• 생물정신의학
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• 제2권1호
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• pp.91-99
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• 1995

A on-off study was designed to evaluate the effects of addition of transdermal esrtradiol to tricyclic antidepressants on depression level, vasomotor symptom(hot flush), sexual functions and hormonal status, plasma 5-hydroxyindoleascetic acid(5-HIAA) level in postmenopausal women with depression. Plasma level of estradiol, progesterone, LH, FSH, prolactin and 5-HIAA was measured by Time-resolved fluoroimmunoassay and HPLC(High Performance Liquid Chromatography). To asses their symptoms, the BDI(Beck Depression Inventory) and modified symptom scale, extracted from women's health questionnaire were used. Depression score, sexual function score were decreased by the last 4-weeks of addition of transdermal estradiol to antidepressant treatment, not Significant, but vasomotor symptom (hot flushes) score was decreased significantly(p<0.05) by the last 4-weeks of the given treatment. Thus, during addition of transdermal estradiol to antidepressants treatment, only vasomotor symptom(hot flushes) was improved significantly, but depression level was not changed in postmenopausal women with depression. Plasma FSH, estradiol and prolactin level was not changed in postmenopausal women with depression. Plasma FSH, estradiol and prolactin levels were increased by the last 4-weeks of the treatment. There were not significant correlations between clinical symptoms and plasma hormonal status and 5-HIAA level in baseline. After the last 4-weeks of transdermal estradiol treatment, the change of depression score was correlated significantly with change of serum prolactin and 5-HIAA level and the change of vasomotor symptom score was correlated significantly with the change of plasma prolactin level.

• 한국콘텐츠학회논문지
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• 제18권10호
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• pp.657-668
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• 2018

이 연구의 목적은 비혼모가 되기 전 삶과 출산 전 양육비혼모 삶의 경험에 대하여 구조와 본질을 심층적으로 알아보고 이해하기 위함이다. 비혼모 10명을 대상으로 심층개별면담을 통하여 자료를 수집한 후, Colazzi의 현상학적 연구방법을 이용한 질적 연구를 하였다. 연구결과 '상처로 얼룩진 시절' 주제모음은 비혼모가 되기 전 어린 시절 단절된 가족관계와 가족기능의 해체로 인하여 부모에게 버림받거나 보호받지 못한 삶의 경험으로 나타났다. '위태로운 일상' 주제모음은 비혼모들의 이른 학업중단과 가출은 위태로운 생활로 이어졌다. 또한 무분별한 성문화와 낮은 성인식, 태도는 성을 일찍 경험하는 것으로 나타났다. '당혹스러운 임신사실' 주제모음은 비혼부의 피임 거부와 비혼모의 부정확한 피임지식과 피임방법 사용은 원치 않은 임신으로 나타났다. 마지막 주제모음 '힘들게 결정한 출산'은 임신사실을 너무 늦게 인지하여 어쩔 수 없는 출산을 선택하기도 하지만 생명의 소중함을 느껴 낙태를 거부하고 출산을 결정하는 것으로 나타났다. 이상의 연구결과를 바탕으로 비혼모를 대상으로 성교육을 강화 할 뿐 아니라 남성을 대상으로 정확한 피임지식과 방법을 제공하는 성교육 실시의 필요성을 논의하였다.

• Mycobiology
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• 제43권1호
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• pp.31-36
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• 2015

We have previously isolated ${\varepsilon}$-COP, the ${\alpha}$-COP interactor in COPI of Aspergillus nidulans, by yeast two-hybrid screening. To understand the function of ${\varepsilon}$-COP, the $aneA^+$ gene for ${\varepsilon}$-COP/AneA was deleted by homologous recombination using a gene-specific disruption cassette. Deletion of the ${\varepsilon}$-COP gene showed no detectable changes in vegetative growth or asexual development, but resulted in decrease in the production of the fruiting body, cleistothecium, under conditions favorable for sexual development. Unlike in the budding yeast Saccharomyces cerevisiae, in A. nidulans, over-expression of ${\varepsilon}$-COP did not rescue the thermo-sensitive growth defect of the ${\alpha}$-COP mutant at $42^{\circ}C$. Together, these data show that ${\varepsilon}$-COP is not essential for viability, but it plays a role in fruiting body formation in A. nidulans.

• 한국어류학회지
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• 제24권4호
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• pp.263-271
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• 2012

암컷의 배우자 선택은 여러 수컷들이 가지고 있는 다양한 특성에서 각기 다른 종류의 정보를 수집, 종합하여 가장 최적의 개체를 배우자로 결정하는 매우 복잡한 행동이다. 본 연구에서는 순차적인 교배 시스템($4{\times}4$ block breeding)을 이용하여 각시붕어(Rhodeus uyekii) 암컷의 배우자 선택방식을 조사하였고, 가중과 비가중 유전적 이득의 상대적 기여도를 추정해 보고자 하였다. 실험장치 내에서 총 48회의 암, 수간 배우자 상호작용이 관찰되었고, 암컷은 일반적으로 카로티노이드 혼인색 발현이 강한 수컷들을 배우자로 선호하는 것으로 나타났다. 하지만, 배우자 선호 정도가 개체에 따라 차이가 나타나므로, 비가중적 요소도 암컷이 배우자를 선택하는데 있어 기여를 할 것으로 예상된다.

• 한국가금학회지
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• 제46권4호
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• pp.287-296
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• 2019

Avian sex determination system involves the male ZZ and female ZW chromosomes. However, very few studies are reported the expression, functional role and importance of genes on the W chromosome because of its small and highly heterochromatic genomic regions. Recent studies demonstrated that the W chromosome may have critical roles in physiology, sex determination and subsequent sexual differentiation in chickens. Therefore, gene annotation, including describing the expression and function of genes in the chicken W chromosome, is needed. In this study, we have searched the W chromosome of chickens and selected a total of 36 genes to evaluated their specific expression in the testis and ovary at various developmental stages such as embryonic day 6 (E6), hatch and adult. Interestingly, out of 36 genes in chicken W chromosome, we have found seven female-specific expression at E6.5 day, indicating that they are functionally related to female chicken gonadal differentiation. In addition, we have identified the stage specific gene expression from the sex specific genes. Furthermore, we analyzed the relative location of genes in the chicken W chromosome. Collectively, these results will contribute molecular insights into the sexual determination, differentiation and female development based on the W chromosome.

• 한국콘텐츠학회논문지
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• 제13권9호
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• pp.455-466
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• 2013

본 연구의 목적은 지능형 로봇 IrobiQ를 활용한 유아용 학교폭력 예방교육 프로그램 [모두 지킴이]를 개발하는 것이다. 개발 내용은 첫째, 현장에서 실제 발생될 수 있는 폭력 유형인 집단 따돌림(왕따), 성폭력 그리고 기본 인성교육이다. 둘째, 각 주제에 적합한 활동형태는 대집단, 개별, 소집단, 자유선택활동 및 학교와 부모의 연계를 목적으로 하는 부모교육이다. 셋째, 활동유형은 동시, 동화, 동요, 미술, 이야기 나누기 등이다. 넷째, 콘텐츠는 이미지, TTS(text to speech), 터치기능, 음량인식기능 및 녹음기능 등을 활용하여 제작하였다. 본 콘텐츠를 유아에게 적용하고 30명의 전문가들을 대상으로 시연하여 수용성 설문을 실시한 결과, 긍정 반응을 보였다. 본 연구의 결과는 로봇을 활용한 학교 폭력 예방 프로그램의 효과를 최적화하기 위한 기초 자료로서 상호 작용성을 보다 증진시킬 수 있는 추후 연구를 제안한다.

• International Journal of Industrial Entomology and Biomaterials
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• 제23권1호
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• pp.143-146
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• 2011

Some of men have been suffered from the insufficient secretion of testosterone causing by physical factors, social and psychological factors. Testosterone is an essential steroid hormone controlling male reproductive function. Alternative medicines in plants, fungi, and insects have been studied to enhance sexuality. $Cordyceps$ species including $Cordyceps$ $sinensis$ (CS) and $C.$ $militaris$(CM) has been used as for the enhancement of sexual functionfor hundreds of years in Far East Asian. In the present study, we determined the effect of fruiting bodies of $C.$ $militaris$ which cultured on bee drone medium (CMD) and brown rice medium (CMB) on testosterone concentration in Sprague-Dawley rats. Eighteen rats per group were housed to regular diet or diet supplemented with CMB and CDD, respectively for 4 weeks. Serum was collected from 6 rats per group. Results showed that changes of the body weight, food and water intake of the rats were not observed in this study. However, both CMB and CDD increased the serum testosterone concentration in rats. Furthermore, CMD significantly stimulated testosterone production (p <0.05) compared to the control. Hence, it suggests that $C.$ $militaris$ fruiting bodymight be developed as a complementary medicine to improve sexual hormones.

• Journal of Ginseng Research
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• 제23권4호
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• pp.247-256
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• 1999

Ginseng has been used in maintaining physical vitality throughout the far-eastern countries and recently its metabolism and actions on neurologic, cardiovascular, and endocrinologic systems are studied. Korean red ginseng (KRG) has been used in various ailments, and to prove its efficacy for erectile dysfunction an international study on Asians other than Korean was performed. Patients with borderline organic and psychogenic erectile dysfunction were included. KRG were given daily, and placebo were given as controls. Treatment lasted a total of 3 months. Surveys including libido, erection, ejaculation, sexual activity, and sexual satisfaction were given. Serum testosterone and erectile function study were taken. Among the 64 patients, 37 patients were followed with KRG. Five had diabetes, 5 hypertension, 5 hypercholesterolemia, 6 low testosterone, 6 psychogenic, and 11 idiopathic. The improvement after KRG administration was $70.2\%$ on objective questionnaire and $75.7\%$ on subjective analysis. When KRG were given, all parameters surveyed have shown improvements compared to the placebo. The effects of KRG in Chinese and Singapores were similar to the Koreans. Serum testosterone levels were nonnalized in 6 patients with KRG, who's serum testosterone levels were reduced from pre-study. Two patient reported constipation, and 2 gastric upsets in the KRG group. In conclusion, KRG has beneficiary action on male erectile capabilities with little side effects. KRG is effective in Koreans and also Asians. The exact action mechanism and the active ingredients in KRG need to be studied.

• Clinical and Experimental Reproductive Medicine
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• 제49권1호
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• pp.9-15
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• 2022

The angiotensin-converting enzyme 2 receptor (ACE2) appears to be widely expressed in cells in the testes, predominantly in spermatogonia, Sertoli cells, and Leydig cells, and its co-expression with transmembrane protease serine 2 (TMPRSS2) is essential for the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For this reason, the male reproductive system could be considered a potential target for SARS-CoV-2, as well as a possible reservoir of infection. However, to date, there is very little evidence about the presence of SARS-CoV-2 in semen and testicular samples. The aim of this paper was to review the current evidence regarding the impact of SARS-CoV-2 on male fertility and sexual health, with a particular focus on reproductive hormones, the presence of the virus in seminal fluid and testis, and its impact on fertility parameters. We found very limited evidence reporting the presence of SARS-CoV-2 in semen and testicular samples, and the impact of SARS-CoV-2 on reproductive hormones and fertility parameters is unclear. The quality of the examined studies was poor due to the small sample size and several selection biases, precluding definitive conclusions. Hence, future well-designed prospective studies are needed to assess the real impact of SARS-CoV-2 on male reproductive function.

• 한국심리학회지:법
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• 제12권3호
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• pp.323-341
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• 2021

본 연구는 우리나라 성인 522명을 대상으로 지적장애인 성범죄 하급심 판결문에서 인용된 감경 사유에 대한 동의 여부 및 법정 형량의 적절성에 대한 온라인 설문조사를 실시하였다. 전체 응답자의 약 80%은 현행 지적장애인 성범죄 법정 형량을 적절하다고 판단하는 것으로 나타났다. 다만, 동의하지 않는 경우 현재보다 더 엄벌이 필요하다고 인식하였다. 거의 대부분의 응답자는 피고인의 '연령', '건강 상태', '사회경제적 수준', '성장배경 및 가정환경'과 같은 일신상의 이유 또는 범행이 '음주', '성적 충동', '우발적'으로 발생했다는 점을 감경 사유로 사용하는데 있어 동의하지 않았다. 반대로 '자수', '미수', '피고인의 지적장애', '진지한 반성' 등을 감경 사유로 사용하는데 있어서 동의 비율은 상대적으로 높았으나, 여전히 응답자의 절반 이상은 동의하지 않는 것으로 나타났다. 성별과 학력에 따른 감경사유 인식의 차이는 존재하지 않았다. 반면 응답자의 연령이 낮을수록 감경에 대해 더 엄격한 태도를 갖는 것으로 나타났다. 마지막으로 본 연구는 국민들의 의견이 반영된 양형기준의 필요성을 제안하였다.