• Nutritional Sciences
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• 제6권4호
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• pp.209-215
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• 2003

This research was performed to investigate the effects of the supplementation of multi-extracts of mori folium (MF) and of exercise on blood lipid profiles and tissue differentiation in streptozotocin (STZ)-induced diabetic rats. The animal groups consisted of a normal-control group, a STZ-control group, three STZ-induced diabetic groups supplemented ad libitum with various amounts of MF extracts (MF-720, MF-360, and MF-180 groups), and a STZ-induced diabetic group supplemented with MF-360 combined with exercise; eight male Sprague-Dawley rats, 4 weeks old, were assigned to each experimental group and were raised in the laboratory for a 10 week experimental period. The MF supplementation group showed a significant reduction in levels of serum total cholesterol and triglyceride compared to the STZ-control group. HDL-cholesterol levels were significantly increased in the MF supplementation group compared to STZ-control group. The ratio of HDL-cholesterol to total cholesterol was significantly higher in MF supplementation group compared to the STZ-control group. The Atherogenic Index (AI) values in the MF supplementation groups were found to be significantly lower than in the STZ-control group. Serum AST and ALT levels were significantly reduced in the MF-supplementation groups compared to the STZ-control group. Total cholesterol level in the liver tissue was significantly decreased in the MF-360 group and in the MF-360 + exercise group compared to the STZ-control group. In immunohistochemical staining of the pancreatic islets of the MF-supplemented groups, a significantly higher number of insulin-immunoreactive cells were observed compared to the STZ-control group. In the MF supplementation groups, Bowman's capsules were clearly observed as hypertrophy of the glomeruli was not obvious. In the MF supplementation groups, a relative reduction in the hypertrophy of the basement membrane of the glomeruli and a significant reduction in the mesangium were observed compared to the STZ-control group. The results of this study suggest that supplementation of MF has beneficial effect in improving plasma lipid and tissue metabolism in streptozotocin-induced rats.

• 대한지역사회영양학회지
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• 제12권2호
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• pp.142-149
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• 2007

To evaluate the seasonal differences of nutrient intake and serum biochemical indices (total cholesterol, HDL-, LDL- cholesterol, TG, MDA : malondialdehyde, TAS : total antioxidant status, folate) in Korean college women with a mean age of 20.15y, this study was conducted twice: once in winter and a second time in summer. Anthropometric assessment was also measured in the two seasons. As a result body fat mass (p<0.05), body fat% (p<0.05), and abdominal fat% (p < 0.01) in the summer were significantly lower than those in winter. Intake of fat (p < 0.05), polyunsaturated fatty acid (p < 0.01), zinc (p < 0.05), and vitamin E (p < 0.05) were at significantly higher levels in the summer period compared with the winter period. In addition, nutrients with an intake level less than 75% RI of KDRIs were folate in winter and calcium, and folate in the summer. Total cholesterol (p < 0.05) and HDL-cholesterol in summer, according to lipid profiles, were significantly lower than those in winter. Although MDA, one of the products of lipid peroxidation, remained unchanged, TAS was significantly higher in summer than in winter. The level of folate in summer showed significantly lower than that in winter. The present study suggests that nutrient intake of college women women differs according to the seasons and anthropometric indices and serum biochemical indexes were associated with seasons. Thus nutritional education programs on the basis of season are needed for college women.

• Journal of Nutrition and Health
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• 제36권8호
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• pp.834-840
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• 2003

지방간 소견을 나타낸 12인의 피검자를 대상으로 하여 3개월간 1일 2회, 아침과 저녁 식사를 생식으로 대용시킨 후 3개월후 혈액 및 신체계측 조사를 통하여 생식의 지방간 개선 효과를 관찰하였다. 그 결과 생식 섭취 3개월후 체지방 양 및 체중의 감소가 나타났으며, 간손상의 지표로 사용되는 AST, ALT, r-GTP 및 ALP의 활성이 모두 유의적으로 저하되는 모습이 관찰되어 생식의 섭취가 지방간을 개선시키는데 유용한 도구가 될 수 있는 것으로 판명되었다. 생식의 지방간 개선 기작을 탐구하기 위하여 고지방 사료를 통하여 흰 쥐에게 고지혈증을 유도한 이후 생식을 6주간 섭취시킨 결과에서도 실험 동물의 혈중 콜레스테롤, 중성지방의 농도가 모두 낮아지는 것으로 나타나 생식 섭취가 체내지질 대사의 정상화에 기여하는 능력이 있는 것으로 판단되었다. 지방간은 다양한 원인에 의해서 발생되나 그 중 가장 중요한 인자는 체내 높은 지방 함량이라 할 수 있으며, 생식의 섭취는 체내 지질 대사를 정상화함으로서 지방간의 개선에 높은 효과를 발휘 할 수 있을 것으로 추측된다.

• 한국환경과학회지
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• 제22권3호
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• pp.341-346
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• 2013

The purpose of this study was to assess the effects of Cordyceps militaris extract supplementation on the improvement of blood glucose, lipid compositions and hepatic functional enzyme activities in the serum of streptozotocin(STZ, 50 mg/kg BW, IP injection)-induced diabetic rats fed the experimental diets for 5 weeks. The concentrations of blood glucose and lipid compositions(total cholesterol, ${\beta}$-lipoprotein, free cholesterol, cholesteryl ester, triglyceride and phospholipid) and atherosclerotic index in serum were significantly lower in the DM+CM group than in the DM group, whereas the ratio of HDL-cholesterol concentration to total cholesterol in the DM+CM group were higher than in the DM group. The activities of hepatic functional enzymes(aminotransferase, LDH and ALP) in serum were lower in the Cordyceps militaris extract administration group(group DM+CM) than in the hyperglycemic DM group. The results shown above suggested that Cordyceps militaris extract supplementation effectively improves blood glucose and atherosclerosis in the serum of diabetic rats.

• 한국식품영양학회지
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• 제20권4호
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• pp.460-466
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• 2007

The purpose of this study was to estimate coffee consumption and it's relationship to blood pressure and blood lipid profiles in Korean adult men and women. Antheropometrics, dietary intake by 24-hour recall, and serum lipid profiles were measured in 354 subjects. The average subject ages for the age ranges of $20{\sim}49$, $50{\sim}64$, and over 65 years, were 39.7, 57.5, and 70.6 years for the men, and 40.7, 56.9, and 70.9 years for the women, respectively. Mean height and weight were significantly higher in the men and decreased with increasing of age. Thirty percent and 28% of the men and women, respectively, consumed coffee. The proportions of coffee consuming subjects in the age rangers of $20{\sim}49$ years(34.9%) and $50{\sim}64$ years(35.6%) were significantly higher than in the group over 65 years(11.5%). The mean daily intakes of food and energy were showed the same results according to sex and age. Mean daily coffee intake was not significantly different between the men and women, but it was significantly lower in the over 65 age group. Systolic blood pressure was significantly higher in the men and increasing age. The atherogenic index was significantly higher in the $20{\sim}49$ year-old men, and in the women over 65 years. There were no significant correlations among coffee consumption, blood pressure, and the serum lipid profile. In conclusion, the daily coffee consumption by adult men and women, with the exception of the elderly, was $50{\sim}90m{\ell}$, and it was not significantly correlated to blood pressure or blood lipids.

• Preventive Nutrition and Food Science
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• 제16권3호
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• pp.195-201
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• 2011

Opuntia humifusa contains high levels of antioxidants including vitamin C, flavonoids and polyphenols, which may provide beneficial effects such as hypolipidemic activity and the reduction of atherosclerosis in postmenopausal women. This study was conducted to determine if the intake of O. humifusa seeds powder (OHS) regulates lipid concentrations, glutamate-oxaloacetate transaminase (GOT), and glutamate-pyruvate transaminase (GPT) in the serum of ovariectomized rats. Sprague-Dawley female rats were randomly assigned to either a sham-operated group (Sham) or one of the following four ovariectomy (OVX) subgroups: OVX with vehicle (OVX), OVX with 100, 200, and 500 mg/kg/day OHS (OHS100, OHS200, OHS500). Daily oral administration of OHS was initiated one week after ovariectomy and continued for seven weeks. Upon completion of treatments, organs were weighed and GOT, GPT, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels were determined enzymatically. No significant differences in feed intake and organ index were observed among the groups. Significant decreases in GPT, TC and LDL-C (p<0.05) were observed in all of the OHS groups (OHS100, 200 and 500), while no significant changes in HDL-C were observed. In addition, the OHS200 and OHS500 treatment groups exhibited a lower level of serum GOT compared to the OVX group. These results indicate that supplementation with O. humifusa seeds could induce favorable changes in serum lipoprotein and lipid profiles, which frequently worsen with inadequate estrogen availability.

• 한국식품영양과학회지
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• 제28권3호
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• pp.625-631
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• 1999

A study was carried out to investigate the effects of safflower seed powder on the improvement of lipid metabolism in high fat and high cholesterol fed rats. Male Sprague Dawley rats of 10 weeks old, weighing 325$\pm$5g, were divided into two groups; the control group(C group, high fat(10% lard) and high cholesterol(1% cholesterol)) and safflower seed group(S group, 10% safflower seed powder), they were fed experimental diets for 6 weeks. Food intake, body weight gains and organ weight had little differences between the groups. Concentration of lipoprotein in serum was remarkably lower in S group than in C group. Serum cholesterol levels were significantly lower in S group(72.94$\pm$4.08 mg/dl) than in C group(89.41$\pm$4.19mg/dl). The level of serum HDL cholesterol was higher in S group than in C group. The level of serum LDL C was significantly lower in S group than in C group. The ratio of HDL cholesterol to total cholesterol were higher in the S group than in the C group, too. The value of atherogenic index(AI) was determined to be low in S group. The content of liver triglyceride and cholesterol in the S group was lower than that of C group. ACAT activities which involves in cholesterol esterification in liver, was not significantly different between two groups.

• 생명과학회지
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• 제20권10호
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• pp.1525-1531
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• 2010

이상지질혈증 흰쥐에 있어서, 누에로부터 효소 처리하여 추출한 세리신의 섭취가 혈청 지질대사 개선효과 및 지질대사 이상 등에 관여하는 지질성분 및 효소의 활성 변동을 검토하기 위하여 이상지질혈증 Sprague Dawley계 흰쥐 수컷을 사용하여 본 실험을 행하였다. 기본식이만을 섭취한 대조군인 BW군을 비롯한 이상지질혈증 유발군(HCW군), 이상지질혈증 유도에 세리신을 급여시킨 군(HCS군)을 5주간 실험 사육하였다. 혈청 총 콜레스테롤, 동맥경화지수, LDL-콜레스테롤, 중성지방, 인지질, 유리 콜레스테롤 농도, 콜레스테롤 에스테르 비 및 혈당 농도 등은 실크 세리신을 급여시킨 군(HCS군)에서 농도가 감소되는 것으로 나타났다. 한편, HDL-콜레스테롤 및 총 콜레스테롤에 대한 HDL-콜레스테롤 비 등은 세리신 섭취(HCS군)에 의해서 증가되는 것으로 나타났다. 혈청 중 alkaline phosphatase (ALP) 및 aminotransferase (AST & ALT)의 활성은 이상지질혈증을 유도 시킨 후 실크 세리신을 섭취시킴으로써 효소 활성이 억제되는 것으로 나타났다. 이상과 같은 결과에서, 실크 세리신이 흰쥐의 혈청 지질대사 이상 등에서 오는 이상지질혈증의 예방 및 개선에 효과가 있을 것으로 생각된다.

• 한국식생활문화학회지
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• 제21권2호
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• pp.216-224
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• 2006

This study was conducted to examine the correlation among meals variety, obesity index, blood pressure, and lipid profiles of Korean adults. A total of 308 adults(men 124, women 184) measured the anthropometric characteristics, blood pressure, dietary intake using 24-hour recall method, and serum lipid profile. The average ages of the study subjects were 50.9 yrs in men and 51.4 yrs in women. The average height, weight and BMI were 166.3 cm, 68.4 kg, $24.7\;kg/cm^2$ in men and 154.3 cm, 59.8 kg, $25.0\;kg/cm^2$ in women, respectively. The numbers of food items in meal of men and women were 14.1, 15.9 for breakfast, 15.7, 15.9 for lunch, 14.7, 14.1 for dinner, respectively. The numbers of dish items in meal of men and women were 4.0, 4.3 for breakfast, 4.3, 4.3 for lunch, 4.2, 3.9 for dinner, respectively. The average blood pressure, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and atherogenic index were 126.6/76.0 mmHg, 181.0 mg/dL, 157.7 mg/dL, 40.9 mg/dL, 108.6 mg/dL, 3.5 in men and 123.2/73.6 mmHg, 185.0 mg/dL, 137.3 mg/dL, 44.8 mg/dL, 112.7 mg/dL, 3.2 in women, respectively. The total cholesterol was negatively correlated to the number of food item for lunch(p<0.05). Therefore, more systematic studies to investigate the meal variety roles of blood lipids in meals of adults were required.

• 성인간호학회지
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• 제19권3호
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• pp.339-352
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• 2007

Purpose: The purpose of this study was to investigate the effect of weight control program on body composition(body mass index and waist-hip ratio), blood pressure, serum lipids(total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein) and self-regulation behavior in obese college women. Methods: Forty seven obese subjects were divided into experimental(22) and control(25) groups. The weight control program lasting 12 weeks consisted of a traffic-light diet, jumping-rope exercises, and behavior modification methods with e-mail counseling. The data were collected from 29 March to 17 September of 2004. The variables were assessed before and after intervention for 12 weeks in two groups. Then, those were repeated after a 12 week suspension of intervention in the experimental group. The data were analysed by the SPSS computer program. Results: BMI, HDL, LDL and self-regulation behavior levels showed significant differences between the experimental and control groups. While there were no significant differences in waist-hip ratio, blood pressure, total cholesterol and triglyceride. Conclusion: The weight control program had a positive effect on obese college women, and can be used to control obesity.