• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.23 no.1
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• pp.111-117
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• 2010

Objectives : This study was conducted to evaluate the acute toxicity and safety of Bangpungtongsung-san (Fangfengtongsheng-san) in Sprague-Dawley rat though the current regulatory guideline. Methods : The preliminary study showed that the single oral administration of Bangpungtongsung-san (Fangfengtongsheng-san) did not induce any toxic effect at a dose level of 2000 mg/kg. Based on the results, 2000 mg/kg was selected as the limited dose. In this study, 10 rats of each sex were randomly assigned to two groups of 5 rats each and were administrated singly by gavage at dose levels of 0 and 2000 mg/kg. Mortalities, clinical signs, and body weight changes were monitored for the 15-day period following administration. At the end of observation period, all animals were sacrificed and complete gross postmortem examinations were performed. Results : Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups. Conclusions : These results showed that the single oral adminstration of Bangpungtongsung-san (Fangfengtongsheng-san) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. In conclusion, the $LD_{50}$ of Bangpungtongsung-san (Fangfengtongsheng-san) was considered to be over 2000 mg/kg body for both sexes.

• Journal of Korean Neurosurgical Society
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• v.65 no.2
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• pp.276-286
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• 2022

Objective : Spinal cord stimulation (SCS) is an effective treatment for chronic neuropathic pain. However, its clinical efficacy in regard to specific types of pain has not been well studied. The primary objective of this study was to retrospectively analyze the clinical outcomes of paddle-type SCS according to the type of neuropathic pain. Methods : Seventeen patients who underwent paddle-lead SCS at our hospital were examined. Clinical outcomes were evaluated pre- and postoperatively (3 months, 1 year, and last follow-up) using the Neuropathic Pain Symptom Inventory (NPSI). The NPSI categorizes pain as superficial, deep, paroxysmal, evoked, or dysesthesia and assess the duration of the pain (pain time score). Changes in NPSI scores were compared with change in Visual analogue scale (VAS) scores. Results : After SCS, the pain time score improved by 45% (independent t-test, p=0.0002) and the deep pain score improved by 58% (independent t-test, p=0.001). Improvements in the pain time score significantly correlated with improvements in the VAS score (r=0.667, p=0.003, Spearman correlation). Additionally, the morphine milligram equivalent value was markedly lower after vs. before surgery (~49 mg, pared t-test, p=0.002). No preoperative value was associated with clinical outcome. Conclusion : The NPSI is a useful tool for evaluating the therapeutic effects of SCS. Chronic use of a paddle-type spinal cord stimulation improved the deep pain and the pain time scores.

• Journal of Microbiology and Biotechnology
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• v.33 no.9
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• pp.1197-1205
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• 2023

Osteoporosis, Greek for "porous bone," is a bone disease characterized by a decrease in bone strength, microarchitectural changes in the bone tissues, and an increased risk of fracture. An imbalance of bone resorption and bone formation may lead to chronic metabolic diseases such as osteoporosis. Wolfiporia extensa, known as "Bokryung" in Korea, is a fungus belonging to the family Polyporaceae and has been used as a therapeutic food against various diseases. Medicinal mushrooms, mycelium and fungi, possess approximately 130 medicinal functions, including antitumor, immunomodulating, antibacterial, hepatoprotective, and antidiabetic effects, and are therefore used to improve human health. In this study, we used osteoclast and osteoblast cell cultures treated with Wolfiporia extensa mycelium water extract (WEMWE) and investigated the effect of the fungus on bone homeostasis. Subsequently, we assessed its capacity to modulate both osteoblast and osteoclast differentiation by performing osteogenic and anti-osteoclastogenic activity assays. We observed that WEMWE increased BMP-2-stimulated osteogenesis by inducing Smad-Runx2 signal pathway axis. In addition, we found that WEMWE decreased RANKL-induced osteoclastogenesis by blocking c-Fos/NFATc1 via the inhibition of ERK and JNK phosphorylation. Our results show that WEMWE can prevent and treat bone metabolic diseases, including osteoporosis, by a biphasic activity that sustains bone homeostasis. Therefore, we suggest that WEMWE can be used as a preventive and therapeutic drug.

• Journal of Trauma and Injury
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• v.19 no.2
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• pp.178-182
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• 2006

Compartment syndrome has a wide spectrum from muscle pain to a life- threatening condition, such as acute renal failure and disseminated intravascular coagulation (DIC). Intracerebral hemorrhage (ICH) due to compartment syndrome has not been reported. We report a patient who presented with ICH leading to death. A 25-year-old female with no significant past history developed extensive compartment syndrome followed by rhabdomyolysis, acute renal failure, DIC, and ICH. Although the patient underwent a fasciotomy and hemodialysis and received aggressive resuscitation with massive transfusions of blood and intravenous fluids, she died. This case stresses the importance of early diagnosis and prompt treatment of compartment syndrome to prevent devastating complications.

• Journal of the Korean Society of Propulsion Engineers
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• v.11 no.6
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• pp.42-49
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• 2007

In this study, we analyzed flow characteristics of micro-nozzles for basic research to develop micro propulsion system. Cold gas propulsion system was used, and micro-nozzles having nozzle throat diameters of 1.0, 0.5, 0.25 mm were fabricated with EDM method. Thrust was measured through the use of plate-spring and strain gage based thrust measurement system, and flow characteristics of micro-nozzles were analyzed under ambient condition and vacuum condition. We used argon and nitrogen gases as propellant, and compared experimental results with CFD analysis. From the result, we verified the flow losses of viscosity and back-pressure caused by minimization of nozzle.

• Journal of the Korean Ceramic Society
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• v.53 no.1
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• pp.13-17
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• 2016

It is highlighted that increasing the adsorbent surface area on volumetric basis is very important in providing an easy access for gas molecules. Fine particles around $3{\mu}m$ of soft-burned dolomite kiln dust (SB-DKD) were hydrated to wet slurry samples by ball mill process and then placed in a chamber to use spray dryer method. Spherical granules with particle size distribution of $50{\sim}60{\mu}m$ were prepared under the experimental condition with or without addition of a pore-forming agent. The relationship between bead size of the pore-forming agent and size of SB-DKD particles is the most significant factor in preparation of spherical granules with a high porosity. Whereas addition of smaller beads than SB-DKD resulted in almost no change in the surface porosity of spherical granules, addition of larger beads than SB-DKD contributed to obtaining of the particles with both 15 times larger average pore volume and 1 order of magnitude larger porosity. It is considered that spherical granules with improved $N_2$ gas adsorption ability may also be utilized for other atmospheric gas adsorption.

• Bulletin of the Korean Chemical Society
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• v.33 no.2
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• pp.721-724
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• 2012

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.50 no.7
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• pp.313-317
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• 2001

This paper proposed a fuzzy logic cross coupled controller which can enhance the path tracking performance of optically guided AGV(Automated Guided Vehicle). The AGV follows the guide path, it cannot be avoid the deviation from the path due to the inevitable error and the deviation must be corrected. Optically guided AGV used in industrial area is controlled by On-Off controller generally, the experimental AGV has three optical sensors in front body. In this structure, we could not know the leaving distance accurately and steering angle from the guided line, so AGV could not be controlled properly with conventional controller in the case of increasing or decreasing velocity. If we mount additional sensors the AGV, we could know the leaving distance and steering angle from the guided line and proper error compensating methode can be applied. But because cost of sensors are high, the cost of total system is increasing. So, in this paper, to improve the tracking performance of AGV which has the minimum number of sensors and fuzzy logic cross coupled controller is proposed. Some simulations and experimental results are presented to illustrate the performance of the proposed controller.

• Proceedings of the KIEE Conference
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• 1996.07a
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• pp.15-17
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• 1996

In this paper, a modified microstep drive of PM step motor is presented. The open-loop drive of a step motor is attractive and widely accepted in applications of speed and position controls. However, the performance of the step motor is limited under the open-loop drive. The closed-loop control is advantages over the open-loop control not only in that step failure never occurs but that the motion is much quicker and smoother. However, a high resolution sensor is needed for detecting position and speed. The modified microstep drive is constructed as a microstep drive with speed feedback. The advantages of the proposed method is that the controller can be designed by a low resolution sensor and is simpler than other closed-loop controller. A concept of vector control is used for verifying the proposed scheme. Simulations show the performance of the proposed method and a comparison with a classic drive method.

• Journal of radiological science and technology
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• v.11 no.1
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• pp.17-23
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• 1988

As the reutilizing method of exhausted screen, authors used it as a filter and compared with the aluminium filtration. The results are as followed; 1. One sheet of gadolinium front screen has the same radiation absorption as $2.8{\sim}3.3\;mm$ Al equivalent and regular tungsten screen $2.3{\sim}2.7mm$ Al. 2. HVL after Gd-screen filtration was less than the values after aluminium and tungsten-screen filtration. And, image definition with Gd-screen filtration was better than other two cases. Ana surface dose to produce a same film density was more than other two cases. It will be very useful to apply, Gd-screen filter in clinics as it has no deficiency of image quality.