• 지질공학
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• 제32권4호
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• pp.643-659
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• 2022

최근 지중저장기술(예, 온실가스 심지층 처분, 인공지열저류층 발전 등)이 활발히 수행됨에 따라, 유체 주입과 저장부지 안정성 사이의 역학적 관계에 관한 정량적 이해의 중요성이 인지되고 있다. 지중 유체 주입은 공극압 및 지중응력 교란과 지층의 역학적 불안정성을 야기할 수 있어, 유체 주입에 대한 다공탄성 수치 모형 구축이 요구된다. 본 연구에서는 순차적인 COMSOL-PyLith-COMSOL 유체 주입-유발지진 다공탄성 수치 모사를 수행한다. 유한요소 상용 소프트웨어인 COMSOL을 이용해 단층에 가해지는 쿨롱 파괴 응력(CFS) 변화를 시간에 따라 추적하였고, CFS 변화량이 임계값(예, 0.1 MPa)을 초과할 경우, 모형의 정보(기하구조, 물성 등)를 유한요소 오픈소스 코드인 PyLith로 이동시키는 알고리즘을 구축했다. PyLith는 단층의 미끄러짐을 모사하고, 미끌림에 의한 변위장을 획득한다. 이후 변위장을 COMSOL로 이동시켜 지진에 의한 응력 및 표면 변위를 계산한다. 수치 모사 결과, 주입 기간 중엔 주입정 근거리에서 큰 변화(공극압, CFS 변화 등)를 보였고, 주입 종류 후에는 잔류 응력이 원거리 영역으로 확산하는 양상이 나타났다. 이는 주입 종료 후 지속적인 모니터링의 필요성을 제안한다. 또한, 단층과 주입층 물성(예, 투수계수, Biot-Willis 계수)에 따른 CFS 변화량 비교는 주입정 위치 선정 시 주입층 및 주변 지층에 대한 물성 파악이 중요함을 의미한다. 단층 미끄러짐 양에 따른 표면 변위 및 이암층에 가해지는 편차응력은 다양한 단층 미끌림 시나리오 설정의 필요성을 지시한다.

• 디자인학연구
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• 제15권1호
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• pp.113-122
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• 2002

본 연구에서는 멀티미디어와 네트워크를 중심으로 변화하고 있는 교육환경에서, 온라인교육을 위한 학습이론과 멀티미디어 표현기법을 선택하는 과정을 도울 수 있는 방법에 대하여 고찰하였다. 진행은 객관주의와 구성주의, 두가지 교육이론의 고찰과 멀티미디어표현의 특성분석을 통하여 가이드라인을 제시하고 이를 CAI 각 형태에 적용하는 방법으로 이루어졌다. 객관주의와 구성주의는 CAI의 기초 환경구성의 토대가 되며, 객관주의는 고정적, 순차적, 구조적, 수동적인 학습에, 구성주의는 자율적, 선택적, 비구조적, 능동적인 학습에 적합한 것으로 나타났다. 그리고, CAI에 활용되는 멀티미디어요소의 표현을 위한 기준을 선정하기 위한 요소로는 미디어의 특성, 학습자의 특성(인지모델, 숙련도, 수용성), 그리고 컨텐츠의 특성을 고려하였다. 이 과정에서 선정된 기준을 바탕으로 현재 활용되고 있는 CAI의 6가지 형태에 대하여 이를 구성하는데 가장 적합한 교육이론, 효과적인 미디어, 학습자 수준, 학습컨텐츠의 종류 및 특성을 분류하였다.

• 한국BIM학회 논문집
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• 제6권3호
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• pp.34-41
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• 2016

The previous studies argue that using the semantic properties of BIM objects is efficient for simulating the behaviors of autonomous, computer agents, called virtual-users, but such assumption is not proven via evidence-based research approaches. Hence, this present study aims to investigate the empirical effects of a human behavior simulation model equipped the semantics of spaces on the architecture-major students' operation and understanding of the simulation system, compared to a typical path-finding model. To achieve the aim, this study analyzed the survey and interview data, collected in the authentic design projects. The analysis indicates that (1) using a simulation model equipped the semantics of spaces helps the students' operation of the simulation, and (2) it also aids understanding the relationship between the variables of spaces and virtual-users (${\alpha}=0.74$). In addition, the qualitative data inform that the advantages of the simulation model that computes the semantics of spaces stem in the automatic behavioral changes of massive numbers of virtual-users, and efficient detection and activation on the what-if situations. The analysis also reveals that the simulation model has shortcomings in orchestrating the complex data structure between the semantics properties of spaces and virtual-users under multi-sequential scenarios. The results of this study contribute to develop a future design system combining BIM with human behavior simulation.

• Restorative Dentistry and Endodontics
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• 제45권3호
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• pp.39.1-39.11
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• 2020

Despite the vast literature on the effects of root canal irrigants on the dentin characteristics, the precise effects of clinically relevant irrigation sequences remain unclear. In this review, we systematically dissect the role of different sequential irrigation approaches that are used in clinical endodontics. Using a systematic search strategy, we attempt to answer the question: 'Which irrigating sequence has the most deleterious effects on dentin structure and properties?' The effect of irrigants on the dentin composition and mechanical properties have been reviewed. A wide variety of concentrations, duration and techniques have been employed to characterize the effects of chemicals on dentin properties, thus making it impossible to draw guidelines or recommendations of irrigant sequences to be followed clinically. It was apparent that all the studied irrigation sequences potentially result in some deleterious effects on dentin such as decrease in the flexural strength, microhardness, modulus of elasticity and inorganic content and organic-inorganic ratio of the dentin. However, the literature still lacks comprehensive investigations to compare the deleterious effect of different irrigation sequences, using a wide variety of qualitative and quantitative methods. Such investigations are essential to make clinical recommendations and strategize efforts to minimize chemically-induced damage to dentin characteristics.

• 한국표면공학회지
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• 제43권3호
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• pp.148-153
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• 2010

Transparent conducting films having a hybrid structure of GZO/Metal/GZO were prepared on glass substrates by sequential deposition using DC magnetron sputtering. Silver, copper, aluminum and zinc thin films were used as the intermediate metal layers in the hybrid structure. The electrical and optical properties of hybrid transparent conducting films were investigated with varying the thickness of metal layer or GZO layers. With increasing the metal thickness, hybrid films showed a noticeable improvement of the electrical conductivity, which is mainly dependent on the electrical property of the metal layer. GZO(40 nm)/Ag(10 nm)/GZO(40 nm) film exhibits a resistivity of $5.2{\times}10^{-5}{\Omega}{\cdot}cm$ with an optical transmittance of 82.8%. For the films with Zn interlayer, only marginal reduction in the resistivity was observed. Furthermore, unlike other metals, hybrid films with Zn interlayer showed a decrease in the resistivity with increasing the GZO thickness. The optimal thickness of GZO layer for anti-reflection effect at a given thickness of metal (10 nm) was found to be critically dependent on the refractive index of the metal. In addition, x-ray diffraction analysis showed that the insertion of Ag layer resulted in the improvement of crystallinity of GZO films, which is beneficial for the electrical and optical properties of hybrid-type transparent conducting films.

• Biotechnology and Bioprocess Engineering:BBE
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• 제7권5호
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• pp.311-315
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• 2002

By the in vitro combinatorial mutagenesis, which is a sequential reaction of PCR mutagenesis and in vitro coupled transcription/translation with Escherichia coli S30 extract, S65 and E222 of green fluorescent protein of Aequarea victoria were comprehensively changed to all possible combinations of amino acids, thus totally 400 mutant (including a wild type) proteins were simultaneously produced and their fluorescent properties were analyzed. Although a few mutations had been reported so far at the 222nd position, replacement E222 to all other19 amino acids gave fluorescent signal to the mutants by changing Ser 65 to Ala together. Among the mutants, replacement to G, A, S, Q, H and C gave relatively high fluorescence. The in vitro combinatorial mutagenesis, therefore, has been proved valuable for comprehensive structure-function studies of proteins.

• 산업기술연구
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• 제20권A호
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• pp.57-62
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• 2000

This experiment was done to investigate the leaching and adsorption properties of heavy metals on porphyry. The comparison with respect to the leachability of heavy metals from porphyry between the Korea Standard Leaching Test (KSLT) and the Toxicity Characteristic Leaching Procedure (TCLP) was carried out. The fractional composition of leachate and the total concentration of heavy metal of porphyry were studied through Sequential Extraction Procedure (SEP) and EPA Method 3050. Adsorption experiment of porphyry has pointed out that the optimum dosage of porphyry for 50ppm Pb was over 10g/L, the effective particle size for absorption was below 200 mesh and the optimum pH was about 7. From the Freundlich' adsorption equation, 1/n was 1.0722, and k was 0.0041. After adsorption, the fractional composition of Pb was changed. The exchangeable, carbonate, reducible fractions were increased, and the organic fraction was not changed, and the residual fraction was decreased.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권4호
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• pp.1887-1898
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• 2018

In this paper, a method to classify insider threat activity is introduced. The internal threats help detecting anomalous activity in the procedure performed by the user in an organization. When an anomalous value deviating from the overall behavior is displayed, we consider it as an inside threat for classification as an inside intimidator. To solve the situation, Markov Chain Model is employed. The Markov Chain Model shows the next state value through an arbitrary variable affected by the previous event. Similarly, the current activity can also be predicted based on the previous activity for the insider threat activity. A method was studied where the change items for such state are defined by a transition probability, and classified as detection of anomaly of the inside threat through values for a probability variable. We use the properties of the Markov chains to list the behavior of the user over time and to classify which state they belong to. Sequential data sets were generated according to the influence of n occurrences of Markov attribute and classified by machine learning algorithm. In the experiment, only 15% of the Cert: insider threat dataset was applied, and the result was 97% accuracy except for NaiveBayes. As a result of our research, it was confirmed that the Markov Chain Model can classify insider threats and can be fully utilized for user behavior classification.

• 센서학회지
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• 제3권1호
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• pp.83-87
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• 1994

EBE법으로 S,In과 Cu를 순차적으로 증착하여 S/In/Cu 적층막을 제작하고, 진공 및 별도 S(Sulphur)공급하면서 열처리하여 다결정 $CuInS_{2}$ 박막을 제작하였다. 진공중에서 열처리한 박막은 chalcopyrite 구조를 갖는 n형 $CuInS_{2}$ 이었고 이때 최저 저항율은 $142{\Omega}Cm$이었다. 또한 별도 S 공급하면서 열처리한 박막은 p형으로 chalcopyrite 구조를 갖고 성장되었으며 최저 저항율은 $137{\Omega}Cm$ 이었다.

• BMB Reports
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• 제38권6호
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• pp.633-638
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• 2005

Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase $A_2$ enzymes, cyclooxygenase (COX) enzymes, and various lineage-specific terminal prostanoid synthases. Prostaglandin E synthase (PGES), which isomerizes COX-derived $PGH_2$ specifically to $PGE_2$, occurs in multiple forms with distinct enzymatic properties, expressions, localizations and functions. Two of them are membrane-bound enzymes and have been designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein that is markedly induced by proinflammatory stimuli, is down-regulated by anti inflammatory glucocorticoids, and is functionally coupled with COX-2 in marked preference to COX-1. Recent gene targeting studies of mPGES-1 have revealed that this enzyme represents a novel target for anti-inflammatory and anti-cancer drugs. mPGES-2 is synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. This enzyme is rather constitutively expressed in various cells and tissues and is functionally coupled with both COX-1 and COX-2. Cytosolic PGES (cPGES) is constitutively expressed in a wide variety of cells and is functionally linked to COX-1 to promote immediate $PGE_2$ production. This review highlights the latest understanding of the expression, regulation and functions of these three PGES enzymes.