• 대한한의학방제학회지
• /
• 제17권2호
• /
• pp.123-132
• /
• 2009

Acetaminophen (AP) is widely used as an over-the-counter analgesic and antipyretic drug. AP-induced hepatotoxicity is a common consequence of AP overdose and may lead to acute liver failure. In this study, we investigated the liver damage in mice using single dose (300 mg/kg) of AP and the possible protective effects of administration (50-200 mg/kg body weight) of Joo-Juk on acetaminophen-induced liver damage in mice. The alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activities were determined in the plasma of mice. The effect of Joo-Juk on lipid peroxidation product thiobarbituric reacting substances (TBARS) and some antioxidant enzymes superoxide dismutase (SOD), catalase, d-aminolevulinate dehydratase ($\sigma$-ALA-D) activities, and gluthathione peroxidase (GPx), were also evaluated in the mouse liver homogenate. AP caused liver damage as evident by statistically significant increased in plasma activities of AST and ALT. There were statistically significant losses in the activities of SOD, catalase, $\sigma$-ALA-D, and GPx and an increase in TBARS in the liver of AP-treated group compared with the control group. However, Joo-Juk was able to counteract these effects. These results suggest that Joo-juk can act as hepato-protectant against AP toxicity and is a good candidate for further evaluation as an effective chemotherapeutic agent.

• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1998년도 추계학술대회
• /
• pp.104-105
• /
• 1998

To minimize the Y2K (year 2000) date aware problem of medical devices, we are developing a database that keeps the data such as equipment type, specification, serial number, model number, acquisition date, vendor, manufacturer of the device as well as the names of departments that installed and that is currently responsible for the management of the medical device. The database also keeps the information as to whether the device awares the date, whether it is affected by the Y2K problem or not, how to solve the problem, reference home page address, and so on. The data was collected via internet search of the FDA web site and related of manufacturers homepages. To manage the Y2K problem effectively, the database should be updated regularly to include recent information.

• The Korean Journal of Physiology and Pharmacology
• /
• 제4권2호
• /
• pp.99-104
• /
• 2000

We investigated the action of NOS inhibitors on NOS in rats. Both of nitric oxide synthase inhibitors, $N^G$-monomethyl-L-arginine $(L-NMMA,\;3\;{\mu}M)$ or $N^G$-nitro-L-arginine methylester $(L-NAME,\;30\;{\mu}M),$ augmented phenylephrine $(PE,\;10^{-7}\;M)-induced$ contraction which was inhibited by acetylcholine (ACh) in rat thoracic aorta. This augmentation by L-NAME or L-NMMA was attenuated with the treatment of NO precursor, arginine. ACh, however, decreased the augmentation induced by L-NMMA, but not by L-NAME. Superoxide dismutase (SOD, 50 u/ml) potentiated an inhibitory effect of ACh on the PE $(10^{-7}\;M)-induced$ contraction. It has been known that platelet activating factor itself induces iNOS. Platelet activating factor $(PAF,\;10^{-7}\;M)$ inhibited PE $(10^{-7}\;M)-induced$ contraction. Pretreatment with L-NMMA (30 mM) or L-NAME (30 mM) significantly blocked the inhibitory action of PAF on PE-induced contraction. L-NMMA (100 mM) or L-NAME (100 mM) reduced nerve conduction velocity (NCV) relevant to nNOS in rat sciatic nerve. ACh attenuated the reduction of NCV by L-NMMA-, but not by L-NAME-induced reduction of NCV. These results suggest that L-NMMA and/or L-NAME have different action on three types of NOS in rats.

• The Korean Journal of Physiology and Pharmacology
• /
• 제7권3호
• /
• pp.125-130
• /
• 2003

The aim of this study was to provide a basis for studying the molecular mechanism of pharmacological action of chlorhexidine digluconate. Fluorescence polarization of n-(9-anthroyloxy)stearic acid was used to examine the effect of chlorhexidine digluconate on differential rotational mobility of different positions of the number of membrane bilayer phospholipid carbon atoms. The six membrane components differed with respect to 2, 3, 6, 9, 12, and 16-(9-anthroyloxy)stearic acid (2-AS, 3-AS, 6-AS, 9-AS, 12-AS and 16-AP) probes, indicating different membrane fluidity. Chlorhexidine digluconate increased the rate of rotational mobility of hydrocarbon interior of the cultured Porphyromonas gingivalis outer membranes (OPG) in a dose-dependent manner, but decreased the mobility of surface region (membrane interface) of the OPG. Disordering or ordering effects of chlorhexidine digluconate on membrane lipids may be responsible for some, but not all of its bacteriostatic and bactericidal actions.

• 대한예방한의학회지
• /
• 제17권1호
• /
• pp.107-116
• /
• 2013

Objectives : This study was aimed to facilitate mutual comprehension between Western and Traditional Korean Medicine (TKM) by analyzing recognition of medical school students on traditional medical prescription and treatment such as herbal medicines and acupuncture. Methods : We conducted a survey targeting medical school students of four medical schools from April through May 2009, and analyzed 208 cases responded. Results : Survey results revealed that medical school students took knowledge of traditional medicine from TV programs and on the Web in general. They thought they had considerable traditional medical knowledge but did not almost understand for professional contents. Regardless of some positive recognition for traditional herbal medicine, negative perspectives were more common and its safety and efficacy on the drug reference were considered as a major reason. On the other hand, recognition on acupuncture was comparatively positive. Scientific data for both herbal medicine and acupuncture are lacking in reality but the attitude only for acupuncture was different. Of the survey respondents, 57.8% had negative attitude against diagnostic methods of TKM and 59.1% opposed to the usage of modern medical equipments by TKM doctors. With regard to the future position of TKM, they tacitly approved that TKM would be absorbed into the complementary and alternative medicine (CAM) and importance of TKM objectification, followed by Government's support. Conclusions : Medical school students neither affirm nor deny TKM as a whole but the state of awareness for each item was similar to the physician. In terms of TKM its internal and external innovation would be required to continuously establish objectification of TKM prescription and scientific research on treatment technology.

• 한국생산제조학회지
• /
• 제22권3_1spc호
• /
• pp.573-579
• /
• 2013

Once-through helically coiled steam generator tubes subjected to external pressure are of interest because of their application to advanced small- and medium-sized integral reactors, in which a primary coolant with a relatively higher pressure flows outside the tubes, while secondary water with a relatively lower pressure flows inside the tubes. Another notable point is that the values of the mean radius to thickness ratio of these steam generator tubes are very small, which means that a thick-walled cylinder is employed for these steam generator tubes. In the present paper, the maximum allowable pressure of helically coiled and thick-walled steam generator tubes with through-wall cracks under external pressure is investigated based on a detailed nonlinear three-dimensional finite element analysis. In terms of the crack orientation, either circumferential or axial through-wall cracks are considered. In particular, in order to quantify the effect of the crack location on the maximum external pressure, these cracks are assumed to be located in the intrados, extrados, and flank of helically coiled cylinders. Moreover, an evaluation is also made of how the maximum external pressure is affected by the ovality, which might be inherently induced during the tube coiling process used to fabricate the helically coiled steam generator tubes.

• 한국식품조리과학회지
• /
• 제28권5호
• /
• pp.613-622
• /
• 2012

To develop the tailor made rice flour products for consumers with increasing functionality of pine needles, rice cupcakes were prepared with adding different contents of pine needle powder (PP) and extract (PE, by pressing pine needle). The physicochemical, textural, sensory properties, and antioxidative activities of rice cupcakes were investigated. The antioxidative activities of rice cupcakes with PP and PE were higher than those of the control and were significantly different with adding pine needle type (PP or PE). The specific volume of rice cupcakes increased with adding PP and PE, except for 10 g PP added cupcake. Textural properties were also significantly different with pine needle types and contents. On the sensory preference test data, the scores of the teens, the twenties, and the thirties were higher in PP added rice cupcakes (3 and 5 g added), but those in the forties, the fifties, and above the sixties were higher in PE added rice cupcakes (3 g added). From these above results, the PP addition improved the processing quality of rice cupcakes (under 10 g added), but reduced unique flavor of pine needle. It was suggested that rice products added with pine needle would be developed to consider consumer's age, type of pine needle and its content.

• 한국정보과학회논문지:정보통신
• /
• 제32권3호
• /
• pp.350-358
• /
• 2005

최근 VoIP 기술이 음성 관련 부가가치 서비스에 쉽게 적용될 수 있어 현재 각광을 받고 있다. 특히, 인터넷 전화 서비스가 기존 전화 서비스를 대체할 수 있어 이에 대한 관심이 커졌다. 인터넷 전화 서비스를 위한 시그날링 프로토콜로 ITU-T에서 정의한 H.323 프로토콜이나 IETF에서 정의한 SIP 프로토콜이 가능하다. 그러나, SIP가 H.323보다 복잡도가 낮고, 확장성이 높아 최근에는 SIP를 선호하는 추세이다. 따라서, 다양한 서비스를 개발하기 위한 SIP 구성요소의 확보가 중요하다. 그러나, 오픈 소스 코드는 기본적인 기능만을 제공하고 있고, 전체적인 구조가 하나로 묶여 있어 확장이 용이하지 않다. 특히, 사용자 에이전트는 VoIP 서비스에서 적용 가능한 다양한 여러 서비스가 결합되는 부분이다. 이는 SIP에서 정의한 사용자 에이전트의 동작(behaviour)을 지원하면서 다양한 여러 서비스의 기능을 제공할 수 있어야 하기 때문이다. 따라서, 본 논문에서는 SIP의 세부 기능에 독립적으로 다양한 서비스 창출이 가능하게 하기위한 사용자 에이전트의 구조 및 응용과의 인터페이스 방법, 사용자 에이전트에서 제공되어야 할 주요 기능 및 내부 처리 절차, 다양한 상호운용성 시험을 통해 도출된 안정화된 사용자 에이전트를 위한 점검 목록들을 제시하고자 한다.

• 인터넷정보학회논문지
• /
• 제7권1호
• /
• pp.131-141
• /
• 2006

최근 들어, 고에너지 물리학 등의 과학 기술이 고도로 발전함에 따라 실험 데이터 등이 대량으로 생산되고 있다. 따라서 이러한 데이터를 분산된 스토리지를 이용하여 저장하고 있으며, 이로 인해 지역적으로 분산된 자원을 하나의 자원처럼 사용 할 수 있는 환경이 요구되고 있다. 그러나 분산된 자원을 관리하는 대부분의 시스템은 다른 관리 시스템과 호환이 되지 않는다는 문제점을 가지고 있다. 데이터 그리드는 이러한 문제를 해결하고 있으며, 효율적인 데이터 관리를 위해 데이터 전송의 안전성과 신속성을 보장하는 GridFTP를 이용하고 있다. 그러나 이러한 툴의 사용은 병렬 전송 기술을 이용하기 때문에 네트워크 과부하가 발생할 가능성이 높으며, 많은 소켓연결을 생성한 응용 프로그램이 네트워크 대역폭의 대부분을 점유하는 문제점이 발생한다. 그러나 현재 병렬 전송 기술의 특성이나 문제점에 대한 분석이 이루어지지 않고 있으며, 특히, 소켓 연결들 간의 간섭 현상에 대한 분석이 이루어지지 않고 있다. 따라서 본 논문에서는 병렬 전송의 특성을 여러 실험 결과를 통하여 분석하고, 소켓 연결들 간의 간섭 현상을 분석한다. 응용 프로그램이 요구하는 네트워크 대역폭 확보를 위한 소켓 연결의 개수 계산과 새로운 소켓 연결에 의한 간섭 발생 이후 기존의 응용프로그램이 사용할 대역폭을 예측한다.

• 대한한의학회지
• /
• 제16권2호
• /
• pp.100-114
• /
• 1995

This bibliographic study was designed to research indications of the Moschus which was representatively used for resuscitation in acute stage of stroke throughout successive books of oriental medicine. Especially, in this study, severe cases with disturbance of consciousness and acute stage of stroke were investigated. The results were summarized as the followings: 1. The Moschus was dried material which secreted from aromatic vescicle of Moschus moschiferus L.. which was pungent in flavor, warm in nature, nontoxic and strongly aromatic. The Moschus removed the obstruction in the channels and used to early stage of stroke. 2. The Moschus was aromatic resuscitatable medicine, which recovered disturbance of consciousness due to stroke. 3. The Moschus had excitatory actions of respirtory center and vascular motor center, heart stimulating action, inhibitatory action of the platelet aggregation and anti thrombin action and recovered cerebral ischemic change. According to these actions, the Moschus could be used cerebral infarction. 4. Prescriptions included the Moschus was used to symptoms of unconsciousness, secretion, stuporous mental state, dysarthria, facial palsy and hemiplegia. That was Angungwoohwangh wan(安宮牛黃丸), Woohwangchungshimwon(牛黃淸心元), Sahyangsohaphangwon(麝香蘇合香元), etc. According to the above mentioned results, the Moschus was aromatic resuscitatable medicine which was used for symptoms of conscius disturbance, convulsion, sudden fainting etc., promoted cerebral blood flow and had good effect on acute stage of stroke and severe cases with conscious disturbance. Therefore, it is considered that the Moschus must be studied for effect of cerebral infarction and hemorrhage in clinic with animal's and pharmacological experimental results.