• Molecules and Cells
• /
• v.40 no.5
• /
• pp.322-330
• /
• 2017

This study investigated the role of cancer/testis antigen DDX53 in regulating cancer stem cell-like properties. DDX53 shows co-expression with CD133, a marker for cancer stem cells. DDX53 directly regulates the SOX-2 expression in anti-cancer drug-resistant $Malme3M^R$ cells. DDX53 and miR-200b were found to be involved in the regulation of tumor spheroid forming potential of Malme3M and $Malme3M^R$ cells. Furthermore, the self-renewal activity and the tumorigenic potential of $Malme3M^R$-CD133 (+) cells were also regulated by DDX53. A miR-200b inhibitor induced the direct regulation of SOX-2 by DDX53 We therefore, conclude that DDX53 may serve as an immunotherapeutic target for regulating cancer stem-like properties of melanomas.

• International Journal of Advanced Culture Technology
• /
• v.10 no.4
• /
• pp.403-411
• /
• 2022

Appearance management is evolving as a means of self-expression or as a way of expressing one's individuality. In particular, hairstyle is the most important part of a person's appearance and accounts for 70% of the appearance. Improving people's appearance by changing their hairstyle gives them confidence. Among them, the fringe hair style plays an important role in determining the first impression and reflects the trend. Fringe is shorter and simpler than general hair treatment, but even these small treatments have the effect of changing the impression, so women are trying to transform into a fringe hair style. A previous study was conducted on four lines classified: round, heart, square, and triangular. In this study, we added them to define 5 hairlines and created them by combining each hairline. that have been produced 5 fringe hair styles that suit the shape of the face. It is expected that the results of this study will be used as educational materials for hair line and fringe hair styles in the field, contributing to the beauty industry.

• Electronics and Telecommunications Trends
• /
• v.39 no.1
• /
• pp.74-82
• /
• 2024

Music is a means of emotional expression and self-expression. In addition, it allows to interact with others and communicate with the world. Music may be considered as inaccessible for people with hearing impairment, who are sometimes discriminated from the music community. We explore trends in various technologies and research that enable everyone to access and enjoy music through experiences that leverage new and innovative technological approaches and bridge the gap between people with and without hearing impairment. Various aspects of haptic systems are being studied, but most of them are performance-oriented and focus only on technical functions. As research matures, more detailed and new studies that converge with various senses are being attempted. These studies will likely evolve into influential research areas that can positively affect the lives of people in terms of accessibility and inclusion by providing detailed functions and stimuli to specific users, including those with hearing impairment.

• Korean Institute of Interior Design Journal
• /
• v.21 no.4
• /
• pp.138-145
• /
• 2012

The epidermal color is one of factors the space for ages. Instead of the epidermal color expression, it made with material and decoration under structure for make shade of meaning before have the new media. But now a days, the epidermal color of the fashion store is getting free owe to the development of color harmony, has a great notion that gets out of the subordinate from color, and it is a emphasized factor with expression and self-control. The epidermal color of the fashion store makes an effort to accept the development and changing of new media. It should show that there role and function is changing constantly according to a new technology, and it gave a motivation for reanalysis about existence and expression of the epidermal color. The purpose of this research is that look around the feature of the epidermal color system, elements, and principle. Then contemporary fashion store is expressive characteristics of epidermal color. Using epidermal color is not common, we can find lots of the case with surface color, layer color, interface color, though. The paper reflects on the meaning and concept of fashion store which enables the application of expressive characteristics on space through advanced technology. Meanwhile, the features of epidermal color such as immateriality of process and communication can be inferred from case analysis.

• Asian-Australasian Journal of Animal Sciences
• /
• v.25 no.10
• /
• pp.1473-1480
• /
• 2012

The Galactose-${\alpha}1$,3-galactose (${\alpha}1$,3Gal) epitope is responsible for hyperacute rejection in pig-to-human xenotransplantation. Human decay-accelerating factor (hDAF) is a cell surface regulatory protein that serves as a complement inhibitor to protect self cells from complement attack. The generation of ${\alpha}1$,3-galactosyltransferase (GGTA1) knock-out pigs expressing DAF is a necessary step for their use as organ donors for humans. In this study, we established GGTA1 knock-out cell lines expressing DAF from pig ear fibroblasts for somatic cell nuclear transfer. hDAF expression was detected in hDAF knock-in heterozygous cells, but not in normal pig cells. Expression of the GGTA1 gene was lower in the knock-in heterozygous cell line compared to the normal pig cell. Knock-in heterozygous cells afforded more effective protection against cytotoxicity with human serum than with GGTA1 knock-out heterozygous and control cells. These cell lines may be used in the production of GGTA1 knock-out and DAF expression pigs for xenotransplantation.

• Journal of Korean Academy of Nursing
• /
• v.44 no.4
• /
• pp.437-445
• /
• 2014

Purpose: This study was done to identify pain perception (P-PER) by nurses and pain expression (P-EXP) by patients in critical care units (ICUs) and degree of agreement between nurses' P-PER and patients' P-EXP. Methods: Nurses' P-PER was measured with a self-administered questionnaire completed by 99 nurses working in ICUs during May, 2013. Patients' P-EXP was measured with the Critical Care Non-Verbal Pain Scale through observations of 31 ICU patients during nine nursing procedures (NPs) performed between May and July, 2013. Results: Nurses' P-PER was from 4.49 points for nasogastric tube (NGT) insertion to 0.83 for blood pressure (BP) measurement based on a 9-point scale, Patients' P-EXP was 4.48 points for NGT to 0.18 for BP measurement based on a 10-point scale. Eight NPs except oral care showed higher scores for nurses' P-PER than for patients' P-EXP. Position change (p=.019), subcutaneous injection (p<.001), blood sugar test (p<.001), and BP measurement (p<.001) showed significant differences between nurses' P-PER and patients' P-EXP. Conclusion: Nasogastric tube (NGT) insertion was scored highest by both nurses and patients. Eight NPs except 'oral care' showed nurses' P-PER was higher or similar to patients' P-EXP, which indicates that nurses may overestimate procedural pain experienced by patients.

• Korean Institute of Interior Design Journal
• /
• v.20 no.3
• /
• pp.119-126
• /
• 2011

Recently, in the fields of fashion, advertisement, film, literature, philosophy, etc., the word, 'Nomad', is being used frequently across the overall society. The contemporary society is actively incorporating "nomadic thinking" as a new social phenomenon across the boundaries of conventional fields. This is not an exception in the field of space design. This study, via the contemporary nomadic thinking, examined the relationship between space design's application possibility as a new trend and flexible space; then categorized the characteristics of flexible space into flexibility, temporariness, changeability, and correlation; and then analyzed expression characteristics of flexible space. As for unrestricted expression of scene, it was recognized that separation of scene and space leads space to meet the needs of surrounding environment and users; formation of changeable space enables uses of space from various perspectives; and combining external factors (energy, media technologies) with space leads space to self-evolution. Space is perceived as an living organism that is flexibly corresponding, via realistic movement and virtual movement, to the indefinite, diversified thinking of the contemporary society. Therefore, this study illuminates that nomadic thinking has significance as basic thinking to predict development and characteristics of design thinking through understanding the contemporary society with the basic thinking system that has been inherent without restrictions of being fixed to the present, past, and future.

• Korean Institute of Interior Design Journal
• /
• v.16 no.2 s.61
• /
• pp.163-171
• /
• 2007

The present study approached the characteristics of various space compositions in contemporary residential architecture through the concept of ex-formality, and found that ex-formal spaces are composed through the variation of floor, wall, ceiling or roof and derived four types of ex-formal space composition - ex-cubic space composition using folding, plastic space composition using the plasticity of concrete, atypical space composition using geometric manipulation, and non linear space composition using digital technology. Based on this, additionally, we derived elements expressing the characteristics of ex-formal space composition, which are obliqueness, inclination, flexibility in ex-cubic space composition using folding, plasticity and fluidity in plastic space composition using the plasticity of concrete, ex-construction, dynamism and asymmetry in atypical space composition using geometric manipulation, and flexibility, fluidity, self similarity and plasticity in non linear space composition using digital technology. On the other hand, this study purposed to help understand various space expression patterns of contemporary residential architecture by analyzing how these types of ex-formal space composition and polysemous expression characteristics have been represented in contemporary residential architecture since the 1990s.

• Journal of the Korean Society of Tobacco Science
• /
• v.21 no.1
• /
• pp.77-81
• /
• 1999

Tobacco plants(Nicotiana tabacum cv. NC82) transformed with TMV CP cDNA were self-fertilized until 8th generation (R$_{8}$), and the transgenic plants from 6th to 8th generation were analized for their resistance to tobacco mosaic virus(TMV) and stability of the gene expression. The 6th generation of the plants(R$_{6}$) showed high resistance(81-91 %) to TMV at eight weeks after artificial inoculation with the virus. The transgenic cell line 601 was the most prominant in the expression of resistance. 98 % of the plants showed no symptom without any agronomic phynotepe variation when they were inoculated with the virus in a experimental field. However, 2% of the plants were revealed as delay type of symptom with mild mosaic on a few leaves. The viral resistance in greenhouse tests of the 7th generation (R$_{7}$) was 54-64%, and the number of delay type plants were increased than that of 6th generation plants. In the 8th generation, 81 % of the plants was complete resistant to the virus. The TMV CP cDNA of the transgenic plants of each generation was also confirmed by genomic PCR, and there was no systemic viral multiplication in the resistant plants. It suggests that the viral resistance and gene expression of the transgenic plants might be stable through the generations.ons.s.

• Korean Institute of Interior Design Journal
• /
• no.33
• /
• pp.19-26
• /
• 2002

This study analyzed the characteristics of spatial expression in the Barcelona Pavilion to be based on tectonics. Mies pointed out the image of materiality about the material rather than the process of tectonics using the material, and he also expressed demateriality in the image of each material through the reflection. To be liberated from structural matters, the wall has been introduced. He intended to show the design plan as the independent structural system, however, the wall actually seems to be supporting the roof that shows rather clearly self-contradictory because of the expression of materiality in the material. In terms of architectural elements; wall, roof, column, floor, and so forth, tectonic expression and abstract aesthetics stands face to face, because of hiding the productional process and transforming to line and surface in the image of materiality. The interior of the glass wall seems fairly closed space from the exterior, because materiality and reflection of materials of columns and podium. The character of experiential space is inconsistent and fragmentary because of the splendid images from maternality and reflection on the wall, and collision with the reality and the image the wall reflects, even though the geometrical space of the Pavilion's plan has the mutual penetrability and organic character.