• Structural Engineering and Mechanics
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• v.62 no.4
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• pp.497-506
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• 2017

A low damage self-centering braced frame equipped with post-tensioning strands is capable of directing damage to replaceable butterfly-shaped fuses. This paper investigates the seismic performance of rocking braced frame under near-field pulse-like ground motions compared to far-field records. A non-linear time history analysis is performed for twelve self-centering archetypes. A sensitivity analysis is carried out to examine the influences of ground motion types and modeling parameters. Findings represent the proper efficiency of the self-centering system under both far-field and near-field pulse-like ground motions.

• Biomolecules & Therapeutics
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• v.20 no.3
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• pp.268-272
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• 2012

Nephrotoxicity occurs when kidney-specific detoxification and excretion do not work properly due to the damage or destruction of kidney function by exogenous or endogenous toxicants. Exposure to drugs often results in toxicity in kidney which represents the major control system maintaining homeostasis of body and thus is especially susceptible to xenobiotics. Understanding the toxic mechanisms for nephrotoxicity provides useful information on the development of drugs with therapeutic benefits with reduced side effects. Mechanisms for drug-induced nephrotoxicity include changes in glomerular hemodynamics, tubular cell toxicity, inflammation, crystal nephropathy, rhabdomyolysis, and thrombotic microangiopathy. Biomarkers have been identified for the assessment of nephrotoxicity. The discovery and development of novel biomarkers that can diagnose kidney damage earlier and more accurately are needed for effective prevention of drug-induced nephrotoxicity. Although some of them fail to confer specificity and sensitivity, several promising candidates of biomarkers were recently proved for assessment of nephrotoxicity. In this review, we summarize mechanisms of drug-induced nephrotoxicity and present the list of drugs that cause nephrotoxicity and biomarkers that can be used for early assessment of nephrotoxicity.

• Transactions of the Korean Society of Automotive Engineers
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• v.10 no.6
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• pp.125-132
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• 2002

Bumpers are structural components to reduce physical damage to the front and rear ends of a passenger motor vehicle from low speed collisions. Damage assessment and the protectiveness are the commonly used designing criteria but in this study, relative displacements of the bumper are examined. To absorb the crash energy without significant damage to the bumper itself, foam material is installed between fascia and beam. However, it is not easy to predict the exact displacements generated in bumper structures through FEM because the compressive stress-strain curve of a foam material depends on strain rates that deviates significantly on each trial. Under this uncertain condition, a range of displacements is calculated and the optimum design is performed using the design of experiments. The result will be used to find the design that minimizes the weight within displacement constraints. The orthogonal array of L9 is introduced to find the optimum of the design variables that considers the thickness of inner beam, outer beam and stay, This study will suggest the design procedure of a front bumper using the uncertain stress-strain curve of a foam material.

• Smart Structures and Systems
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• v.28 no.6
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• pp.799-810
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• 2021

When monitoring the structural integrity of a bridge using data collected through accelerometers, identifying the profile of the load exerted on the bridge from the vehicles passing over it becomes a crucial task. In this study, the speed and location of vehicles on the deck of a bridge is reconfigured using real-time video to implicitly associate the load applied to the bridge with the response from the bridge sensors to develop an image-based deep learning network model. Instead of directly measuring the load that a moving vehicle exerts on the bridge, the intention in the proposed method is to replace the correlation between the movement of vehicles from CCTV images and the corresponding response by the bridge with a neural network model. Given the framework of an input-output-based system identification, CCTV images secured from the bridge and the acceleration measurements from a cantilevered beam are combined during the process of training the neural network model. Since in reality, structural damage cannot be induced in a bridge, the focus of the study is on identifying local changes in parameters by adding mass to a cantilevered beam in the laboratory. The study successfully identified the change in the material parameters in the beam by using the deep-learning neural network model. Also, the method correctly predicted the acceleration response of the beam. The proposed approach can be extended to the structural health monitoring of actual bridges, and its sensitivity to damage can also be improved through optimization of the network training.

• Toxicological Research
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• v.22 no.4
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• pp.423-429
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• 2006

Recent reports on the photocarcinogenicity and photogerotoxicity of many compounds led to an increasing awareness for the need of a standard approach to test for photogenotoxicity. The comet assay has been recently validated as a sensitive and specific test system for the quantification of DNA damage. Thus, the objectives of this study are to investigate the utility of photo-comet assay for detecting photo-mutagens, and to evaluate its ability to predict rodent photo-carcinogenicity. Photo-comet assays were performed using L5178Y $Tk^{+/-}$ mouse lymphoma cells on five test substances (8-methoxypsoralen, chlorpromazine, lomefloxacin, anthracene and retinoic acid) that demonstrated positive results in photocarcinogenicity tests. For the best discrimination between the test substance-mediated DNA damage and the undesirable DNA damage caused by direct UV absorption, a UV dose-response of the cells in the absence of the test substances was firstly fnalized. Out of 5 test substances, positive comet results were obtained for chlorpromazine, lomefloxacin, anthracene and retinoic acid while 8-methoxypsoralen found negative. An investigation into the predictive value of this photo-comet assay for determining the photocarcinogenicity showed that photo-comet assay has relatively high sensitivity. Therefore, the photo-comet assay with mammalian cells seems to be a good and sensitive predictor of the photocarcinogenic potential of new substances.

• Korean Journal of Environmental Biology
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• v.29 no.1
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• pp.23-30
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• 2011

In this study, the Comet assay (evaluation of DNA damage) used the fish hepatocellular carinoma cell, PLHC-1, was tried to the sediment extract obtained from freshwater to understand its applicability as a tool for monitoring sediment toxicity. In parallel, induced EROD (7-ethoxyresorufin- O-deethylase) activity and DNA damage (TEM values) in PLHC-1 cells were measured for establishing the tandem endpoints of the PLHC-1cell test to test the ecotoxicity of sediment. Among several study sites in a small river passed through downtown and industrial park area, one of them, site B, showed a higher level of EROD activity and DNA damage than other sites. It indicates that a tandem endpoints of PLHC-1 cells could be useful tools for assessing the toxicity of sediment. The sensitivity of Comet assay with PLHC-1 cells was a little higher than that with a blood cell of frog tadpoles to the solvent extract of sediment. According to the results, a PLHC-1 cell-Comet assay could be used as a useful tool for evaluating ecotoxicity of the freshwater sediment. In addition, more detailed studies are needed to the contaminated site.

• Journal of Korean Society of Steel Construction
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• v.22 no.5
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• pp.477-485
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• 2010

Various monitoring sensors are used to predict and detect structural damage. Smart sensors, such as glass-fiber sensors, PZT, and MEMS, among others, have replaced traditional sensors. They are now being used in many areas. This study aims to predict the damage by measuring the PZT voltage attached on the specimen by the applied impact load. In the experiment to detect damages in beam connection, simple $H-400{\times}200{\times}8{\times}13$ beams were spliced with bolts. The results of FFT between PZT sensor and accelrometer were compared to measure the sensitivity of the PZT sensor. The damage to the beam was presumed by loosening the bolt, and then the damage measurement was accompanied. Secondly, a steel $PL600{\times}65{\times}5.8$ plate beam was fabricated for the purpose of experimenting on damage measurement. Impact loading test on three different locations was carried out. Damage width varied between 6~42mm on both sides by cutting, using a steel saw. The ratio of frequencies before and after the damage was computed to quantify the damage level by using FFT, and the change in mode pattern with the increased damage was investigated to measure the damage.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.18 no.2
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• pp.43-49
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• 2022

The purpose of this study is to evaluate the radiation effect on damage when the external shield of the spent nuclear fuel transport cask is damaged due to impact as the cause of an unexpected accident. The neutron and gamma-ray intensities and spectra are calculated using the ORIGEN-Arp module in the SCALE 6.2.4 code package⁽¹⁾ and then using MCNP6.2⁽²⁾ code calculate the dose rate. In order to evaluate the radiation dose according to the size of damage caused by external impact, various sized holes of 0.3~13.7% are assumed in the outer shield of the cask to evaluate the sensitivity to the dose. In the case of radiation source leakage, damage to the nuclear fuel assembly is assumed to be up to 6% based on overseas test cases. When only the outer shield is damaged, the maximum surface dose is calculated as 3.12E+03 mSv/hr. However, if the radiation source is leaked due to damage to the nuclear fuel assembly, it becomes 7.00E+05 mSv/hr which is about 200 times greater than the former case.

• Journal of Advanced Marine Engineering and Technology
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• v.17 no.3
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• pp.42-49
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• 1993

Recently, because the lubricating oil showed a tendency to be emulsified and oxidized by high speed, high output and the extension of maintenance & conservation of marine engine, the cavitation erosion-corrosion at such an environment became a big problem on effective performance of engine. Therefore, there was a need to study the behavior and protection of erosion-corrosion damage, and then applied inhibitor to a protective method of cavitation erosion- corrosion damage. At this time, test environments were marine lubricating oil & various emulsified oil that mixed distilled water and sea water etc., and also used 20KHz, 24.mu.m piezoelectric vibrator as an experimental apparatus of cavitation erosion. With this apparatus, we investigated an influence of the emulsified oil on characteristics of erosion-corrosion and protection for erosion-corrosion by inhibitor at slide bearing metals.

• Proceedings of the Korea Concrete Institute Conference
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• 1995.10a
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• pp.334-338
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• 1995

In recent years, the prediction of the deterioration rate of concrete structures has become major research interest. However, there are still many uncertain factors in the deterioration process and the relation between deterioration and durability of structures. This is mainly due to various uncertainties involved in the construction process and the environmental conditions which affect the rate of deterioration of concrete structures. In this study a limit state model in terms of random crack width due to applied dead and live loads is proposed for the assessment of crack damage of reinforced concrete structures. The AFOSM reliability method is used for the reliability evaluation of the crack durability of concrete bridges. The proposed model for crack durability of concrete bridges is applied to the Seoul interior circuit elevated expressway. The sensitivity analyses are performed for the proposed model.