• 한국정보과학회논문지:소프트웨어및응용
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• 제29권7호
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• pp.425-435
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• 2002

본 논문에서는 SOFM기반 신경망 분류기를 이용한 매크로블록 기반 전송률제어 방식을 제안한다. 수학적 왜곡 비트율 모델과 귀환회기 방식을 기반으로 하는 기존의 전송률 제어 방법에 비하여, 제안된 방법은 전송비트 제어용 전역모델을 설정하고 이를 최적으로 제어할 수 있는 SOFM기반 신경망 분류기를 이용하여 영상특성 변화에 적극적인 대처를 할 수 있다. 제안된 전송률 제어 알고리즘은 기존의 MPEG-4 매크로블록 기반 전송률 제어 알고리즘에 비해 전체 연산 복잡도는 비슷하게 유지하면서 피크신호 대 잡음비의 비교에 있어서 0.2 dB ~ 0.6 dB 정도 성능이 우수함을 확인하였다.

• Journal of Microbiology and Biotechnology
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• 제29권7호
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• pp.1137-1143
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• 2019

Hepatitis E virus (HEV) accounts for 20 million infections in humans worldwide. In most cases, the infections are self-limiting while HEV genotype 1 infection cases may lead to lethal infections in pregnant women (~ 20% fatality). The lack of small animal models has hampered detailed analysis of virus-host interactions and HEV-induced pathology. Here, by employing a recently developed culture-adapted HEV, we demonstrated that methyltransferase, a non-structural protein, strongly inhibits melanoma differentiation-associated gene 5 (MDA5)-mediated activation of type I interferon responses. Compared to uninfected controls, HEV-infected cells display significantly lower levels of $IFN-{\beta}$ promoter activation when assessed by luciferase assay and RT-PCR. HEV genome-wide screening showed that HEV-encoded methyltransferase (MeT) strongly inhibits MDA5-mediated transcriptional activation of $IFN-{\beta}$ and $NF-{\kappa}B$ in a dose-responsive manner whether or not it is expressed in the presence/absence of a tag fused to it. Taken together, current studies clearly demonstrated that HEV MeT is a novel antagonist of MDA5-mediated induction of $IFN-{\beta}$ signaling.

• 대한치과기공학회지
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• 제27권1호
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• pp.131-153
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• 2005

The purpose of this study was to identify the accidents happened in the college dental laboratory technique classes and to realize the level of safety education for the dental laboratory technique major students. The research data were collected from a self-administered survey distributed to the conveniently selected college students whose majors were dental laboratory technology in Suwon, Daejeon, Daegu, Kimcheon, and Icsan. The study participants were 422 freshmen, sophomore and junior students in the selected cities. All collected survey responses were encoded and analyzed in SPSS 12.0. The findings were as follows. 1. The students who had any accidents in their laboratory classes were 36% and the other 64% answered 'no.' 2. Most injuries which the participants had were not significant. 3. The medical treatment periods of most injury cases were less than one week; however, approximately 20% of the self-reported injury cases reported that their treatment periods were longer than one week. 4. The body parts frequently injured from accidents were hands with 84.7% and arms, eyes, face, head, and legs in order. 5. Concerning the materials involved in the laboratory classes, most accidents happened when working with wax in 59.9%, with plaster in 52.3%, with wire in 39.8%, with alcohol in 34.6%, and casting iron in 22.2% in order. 6. The accident-prone laboratory methods were polishing with 53.5%, pickling or sanding with 17.4%, and casting or burning with 5.8% in order. 7. Most students wore their laboratory gowns well; however, few students wore mask before dust-involved jobs. Furthermore, only 57.1% students answered their laboratory fans worked during the polishing job. 8. Approximately 54% participant students answered that they took laboratory safety education when necessary only from the class instructors. 9. The 76.1% students responded that they needed laboratory safety education at least 1-2 times every semester. 10. The survey participants answered that the primary factors for injury prevention in their laboratory were taking safety education, wearing safety equipments, and providing safety-focused facilities. Concludingly, comprehensive evaluation and monitoring for potential risk factors from both the human side and the environment side should be continually provided to minimize the college laboratory accidents.

• Molecules and Cells
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• 제42권7호
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• pp.503-511
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• 2019

As sessile organisms, plants have developed sophisticated system to defend themselves against microbial attack. Since plants do not have specialized immune cells, all plant cells appear to have the innate ability to recognize pathogens and turn on an appropriate defense response. The plant innate immune system has two major branches: PAMPs (pathogen associated molecular patterns)-triggered immunity (PTI) and effector-triggered immunity (ETI). The ability to discriminate between self and non-self is a fundamental feature of living organisms, and it is a prerequisite for the activation of plant defenses specific to microbial infection. Arabidopsis cells express receptors that detect extracellular molecules or structures of the microbes, which are called collectively PAMPs and activate PTI. However, nucleotidebinding site leucine-rich repeats (NB-LRR) proteins mediated ETI is induced by direct or indirect recognition of effector molecules encoded by avr genes. In Arabidopsis, plasmamembrane localized multifunctional protein RIN4 (RPM1-interacting protein 4) plays important role in both PTI and ETI. Previous studies have suggested that RIN4 functions as a negative regulator of PTI. In addition, many different bacterial effector proteins modify RIN4 to destabilize plant immunity and several NB-LRR proteins, including RPM1 (resistance to Pseudomonas syringae pv. maculicola 1), RPS2 (resistance to P. syringae 2) guard RIN4. This review summarizes the current studies that have described signaling mechanism of RIN4 function, modification of RIN4 by bacterial effectors and different interacting partner of RIN4 in defense related pathway. In addition, the emerging role of the RIN4 in plant physiology and intercellular signaling as it presents in exosomes will be discussed.

• 한국정보통신학회논문지
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• 제15권12호
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• pp.2641-2646
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• 2011

본 논문에서는 Haar Wavelet Transform(HWT)에 기반한 EZW 알고리즘을 적용하여 효율성 있는 영상 압축방법을 제시하였다. 제안된 Haar-EZW 알고리즘은 입력 영상을 자기유사성이 있는 상관관계를 사용한 HWT 계수를 이용하여 제로트리 부호화하는 코딩방법이다. HWT 계수가 임계값보다 크면 POS로 부호화되고, 임계값보다 작다면 NEG로 부호화된다. HWT 계수가 제로트리의 제곱근보다 크다면 ZTR로 부호화되고, HWT 계수가 임계값보다 적고 제로트리의 제곱근이 아니라면 IZ로 부호화된다. 모든 HWT 계수가 완전하게 부호화돨 때까지 이 프로세스는 반복된다. 본 논문에서는 제안된 Haar-EZW 알고리즘을 Daubechies, Antonini와 비교하였다. 그 결과로 Haar-EZW 알고리즘의 PSNR이 Daubechies, Antonini보다 우수한 것으로 나타났다.

• 보건교육건강증진학회지
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• 제22권4호
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• pp.41-56
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• 2005

Objectives: More than 80% of unintentional injury was related to risk-taking behaviors involved in child accidents. Therefore, diverse care and concerns on safety should be provided from teachers as well as parents to build child safety behaviors. The purpose of this study was to identify the effects of safety concerns from students, teachers, and parents on elementary students' safety behaviors in Korea. Methods: The 5th and 6th grade students participated in this study in 14 elementary schools in Korea and the total number of students was 1,033. The study schools were selected by the stratified cluster sampling method throughout 7 metropolitan areas in Korea. Data were collected by the self-administered survey and the questionnaires were delivered to the vice-principals of the designated schools by ground postal service and the vice-principals conducted survey data collection. The questions on students' safety concerns, teachers' safety concerns, parents' safety concerns, safety practices, safety education, and demographics were included in the survey. All survey responses were encoded into SPSS program and t-test, ANOVA, and multiple regression analysis were utilized. Results: The students taking accidents one time more per year were more than 60% and the two thirds of them recognized that their accidents were due to their risk behaviors. Parents' education on safety practices was more frequent than teachers' education; furthermore, teachers' concerns on safety behaviors were poorer than students' or parents' concerns. In terms of safety behaviors, the scores of fire and home-related safety behavior were high but the scores of traffic and bicycle, in particular, helmet wearing practice were low. Three concerns from students, parents, and teachers all were significantly related to children's safety behaviors. Conclusions: In conclusion, safety concerns from the close networks are the important indicator of child safety behaviors and, the safety training programs, therefore, for parents and teachers as well as for students need to be developed for improving children's safe behaviors.

• 융합보안논문지
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• 제9권2호
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• pp.79-84
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• 2009

현재의 동영상 파일은 WMV(Window Media Video)형식과 같은 극일 포맷과 압축 기술들이다. 이 같은 파일 포맷과 압축 기술을 이용한 동영상들은 화질과 압축율에 문제점을 가지고 있다. 이에 본 논문은 Macromedia(Adobe 사가 인수함)사에서 개발한 FLV(Flash Video)와는 다른 FLY 솔루션 EZ-MOV를 설계 및 구현하였다. EZ-MOV는 다음과 같은 장점들을 가지고 있다. 첫째, FLV플레이어가 배속이 가능하며 자체 DRM이 내장 죄어 있어서 불법 녹화가 불가능하고 둘째, WMV 형식 파일을 FLV로 인코딩시에 최대한 50%까지 무손실로 압축이 가능하며 셋째, 버퍼링 없는 동영상 스트리밍이 가능하다. 넷째, 스트리밍 서버 없이도 FLV 파일을 스트리밍으로 서비스가 가능하다. 다섯째, 다운로드와 스트리밍을 병행한 동영상 서비스도 가능하다. 여섯째, 양방향으로의 서비스도 가능하다.

• 대한전기학회논문지:시스템및제어부문D
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• 제51권1호
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• pp.8-17
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• 2002

This paper suggests that the immune algorithm can effectively be used in tuning of a PID controller. The artificial immune network always has a new parallel decentralized processing mechanism for various situations, since antibodies communicate to each other among different species of antibodies/B-cells through the stimulation and suppression chains among antibodies that form a large-scaled network. In addition to that, the structure of the network is not fixed, but varies continuously. That is, the artificial immune network flexibly self-organizes according to dynamic changes of external environment (meta-dynamics function). However, up to the present time, models based on the conventional crisp approach have been used to describe dynamic model relationship between antibody and antigen. Therefore, there are some problems with a less flexible result to the external behavior. On the other hand, a number of tuning technologies have been considered for the tuning of a PID controller. As a less common method, the fuzzy and neural network or its combined techniques are applied. However, in the case of the latter, yet, it is not applied in the practical field, in the former, a higher experience and technology is required during tuning procedure. In addition to that, tuning performance cannot be guaranteed with regards to a plant with non-linear characteristics or many kinds of disturbances. Along with these, this paper used immune algorithm in order that a PID controller can be more adaptable controlled against the external condition, including moise or disturbance of plant. Parameters P, I, D encoded in antibody randomly are allocated during selection processes to obtain an optimal gain required for plant. The result of study shows the artificial immune can effectively be used to tune, since it can more fit modes or parameters of the PID controller than that of the conventional tuning methods.

• 대한치과기공학회지
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• 제27권1호
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• pp.115-129
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• 2005

The purpose of this study was to identify injury characteristics happened in the college dental laboratory technique classes and to provide the empirical accident findings for safety education development for the college dental technology classes. The research data were collected from a self-administered survey distributed to the conveniently selected college students. The study participants were 476 freshmen, sophomore and junior students whose major was the dental laboratory technology of the 4 colleges in 2 metropolitan cities and 2 medium-size cities. All collected survey responses were encoded and analyzed in SPSS 12.0. The findings were as follows. The accidents happened to the college students during the dental laboratory technology classes: 1. The accident rate was the highest in the sophomore and the freshmen, junior in order. 2. The body parts frequently injured were hands, face, eyes, arms, and legs in order. 3. The frequent injury types were cut, burnt, stuck, wound, and suffocated in order. 4. The treatment methods for their accidents were the simple first-aids, no treatment, and the emergency room visits in order. 5. The laboratory training conditions inducing the accidents were significantly frequent under wire-related, and wax-related, iron-related, alcohol-related jobs in order, but not frequent in investing material-related, porcelain-related, resin-related, and agar-related jobs. Polishing was the most accident-prone job explaining 63% of the laboratory accidents and then, model producing, wax patterning, casting, burning, and investing jobs in order. In summary, the college dental laboratory accidents had the certain patterns by the training level and by the material or machine involved in each class. Thus, the planned and organized safety education programs should be produced and investigated for college students before their major laboratory classes.

• Biomolecules & Therapeutics
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• 제17권2호
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• pp.156-161
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• 2009

The human cytochrome P450 4A11 is the major monooxygenase to oxidize the fatty acids and arachidonic acid. The production of 20-hydroxyeicosatetraenoic acid by P450 4A11 has been implicated in the regulation of vascular tone and blood pressure. Oxidation reaction by P450 4A11 requires its reduction partners, NADPH-P450 reductase (NPR). We report the functional expression in Escherichia coli of bicistronic constructs consisting of P450 4A11 encoded by the first cistron and the electron donor protein, NPR by the second. Typical P450 expression levels of wild type and several N-terminal modified mutants was observed in culture media and prepared membrane fractions. The expression of functional NPR in the constructed P450 4A11: NPR bicistronic system was clearly verified by reduction of nitroblue tetrazolium. Membrane preparation containing P450 4A11 and NPR efficiently oxidized lauric acid mainly to $\omega$-hydroxylauric acid. Bicistronic coexpression of P450 4A11 and NPR in E. coli cells can be extended toward identification of novel drug metabolites or therapeutic agents involved in P450 4A11 dependent signal pathways.