• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1990년도 한국자동제어학술회의논문집(국내학술편); KOEX, Seoul; 26-27 Oct. 1990
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• pp.406-410
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• 1990

This paper presents an approximate analysis of the serial production lines using decomposition technique. A serial production line consists of a series of unreliable machines separated by finite buffers. The serial production line is evaluated by approximation method, the results of which are compared with those examined by the discrete time event simulation, based on this approximation method, a gradient technique is proposed, which improves the efficiency of an operation of production line through the re-allocation of buffers.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1995년도 Proceedings of the Korea Automation Control Conference, 10th (KACC); Seoul, Korea; 23-25 Oct. 1995
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• pp.259-262
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• 1995

In this paper, a model of an asymptotically reliable serial production line with quailty control devices is introduced and analyzed. By an asymptotic technique and Taylor series expansion, its average production rate is approximated in a closed form. The results are applied to a case study of a surface mount system.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1996년도 Proceedings of the Korea Automatic Control Conference, 11th (KACC); Pohang, Korea; 24-26 Oct. 1996
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• pp.350-353
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• 1996

In this paper, based on the performance analysis of serial production lines with quality inspection machines, we develope an buffer size optimization method to maximize the production rate. The total sum of buffer sizes are given and a constant, and under this constraint, using the linear approximation method, we suggest a closed form solution for the optimization problem with an acceptable error. Also, we show that the upstream and downstream buffers of the worst performance machine have a significant effect on the production rate. Finally, the suggested methods are validated by simulations.

• 전자공학회논문지B
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• 제30B권8호
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• pp.23-32
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• 1993

This paper presents a decomposition method to evaluate the performance measures of the serial production lines with unreliable machines and finite buffers. This method is to decompose the transfer line into a set of two machine lines for analysis. Bases on this approximation method, we consider nonhomogeneous lines. In such lines, the machines may take the different lengths of time performing operations on parts. A new transformation is employed in order to replace the line by a homogeneous line. The approximate transformation enables one to determine parameters of performance such as production rate and average buffer levels, and it also shows better application for a large class of systems.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1990년도 한국자동제어학술회의논문집(국내학술편); KOEX, Seoul; 26-27 Oct. 1990
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• pp.519-522
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• 1990

This paper formulates a problem of analysis and design of serial production lines, closed with respect to the number of carriers available in the system for parts transportation between operations. For two machines - two buffers systems, the paper gives an asymptotic solution and shows that optimization of the system with respect to the number of carriers available and the capacity of the feedback buffer may lead to substantial improvements of system's performance.

• 한국시뮬레이션학회논문지
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• 제19권2호
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• pp.107-118
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• 2010

자동차 제조업은 수천 가지의 다른 구성품 또는 부품의 조립이 필요한 복잡한 생산시스템이다. 엔진과 트랜스미션은 자동차의 동력을 담당하는 주요 구성품이다. 엔진의 경우 생산공정이 대부분 유사한 공정들로 구성되어 있음에도 불구하고 공장별로 생산시스템의 배치안은 상이하다. 그 이유는 각 공장마다 기계들을 어떠한 직렬구조와 병렬구조를 조합하여 배치하는지에 대한 개념이 다르기 때문이다. 이 논문에서는 서로 다른 공장에서 적용하고 있는 세 종류의 엔진 라인을 소개한다. 그리고 시뮬레이션을 이용하여 각 라인의 설계개념이 라인의 성과에 미치는 영향에 대해 비교분석하고자 한다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1992년도 한국자동제어학술회의논문집(국제학술편); KOEX, Seoul; 19-21 Oct. 1992
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• pp.458-462
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• 1992

This paper presents a decomposition method to evaluate the performance measures of transfer line with unreliable machine and finite buffers. The proposed method is to decompose the transfer fine into a set of two machine lines for analysis. Nonhomogeneous lines are considered. In such fines, the machines may take the different lengths of time performing operations on parts. A simple transformation is employed in order to replace the line by a homogeneous line. The approximate transformation enables one to determine parameters of performance such as production rate and average buffer levels, and it also shows better applications for a large class of systems.

• Journal of Microbiology and Biotechnology
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• 제28권6호
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• pp.997-1006
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• 2018

As shown during the 2009 pandemic H1N1 (A(H1N1)pdm09) outbreak, egg-based influenza vaccine production technology is insufficient to meet global demands during an influenza pandemic. Therefore, there is a need to adapt cell culture-derived vaccine technology using suspended cell lines for more rapid and larger-scale vaccine production. In this study, we attempted to generate a high-growth influenza vaccine strain in MDCK cells using an A/Puerto/8/1934 (H1N1) vaccine seed strain. Following 48 serial passages with four rounds of virus plaque purification in MDCK cells, we were able to select several MDCK-adapted plaques that could grow over $10^8PFU/ml$. Genetic characterization revealed that these viruses mainly had amino acid substitutions in internal genes and exhibited higher polymerase activities. By using a series of Rg viruses, we demonstrated the essential residues of each gene and identified a set of high-growth strains in MDCK cells ($PB1_{D153N}$, $M1_{A137T}$, and $NS1_{N176S}$). In addition, we confirmed that in the context of the high-growth A/PR/8/34 backbone, A/California/7/2009 (H1N1), A/Perth/16/2009 (H3N2), and A/environment/Korea/deltaW150/2006 (H5N1) also showed significantly enhanced growth properties (more than $10^7PFU/ml$) in both attached- and suspended-MDCK cells compared with each representative virus and the original PR8 vaccine strain. Taken together, this study demonstrates the feasibility of a cell culture-derived approach to produce seed viruses for influenza vaccines that are cheap and can be grown promptly and vigorously as a substitute for egg-based vaccines. Thus, our results suggest that MDCK cell-based vaccine production is a feasible option for producing large-scale vaccines in case of pandemic outbreaks.