• 운동영양학회지
• /
• 제13권1호
• /
• pp.9-14
• /
• 2009

The effects of a hypocaloric diet with or without strength training on body fat distribution and serum lipid concentrations in obese elderly women were investigated. Twenty-six healthy women (age 66±4.6 yr; body mass index 32.3±2.9 kg/m²) were randomly assigned to 3 groups: control (C; n=8), hypocaloric diet (DO; n=9) or hypocaloric diet with strength training (DST; n=9). Subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and inter and intra muscular adipose tissue (IMAT) were measured using magnetic resonance imaging. Serum lipid concentrations including total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), and triglycerides (TG) were measured. No significant changes occurred in body weight and percent body fat in the C group over the 16-week period. The DO and DST groups lost similar amounts of weight and fat after 16 weeks. SAT and VAT decreased after weight loss in the DO and DST groups but not in the C group. IMAT was significantly reduced in the DO and DST groups, whereas in the C group IMAT increased. The loss in IMAT mass was similar in the DO and DST groups. TC and LDLC decreased in the DO and DST groups but not in the C group. There were no differences between the DO and DST groups in decrease in TC and LDLC. HDLC decreased in the DO group but not in the C and DST groups. TG tended to decrease in the DST group. In conclusion, body fat distribution including SAT, VAT, and IMAT and serum lipid concentratons were modulated by weight loss resulting from the hypocaloric diet with or without strength training in obese elderly women. Strength training did not enhance the improvement in body fat distribution and serum TC and LDLC concentrations by the hypocaloric diet.

• 한국식품영양과학회지
• /
• 제27권4호
• /
• pp.718-723
• /
• 1998

This study was designed to observe the effects of the feeding of Hijikia fusiforme(Harvey) Okamura juice extract on the improvement of lipids in the serum of cholesterol-supplemented diet induced dietary hyperlipidemic rats fed experimental diets for 4 weeks. Concentration of total cholesterol and LDL-choloesterol in serum was significantly lower in the Hijikia fusiforme juice extract group than in the cholestero diet group. Concentration of HDL-cholesterol in serum was higher in the Hijikia fusiforme juice extract group than the cholesterol supplemented diet group. Those in the Hijikia fusiforme juice extract group were higher than those in the cholesterol diet group. In the ration of HDL-cholesterol concentration to total cholesterol concentration, Hijikia fusiforme juice extract administration group was higher percentage than the other groups. Atherosclerotic index was lower in the Hijikia fusiforme juice extract group than in the cholesterol diet group. Concentration of free cholesterol and cholesteryl ester in serum was rather lower in the Hijikia fusiforme juice extract group than the other groups. Triglyceride concentration in serum was significantly lower in the Hijikia fusiforme juice extract group than in the cholesterol diet group. Concentration of phospholipid in serum was more decreased in the Hijikia fusiforme juice extract group than in the cholesterol diet group. The activities of aspartate aminotransferase and alanine aminotransferase in serum were rather lower in the Hijikia fusiforme juice extract group than the cholesterol supplemented diet group. From the avove research, the Hijikia fusiforme juice extracts were effective on the improvement of the lipid compositions in serum of high fat diet induced dietary hyperlipidemic rats.

• 대한지역사회영양학회지
• /
• 제10권3호
• /
• pp.253-263
• /
• 2005

This study was conducted to investigate health status of preschool children utilizing anthropometric values and serum biochemical indices. The subjects were 1,159 boys and 1,019 girls in Gumi day-care centers aged 4 to 6 years. The mean height and weight of 4, 5 and 6 year old children were 103.0 cm and 17.1 kg, 107.2 cm and 18.3 kg and 113.4 cm and 20.6 kg, respectively. By the obesity index criteria, $5\%$ of boys and $4\%$ of girls were obese whereas $10\%$ of boys and $9\%$ of girls were underweight. By the Kaup index criteria, $7\%$ of boys and $4\%$ of girls were obese. By the percentage of body fat criteria, $5\%$ of boys and girls were obese. The mean concentrations of serum total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, Atherogenic Index and serum glucose were 154.1-156.5 mg/dL, 80.1-81.9 mg/dL, 46.8-47.4 mg/dL, 90.9-92.8 mg/dL, 2.34-2.39 and 76.4-77.8 mg/dL, respectively. Serum triglyceride level, AI and body fat percentage of obese children were significantly higher than other children and were significantly lower in HDL-cholesterol level (p < 0.05). In addition there were significant correlation between anthropometric values and serum biochemical indices : Kaup index and obesity index were positively correlated to the systolic blood pressure and diastolic blood pressure in boys and girls (p < 0.01) and to the triglyceride concentration in boys (p < 0.05). These results indicate the need of developing and implementation of nutrition education program for preschool children to prevent further development of childhood obesity and to maintain normal serum lipid profiles.

• 동아시아식생활학회지
• /
• 제20권1호
• /
• pp.46-53
• /
• 2010

The study examined the effects of dietary green tea powder supplementation on blood glucose, and plasma and liver lipid concentrations in diabetic rats. Twenty-five male Sprague-Dawley rats (body weight $200{\pm}5\;g$) were divided into two groups (diabetic and non-diabetic), which were each randomly divided into two subgroups that were fed a control and 1% green tea powder-supplemented diet. Serum and liver lipid concentrations were measured by established techniques. Low density lipoprotein-cholesterol (LDL-C) was calculated from an established equation. Body weight gain and feed efficiency ratio were lower in diabetic rats than in non-diabetic rats regardless of diet. There were no differences in weight gain in diabetic and non-diabetic rats consuming the control and green tea powder-supplemented diets. The levels of fasting plasma glucose, serum total cholesterol, triglyceride, LDL-C and atherogenic index of diabetic rats were significantly higher than that of non-diabetic rats. Conversely, the levels of high density lipoprotein-cholesterol (HDL-C) of diabetic rats was significantly lower than that of non-diabetic rats. Fasting plasma glucose, serum total cholesterol, triglyceride, LDL-C and atherogenic index were significantly lower in diabetic rats fed the green tea powder diet than in rats fed the control diet, and HDL-C was significantly higher in rats fed the green tea powder diet than in rats fed the control diet. The content of liver total cholesterol and triglyceride of diabetic rats were significantly higher than that of non-diabetic rats. Liver total cholesterol and triglyceride were significantly lower in diabetic rats fed green tea powder-supplemented diet than in rats fed the control diet. It is concluded that green tea powder supplementation positively influences blood glucose and lipid metabolism in diabetic rats. The present study, although not directly applicable to humans, may have some implications for individuals who habitually consume green tea powder.

• 생명과학회지
• /
• 제14권4호
• /
• pp.531-536
• /
• 2004

신령버섯 균사체 액체배양액이 고콜레스테롤 식이를 섭취한 흰쥐의 지질대사에 미치는 영향을 조사하고자, 생후 7주령의 숫쥐에 표준식이를 급여한 정상군, 표준식이에 15% 돈지와 0.5% 콜레스테롤을 첨가한 식이를 급여한 대조군, 대조식이에 신령버섯 균사체 액체배양액을 음료수에 30% 및 40%로 혼합 급여한 군(30% 및 40% 신령버섯군) 등 4군으로 나누어 6주간 사육한 결과는 다음과 같다. 실험동물의 체중 증가량, 식이섭취량 및 식이효율은 대조군과 30%와 40% 신령버섯군이 유사하였다. 간, 신장 및 부고환지방의 무게는 대조군과 신령버섯군들이 비슷하였다 간의 콜레스테롤 농도, 간과 혈청의 중성지질 농도는 대조군과 신령버섯군들이 비슷한 수준으로 감소효과가 나타나지 않았다. 혈청의 총 콜레스테롤과 LDL-콜레스테롤 농도 및 동맥경화지수는 대조군에 비해 30% 및 40% 신령버섯군이 유의하게 감소되었다. 총콜레스테롤에 대한 HDL-콜레스테롤의 비율은 대조군에 비해 신령버섯군들이 유의하게 증가되었다. HDL-콜레스테롤 농도는 대조군과 신령 버섯군들이 비슷한 수준으로 신령 버섯섭취에 따른 영향은 나타나지 않았다. 분으로 배설된 지방은 대조군에 비해 40% 신령버섯군이 유의하게 증가되었다. 이상의 결과로 보아 고콜레스테롤 식이를 급여한 흰쥐에 신령버섯 균사체 액체배양액을 30%나 40% 급여시 혈청의 총 콜레스테롤, LDL-콜레스테롤 농도 및 동맥경화지수를 낮추고, 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율을 증가시키는 것으로 나타났다.

• 한국산학기술학회논문지
• /
• 제15권8호
• /
• pp.5009-5022
• /
• 2014

본 연구는 한 대학병원 건강검진센터에서 종합건강검진을 받은 일반 성인들을 대상으로 생활습관에 따른 혈청지질치의 수준을 알아보고, 생활습관 인자들이 혈청지질치에 미치는 영향을 파악하고자 하였다. 조사대상은 2012년 1월부터 2013년 12월까지의 기간에 대전광역시에 소재하고 있는 C대학교병원 건강검진센터에서 건강검진을 받았던 4,112명을 대상으로 하였다. 자료 수집은 건강검진 시에 수검자들에게 배포하여 기입하도록 한 문진표와 건강검진결과표로부터 인구사회학적 특성, 생활습관 및 혈청지질치 등의 자료를 수집하여 분석하였다. 연구결과, 조사대상자의 TC, HDL-C. LDL-C 및 TG 등의 혈청지질치나 동맥경화지수(AI)의 평균치는 남녀 모두 연령, 음주, 흡연, 규칙적인 운동, 과식 및 육류섭취 등의 생활습관 특성에 따라 유의한 차이를 보였다. 조사대상자의 TC, HDL-C. LDL-C, TG 및 AI는 남녀 모두 연령, AUDIT점수와 유의한 양의 상관관계를 나타낸 반면, HPI점수와는 유의한 음의 상관관계를 보였다. 조사대상자의 혈청지질치에 대한 생활습관의 영향요인으로 TC, HDL-C. LDL-C, TG 및 AI가 비정상치에 속할 위험비는 남녀 모두 과식을 매일 한다는 군, 육류섭취를 매일 한다는 군, 흡연군, 규칙적인 운동을 하지 않는다는 군, HPI가 낮은 군에서 그렇지 않다는 군보다 유의하게 증가하였다. 이상과 같은 결과는 조사대상자의 혈청지질치나 AI는 연령증가와 함께 음주, 흡연, 규칙적인 운동, 과식 및 육류 섭취 등의 생활습관 특성에 따라 영향을 받고 있음을 시사한다.

• Journal of Nutrition and Health
• /
• 제36권9호
• /
• pp.924-932
• /
• 2003

In middle-aged men, abdominal obesity has been an important risk factor of coronary artery disease (CAD) as well as a predictor of hypertension, dyslipidemia, insulin resistance and glucose intolerance. Particularly, risks from abdominal obesity increase when adipose tissue accumulates in visceral compartment. Many studies showed that weight reduction by caloric restriction improves abdominal obesity and reduces lots of cardiovascular risk factors. Testosterone treatment also results in a significant decrease in visceral fat area and normalizes endocrine metabolism. However there is no study that compare the effect of caloric restriction with that of testosterone treatment. The purpose of this study is to investigate the effect of caloric restriction and that of testosterone treatment on body fat distribution, serum lipids and glucose metabolism in male patients with CAD. Forty five middle-aged overweight-obese men with CAD participated in 12 weeks' program. They were matched with age, body weight, body mass index (BMI) and divided into three groups : control group (n = 15) , caloric restriction group (-300 kcal/day, n = 15) and testosterone treatment group (testosterone undecanoate tablets, n = 15) . After 12 weeks, control group did not have any changes in anthropometries, lipid profile, body fat distribution, glucose metabolism and hormonal status. Expectedly, caloric restriction group showed decreases in body weight, BMI, waist to hip ratio, ％ body fat. Ten percentage of total cholesterol and 23% of triglyceride in serum were also decreased. In body fat distribution, total fat areas at both L1 and L4 levels were significantly reduced in this group without reduction in muscle of thigh and calf. However, testosterone treatment group did not have any significant changes in body weight, ％ body fat, serum lipid profile and abdominal fat distribution. In conclusion, weight reduction by caloric restriction is more beneficial in body fat distribution and serum lipid level than testosterone treatment in overweight male patients with CAD. This result suggests that modest weight reduction is possible to help decrease risk factors of CAD.

• 한국식품영양과학회지
• /
• 제27권2호
• /
• pp.313-318
• /
• 1998

This study investigated the effect of raw soybean yellow(RSY) and raw soybean black(RSB) on body weights, pancreas weights, serum glucose and lipid concentrations of boty normal and diabetic male rats(Sprague-Dawley, body weight 338.8$\pm$19.2g). For each experimental, some rats were injected with streptozotocin intraperitoneal(i.P.) to induce diabets, and other rats were injected with buffer i.P. as a control group. Body weight gain(BWG) was lower in rats fed both RSY and RSB diet(3.4~5.0g BWG) than in those fed control diet(58.1g BWG). The diabetic rats showed significant decrease of bo요 weight (-50~-67g) compared with the control rats. RSY and RSB feeding resulted in greater pancreatic weight relative to body weight, and diabetic rats fed RSY and RSB had heavier pancreatic weights relative to body weight than control rats. The levels of fasting serum glucose in diabetic rats fed both RSY and RSB decreased by 42 and 31%, respectively, compared with the diabetic control rats, but they increased by 80 and 110% compared with the normal control rats. The concentrations of total lipid, triglyceride, phospholipid and total cholesterol in serum of diabetic rats fed RSB diet were lower than those in control rats, but serum HDL-cholesterol, HDL-cholesterol/total cholesterol ratio were not affected by raw soybeans feeding. Atherogenic index wa lower in diabetic rats fed RSY and RSB diet than those in control rats. The concentrations of total lipid, triglyceride and phospholipid in liver were lower in raw soybean groups than those in control group. The concentrations of cholesterol in liver of groups treated raw soybean were decreased compared with the control group.

• Journal of Periodontal and Implant Science
• /
• 제49권2호
• /
• pp.105-113
• /
• 2019

Purpose: An unresolved inflammatory state contributes to the pathogenesis of periodontal disease and metabolic syndrome (MetS). Therefore, the purpose of this study was to evaluate the role of lipoxin A4 (LXA4), a proresolving lipid mediator, in the association between periodontal disease and MetS. Methods: Sixty-seven patients with MetS and 65 patients without MetS were included in the study. Sociodemographic information was obtained via a questionnaire, and detailed medical diagnoses were made. Periodontal parameters (plaque index [PI], gingival index [GI], probing pocket depth [PD], and clinical attachment level [CAL]) and metabolic parameters were measured, and serum LXA4 levels were determined. The associations among MetS, periodontal parameters, and serum LX levels were evaluated by adjusted multivariate linear regression analyses. Results: Patients with MetS were older and had a higher body mass index than patients without MetS. Periodontal parameters (PI, GI, PD, and CAL) were higher in patients with MetS than in those without MetS. Serum LXA4 levels were higher in patients without MetS. Multivariate linear regression analysis indicated a positive association between MetS and periodontal parameters (PD and CAL). Negative associations were established between MetS and LXA4 levels, and between LXA4 and periodontal parameters (PI, PD, and CAL). Conclusions: The presence of higher values of periodontal parameters in patients with MetS and the negative relationship of LXA4 with MetS and periodontal disease may support the protective role of proresolving lipid mediators in the association between periodontal disease and MetS.

• Clinical and Experimental Pediatrics
• /
• 제46권3호
• /
• pp.217-223
• /
• 2003

목 적 : 소아 및 청소년 비만은 매년 증가되고 있는 추세이다. 소아와 청소년기라는 특성을 고려할 때 비만을 진단하는 기준 중, 어떤 기준을 적용하는 것이 비만아 선별검사에 좀더 유용한가에 대해 알아보고, 이렇게 선별된 비만아에서 비만과 관련된 여러 심혈관계 성인병 발생 위험 인자 중 조기에 예측 가능한 인자를 알아내어, 어떠한 인자가 추적관찰에 유용한지 알아보았다. 방 법 : 2001년 7월부터 11월까지 한국건강관리 협회와 인천광역시 교육청 주관으로 비만도 20% 이상인 중 고등학생 2,814명(남 : 녀=2,011 : 803)을 대상으로 하여 체중, 신장, 신체측정, 혈청지질(총 콜레스테롤, 혈청지질, HDL 콜레스테롤, LDL 콜레스테롤)을 측정하였다. 결 과 : 비만도 20% 이상인 중고생에서 BMI 95 백분위수 이상은 86.6%였으며, 체지방 기준에 의한 비만은 93.2%, 피하지방 두께에 의한 비만은 45.6%였다. BMI에 따른 비만아 중 고콜레스테롤혈증은 남아 21.0%, 여아 21.4%를 보였고, 비만도에 따라 나눈 남아 20.7%, 여아는 19.2%로 BMI와 큰 차이를 보이지 않았다. BMI에 따라 판정된 비만아를 세분하여 제 I도 과체중(고위험군, group I), 제 II도 과체중(비만, group II), 제 III도 과체중(과비만, group III)으로 나누어 보면, 남아에서는 고중성지방의 빈도가 group I에서는 15.0%, group II에서는 23.2%, group III은 34.5%로 비만할수록 더욱 증가하였고, 여아에서는 group I에서는 11.8%, group II는 20.7%, group III은 28.2%였다. 비만도에 의하면 남아에서 경도비만은 17.2%, 중증도 비만은 29.2%, 고도비만은 39.7%였고, 여아에서는 10.0%, 19.5%, 29.8%였다. 결 론 : 본 연구에서는 청소년기의 비만시 혈청지질 검사를 BMI만으로 하였을 경우 10.0-17.0%의 누락을 보였으므로 BMI 기준에 의한 혈중 지질의 측정은 한계가 있었다. 또한, 비만할수록 높아지는 고지혈증의 빈도는 비만도에 의한 것이 BMI보다 더 잘 반영하였다. 따라서 성인병 선별검사는 비만도에 의한 것이 좀더 누락율을 줄일 수 있을 것으로 사료된다. 심혈관 질환발생 위험 예측인자로는 남녀 모두 비만할수록 중성지방이 증가하여 중성지방이 관련 있는 것으로 나타났다.