• Journal of Sasang Constitutional Medicine
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• v.10 no.2
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• pp.513-532
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• 1998

In order to investigate the effect of the Soyangin Yangkyuksanwhatang, Indongduengjigolpitang and Sookjiwhanggosamtang that are the model prescriptions for diabetic soyangin. The contents of serum glucose, insulin, total triglyceride and urine glucose, ketone-body and urine volumn and body-weights were mesured on the Alloxan-Induced diabetic Rats. The following results have been measured. 1. Yangkyuksanwhatang, Indonduengjigolpitang and Sookjiwhanggosamtang showed significant decreases on the serum glucose and particulruy Sookjiwhanggosamtang decreased significantly. 2. The contents of serum insulin on the Alloxan-Induced diabetic Rats comparing with normal group were increased in Yangkyuksanwhatang and Indongduengjigolpitang with no significance but Sookjiwhanggosamtang showed a significant increase on the serum insulin. 3. The contents of serum triglyceride were decreased in three groups, but Indongduengjigolpitang showed the significant decrease and others did not. 4. The contents of serum total cholesterol were signicantly decreased In indongduengjigolpitang but Yangkyuksanwhatang and Sookjiwhanggosamtang did not. 5. The contents of urine glucose simillary decreased in three groups. 6. The contents of urine ketone-body were not changed comparing with control group in Yangkyuksanwhatang and Indongduengjigolpitang groups, but Sookjiwhanggosamtang group showed some increase. 7. The urine volume were significantly decreased in Yangkyuksanwhatang, but Indongduengjigolpitang and Sookjiwhanggosamtang showed the decrease of urine volume with no significance. 8. Body weights were regained comparing with control group, but only Indongduengjigolpitang showed significant increase. According to the above results, Yangkyuksanwhatang, Indongduengjigolpitang and Sookjiwhanggosamtang had the effect for hyperglycemia, particulary Indongduengjigolpitang was assumed as having the effect for hyperlipemia and weight-loss induced by D. M.. Therefore, by this experiments it can be concluded that Yangkyuksanwhatang, indongduengjigolpitang and Sookjiwhanggosamtang recorded in "DongYi Soose Bowon" have the effect for soyangin diabetics.

• Preventive Nutrition and Food Science
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• v.9 no.4
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• pp.342-345
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• 2004

This study evaluated the effects of different forms of chromium supplements on serum glucose, insulin and lipid concentrations in rats. Sprague-Dawley male rats were randomly assigned to one of three dietary groups and fed AIN-76 semi-purified basal diets supplemented with 300 ppb Cr from Cr methionine (CrMet) and Cr chloride $(CrCI_3)$ or without Cr (control). By the end of the $4^{th}$ week, all rats were decapitated, blood collected, and serum glucose, insulin and lipid concentrations were determined. The CrMet and $CrCl_3$ supplementation did not affect weight gain and feed efficiency ratio. However, feed intake was significantly higher in CrMet groups than control (p < 0.05). CrMet-supplemented rats had markedly increased insulin levels (p < 0.05) compared with controls. Serum lipids were not significantly different between the control and the CrMet groups. $CrCl_3$ supplementation decreased total cholesterol and triglyceride, but the decreases were only significant for the control group. $CrCl_3$ supplementation was associated with significant decreases in total cholesterol compared with CrMet supplementation. These results indicate that CrMet supplementation is effective for increasing serum insulin, and $CrCl_32$ may improve lipid concentrations, because we observed decreased serum total cholesterol and an improved total cholesterol/HDL-cholesterol ratio (THR).

• Journal of Sasang Constitutional Medicine
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• v.2 no.1
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• pp.149-166
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• 1990

In order to investigate experimented effects of Indongdeung Jigolpi-Tang, which is applied to Soyangin, to diabetes, the measurement, comparison and observation made on the contents of volumes of blood glucose, total cholesterol, triglyceride, phospholipid, total protein and electrolyte($K^+$, $Na^+$) in blood serum by giving a high blood glucose, induced by streptozotocin, to hyperglycemic rats, dosing the cooked liquid of I.J.T., and following conclusion was attained. 1. The volume of glucose urine, induced by streptozotocin to hyperglycemic rats, was shown an increase in comparision to a normal flock when $12.50m{\ell}/kg$ of I.J.T. dosed to the rats and checked after two and four weeks and thereby, a sinificant reduction in the volume of blood glucose was made. 2. The volume of total cholesterol of blood serum in the diabetic rats, induced by streptozotocin, was increased in comparision to the normal flock, and in the fouth week of dosing $1.25m{\ell}/kg$ of I.J.T., a significant reduction of total cholesterol volum was shown in the blood serum. 3. The volume of triglyceride in the blood serum of the diabetic rats, induced by the streptozotocin, was increased in comparision to the normal flock, and with dosing $1.25m{\ell}/kg$ and $12.50m{\ell}/kg$ of I.J.T., a significant reduction of triglyceride volium was shwon in the blood serum after second and fourth week. 4. The volume of phospholipid in the blood serum of the diabetic rats, induced by the streptozotocin, was somewhat reduced in comparision to the normal flock, and with dosing $1.25m{\ell}/kg$ of I.J.T., a significant reduction of phospholipid volium in the blood serum was shown after first and second week. 5. The volume of total protein in the blood serum of the diabetic rats, induced by the streptozotocin, was somewhat reduced in comparison to the normal flock however, with dosing the I.J.T., no significant change on the volium of total protein was made in the blood serum. 6. The volume of potassium in the blood serum of the diabetic rats, induced by the streptozotocin, was increased in comparision to the normal flock however, with dosing the I.J.T., no significant change of potassium content was made in the blood serum. 7. The volume of sodium in the blood serum of the diabetic rats, induced by the streptozotocin, was somewhat reduced in comparision to the normal flock, and with dosing $12.50m{\ell}/kg$ of the I.J.T., a significant increase was shown in the blood serum after first week. Soyangin, accompanying with a middle and upper heat, the I.J.T. - that has a merits of cleaning up fever, solving fever, solving poison, solving thirst and restoring exhaustion - can be proved that it has a blood sugar reduction effect and it is considered that it can be meritorious for strengthening vitality, further, many other exhausting diseases, and can actively used for the cases such as thirst causing disease and a disease that causes an abnormal food hunger, thirst causing and frequent going to pass urine, in particular.

• Korean Journal of Acupuncture
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• v.20 no.2
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• pp.93-100
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• 2003

Effects of Wisoo and Baekwhe acupuncture on serum glucose and lipid composition were investigated in high fat diet induced diabetic rat. Plasma glucose, free fatty acids and $\Beta-lipoprotein$ concentration showed a high reduction in wisoo acupuncture group compared to those of control group, however the values of baekwhe acupuncture group showed no significantly different those of control group. Plasma triglyceride and LDL-cholesterol concentration showed a tendency to decrease in the wisoo acupuncture groups, however the values of baekwhe showed no significantly different those of control group. Total cholesterol concentration showed a high reduction in wisoo acupuncture groups and HDL-cholesterol concentration showed a high values in wisoo acupuncture group, however these values no significantly different in all treatment groups.

• The Journal of Internal Korean Medicine
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• v.24 no.2
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• pp.358-364
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• 2003

Effects of Cheunhwasangamibang on serum glucose and lipid composition were investigated in high fat diet induced diabetic rat. Plasma glucose and free fatty acids concentration showed a high reduction in Cheunhwasangamibang groups compared to those of control group and these values decreased to increasing Cheunhwasangamibang concentration. Plasma ${\beta}$-lipoprotein and triglyceride concentration showed a low values in Cheunhwasangamibang groups, however these values showed no significantly different in 4 ml and 6 ml treatment groups. Total cholesterol concentration showed no significantly different in control group and 2 ml Cheunhwasangamibang group, however these values in 4 ml and 6 ml treatment groups showed a reduction compared to those of control group. Plasma LDL-cholesterol concentration showed a reduction in Cheunhwasangamibang group and HDL-cholesterol showed no significantly different in all treatment groups.

• Journal of the Korean Society of Food Science and Nutrition
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• v.20 no.4
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• pp.300-305
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• 1991

To investigate possible effects of buckwheat on blood glucose level and blood pressure, Sprague-Dawley rats were divided into two groups and fed either AIN-76 diet or modified AIN-76 diet with buckwheat flour for 4 weeks. At the end of experiment, determinations of blood pressure and blood glucose level(glucose tolerance test) were performed. In order to determine insulin levels in both fasted and glucose loaded serum, the animals in both groups were subdivided into two groups. Blood pressure was slightly decreased in the group fed buckwheat( 6mmHg) but not significantly. Glucose tolerance curve of the animal fed buckwheat flour showed clearly different pattern from that of the control group with decreasing tendency. Mobilization of serum insulin was 1.5 times faster in buckwheat group than in control group 1 hour after glucose loading. Further research is needed to find what substance(s) in buckwheat do this role.

• Journal of Veterinary Clinics
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• v.17 no.1
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• pp.28-31
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• 2000

An animall health monitoring system in Gyeongnam area(near Chinju) was studied to analysis of biochemical risk factors in 617 herds. Clinical serum factors such as glutamate oxaloacetate transaminase(GOT), glutamate pyruvate transaminase(GPT), Ca, P, Mg, glucose, and cholesterol were measured with automatic biochemical analyzer(Ra-X7T Techmmicon, USA). In serum analysis, 613 cattle were within normal llimits(GOT: 9.5-85 IU-dl, GPT: 25-77IU/dl, total protein: 5.8-8.5g/dl, Ca: 4.2-12.4mg/dl, P: 4.6-9.7mg/dl, Mg: 1.5-3.0mg/dl, glucose: 48-120mg/dl, Cholesterol: 70-170mg/dl), the other cattle showed high glucose and high cholesterol level. It is proposed that clinical serum factors to be estimated may be valuable for developing of animal health monitoring system model.

• Journal of Nutrition and Health
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• v.28 no.9
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• pp.809-816
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• 1995

We have studied the effects of buckwheat diet on serum glucose and lipid metabolism in 9 NIDDM volunteers during 2 weeks. The subjects were given dietary counseling in their own homes at 2-3 day intervals throughout experimental periods and the dietary intake were determined by interview and record methods. The intake of calorie, carbohydrate, protein and fat during the buckwheat diet period were not significantly different compared with control diet and body weight was maintained within 1-2kg. The mean total glycohemoglobin, fructosamine, total cholesterol and LDL-cholesterol levels at the end of buckwheat diet were significantly lower than the end of control diet (P<0.05). Fasting serum glucose, insulin and HDL-chloesterol levels were slightly decreased. The mean triglyceride level was increased but it was not significant. These results indicate that buckwheat diet is an effective therapeutic regimen for the control of metabolic derangements in diabetes mellitus.

• Journal of Nutrition and Health
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• v.30 no.7
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• pp.781-788
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• 1997

This present study was undertaken to evaluate the effects of 5 % chicory extract on serum glucose and lipid metabolism in diabetic rats treated with streptozotocin (STZ). The experimental subjects were divided into 4 groups. : No-fiber , cellulose, insulin, and chicorygroup. The animals were fed ad libitum each of the experimental diets for 4 weeks. The food intake and food efficiency ratio in chicory group was significantly higher than in no-fiber, cellulose, and inulin groups. The reduction of body weight was also significantly lower. The wet weights of cecum and cecal contents were significantly increased in rat fed chicory extract. Total glycated hemoglobin was significantly decreased by chicory extract feeding whereas serum total cholesterol . LDL-choelsterol, and HDL-choelsterol levels were significantly increased. But there were no differences between HDL-choesterol/total cholesterol ratios, LDL-cholesterol/HDL-cholesterol ratios, and atherogenic index. After 10 -hour fast, the levels of hepatic triglyceride and phospholipid were significantly higher in the chicory group than any in other groups. These results indicated that chicory extract is an effective therapeutic regimen for control of metabolic deragements in diabetics.

• Korean Journal of Community Nutrition
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• v.4 no.1
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• pp.57-63
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• 1999

This study was done to investigate the blood pressure, BMI and serum lipids of cerebrovascular accident patients in Seoul. The subjects were 195 Korean urban cerebrovascular accident patients who were hospitalized at Dong Seo Oriental Hospital in Seoul from June, 1997 to December, 1997. There were more cerebral infarction patients(164) than cerebral hemorrhage patients(31). Cerebral infraction patients were prevalent for subjects in their sixties, but cerebral hemorrhage patients were most commonly in their fifties. The BMI of cerebral infarction accidents was significantly higher than that of cerebral hemorrhage patients(p<0.05). Mean diastolic blood pressure of cerebral hemorrhage patients was significantly higher than that of the cerebral infarction patients(p<0.05). The mean systolic blood pressure of the cerebral hemorrhage patients was higher than that of the cerebral infarction patients, not statistically significant. The serum total cholesterol and glucose levels of the cerebral infarction patients was significantly higher than those of the cerebral hemorrhage patients(p<0.05). Serum total cholesterol(p<0.01), triglyceride(p<0.05) and LDH(p<0.01) levels of female subjects were significantly higher than those of male subjects. Serum total cholesterol has a negative correlation with serum GOT and GPT, but has a positive correlation with triglyceride. Serum triglyceride has a negative correlation with diastolic blood pressure but has a positive compellation with serum glucose.