• Korean Journal of Veterinary Research
• /
• v.58 no.4
• /
• pp.193-199
• /
• 2018

As animal welfare issue becomes important, the European Union bans conventional cages for laying hens from 2012. So the alternative housing systems like floor pens, aviaries or free range systems have been suggested. From 2011 to 2014, we monitored 20 welfare-oriented laying hen farms in South Korea to figure out serological status of major viral diseases. During this period, total 3,219 blood samples were collected from the randomly selected chickens to test and evaluate the hemagglutination inhibition titers for low pathogenic avian influenza, Newcastle disease and egg drop syndrome '76. A total of 2,926 blood samples were tested through enzyme linked immunosorbent assay (ELISA) to assess the serological status of infectious bronchitis (IB). The distribution of ELISA titers for IB was various from almost 0 to 20,000 through the all weeks of age. Also, the antibody coefficient of variation for most of the diseases in this study was higher than those of typical cage layers. As this study was the first surveillance for major avian viral diseases of the animal welfare-oriented farms in South Korea, the results obtained from this study will help to determine what information and resources are needed to maintain better biosecurity and to improve the health and welfare of laying hen flocks.

• Journal of Medicine and Life Science
• /
• v.15 no.2
• /
• pp.79-83
• /
• 2018

Jejudo has unique geographical and climatologic characteristics compared with other areas in Korea. The aim was to evaluate differences of the nationwide notifiable infectious diseases (NND) occurred in Jejudo, 2011~2018. The source of data was on the Infectious Disease Statistics System operated by Centers for Diseases Control & Prevention in Korea between 1 January 2001 and 30 September 2018. After calculating the proportion of sum of years showing a higher incidence in Jejudo than nationwide divided by sum of comparing years(PSYH), authors defined the infectious diseases for control in Jejudo (IDCJ) with PSYH over 75%. In addition, the infectious diseases showing increasing trends during recent 2 years(2015~2018) were defined as sudden increase Infectious diseases for control (SIDCJ). IDCJ in 2001~2018 included 3 NNDs such as chicken pox, syphilis, and Streptococcus pneumoniae. The results support main evidences to plan strategies and distribute community resources for control and prevention of NNDs in Jejudo, Korea.

• Archives of Plastic Surgery
• /
• v.46 no.1
• /
• pp.79-83
• /
• 2019

Robotic surgery facilitates surgical procedures by employing flexible arms with multiple degrees of freedom and providing high-quality 3-dimensional imaging. Robot-assisted nipple-sparing mastectomy with immediate reconstruction is currently performed to avoid breast scars. Four patients with invasive ductal carcinoma underwent robot-assisted nipple-sparing mastectomy and immediate robot-assisted expander insertion. Through a 6-cm incision along the anterior axillary line, sentinel lymph node biopsy and nipple-sparing mastectomy were performed by oncologic surgeons. The pectoralis major muscle was elevated, an acellular dermal matrix (ADM) sling was created with robotic assistance, and an expander was inserted into the subpectoral, sub-ADM pocket. No patients had major complications such as hematoma, seroma, infection, capsular contracture, or nipple-areolar necrosis. The mean operation time for expander insertion was 1 hour and 20 minutes, and it became shorter with more experience. The first patient completed 2-stage prosthetic reconstruction and was highly satisfied with the unnoticeable scar and symmetric reconstruction. We describe several cases of immediate robot-assisted prosthetic breast reconstruction. This procedure is a feasible surgical option for patients who want to conceal surgical scars.

• Medical Lasers
• /
• v.10 no.3
• /
• pp.123-131
• /
• 2021

Optical imaging modalities with properties of real-time, non-invasive, in vivo, and high resolution for image-guided surgery have been widely studied. In this review, we introduce two optical imaging systems, that could be the core of image-guided surgery and introduce the system configuration, implementation, and operation methods. First, we introduce the optical coherence tomography (OCT) system implemented by our research group. This system is implemented based on a swept-source, and the system has an axial resolution of 11 ㎛ and a lateral resolution of 22 ㎛. Second, we introduce a fluorescence imaging system. The fluorescence imaging system was implemented based on the absorption and fluorescence wavelength of indocyanine green (ICG), with a light-emitting diode (LED) light source. To confirm the performance of the two imaging systems, human malignant melanoma cells were injected into BALB/c nude mice to create a xenograft model and using this, OCT images of cancer and pathological slide images were compared. In addition, in a mouse model, an intravenous injection of indocyanine green was used with a fluorescence imaging system to detect real-time images moving along blood vessels and to detect sentinel lymph nodes, which could be very important for cancer staging. Finally, polarization-sensitive OCT to find the boundaries of cancer in real-time and real-time image-guided surgery using a developed contrast agent and fluorescence imaging system were introduced.

• Clinical Pain
• /
• v.19 no.2
• /
• pp.129-132
• /
• 2020

Fracture is uncommon cause of lymphedema. The mechanism of lymphedema progression is still unknown, but disruption of the lymphatic system during and after fracture might be involved. In contrast, breast cancer surgery is a common cause of lymphedema and is usually caused by the removal of axillary lymph nodes. Sentinel node biopsy (SNB) has been adopted in early breast cancer to reduce the risk of lymphedema. Thus, the incidence of lymphedema in SNB was lowered. However, less than 10% of SNB patients are still diagnosed with lymphedema, but it is known that it took years to diagnose. Recently, we encountered atypical lymphedema occurred after breast cancer surgery with SNB. Symptoms started earlier than usual and were more severe. Interestingly, she has a history of a proximal radial fracture on the same side of SNB. We thought there could be a relationship between the acceleration of breast cancer-related lymphedema and fracture.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2023.05a
• /
• pp.444-444
• /
• 2023

하천 및 저수지와 같은 공간의 수체 탐지는 수자원 관리에서 매우 중요하며, 유역의 수문학적 과정을 이해하는데 도움을 준다. 수문학적 데이터 수집은 우량계, 수위계와 같은 물리적 인프라의 배치가 필요하다. 그러나 상대적으로 저개발된 국가는 수문학적 측정을 위한 인프라가 매우 미흡한 것이 현실이며, 북한과 같은 비접근 지역에 대한 수문학적 과정을 분석하는데는 한계가 있다. 인공위성 원격탐사 센서 중 SAR영상은 지표면에 직접 전파를 방사하고 산란되어 돌아오는 신호를 수신하여 영상을 만들기 때문에 일반적인 광학영상과는 달리 햇빛의 유무와 강우, 구름여부 등의 기상 조건의 영향을 거의 받지 않는 장점이 있다. 또한 국내와 같이 계절적인 요인과 인간활동에 의해 변화되는 물 순환을 SAR 영상은 지표수의 계절적 및 연간 변동성을 모니터링하는데 매우 유용한 자료로 평가되고 있다. 본 연구는 SAR영상을 이용하여 국내의 검증 가능한 지역의 저수지 수면적 변화를 모니터링하고 저수지 수면적과 저수량 분석을 수행하는 것을 목적으로 하였다. 분석자료인 SAR영상은 ESA의 Sentinel-1영상을 2022년 4월부터 2022년 11월의 자료를 수집하여 소양강댐 저수지 수면적과 저수량과의 관계식을 도출하였다. 수체 추출을 위한 SAR 영상은 특히 수로의 일부 가장자리와 홍수터의 식물 존재로 인한 제외지의 매핑에 부정확성을 포함하여 처리에 몇 가지 단점을 갖는 한계도 존재하지만 악천후의 기상 조건에서도 작동할 수 있는 SAR 영상의 능력 덕분에 규칙적인 시간 간격으로 수체면적의 변화에 대한 정보를 제공할 수 있다. 향후 북한 지역의 주요 댐 저수지 수면적에 대한 연간변화와 장기간의 추세를 분석하는 연구를 진행할 계획이다.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2023.05a
• /
• pp.359-359
• /
• 2023

최근 기후변화로 인한 홍수 및 가뭄과 같은 자연재해가 증가함에 따라 이를 선제적으로 탐지 및 예방할 수 있는 해결책에 대한 필요성이 증가하고 있다. 이러한 수재해를 예방하기 위해서 하천, 저수지 등 가용수자원의 지속적인 모니터링은 필수적이다. SAR 위성 영상의 경우 주야간 및 기상상황에 상관없이 지속적인 수체 탐지가 가능하다. 일반적으로 SAR 기반 수체 탐지 시 송수신 방향이 동일한 편파(co-polarized) 영상을 사용한다. 하지만 co-polarized 영상의 경우 바람 및 강우에 민감하게 반응하여 수체 미탐지의 가능성이 존재한다. 한편 송수신 방향이 서로 다른 편파(cross-polarized) 영상은 강우 및 바람의 영향에 민감하지 않지만 식생에 민감하게 반응하여 수체의 오탐지율이 높다는 단점이 존재한다. 이에 SAR 영상의 편파 특성에 따라 수체 탐지의 정확도 차이가 발생하여 최적의 편파 영상 조합을 구성하는 것이 중요하다. 본 연구에서는 Sentinel-1 SAR 위성의 VV, VH, VV+VH 편파 영상과 머신러닝 알고리즘 중 하나인 SVM (support vector machine)을 활용하여 수체탐지를 수행하였다. 편파 영상 조합별 수체 탐지 결과의 검증을 위하여 혼동행렬 (confusion matrix) 기반 평가지수를 사용하였다. 각각의 수체탐지 결과의 비교 및 분석을 통하여 SAR 기반 수체 탐지를 위한 최적의 밴드 조합을 도출하였다. 본 연구결과를 바탕으로 차후 높은 시공간 해상도를 가진 SAR 영상의 활용이 가능하다면 수재해 및 수자원 관리의 효율성을 높일 수 있을 것으로 기대된다.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2021.06a
• /
• pp.36-36
• /
• 2021

최근 기후변화로 인한 집중홍우 등으로 홍수 등 재난이 증가하고 있으며, 이를 과학적으로 조사하고 분석하기에는 공간적으로 범위가 넓다. 특히, 미계측유역은 자료를 수집하고 정량적으로 분석 및 예측하는 데에는 한계가 많은 실정이다. 따라서 본 연구에서는 위성영상 자료를 활용하여, 하천폭, 수면경사, 수위 등 자료를 추출하고, 이를 유량조사를 수행한 지점의 자료와 비교하여 수리 기하적 상관성을 분석하였다. 특히, 하도특성을 고려하여 중·하류로 구분하고 유량과 수리기하 학의 관계를 분석하였다. 위성영상 중 취득이 용이한 Sentinel 자료를 선별하여 수리특성인자를 추출하였다. 영상자료의 해상도가 20 m이며, 자료의 한계에 따른 하천폭, 경사, 수위에 대한 유효 기준을 제시하고 경사가 완만하고 하폭이 넓은 대하천에 적용하였다. 그리고, 하천수리인자 특성을 입력변수로 하는 유량을 추정하기 위한 회귀모형을 구축하고, 모의유량과 실측유량을 비교하여 그 적용성을 평가하였다. 개발된 모형은 규모가 유사한 시험유역을 미계측 유역으로 간주하여 평균제곱근오차(RMSE) 와 평균절대오차(MAE)를 이용하여 정확도를 추정하였다. 본 연구를 통해 주요하천의 수리기하 특성을 통계화하고 유량과의 특성을 도출하여 국내하천의 특성을 범주화 할 수 있었고, 미계측 유역에서의 유량을 원격탐사와 같은 간접적인 방법을 통해 추정하고 적용할 수 있을 것으로 기대된다.

• Hanyang Medical Reviews
• /
• v.33 no.1
• /
• pp.59-64
• /
• 2013

Cancer remains the leading cause of death worldwide despite intense efforts in developing innovative treatments. Current approaches in cancer therapy are mainly directed to a selective targeting of cancer cells to avoid potential side effects associated with conventional therapy. In this respect, Natural killer (NK) cells have gained growing attention and are now being considered as promising therapeutic tools for cancer therapy owing to their intrinsic ability to rapidly recognize and kill cancer cells, while sparing normal healthy cells. NK cells play a key role in the first line of defense against transformed and virus-infected cells. NK cells sense their target through a whole array of receptors, both activating and inhibitory. Functional outcome of NK cell against target cells is determined by the balance of signals transmitted from diverse activating and inhibiting receptors. Despite significant progress made in the role of NK cells attack as a pivotal sentinel in tumor surveillance, the molecular has been that regulate NK cell responses remain unclear, which restricts the use of NK cells as a therapeutic measure. Accordingly, current efforts for NK cell-based cancer therapy have largely relied on the strategies that are based on the manipulation of inhibitory receptor function. However, if we better understand the mechanisms governing NK cell activation, including those mediated by diverse activating receptors, this knowledge can be applied to the development of optimal design for cancer immunotherapy by targeting NK cells.

• Journal of Ecology and Environment
• /
• v.47 no.2
• /
• pp.42-48
• /
• 2023

An adult male Eurasian river otter (Lutra lutra) with ataxia and lethargy was rescued. Through the necropsy of this otter with neurological symptoms, a broad range of vascular damage caused by mercury toxicity in several organs, hepatocellular necrosis, and vacuolation in the brain. In mercury examination, liver, kidney, and hair showed values of 0.878 ± 0.027, 1.807 ± 0.049, and 5.712 ± 0.102 ㎍/g, respectively. Compared with certified reference material, it was confirmed that the concentration of mercury were 6.7 times, 13.7 times, and 43.3 times higher, respectively. When the symptoms and diagnosis results were comprehensively reviewed, this otter's demise was revealed due to mercury poisoning. The mercury concentration in the liver does not exceed the lowest observed effect level of 3.4 ㎍/g. However, even at low concentrations, long-term accumulation can cause symptoms including neuropathy, and the possibility that these heavy metals have accumulated in other wild animals cannot be ruled out. It seems that continuous monitoring using sentinel animals is necessary.