompanied by a linear growth in the grain size of the microstructure. In particular, the 316 stainless steel had a flexural strength of about 500 MPa at 100 thermal-shock cycles, which corresponded to about 80% of the strength of the as-received materials.

• Korean Journal of Materials Research
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• v.24 no.10
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• pp.526-531
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• 2014

Thermal shock resistance property has recently been considered to be one of the most important basic properties, in the same way that the transverse-rupture property is important for sintered hard materials such as ceramics, cemented carbides, and cermets. Attempts were made to evaluate the thermal shock resistance property of 10 vol% TaC added Ti(C,N)-Ni cermets using the infrared radiation heating method. The method uses a thin circular disk that is heated by infrared rays in the central area with a constant heat flux. The technique makes it possible to evaluate the thermal shock strength (Tss) and thermal shock fracture toughness (Tsf) directly from the electric powder charge and the time of fracture, despite the fact that Tss and Tsf consist of the thermal properties of the material tested. Tsf can be measured for a specimen with an edge notch, while Tss cannot be measured for specimens without such a notch. It was thought, however, that Tsf might depend on the radius of curvature of the edge notch. Using the Tsf data, Tss was calculated using a consideration of the stress concentration. The thermal shock resistance property of 10 vol% TaC added Ti(C,N)-Ni cermet increased with increases in the content of nitrogen and Ni. As a result, it was considered that Tss could be applied to an evaluation of the thermal shock resistance of cermets.

• Proceedings of the KSME Conference
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• 2001.06e
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• pp.349-354
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• 2001

The present study addresses the open end correction associated with the reflection and discharge phenomena of a weak shock wave from an open end of a duct. The open end correction of the weak shock wave is investigated experimentally and by numerical computation. An experiment is made using a simple shock tube with an open end, and computation is performed to simulate the experimental flow field using the unsteady, axisymmetric, compressible, flow governing equations. The results obtained show that an open end correction should be involved for shock wave discharge and reflection problems generated from the exit of the duct with an open end baffle plate. With a baffle plate less than three times the duct diameter, it is found that the open end correction is a function of both the diameter of the baffle plate and normal shock wave magnitude. However, for a baffle plate larger than three times the duct diameter, it is independent of the baffle plate diameter. The present computations predict the results of shock tube experiment with good accuracy. A new empirical equation for prediction of the open end correction is found for the weak shock reflection and discharge phenomena occurring at the open end of the duct with and without a baffle plate.

• Laser Solutions
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• v.6 no.1
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• pp.17-24
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• 2003

The purpose of this study is to evaluate thermal shock resistance and thermal shock fracture toughness for ATJ graphite. Thermal shock resistance and thermal shock fracture toughness of ATJ graphite are evaluated by using CO$_2$ laser irradiation technique. The laser heat source is irradiated at the center of specimens. Temperature distribution on the specimen surface is measured using the thermocouples of type K and C. SEM and radiographic images are used to observe the cracks which are formed at the thermal shock specimens.