Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Different Forms of Chromium Supplements on Serum Glucose, Insulin and Lipids in Rats

  • Ohh, Sang-Jip (College of Animal Resources Science, Kangwon National University) ;
  • Kim, Chang-Hyeuk (Institute of Animal Resources, Kangwon National University) ;
  • Shin, Jong-Seo (College of Animal Resources Science, Kangwon National University) ;
  • Sung, Kyung-Il (College of Animal Resources Science, Kangwon National University) ;
  • Kim, Hyun-Sook (Institute of Animal Resources, Kangwon National University)
  • Published : 2004.12.01
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Abstract

This study evaluated the effects of different forms of chromium supplements on serum glucose, insulin and lipid concentrations in rats. Sprague-Dawley male rats were randomly assigned to one of three dietary groups and fed AIN-76 semi-purified basal diets supplemented with 300 ppb Cr from Cr methionine (CrMet) and Cr chloride $(CrCI_3)$ or without Cr (control). By the end of the $4^{th}$ week, all rats were decapitated, blood collected, and serum glucose, insulin and lipid concentrations were determined. The CrMet and $CrCl_3$ supplementation did not affect weight gain and feed efficiency ratio. However, feed intake was significantly higher in CrMet groups than control (p < 0.05). CrMet-supplemented rats had markedly increased insulin levels (p < 0.05) compared with controls. Serum lipids were not significantly different between the control and the CrMet groups. $CrCl_3$ supplementation decreased total cholesterol and triglyceride, but the decreases were only significant for the control group. $CrCl_3$ supplementation was associated with significant decreases in total cholesterol compared with CrMet supplementation. These results indicate that CrMet supplementation is effective for increasing serum insulin, and $CrCl_32$ may improve lipid concentrations, because we observed decreased serum total cholesterol and an improved total cholesterol/HDL-cholesterol ratio (THR).

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References

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